TALLIE Z Z BARAM

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects
    Kristina A Fenoglio
    Department of Anatomy Neurobiology, University of California at Irvine, 92697 4475, USA
    Front Neuroendocrinol 27:180-92. 2006
  2. pmc Tuning synaptic transmission in the hippocampus by stress: the CRH system
    Yuncai Chen
    Departments of Pediatrics, Anatomy Neurobiology, and Neurology, University of California Irvine, Irvine CA, USA
    Front Cell Neurosci 6:13. 2012
  3. pmc Fragmentation and unpredictability of early-life experience in mental disorders
    Tallie Z Baram
    Department of Pediatrics, School of Medicine, University of California, Irvine, Calif, USA
    Am J Psychiatry 169:907-15. 2012
  4. pmc Is neuronal death required for seizure-induced epileptogenesis in the immature brain?
    Tallie Z Baram
    Departments of Pediatrics, Anatomy, Neurobiology and Neurology, University of California at Irvine, Irvine, CA 92697 4475, USA
    Prog Brain Res 135:365-75. 2002
  5. pmc What are the reasons for the strikingly different approaches to the use of ACTH in infants with West syndrome?
    T Z Baram
    Department of Pediatrics, ZOT 4475, University of California at Irvine, Irvine, CA 92697 4475, USA
    Brain Dev 23:647-8. 2001
  6. pmc Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists
    T Z Baram
    Department of Anatomy Neurobiology, University of California at Irvine, CA 92697 4475, USA
    Dev Neurosci 21:281-9. 1999
  7. pmc The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
    T Z Baram
    Department of Pediatrics, University of California, Irvine 92697 4475, USA
    Brain Res 770:89-95. 1997
  8. pmc Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors
    Autumn S Ivy
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 4475, USA
    J Neurosci 30:13005-15. 2010
  9. pmc Stress and the developing hippocampus: a double-edged sword?
    Kristen L Brunson
    Department of Anatomy and Neurobiology, University of CA at Irvine, Irvine, CA 92697, USA
    Mol Neurobiol 27:121-36. 2003
  10. pmc Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner
    Amy Brewster
    Departments of Anatomy Neurobiology, Pediatrics, and Neurology, University of California at Irvine, Irvine, California 92697 4475
    J Neurosci 22:4591-9. 2002

Research Grants

Collaborators

Detail Information

Publications52

  1. pmc Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects
    Kristina A Fenoglio
    Department of Anatomy Neurobiology, University of California at Irvine, 92697 4475, USA
    Front Neuroendocrinol 27:180-92. 2006
    ..We review the cellular mechanisms involved and discuss the roles of stress-mediating molecules, including corticotropin releasing hormone, in the process by which stress impacts the structure and function of hippocampal neurons...
  2. pmc Tuning synaptic transmission in the hippocampus by stress: the CRH system
    Yuncai Chen
    Departments of Pediatrics, Anatomy Neurobiology, and Neurology, University of California Irvine, Irvine CA, USA
    Front Cell Neurosci 6:13. 2012
    ..Thus, the acute effects of CRH may contribute to stress-induced adaptive mechanisms, whereas chronic or excessive exposure to the peptide may promote learning problems and premature cognitive decline...
  3. pmc Fragmentation and unpredictability of early-life experience in mental disorders
    Tallie Z Baram
    Department of Pediatrics, School of Medicine, University of California, Irvine, Calif, USA
    Am J Psychiatry 169:907-15. 2012
    ..Similar variability and inconsistency of maternal signals during both gestation and early postnatal human life may influence development of emotional and cognitive functions, including those that underlie later depression and anxiety...
  4. pmc Is neuronal death required for seizure-induced epileptogenesis in the immature brain?
    Tallie Z Baram
    Departments of Pediatrics, Anatomy, Neurobiology and Neurology, University of California at Irvine, Irvine, CA 92697 4475, USA
    Prog Brain Res 135:365-75. 2002
    ....
  5. pmc What are the reasons for the strikingly different approaches to the use of ACTH in infants with West syndrome?
    T Z Baram
    Department of Pediatrics, ZOT 4475, University of California at Irvine, Irvine, CA 92697 4475, USA
    Brain Dev 23:647-8. 2001
    ..These issues should not detract from the overall agreement that ACTH might be the most useful medication currently available to treat WS...
  6. pmc Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists
    T Z Baram
    Department of Anatomy Neurobiology, University of California at Irvine, CA 92697 4475, USA
    Dev Neurosci 21:281-9. 1999
    ..If 'excess' CRH is involved in the pathogenesis of IS, then blocking CRH receptors should eliminate both seizures and the excitotoxicity of CRH-receptor-rich neurons subserving learning and memory...
