Scott C Baraban

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
  2. ncbi Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors
    Scott C Baraban
    Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Epilepsia 43:9-13. 2002
  3. ncbi Neuropeptide Y and epilepsy: recent progress, prospects and controversies
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuropeptides 38:261-5. 2004
  4. ncbi Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero
    S C Baraban
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    Epilepsy Res 39:87-102. 2000
  5. ncbi Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1
    Yanling Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 61:139-52. 2007
  6. ncbi Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position
    Daniel Vogt
    Department of Psychiatry, Neuroscience Program and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, CA 94158, USA Electronic address
    Neuron 82:350-64. 2014
  7. pmc Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7380-9. 2006
  8. pmc Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
    Yanling Wang
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:5334-45. 2010
  9. pmc Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice
    Daniel L Jones
    Graduate Program in Neuroscience and Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurophysiol 102:648-58. 2009
  10. pmc Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo
    Mackenzie Allen Howard
    Epilepsy Research Laboratory, Department of Neurological Surgery and Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 111:492-7. 2014

Collaborators

Detail Information

Publications59

  1. ncbi Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 503 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuroscience 131:759-68. 2005
    ..Therefore, zebrafish larvae represent a powerful new system to study the underlying basis of seizure generation, epilepsy and epileptogenesis...
  2. ncbi Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors
    Scott C Baraban
    Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Epilepsia 43:9-13. 2002
    ..In vivo studies implicate Y5 receptors. Here we used pharmacologic tools and Y5-receptor knockout mice to examine the role of Y5 receptors in mediating the antiexcitatory and antiepileptic actions of NPY in the hippocampal formation...
  3. ncbi Neuropeptide Y and epilepsy: recent progress, prospects and controversies
    S C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Neuropeptides 38:261-5. 2004
    ..Prominently expressed in brain regions involved in seizure generation and propagation, NPY can exert powerful effects on synaptic transmission. Here, we discuss the anti-epileptic actions of NPY and receptor subtypes responsible...
  4. ncbi Characterization of heterotopic cell clusters in the hippocampus of rats exposed to methylazoxymethanol in utero
    S C Baraban
    Department of Pediatrics, Case Western Reserve University, Cleveland, OH 44106, USA
    Epilepsy Res 39:87-102. 2000
    ....
  5. ncbi Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1
    Yanling Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 61:139-52. 2007
    ..These studies were designed to assess whether TSC gene inactivation alters excitability...
  6. ncbi Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position
    Daniel Vogt
    Department of Psychiatry, Neuroscience Program and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, CA 94158, USA Electronic address
    Neuron 82:350-64. 2014
    ..These data define the molecular identity of Lhx6 mutants and introduce technologies to test mechanisms in GABAergic interneuron differentiation...
  7. pmc Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7380-9. 2006
    ..Grafted MGE cells, therefore, can be used to modify neural circuits and selectively increase local inhibition. These findings could have important implications for reparative cell therapies for brain disorders...
  8. pmc Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
    Yanling Wang
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:5334-45. 2010
    ..This contrasts with Dlx1, whose function is required for dendrite innervating (calretinin(+), somatostatin(+), and neuropeptide Y(+)) interneurons (Cobos et al., 2005)...
  9. pmc Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice
    Daniel L Jones
    Graduate Program in Neuroscience and Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurophysiol 102:648-58. 2009
    ..Taken together, these findings illustrate the extensive redistribution and reorganization of inhibitory connections between interneurons that can take place in a malformed brain...
  10. pmc Bidirectional homeostatic plasticity induced by interneuron cell death and transplantation in vivo
    Mackenzie Allen Howard
    Epilepsy Research Laboratory, Department of Neurological Surgery and Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143
    Proc Natl Acad Sci U S A 111:492-7. 2014
    ..Thus, in vivo homeostatic plasticity is a highly dynamic and bidirectional process that responds to changes in inhibition. ..
  11. pmc Intrinsically determined cell death of developing cortical interneurons
    Derek G Southwell
    Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
    Nature 491:109-13. 2012
    ..Taken together, our findings indicate that interneuron cell death is determined intrinsically, either cell-autonomously or through a population-autonomous competition for survival signals derived from other interneurons...
  12. pmc Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons
    Daniel L Jones
    Department of Neurological Surgery, University of California, San Francisco, Box 0112, 513 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurophysiol 105:1984-91. 2011
    ....
