Research Topics
Genomes and GenesSpecies | SCOTT BARABANSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant miceJoy Y Sebe
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurophysiol 109:429-36. 2013....
Emerging epilepsy models: insights from mice, flies, worms and fishScott C Baraban
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Curr Opin Neurol 20:164-8. 2007..e., seizures). Understanding the pathogenesis of epilepsy and therapy development have greatly benefited from these models. Here we review recent mouse mutants featuring spontaneous seizures and simpler organisms...- A large-scale mutagenesis screen to identify seizure-resistant zebrafishScott C Baraban
Epilepsy Research Laboratory in the Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
Epilepsia 48:1151-7. 2007..Here we describe a novel strategy to isolate seizure-resistant zebrafish mutants from a large-scale mutagenesis screen... - Reduction of seizures by transplantation of cortical GABAergic interneuron precursors into Kv1.1 mutant miceScott C Baraban
Department of Neurological Surgery and Psychiatry, The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:15472-7. 2009..Our findings suggest that MGE-derived interneurons could be used to ameliorate abnormal excitability and possibly act as an effective strategy in the treatment of epilepsy... - Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brainManuel Alvarez-Dolado
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 26:7380-9. 2006..Grafted MGE cells, therefore, can be used to modify neural circuits and selectively increase local inhibition. These findings could have important implications for reparative cell therapies for brain disorders... - Heterotopic neurons with altered inhibitory synaptic function in an animal model of malformation-associated epilepsyMaria Elisa Calcagnotto
Epilepsy Research Laboratory, Department of Neurological Surgery and The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 22:7596-605. 2002..Together, our data demonstrate that GABA-mediated synaptic function at heterotopic synapses is altered and suggests that inhibitory systems are enhanced in the malformed brain... - Neocortical hyperexcitability in a human case of tuberous sclerosis complex and mice lacking neuronal expression of TSC1Yanling Wang
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Ann Neurol 61:139-52. 2007..These studies were designed to assess whether TSC gene inactivation alters excitability... - Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant miceDaniel L Jones
Department of Neurological Surgery, University of California, San Francisco, Box 0520, 533 Parnassus Ave, San Francisco, CA 94143, USA
J Neurophysiol 98:2737-46. 2007.... - Y5 receptors mediate neuropeptide Y actions at excitatory synapses in area CA3 of the mouse hippocampusHui Guo
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurophysiol 87:558-66. 2002..These results suggest that the Y5 receptor subtype, previously believed to mediate food intake, plays a critical role in modulation of hippocampal excitatory transmission at the hilar-to-CA3 synapse in the mouse... - Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouseYanling Wang
Epilepsy Research Laboratory in the Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
Dev Neurosci 29:91-8. 2007..Thus, LIS1 haploinsufficiency can lead to abnormal cell proliferation, migration and differentiation in the adult dentate gyrus... - Embryonic and early postnatal abnormalities contributing to the development of hippocampal malformations in a rodent model of dysplasiaMercedes Paredes
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
J Comp Neurol 495:133-48. 2006..We conclude that prenatal MAM exposure disrupts critical developmental processes and prenatal neocortical structures, ultimately resulting in neocortical disorganization and hippocampal malformations... - Stromal-derived factor-1 (CXCL12) regulates laminar position of Cajal-Retzius cells in normal and dysplastic brainsMercedes F Paredes
Department of Neurosurgery, University of California, San Francisco, California 94143, USA
J Neurosci 26:9404-12. 2006.... 
Aberrant dentate gyrus cytoarchitecture and fiber lamination in Lis1 mutant miceYanling Wang
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
Hippocampus 18:758-65. 2008..The functional consequences of hippocampal granule cell dispersion could offer critical insight to the epileptic and cognitive disorder associated with LIS1 haploinsufficiency...- Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed ratsMaria Elisa Calcagnotto
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, USA
J Neurophysiol 94:153-62. 2005..Changes in NMDAR function may directly contribute to the hyperexcitability and cognitive deficits reported in animal models and patients with brain malformations... - Effects of antiepileptic drugs on induced epileptiform activity in a rat model of dysplasiaMatthew D Smyth
Department of Neurological Surgery, Epilepsy Research Laboratory, University of California at San Francisco, 94143-0112, USA
Epilepsy Res 50:251-64. 2002..p.). Pre-treatment with VPA prolonged seizure latency in control rats, but had no effect in MAM-exposed animals. These results suggest MAM-exposed rats exhibit a dramatically reduced sensitivity to commonly prescribed AEDs... - An examination of calcium current function on heterotopic neurons in hippocampal slices from rats exposed to methylazoxymethanolMaria Elisa Calcagnotto
Epilepsy Research Laboratory, Department of Neurological Surgery and The Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
Epilepsia 44:315-21. 2003..CONCLUSIONS: Heterotopic neurons do not appear to exhibit Ca2+ channel abnormalities that could contribute to the reported hyperexcitability associated with MAM-exposed rats... - Developing cell transplantation for temporal lobe epilepsyR Mark Richardson
Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0112, USA
Neurosurg Focus 24:E17. 2008..These issues are reviewed, with a focus on those factors most likely to influence clinically applicable results... - Antiepileptic actions of neuropeptide Y in the mouse hippocampus require Y5 receptorsScott C Baraban