  7. pmc The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist
    T Z Baram
    Department of Pediatrics, University of California, Irvine 92697 4475, USA
    Brain Res 770:89-95. 1997
    ..Taken together, these facts strongly support the role of the developmentally regulated CRF1 receptor in mediating the convulsant effects of CRF in the developing brain...
  8. pmc Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors
    Autumn S Ivy
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, California 92697 4475, USA
    J Neurosci 30:13005-15. 2010
    ..Reducing CRF(1) occupancy post hoc normalized hippocampal function during middle age, thus offering potential mechanism-based therapeutic interventions for children affected by chronic stress...
  9. pmc Stress and the developing hippocampus: a double-edged sword?
    Kristen L Brunson
    Department of Anatomy and Neurobiology, University of CA at Irvine, Irvine, CA 92697, USA
    Mol Neurobiol 27:121-36. 2003
    ..We highlight the physiological and pathological roles of this peptide in the developing hippocampus, and their relevance to the long-term effects of early-life experience on cognitive function during adulthood...
  10. pmc Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner
    Amy Brewster
    Departments of Anatomy Neurobiology, Pediatrics, and Neurology, University of California at Irvine, Irvine, California 92697 4475
    J Neurosci 22:4591-9. 2002
    ..These changes result in long-lasting alteration of the HCN phenotype of specific hippocampal neuronal populations, with profound consequences on the excitability of the hippocampal network...
  11. pmc Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis
    Celine Dube
    Department of Anatomy Neurobiology, University of California, Irvine, CA 92697 4475, USA
    Brain 129:911-22. 2006
    ....
  12. pmc Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation
    Benno Roozendaal
    Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 99:13908-13. 2002
    ..These findings indicate that activation of CRH receptors in the BLA, likely by training-induced release of endogenous peptide originating from the CEA, participates in mediating stress effects on memory consolidation...
  13. pmc Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression
    Kristina A Fenoglio
    19182 Jamboree Boulevard, University of California, Irvine, Med Sci I Room B160, Irvine, California 92697 4475, USA
    Endocrinology 145:2702-6. 2004
    ....
  14. pmc Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling
    Yuncai Chen
    Department of Pediatrics, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 107:13123-8. 2010
    ..In addition, establishing the contribution of hippocampal CRH-CRFR(1) signaling to these processes highlights the complexity of the orchestrated mechanisms by which stress impacts hippocampal structure and function...
  15. pmc Plasticity of the stress response early in life: mechanisms and significance
    Aniko Korosi
    Department of Anatomy Neurobiology, Pediatrics and Neurology, UC Irvine, CA 92697, USA
    Dev Psychobiol 52:661-70. 2010
    ..Here, we discuss the nature and mechanisms of this programming phenomenon, focusing on work from our lab that was inspired by Seymour Levine and his fundamental contributions to the field...
  16. pmc Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures
    Roland A Bender
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 4475, USA
    Hippocampus 13:399-412. 2003
    ....
  17. pmc Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone
    Yuncai Chen
    Departments of Pediatrics and Anatomy Neurobiology, University of California Irvine, Irvine, California 92697 4475, USA
    J Neurosci 28:2903-11. 2008
    ..In addition, mice lacking the CRFR(1) receptor had augmented spine density. These findings support a mechanistic role for CRH-CRFR(1) signaling in stress-evoked spine loss and dendritic remodeling...
  18. pmc Epileptogenesis in the developing brain: what can we learn from animal models?
    Roland A Bender
    Department of Pediatrics and Anatomy, University of California at Irvine, Irvine, California 92697 4475, USA
    Epilepsia 48:2-6. 2007
    ....
  19. pmc Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers
    Céline M Dubé
    Department of Anatomy and Neurobiology, University of California, Irvine, California 92697, USA
    J Neurosci 30:7484-94. 2010
    ....
  20. pmc A novel mouse model for acute and long-lasting consequences of early life stress
    Courtney J Rice
    Department of Anatomy and Neurobiology, Med Sci I, ZOT 4475, University of California, Irvine, Irvine, California 92697 4475, USA
    Endocrinology 149:4892-900. 2008
    ..This model should facilitate the examination of the specific genes and molecules involved in the generation of this stress as well as in its consequences...
  21. pmc Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor
    Kristina A Fenoglio
    Department of Anatomy Neurobiology, Med Sci I, ZOT 4475, University of California, Irvine, California 92697 4475, USA
    Endocrinology 146:4090-6. 2005
    ..Thus, the extent of CRF1 activation, probably involving changes in hypothalamic CRF levels and release, contributes to the changes in hippocampal GR expression and learning and memory functions...
