SCOTT BARABAN

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi What new modeling approaches will help us identify promising drug treatments?
    Scott C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA, 94143, USA
    Adv Exp Med Biol 813:283-94. 2014
  2. pmc Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
    Scott C Baraban
    1 Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 513 Parnassus Avenue San Francisco, California 94143, USA 2 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California 94143, USA
    Nat Commun 4:2410. 2013
  3. pmc ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice
    Joy Y Sebe
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurophysiol 109:429-36. 2013
  4. ncbi Emerging epilepsy models: insights from mice, flies, worms and fish
    Scott C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Curr Opin Neurol 20:164-8. 2007
  5. pmc A large-scale mutagenesis screen to identify seizure-resistant zebrafish
    Scott C Baraban
    Epilepsy Research Laboratory in the Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Epilepsia 48:1151-7. 2007
  6. pmc Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice
    Scott C Baraban
    Department of Neurological Surgery and Psychiatry, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:15472-7. 2009
  7. pmc Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7380-9. 2006
  8. ncbi Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice
    Daniel L Jones
    Department of Neurological Surgery, University of California, San Francisco, Box 0520, 533 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurophysiol 98:2737-46. 2007
  9. ncbi Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy
    Maria Elisa Calcagnotto
    Epilepsy Research Laboratory, Department of Neurological Surgery and The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:7596-605. 2002
  10. ncbi Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1
    Yanling Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 61:139-52. 2007

Research Grants

  1. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2001
  2. Epileptogenesis in the Malformed Brain
    Scott C Baraban; Fiscal Year: 2010
  3. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2009
  4. Seizure resistance in zebrafish
    SCOTT BARABAN; Fiscal Year: 2009
  5. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2007
  6. Seizure resistance in zebrafish
    SCOTT BARABAN; Fiscal Year: 2007
  7. MGE Progenitor Cell Grafts and Epilepsy
    SCOTT BARABAN; Fiscal Year: 2007
  8. An Interneuron-based Cell Therapy for Epilepsy
    Scott C Baraban; Fiscal Year: 2010
  9. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2002
  10. Genetics of Seizure Resistance: A Mutagenesis Strategy
    SCOTT BARABAN; Fiscal Year: 2004