  13. ncbi An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol
    Maria Elisa Calcagnotto
    Epilepsy Research Laboratory, Department of Neurological Surgery and The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Epilepsia 44:315-21. 2003
    ..To study voltage-dependent calcium currents (VDCCs) on hippocampal heterotopic neurons by using whole-cell patch-clamp techniques in brain slices prepared from methylaxozymethanol (MAM)-exposed rats...
  14. pmc Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains
    Mercedes F Paredes
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    J Neurosci 26:9404-12. 2006
    ....
  15. pmc Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia
    Mercedes Paredes
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 495:133-48. 2006
    ..We conclude that prenatal MAM exposure disrupts critical developmental processes and prenatal neocortical structures, ultimately resulting in neocortical disorganization and hippocampal malformations...
  16. pmc Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish
    Gabriela A Hortopan
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:13718-28. 2010
    ..This work may have important implications for neurological and neurodevelopmental disorders associated with mutations in ubiquitin ligase activity...
  17. doi Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant mice
    Yanling Wang
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Hippocampus 18:758-65. 2008
    ..The functional consequences of hippocampal granule cell dispersion could offer critical insight to the epileptic and cognitive disorder associated with LIS1 haploinsufficiency...
  18. ncbi Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats
    Maria Elisa Calcagnotto
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, USA
    J Neurophysiol 94:153-62. 2005
    ..Changes in NMDAR function may directly contribute to the hyperexcitability and cognitive deficits reported in animal models and patients with brain malformations...
  19. pmc Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice
    Scott C Baraban
    Department of Neurological Surgery and Psychiatry, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:15472-7. 2009
    ..Our findings suggest that MGE-derived interneurons could be used to ameliorate abnormal excitability and possibly act as an effective strategy in the treatment of epilepsy...
  20. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  21. ncbi Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice
    Daniel L Jones
    Department of Neurological Surgery, University of California, San Francisco, Box 0520, 533 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurophysiol 98:2737-46. 2007
    ....
  22. pmc Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain
    John C Silbereis
    Department of Pediatrics, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, San Francisco, CA 94143, USA Department of Neurosurgery, University of California, San Francisco, San Francisco, CA 94143, USA Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA 94143, USA Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA
    Neuron 81:574-87. 2014
    ..These findings establish Olig1 as an essential repressor of Dlx1/2 and interneuron production in developing mammalian brain. ..
  23. pmc Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
    Scott C Baraban
    1 Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 513 Parnassus Avenue San Francisco, California 94143, USA 2 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California 94143, USA
    Nat Commun 4:2410. 2013
    ..This approach represents a new direction in modelling pediatric epilepsy and could be used to identify novel therapeutics for any monogenic epilepsy disorder. ..
  24. doi Expression and function of KCNQ channels in larval zebrafish
    Sally W Chege
    PIBS Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Dev Neurobiol 72:186-98. 2012
    ..These results indicate that functional K(v)7 channels are expressed in the larval zebrafish nervous system and could play a direct role in generation of seizure activity...
  25. ncbi Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in utero
    Emily P Harrington
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Epilepsia 48:158-68. 2007
    ..Alterations in this system can have profound effects on overall excitability, cognitive function, and seizure thresholds...
  26. ncbi Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy
    Maria Elisa Calcagnotto
    Epilepsy Research Laboratory, Department of Neurological Surgery and The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:7596-605. 2002
    ..Together, our data demonstrate that GABA-mediated synaptic function at heterotopic synapses is altered and suggests that inhibitory systems are enhanced in the malformed brain...
  27. ncbi Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia
    Matthew D Smyth
    Department of Neurological Surgery, Epilepsy Research Laboratory, University of California at San Francisco, 94143 0112, USA
    Epilepsy Res 50:251-64. 2002
    ..p.). Pre-treatment with VPA prolonged seizure latency in control rats, but had no effect in MAM-exposed animals. These results suggest MAM-exposed rats exhibit a dramatically reduced sensitivity to commonly prescribed AEDs...
  28. pmc A large-scale mutagenesis screen to identify seizure-resistant zebrafish
    Scott C Baraban
    Epilepsy Research Laboratory in the Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Epilepsia 48:1151-7. 2007
    ..Here we describe a novel strategy to isolate seizure-resistant zebrafish mutants from a large-scale mutagenesis screen...
  29. doi Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice
    Joel S F Greenwood
    Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 66:644-53. 2009
    ..Using this mouse model, we examined the functional impact of LIS1 deficiency with particular focus on excitatory glutamate-mediated synaptic transmission...