  22. pmc Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain
    Kristen L Brunson
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697, USA
    Exp Neurol 176:75-86. 2002
    ....
  23. pmc Stressed-out, or in (utero)?
    Sarit Avishai-Eliner
    Dept of Anatomy and Neurobiology, University of California at Irvine, 92697, USA
    Trends Neurosci 25:518-24. 2002
    ..Importantly, these CRH-mediated processes could be targets of preventive and interventional strategies...
  24. pmc Neuroplasticity of the hypothalamic-pituitary-adrenal axis early in life requires recurrent recruitment of stress-regulating brain regions
    Kristina A Fenoglio
    Department of Anatomy Neurobiology, University of California, Irvine, California 92697 4475, USA
    J Neurosci 26:2434-42. 2006
    ..These studies provide a neurobiological foundation for the profound neuroplasticity of stress-related genes evoked by early-life experience...
  25. pmc Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus
    Roland A Bender
    Department of Anatomy, University of California, Irvine, Irvine, California 92697, USA
    J Neurosci 23:6826-36. 2003
    ....
  26. pmc Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus
    Yuncai Chen
    Departments of Anatomy Neurobiology and Pediatrics, University of California, Irvine, CA 92697 4475
    Proc Natl Acad Sci U S A 101:15782-7. 2004
    ..Taken together, these findings suggest that endogenous CRF, if released excessively by previous early postnatal stress, might influence neuronal connectivity and thus function of the immature hippocampus...
  27. pmc Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death
    Celine Dube
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697 4475, USA
    Ann Neurol 56:709-14. 2004
    ..Although these changes do not signify cell death, they may denote pathological cellular processes that promote epileptogenesis. ...
  28. pmc Cognitive dysfunction after experimental febrile seizures
    Céline M Dubé
    Department of Pediatrics, ZOT 4475, University of California, Irvine 92697 4475, USA
    Exp Neurol 215:167-77. 2009
    ....
  29. pmc Febrile seizures: mechanisms and relationship to epilepsy
    Céline M Dubé
    Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA 92697 4475, USA
    Brain Dev 31:366-71. 2009
    ..These may provide novel drug targets for intervention in the epileptogenic process...
  30. pmc Febrile seizures and mechanisms of epileptogenesis: insights from an animal model
    Roland A Bender
    Department of Anatomy, University of California at Irvine, USA
    Adv Exp Med Biol 548:213-25. 2004
    ..The contribution of these consequences of febrile seizures to the epileptogenic process is discussed...
  31. pmc Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone
    Aniko Korosi
    Anatomy Neurobiology and Pediatrics, University of California Irvine, Irvine, California 92697, USA
    J Neurosci 30:703-13. 2010
    ....
  32. pmc Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold
    Celine Dube
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, CA 92697, USA
    J Mol Neurosci 25:275-84. 2005
    ....
  33. pmc Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death
    Patrick G Sullivan
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA 92697 4475, USA
    Ann Neurol 53:711-7. 2003
    ..This mechanism offers novel neuroprotective strategies for individuals, greater than 1% of the world's population, who are affected by seizures...
  34. pmc Mechanisms of late-onset cognitive decline after early-life stress
    Kristen L Brunson
    Department of Anatomy Neurobiology, University of California, Irvine, California 92697 4475, USA
    J Neurosci 25:9328-38. 2005
    ....
  35. pmc Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation
    Qinqin Zha
    Department of Pediatrics, University of California, Irvine, Irvine, California 92697 4475, USA
    J Neurochem 105:68-77. 2008
    ..Thus, hippocampal HCN1 molecules have a significantly higher probability of being glycosylated after SA, and this might promote a stable heteromerization with HCN2...
  36. pmc Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels
    Cristina Richichi
    Department Anatomy and Neurobiology, University of California, Irvine, CA 92697 4475, USA
    Neurobiol Dis 29:297-305. 2008
    ..The data demonstrate an orchestrated program for seizure-evoked transcriptional channelopathy involving the HCN channels that may contribute to certain epilepsies...
  37. pmc Interleukin-1beta contributes to the generation of experimental febrile seizures
    Celine Dube
    Department of Anatomy and Neurobiology, University of California at Irvine, Medical Science I, ZOT 4475, Irvine, CA 92697 4475, USA
    Ann Neurol 57:152-5. 2005
    ..These data indicate that IL-1beta signaling contributes critically to fever-induced hyperexcitability underlying FS, constituting a potential target for their prevention...
