MARK G BARAD

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Later developments: molecular keys to age-related memory impairment
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, and Neuropsychiatric Institute, UCLA, Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 17:168-76. 2003
  2. ncbi request reprint Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear
    Mark Barad
    Veterans Health Administration, West Los Angeles, California 90073, and Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
    Learn Mem 13:560-1. 2006
  3. ncbi request reprint Fear extinction in rodents: basic insight to clinical promise
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Curr Opin Neurobiol 15:710-5. 2005
  4. ncbi request reprint The role of the amygdala in the extinction of conditioned fear
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 60:322-8. 2006
  5. ncbi request reprint Like extinction, latent inhibition of conditioned fear in mice is blocked by systemic inhibition of L-type voltage-gated calcium channels
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute and Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    Learn Mem 11:536-9. 2004
  6. ncbi request reprint Is extinction of fear erasure or inhibition? Why both, of course
    Mark Barad
    Veterans Health Administration, West Los Angeles, Los Angeles, California 90073, USA
    Learn Mem 13:108-9. 2006
  7. ncbi request reprint L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice
    Chris K Cain
    Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 22:9113-21. 2002
  8. pmc The L-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice
    Christopher K Cain
    Interdepartmental Program in Neuroscience, University of California Los Angeles, Los Angeles, California 90095 1761, USA
    Learn Mem 12:277-84. 2005
  9. pmc Adrenergic transmission facilitates extinction of conditional fear in mice
    Christopher K Cain
    Interdepartmental Program in Neuroscience, Neuropsychiatric Institute, and Brain Research Institute, UCLA, Los Angeles, California 90095, USA
    Learn Mem 11:179-87. 2004
  10. pmc The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear
    Timothy W Bredy
    Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095, USA
    Learn Mem 15:39-45. 2008

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Later developments: molecular keys to age-related memory impairment
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, and Neuropsychiatric Institute, UCLA, Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 17:168-76. 2003
    ....
  2. ncbi request reprint Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear
    Mark Barad
    Veterans Health Administration, West Los Angeles, California 90073, and Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, USA
    Learn Mem 13:560-1. 2006
  3. ncbi request reprint Fear extinction in rodents: basic insight to clinical promise
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Curr Opin Neurobiol 15:710-5. 2005
    ....
  4. ncbi request reprint The role of the amygdala in the extinction of conditioned fear
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90095, USA
    Biol Psychiatry 60:322-8. 2006
    ..Interpreted in the light of these findings, several recent in vitro electrophysiology studies in amygdala-containing brain slices are suggestive of potential synaptic and circuit bases of extinction learning...
  5. ncbi request reprint Like extinction, latent inhibition of conditioned fear in mice is blocked by systemic inhibition of L-type voltage-gated calcium channels
    Mark Barad
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute and Neuropsychiatric Institute, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    Learn Mem 11:536-9. 2004
    ..The results indicate that extinction and LI share a common molecular requirement and may support the notion that LI, like extinction, is a form of inhibitory learning...
  6. ncbi request reprint Is extinction of fear erasure or inhibition? Why both, of course
    Mark Barad
    Veterans Health Administration, West Los Angeles, Los Angeles, California 90073, USA
    Learn Mem 13:108-9. 2006
  7. ncbi request reprint L-type voltage-gated calcium channels are required for extinction, but not for acquisition or expression, of conditional fear in mice
    Chris K Cain
    Interdepartmental Program in Neuroscience, University of California, Los Angeles, Los Angeles, California 90095 1761, USA
    J Neurosci 22:9113-21. 2002
    ....
  8. pmc The L-type calcium channel blocker nifedipine impairs extinction, but not reduced contingency effects, in mice
    Christopher K Cain
    Interdepartmental Program in Neuroscience, University of California Los Angeles, Los Angeles, California 90095 1761, USA
    Learn Mem 12:277-84. 2005
    ..Taken together, the results suggest that reduced contingency effects and extinction depend on different molecular mechanisms and that LVGCC dependence of behavioral inhibition develops with time after associative CS-US learning...
  9. pmc Adrenergic transmission facilitates extinction of conditional fear in mice
    Christopher K Cain
    Interdepartmental Program in Neuroscience, Neuropsychiatric Institute, and Brain Research Institute, UCLA, Los Angeles, California 90095, USA
    Learn Mem 11:179-87. 2004
    ..They also provide clear evidence that spaced CS presentations trigger both fear-reducing (extinction) and fear-increasing (incubation) mechanisms...
  10. pmc The histone deacetylase inhibitor valproic acid enhances acquisition, extinction, and reconsolidation of conditioned fear
    Timothy W Bredy
    Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095, USA
    Learn Mem 15:39-45. 2008
    ..These findings have important implications for the use of HDAC inhibitors as adjuncts to behavior therapy in the treatment of phobia and related anxiety disorders...
  11. pmc Social modulation of associative fear learning by pheromone communication
    Timothy W Bredy
    Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, California 90095, USA
    Learn Mem 16:12-8. 2009
    ..Together, these findings suggest social modulation of higher-order cognitive processing through pheromone communication and support the concurrent excitor hypothesis of extinction learning...
  12. pmc Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear
    Timothy W Bredy
    Department of Psychiatry and Biobehavioral Sciences, Brain Research Institute, Semel Institute for Neuroscience and Human Behavior, Los Angeles, California 90095, USA
    Learn Mem 14:268-76. 2007
    ..In addition, they suggest that HDAC inhibitors may become a useful pharmacological adjunct to psychotherapy for human anxiety disorders...
  13. pmc Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice
    Ravikumar Ponnusamy
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute and Brain Research Institute, University of California, Los Angeles, CA 90095, USA
    Learn Mem 12:399-406. 2005
    ..These findings suggest that dopamine D2-mediated signaling contributes physiological inhibition of extinction, and that D2 antagonists may be useful adjuncts to behavior therapy of human anxiety disorders...
  14. ncbi request reprint Temporally massed CS presentations generate more fear extinction than spaced presentations
    Christopher K Cain
    Interdepartmental Program in Neuroscience, University of California, Los Angeles, CA 90095 1761, USA
    J Exp Psychol Anim Behav Process 29:323-33. 2003
    ..The data also indicate that once CS presentations are sufficiently massed to initiate, or "induce," extinction learning, further CS presentations are more effective when spaced...

Research Grants4

  1. Rodent models of anxiety disorder treatment
    Mark Barad; Fiscal Year: 2004
    ..abstract_text> ..
  2. Translating Extinction of Fear to Anxiety Disorder Treatment
    Mark Barad; Fiscal Year: 2006
    ..These experiments should help establish the translational validity of the extinction model for anxiety disorder treatment and also may yield potential improvements in current anxiety disorder treatments. ..
  3. Conference on Childhood, Culture, and Neurodevelopment
    Mark Barad; Fiscal Year: 2007
    ..abstract_text> ..