  30. pmc Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse
    Yanling Wang
    Epilepsy Research Laboratory in the Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Neurosci 29:91-8. 2007
    ..Thus, LIS1 haploinsufficiency can lead to abnormal cell proliferation, migration and differentiation in the adult dentate gyrus...
  31. pmc GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior
    Robert F Hunt
    Epilepsy Research Laboratory, University of California, San Francisco, California, USA
    Nat Neurosci 16:692-7. 2013
    ..Our results highlight a critical role for interneurons in epilepsy and suggest that interneuron cell transplantation is a powerful approach to halting seizures and rescuing accompanying deficits in severely epileptic mice...
  32. pmc Robust tonic GABA currents can inhibit cell firing in mouse newborn neocortical pyramidal cells
    Joy Y Sebe
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Eur J Neurosci 32:1310-8. 2010
    ....
  33. pmc Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish
    Gabriela A Hortopan
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    Dev Dyn 240:1964-76. 2011
    ....
  34. pmc A novel zebrafish model of hyperthermia-induced seizures reveals a role for TRPV4 channels and NMDA-type glutamate receptors
    Robert F Hunt
    Epilepsy Research Laboratory, Department of Neurological Surgery, Biomedical Graduate Program, University of California San Francisco, San Francisco, CA 94143, USA
    Exp Neurol 237:199-206. 2012
    ..Taken together, our findings suggest a role of heat-activation of TRPV4 channels and enhanced NMDA receptor-mediated glutamatergic transmission in hyperthermia-induced seizures...
  35. ncbi A role for the mTOR pathway in surface expression of AMPA receptors
    Yanling Wang
    Epilepsy Research Laboratory in the Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, Box 0520, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Neurosci Lett 401:35-9. 2006
    ..Our results suggest a role for the mTOR pathway in surface expression of AMPA receptors on cortical neurons...
  36. ncbi Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus
    Hui Guo
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurophysiol 87:558-66. 2002
    ..These results suggest that the Y5 receptor subtype, previously believed to mediate food intake, plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 synapse in the mouse...
  37. ncbi Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia
    Maria Elisa Calcagnotto
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosci 25:9649-57. 2005
    ..Together, these results suggest that profound alterations in GABA-mediated synaptic inhibition play an essential role in the process of epileptogenesis in patients with FCD...
  38. ncbi Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy
    P A Castro
    Department of Neurological Surgery, The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 21:6626-34. 2001
    ..2 potassium channels and that this abnormality could contribute to the increased excitability and decreased seizure thresholds associated with brain malformations in MAM-exposed rats...
  39. pmc LIS1 deficiency promotes dysfunctional synaptic integration of granule cells generated in the developing and adult dentate gyrus
    Robert F Hunt
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosci 32:12862-75. 2012
    ....
  40. doi Zebrafish as a model for studying genetic aspects of epilepsy
    Gabriela A Hortopan
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Dis Model Mech 3:144-8. 2010
    ..Although the adaptation of zebrafish to epilepsy research is in its early stages, these studies highlight the rapid progress that can be made using this simple vertebrate species...
  41. pmc ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice
    Joy Y Sebe
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurophysiol 109:429-36. 2013
    ....
  42. ncbi Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slices
    Marom Bikson
    Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurophysiol 87:62-71. 2002
    ..Furthermore, these data show that nonsynaptic mechanisms can contribute to epileptiform activity in normal Ca(2+) levels...
  43. ncbi Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability
    Scott C Baraban
    Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, San Francisco, CA 94143 0520, USA
    Trends Neurosci 27:135-42. 2004
    ....
  44. pmc Use of "MGE enhancers" for labeling and selection of embryonic stem cell-derived medial ganglionic eminence (MGE) progenitors and neurons
    Ying Jiun J Chen
    Department of Psychiatry and the Nina Ireland Laboratory of Developmental Neurobiology, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 8:e61956. 2013
    ..These data demonstrate unique techniques to follow and purify MGE-like derivatives from ES cells, including GABAergic cortical interneurons and oligodendrocytes, for use in stem cell-based therapeutic assays and treatments...
  45. pmc Familial cortical myoclonus with a mutation in NOL3
    Jonathan F Russell
    Department of Neurology, School of Medicine, University of California at San Francisco, San Francisco, CA 94158, USA
    Ann Neurol 72:175-83. 2012
    ..We identified a family suffering from adult onset, cortical myoclonus without associated seizures. We performed clinical, electrophysiological, and genetic studies to define this phenotype...