  38. pmc Fever, febrile seizures and epilepsy
    Céline M Dubé
    Department of Anatomy Neurobiology, University of California at Irvine, ZOT 4475, Irvine, CA 92697 4475, USA
    Trends Neurosci 30:490-6. 2007
    ....
  39. pmc Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels
    Kristen L Brunson
    Departments of Anatomy Neurobiology and Pediatrics, University of California at Irvine, Irvine, CA 92697 4475, USA
    Hippocampus 15:491-501. 2005
    ..Specifically, chronic modulation of glucocorticoid levels commencing early in life evokes additional, adaptive, and compensatory mechanisms that contribute to the regulation of granule cell proliferation...
  40. pmc Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures
    Amy L Brewster
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697 4475, USA
    Neurobiol Dis 19:200-7. 2005
    ..These data suggest that heteromeric HCN channels may provide molecular targets for intervention in the epileptogenic process...
  41. pmc Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons
    Yoav Noam
    Department of Pediatrics, University of California, Irvine, California 92697, USA
    J Biol Chem 285:14724-36. 2010
    ....
  42. pmc Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation
    Roland A Bender
    Department of Anatomy, University of California, Irvine, Irvine, California 92697 4475, USA
    J Neurosci 27:4697-706. 2007
    ..These findings support a novel developmentally regulated axonal transport of functional ion channels and suggest a role for HCN1 channel-mediated presynaptic I(h) in hippocampal maturation...
  43. pmc The central corticotropin releasing factor system during development and adulthood
    Aniko Korosi
    Department of Anatomy, University of California Irvine, Irvine, CA 92697 4475, USA
    Eur J Pharmacol 583:204-14. 2008
    ..Uniquely during development, the cardinal influence of maternal care on the central stress response governs the levels of central CRH expression, and may alter the 'set-point' of CRH-gene sensitivity to stress in a lasting manner...
  44. pmc Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus
    Amy L Brewster
    Department of Anatomy, University of California, Irvine, CA 92697 4475, USA
    Cereb Cortex 17:702-12. 2007
    ..In addition, these evolving, differential quantitative, and subcellular expression patterns of the HCN channel isoforms support age-specific properties and functions of I(h) within the developing hippocampal formation...
  45. pmc Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function
    Roland A Bender
    Departments Pediatrics, Anatomy and Neurobiology, University of California, Irvine, CA 92697 4475, USA
    Eur J Neurosci 22:2669-74. 2005
    ..These findings support a pivotal role for HCN channels expressed by CA3 neurons, and particularly CA3 pyramidal cells, in GDP-related network synchronization...
  46. pmc Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy
    Mira Kuisle
    Department of Pharmacology and Neurobiology, Klingelbergstr 70, CH 4056 Basel, Switzerland
    J Physiol 575:83-100. 2006
    ..Weakened cAMP binding to HCN channels precedes, and likely promotes, epileptogenesis in GAERS, whereas compensatory mechanisms stabilizing Ih function contribute to the termination of spike-and-wave discharges in chronic epilepsy...
  47. pmc Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus
    Rainer Surges
    Department of Neurology, University Clinics Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Eur J Neurosci 24:94-104. 2006
    ....
  48. pmc Long-term neuroplasticity and functional consequences of single versus recurrent early-life seizures
    Tallie Z Baram
    Ann Neurol 54:701-5. 2003
  49. pmc The multiple personalities of h-channels
    Bina Santoro
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Trends Neurosci 26:550-4. 2003
    ....
  50. pmc Models for infantile spasms: an arduous journey to the Holy Grail
    Tallie Z Baram
    Ann Neurol 61:89-91. 2007

Research Grants29

  1. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2007
    ..In addition, they should yield mechanistic, targeted therapy for reversing the HPA hyperactivity consequent to deficient early-life experience that characterizes, and perhaps underlies, certain human affective and anxiety disorders. ..
  2. Epilepsy Research Training Program
    Tallie Z Baram; Fiscal Year: 2007
    ..The program will thus provide focused yet multi-dimensional research training to generate the next cadre of researchers in the Neurobiology, Genetics, Cellular and Molecular mechanisms of the Epilepsies. ..
  3. Febrile Seizure Model - Neuronal Injury and Mechanisms
    Tallie Z Baram; Fiscal Year: 2007
    ..Understanding the steps and the mechanisms by which febrile seizures convert a 'normal' hippocampus to an epileptic one is a critical first step in intercepting the epilepsy-generating process resulting in temporal lobe epilepsy. ..
  4. CRH-mRNA Regulation: Role in Neonatal Seizure Potential
    Tallie Z Baram; Fiscal Year: 2007
    ....
  5. MRI predicts epileptogenesis and cognitive deficits
    TALLIE BARAM; Fiscal Year: 2005
    ..abstract_text> ..