Collaborators

Detail Information

Publications37

  1. ncbi What new modeling approaches will help us identify promising drug treatments?
    Scott C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA, 94143, USA
    Adv Exp Med Biol 813:283-94. 2014
    ..While these strategies, like any animal model approach also have their limitations, they offer hope that new more effective AEDs will be identified in the coming years. ..
  2. pmc Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment
    Scott C Baraban
    1 Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, Box 0520, 513 Parnassus Avenue San Francisco, California 94143, USA 2 Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, California 94143, USA
    Nat Commun 4:2410. 2013
    ..This approach represents a new direction in modelling pediatric epilepsy and could be used to identify novel therapeutics for any monogenic epilepsy disorder. ..
  3. pmc ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice
    Joy Y Sebe
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurophysiol 109:429-36. 2013
    ....
  4. ncbi Emerging epilepsy models: insights from mice, flies, worms and fish
    Scott C Baraban
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Curr Opin Neurol 20:164-8. 2007
    ..e., seizures). Understanding the pathogenesis of epilepsy and therapy development have greatly benefited from these models. Here we review recent mouse mutants featuring spontaneous seizures and simpler organisms...
  5. pmc A large-scale mutagenesis screen to identify seizure-resistant zebrafish
    Scott C Baraban
    Epilepsy Research Laboratory in the Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Epilepsia 48:1151-7. 2007
    ..Here we describe a novel strategy to isolate seizure-resistant zebrafish mutants from a large-scale mutagenesis screen...
  6. pmc Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant mice
    Scott C Baraban
    Department of Neurological Surgery and Psychiatry, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:15472-7. 2009
    ..Our findings suggest that MGE-derived interneurons could be used to ameliorate abnormal excitability and possibly act as an effective strategy in the treatment of epilepsy...
  7. pmc Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain
    Manuel Alvarez-Dolado
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7380-9. 2006
    ..Grafted MGE cells, therefore, can be used to modify neural circuits and selectively increase local inhibition. These findings could have important implications for reparative cell therapies for brain disorders...
  8. ncbi Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice
    Daniel L Jones
    Department of Neurological Surgery, University of California, San Francisco, Box 0520, 533 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurophysiol 98:2737-46. 2007
    ....
  9. ncbi Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsy
    Maria Elisa Calcagnotto
    Epilepsy Research Laboratory, Department of Neurological Surgery and The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:7596-605. 2002
    ..Together, our data demonstrate that GABA-mediated synaptic function at heterotopic synapses is altered and suggests that inhibitory systems are enhanced in the malformed brain...
  10. ncbi Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1
    Yanling Wang
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 61:139-52. 2007
    ..These studies were designed to assess whether TSC gene inactivation alters excitability...
  11. pmc Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse
    Yanling Wang
    Epilepsy Research Laboratory in the Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
    Dev Neurosci 29:91-8. 2007
    ..Thus, LIS1 haploinsufficiency can lead to abnormal cell proliferation, migration and differentiation in the adult dentate gyrus...
  12. pmc Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasia
    Mercedes Paredes
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 495:133-48. 2006
    ..We conclude that prenatal MAM exposure disrupts critical developmental processes and prenatal neocortical structures, ultimately resulting in neocortical disorganization and hippocampal malformations...
  13. ncbi Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampus
    Hui Guo
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurophysiol 87:558-66. 2002
    ..These results suggest that the Y5 receptor subtype, previously believed to mediate food intake, plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 synapse in the mouse...
  14. doi Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant mice
    Yanling Wang
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Hippocampus 18:758-65. 2008
    ..The functional consequences of hippocampal granule cell dispersion could offer critical insight to the epileptic and cognitive disorder associated with LIS1 haploinsufficiency...
  15. ncbi Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats
    Maria Elisa Calcagnotto
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, USA
    J Neurophysiol 94:153-62. 2005
    ..Changes in NMDAR function may directly contribute to the hyperexcitability and cognitive deficits reported in animal models and patients with brain malformations...
  16. ncbi Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasia
    Matthew D Smyth
    Department of Neurological Surgery, Epilepsy Research Laboratory, University of California at San Francisco, 94143 0112, USA
    Epilepsy Res 50:251-64. 2002
    ..p.). Pre-treatment with VPA prolonged seizure latency in control rats, but had no effect in MAM-exposed animals. These results suggest MAM-exposed rats exhibit a dramatically reduced sensitivity to commonly prescribed AEDs...
  17. pmc Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brains
    Mercedes F Paredes
    Department of Neurosurgery, University of California, San Francisco, California 94143, USA
    J Neurosci 26:9404-12. 2006
    ....
  18. ncbi An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanol
    Maria Elisa Calcagnotto
    Epilepsy Research Laboratory, Department of Neurological Surgery and The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Epilepsia 44:315-21. 2003
    ..To study voltage-dependent calcium currents (VDCCs) on hippocampal heterotopic neurons by using whole-cell patch-clamp techniques in brain slices prepared from methylaxozymethanol (MAM)-exposed rats...
  19. pmc Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice
    Daniel L Jones
    Graduate Program in Neuroscience and Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurophysiol 102:648-58. 2009
    ..Taken together, these findings illustrate the extensive redistribution and reorganization of inhibitory connections between interneurons that can take place in a malformed brain...
  20. ncbi Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant mice
    Joel S F Greenwood
    Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 66:644-53. 2009
    ..Using this mouse model, we examined the functional impact of LIS1 deficiency with particular focus on excitatory glutamate-mediated synaptic transmission...
  21. doi Zebrafish as a model for studying genetic aspects of epilepsy
    Gabriela A Hortopan
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Dis Model Mech 3:144-8. 2010
    ..Although the adaptation of zebrafish to epilepsy research is in its early stages, these studies highlight the rapid progress that can be made using this simple vertebrate species...
  22. pmc Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
    Yanling Wang
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:5334-45. 2010
    ..This contrasts with Dlx1, whose function is required for dendrite innervating (calretinin(+), somatostatin(+), and neuropeptide Y(+)) interneurons (Cobos et al., 2005)...
  23. pmc Robust tonic GABA currents can inhibit cell firing in mouse newborn neocortical pyramidal cells
    Joy Y Sebe
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Eur J Neurosci 32:1310-8. 2010
    ....
  24. pmc Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish
    Gabriela A Hortopan
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 30:13718-28. 2010
    ..This work may have important implications for neurological and neurodevelopmental disorders associated with mutations in ubiquitin ligase activity...
  25. ncbi Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptors
    Scott C Baraban
    Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Epilepsia 43:9-13. 2002
    ..In vivo studies implicate Y5 receptors. Here we used pharmacologic tools and Y5-receptor knockout mice to examine the role of Y5 receptors in mediating the antiexcitatory and antiepileptic actions of NPY in the hippocampal formation...
  26. ncbi Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
    Inma Cobos
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
    Nat Neurosci 8:1059-68. 2005
    ..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss...
  27. doi Developing cell transplantation for temporal lobe epilepsy
    R Mark Richardson
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
    Neurosurg Focus 24:E17. 2008
    ..These issues are reviewed, with a focus on those factors most likely to influence clinically applicable results...
  28. ncbi Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitability
    Scott C Baraban
    Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, San Francisco, CA 94143 0520, USA
    Trends Neurosci 27:135-42. 2004
    ....
  29. ncbi Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in utero
    Emily P Harrington
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    Epilepsia 48:158-68. 2007
    ..Alterations in this system can have profound effects on overall excitability, cognitive function, and seizure thresholds...
  30. ncbi Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampus
    Mercedes F Paredes
    Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Neurosci Lett 340:9-12. 2003
    ..Immunostaining revealed the presence of Y1R on cell somas of hilar NPY-containing interneurons. Thus, our results suggest that Y1R on hilar interneurons may act as a peptide autoreceptor...
  31. ncbi A role for the mTOR pathway in surface expression of AMPA receptors
    Yanling Wang
    Epilepsy Research Laboratory in the Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, Box 0520, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Neurosci Lett 401:35-9. 2006
    ..Our results suggest a role for the mTOR pathway in surface expression of AMPA receptors on cortical neurons...
  32. ncbi Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia
    Maria Elisa Calcagnotto
    Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
    J Neurosci 25:9649-57. 2005
    ..Together, these results suggest that profound alterations in GABA-mediated synaptic inhibition play an essential role in the process of epileptogenesis in patients with FCD...
  33. ncbi Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complex
    D Koji Takahashi
    Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
    Epilepsia 45:1525-30. 2004
    ..Anatomic studies, including standard histologic stains and immunocytochemistry, were performed on young Eker rats exposed to a carcinogen in utero or aged untreated Eker rats (18-24 months old)...
  34. pmc Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneurons
    Daniel L Jones
    Department of Neurological Surgery, University of California, San Francisco, Box 0112, 513 Parnassus Ave, San Francisco, CA 94143, USA
    J Neurophysiol 105:1984-91. 2011
    ....
  35. ncbi Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamus
    Qian Quan Sun
    Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California 94305, USA
    J Neurosci 23:9639-49. 2003
    ....
  36. ncbi Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slices
    Marom Bikson
    Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurophysiol 87:62-71. 2002
    ..Furthermore, these data show that nonsynaptic mechanisms can contribute to epileptiform activity in normal Ca(2+) levels...
  37. ncbi A review of gene expression patterns in the malformed brain
    Mercedes F Paredes
    Mol Neurobiol 26:109-16. 2002
    ..Here we review reported changes in gene expression associated with a malformed brain, with particular emphasis on how these changes provide clues to seizure genesis...