  46. pmc The promise of an interneuron-based cell therapy for epilepsy
    Joy Y Sebe
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California, USA
    Dev Neurobiol 71:107-17. 2011
    ....
  47. ncbi Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus
    Mercedes F Paredes
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Neurosci Lett 340:9-12. 2003
    ..Immunostaining revealed the presence of Y1R on cell somas of hilar NPY-containing interneurons. Thus, our results suggest that Y1R on hilar interneurons may act as a peptide autoreceptor...
  48. ncbi Knock-out mice reveal a critical antiepileptic role for neuropeptide Y
    S C Baraban
    Department of Neurological Surgery, Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 17:8927-36. 1997
    ..Intracerebroventricular NPY infusion, before KA administration, prevented death in NPY-deficient mice. These results suggest a critical role for endogenous NPY in seizure control...
  49. ncbi A potential role for astrocytes in mediating the antiepileptic actions of furosemide in vitro
    N M Barbaro
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, 513 Parnassus Avenue, Box 0520, San Francisco, San Francisco, CA 94143, USA
    Neuroscience 128:655-63. 2004
    ..Thus, furosemide-mediated modulation of inward potassium current (on astrocytes) represents a new target for control of abnormal electrical discharge in the CNS...
  50. ncbi Neocortical integration of transplanted GABA progenitor cells from wild type and GABAB receptor knockout mouse donors
    Joy Y Sebe
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, United States Electronic address
    Neurosci Lett 561:52-7. 2014
    ..Our findings provide insights into the anatomical integration of MGE-derived interneurons following transplantation. ..
  51. doi Developing cell transplantation for temporal lobe epilepsy
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Neurosurg Focus 24:E17. 2008
    ..These issues are reviewed, with a focus on those factors most likely to influence clinically applicable results...
  52. ncbi Hippocampal heterotopia with molecular and electrophysiological properties of neocortical neurons
    P A Castro
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 513 Parnassus Avenue, 94143, USA
    Neuroscience 114:961-72. 2002
    ..The MAM model, therefore, may serve as a useful tool in examination of the factors influencing aberrant brain development and epilepsy...
  53. ncbi Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complex
    D Koji Takahashi
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Epilepsia 45:1525-30. 2004
    ..Anatomic studies, including standard histologic stains and immunocytochemistry, were performed on young Eker rats exposed to a carcinogen in utero or aged untreated Eker rats (18-24 months old)...
  54. ncbi Emerging epilepsy models: insights from mice, flies, worms and fish
    Scott C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Curr Opin Neurol 20:164-8. 2007
    ..e., seizures). Understanding the pathogenesis of epilepsy and therapy development have greatly benefited from these models. Here we review recent mouse mutants featuring spontaneous seizures and simpler organisms...
  55. pmc Osmolarity modulates K+ channel function on rat hippocampal interneurons but not CA1 pyramidal neurons
    S C Baraban
    Department of Neurological Surgery, University of Washington, Seattle 98195, USA
    J Physiol 498:679-89. 1997
    ..5. These results indicate that selective modulation of interneuron ion channel activity may be a critical mechanism by which osmolarity can regulate excitability in the central nervous system...
  56. ncbi Osmolarity, ionic flux, and changes in brain excitability
    P A Schwartzkroin
    Department of Neurological Surgery, University of Washington, Seattle 98195 6470, USA
    Epilepsy Res 32:275-85. 1998
    ..These experiments indicate that manipulation of ionic balance may not only facilitate epileptiform activities, but may also provide insight into new therapeutic strategies to block seizures...
  57. ncbi Evidence for increased seizure susceptibility in rats exposed to cocaine in utero
    S C Baraban
    Department of Neurological Surgery, University of Washington, Seattle 98195, USA
    Brain Res Dev Brain Res 102:189-96. 1997
    ..These studies provide strong experimental evidence that adult animals exposed to cocaine during gestation are at high risk for the development of seizure activity...
  58. ncbi Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus
    Qian Quan Sun
    Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California 94305, USA
    J Neurosci 23:9639-49. 2003
    ....
  59. ncbi A review of gene expression patterns in the malformed brain
    Mercedes F Paredes
    Mol Neurobiol 26:109-16. 2002
    ..Here we review reported changes in gene expression associated with a malformed brain, with particular emphasis on how these changes provide clues to seizure genesis...