  6. FEBRILE SEIZURE MODEL--NEURONAL INJURY AND MECHANISMS
    Tallie Z Baram; Fiscal Year: 2000
    ..The results of the proposed studies may have significant implications for the current management of these seizures in human infants, and could lead to a more aggressive approach to febrile seizures. ..
  7. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2005
    ..In addition, they should yield mechanistic, targeted therapy for reversing the HPA hyperactivity consequent to deficient early-life experience that characterizes, and perhaps underlies, certain human affective and anxiety disorders. ..
  8. CRH-mRNA Regulation: Role in Neonatal Seizure Potential
    Tallie Z Baram; Fiscal Year: 2006
    ....
  9. CRH in stress-induced hippocampal neuroplasticity
    Tallie Z Baram; Fiscal Year: 2009
    ..Our studies will identify new therapies (blocking the actions of CRH) for prevention and/or reversal of the severe impact of early stress on cognitive function- a major advancement in world health. ..
  10. CRH in stress-induced hippocampal neuroplasticity
    TALLIE Z Z BARAM; Fiscal Year: 2011
    ..Our studies will identify new therapies (blocking the actions of CRH) for prevention and/or reversal of the severe impact of early stress on cognitive function- a major advancement in world health. ..
  11. Effects of early-life experience:role of CRH
    TALLIE Z Z BARAM; Fiscal Year: 2010
    ..The resulting information would enable us to use the same mechanisms as a basis for therapy in people who have not had the same type of optimal childhood experience. ..
  12. CRH-mRNA Regulation: Role in Neonatal Seizure Potential
    Tallie Z Baram; Fiscal Year: 2005
    ....
  13. CRH-MRNA REGULATION-- ROLE IN NEONATAL SEIZURE POTENTIAL
    Tallie Z Baram; Fiscal Year: 2002
    ..The proposed studies, delineating age-specific mechanisms for seizure-related neuronal injury and its consequences should lead to the development of novel, age-appropriate, specific therapies to prevent these consequences. ..
  14. Febrile Seizure Model: Neuronal Injury and Mechanisms
    Tallie Z Baram; Fiscal Year: 2004
    ..abstract_text> ..
  15. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2003
    ..Thus, these studies will set the stage for early intervention, with a promise of influencing the consequences of early-life experience on neurobiological correlates of stress throughout life. ..
  16. CRH-MRNA REGULATION-- ROLE IN NEONATAL SEIZURE POTENTIAL
    Tallie Z Baram; Fiscal Year: 2001
    ..The proposed studies, delineating age-specific mechanisms for seizure-related neuronal injury and its consequences should lead to the development of novel, age-appropriate, specific therapies to prevent these consequences. ..
  17. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2001
    ..Thus, these studies will set the stage for early intervention, with a promise of influencing the consequences of early-life experience on neurobiological correlates of stress throughout life. ..
  18. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2002
    ..Thus, these studies will set the stage for early intervention, with a promise of influencing the consequences of early-life experience on neurobiological correlates of stress throughout life. ..
  19. CRH-MRNA REGULATION-- ROLE IN NEONATAL SEIZURE POTENTIAL
    Tallie Z Baram; Fiscal Year: 2000
    ..The proposed studies, delineating age-specific mechanisms for seizure-related neuronal injury and its consequences should lead to the development of novel, age-appropriate, specific therapies to prevent these consequences. ..
  20. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2000
    ..Thus, these studies will set the stage for early intervention, with a promise of influencing the consequences of early-life experience on neurobiological correlates of stress throughout life. ..
  21. Febrile Seizure Model: Neuronal Injury and Mechanisms
    Tallie Z Baram; Fiscal Year: 2002
    ..abstract_text> ..
  22. Febrile Seizure Model: Neuronal Injury and Mechanisms
    Tallie Z Baram; Fiscal Year: 2005
    ..abstract_text> ..
  23. Febrile Seizure Model: Neuronal Injury and Mechanisms
    Tallie Z Baram; Fiscal Year: 2003
    ..abstract_text> ..
  24. CRH-MRNA REGULATION-- ROLE IN NEONATAL SEIZURE POTENTIAL
    Tallie Z Baram; Fiscal Year: 2003
    ..The proposed studies, delineating age-specific mechanisms for seizure-related neuronal injury and its consequences should lead to the development of novel, age-appropriate, specific therapies to prevent these consequences. ..
  25. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2006
    ..In addition, they should yield mechanistic, targeted therapy for reversing the HPA hyperactivity consequent to deficient early-life experience that characterizes, and perhaps underlies, certain human affective and anxiety disorders. ..