Research Grants20

  1. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2001
    ..The results promise to provide new information about cellular mechanisms of epileptogenesis associated with malformations and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
  2. Epileptogenesis in the Malformed Brain
    Scott C Baraban; Fiscal Year: 2010
    ..Using a mouse mutant lacking a gene associated with a malformation of cortical development first identified in humans, we will examine mechanisms contributing to seizure generation and potential avenues for treatment. ..
  3. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2009
    ..The results promise to provide new information about synaptic function in a malformed brain and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
  4. Seizure resistance in zebrafish
    SCOTT BARABAN; Fiscal Year: 2009
    ..The results promise to provide new information about the genetics of seizure resistance and may lead to the design of novel anticonvulsant treatments designed to prevent epilepsy. ..
  5. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2007
    ..The results promise to provide new information about synaptic function in a malformed brain and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
  6. Seizure resistance in zebrafish
    SCOTT BARABAN; Fiscal Year: 2007
    ..The results promise to provide new information about the genetics of seizure resistance and may lead to the design of novel anticonvulsant treatments designed to prevent epilepsy. ..
  7. MGE Progenitor Cell Grafts and Epilepsy
    SCOTT BARABAN; Fiscal Year: 2007
    ..abstract_text> ..
  8. An Interneuron-based Cell Therapy for Epilepsy
    Scott C Baraban; Fiscal Year: 2010
    ..Using mouse embryonic and stem cell derived neural progenitor cells and a common rodent model of temporal lobe epilepsy we propose to develop a novel interneuron-based cell therapy. ..
  9. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2002
    ..The results promise to provide new information about cellular mechanisms of epileptogenesis associated with malformations and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
  10. Genetics of Seizure Resistance: A Mutagenesis Strategy
    SCOTT BARABAN; Fiscal Year: 2004
    ..The results of this unique collaboration promise to provide new insights into the genetic factors that influence epilepsy, and will, perhaps, lead to a cure for this devastating neurological disorder. ..
  11. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2004
    ..The results promise to provide new information about cellular mechanisms of epileptogenesis associated with malformations and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
  12. MGE Progenitor Cell Grafts and Epilepsy
    SCOTT BARABAN; Fiscal Year: 2005
    ..abstract_text> ..
  13. MGE Progenitor Cell Grafts and Epilepsy
    SCOTT BARABAN; Fiscal Year: 2006
    ..abstract_text> ..
  14. MGE Progenitor Cell Grafts and Epilepsy
    SCOTT BARABAN; Fiscal Year: 2005
    ..Our results promise to provide new information about the function of transplanted MGE progenitors in a host brain and may provide a direct demonstration of the potential for progenitor cells to treat intractable forms of epilepsy. ..
  15. MGE Progenitor Cell Grafts and Epilepsy
    SCOTT BARABAN; Fiscal Year: 2006
    ..abstract_text> ..
  16. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2003
    ..The results promise to provide new information about cellular mechanisms of epileptogenesis associated with malformations and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
  17. Epileptogenesis in the Malformed Brain
    SCOTT BARABAN; Fiscal Year: 2006
    ..The results promise to provide new information about synaptic function in a malformed brain and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..