Department of Neurological Surgery, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Epilepsia 43:9-13. 2002..In vivo studies implicate Y5 receptors. Here we used pharmacologic tools and Y5-receptor knockout mice to examine the role of Y5 receptors in mediating the antiexcitatory and antiepileptic actions of NPY in the hippocampal formation... - Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant miceDaniel L Jones
Graduate Program in Neuroscience and Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
J Neurophysiol 102:648-58. 2009..Taken together, these findings illustrate the extensive redistribution and reorganization of inhibitory connections between interneurons that can take place in a malformed brain... - Zebrafish as a model for studying genetic aspects of epilepsyGabriela A Hortopan
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
Dis Model Mech 3:144-8. 2010..Although the adaptation of zebrafish to epilepsy research is in its early stages, these studies highlight the rapid progress that can be made using this simple vertebrate species... - Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneuronsYanling Wang
Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, California 94158, USA
J Neurosci 30:5334-45. 2010..This contrasts with Dlx1, whose function is required for dendrite innervating (calretinin(+), somatostatin(+), and neuropeptide Y(+)) interneurons (Cobos et al., 2005)... - Seizures, enhanced excitation, and increased vesicle number in Lis1 mutant miceJoel S F Greenwood
Graduate Program in Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
Ann Neurol 66:644-53. 2009..Using this mouse model, we examined the functional impact of LIS1 deficiency with particular focus on excitatory glutamate-mediated synaptic transmission... - Robust tonic GABA currents can inhibit cell firing in mouse newborn neocortical pyramidal cellsJoy Y Sebe
Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
Eur J Neurosci 32:1310-8. 2010.... - Altered glutamate receptor - transporter expression and spontaneous seizures in rats exposed to methylazoxymethanol in uteroEmily P Harrington
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
Epilepsia 48:158-68. 2007..Alterations in this system can have profound effects on overall excitability, cognitive function, and seizure thresholds... - Interneuron Diversity series: Interneuronal neuropeptides--endogenous regulators of neuronal excitabilityScott C Baraban
Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, San Francisco, CA 94143-0520, USA
Trends Neurosci 27:135-42. 2004.... - Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafishGabriela A Hortopan
Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 30:13718-28. 2010..This work may have important implications for neurological and neurodevelopmental disorders associated with mutations in ubiquitin ligase activity... - Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsyInma Cobos
Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California San Francisco, San Francisco, California 94158, USA
Nat Neurosci 8:1059-68. 2005..Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss... - A role for the mTOR pathway in surface expression of AMPA receptorsYanling Wang
Epilepsy Research Laboratory in the Department of Neurological Surgery and PIBS Graduate Program in Neuroscience, University of California, Box 0520, 513 Parnassus Ave, San Francisco, CA 94143, USA
Neurosci Lett 401:35-9. 2006..Our results suggest a role for the mTOR pathway in surface expression of AMPA receptors on cortical neurons... - Neuropeptide Y modulates a G protein-coupled inwardly rectifying potassium current in the mouse hippocampusMercedes F Paredes
Department of Neurological Surgery, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Neurosci Lett 340:9-12. 2003..Immunostaining revealed the presence of Y1R on cell somas of hilar NPY-containing interneurons. Thus, our results suggest that Y1R on hilar interneurons may act as a peptide autoreceptor... - Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasiaMaria Elisa Calcagnotto
Department of Neurological Surgery, University of California, San Francisco, California 94143, USA
J Neurosci 25:9649-57. 2005..Together, these results suggest that profound alterations in GABA-mediated synaptic inhibition play an essential role in the process of epileptogenesis in patients with FCD... - Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complexD Koji Takahashi
Epilepsy Research Laboratory, Department of Neurological Surgery, University of California, San Francisco, San Francisco, California, USA
Epilepsia 45:1525-30. 2004..Further analysis of this rodent model may be warranted... - Deletion of Dlx1 results in reduced glutamatergic input to hippocampal interneuronsDaniel L Jones
Department of Neurological Surgery, University of California, San Francisco, Box 0112, 513 Parnassus Ave, San Francisco, CA 94143, USA
J Neurophysiol 105:1984-91. 2011.... - Target-specific neuropeptide Y-ergic synaptic inhibition and its network consequences within the mammalian thalamusQian Quan Sun
Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California 94305, USA
J Neurosci 23:9639-49. 2003.... - Conditions sufficient for nonsynaptic epileptogenesis in the CA1 region of hippocampal slicesMarom Bikson
Neural Engineering Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Neurophysiol 87:62-71. 2002..Furthermore, these data show that nonsynaptic mechanisms can contribute to epileptiform activity in normal Ca(2+) levels... - A review of gene expression patterns in the malformed brainMercedes F Paredes
Mol Neurobiol 26:109-16. 2002..Here we review reported changes in gene expression associated with a malformed brain, with particular emphasis on how these changes provide clues to seizure genesis...
Research Grants
- Epileptogenesis in the Malformed BrainSCOTT BARABAN; Fiscal Year: 2007..The results promise to provide new information about synaptic function in a malformed brain and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
- Seizure resistance in zebrafishSCOTT BARABAN; Fiscal Year: 2009..The results promise to provide new information about the genetics of seizure resistance and may lead to the design of novel anticonvulsant treatments designed to prevent epilepsy. ..
- Epileptogenesis in the Malformed BrainSCOTT BARABAN; Fiscal Year: 2009..The results promise to provide new information about synaptic function in a malformed brain and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
- Epileptogenesis in the Malformed BrainScott C Baraban; Fiscal Year: 2010..Using a mouse mutant lacking a gene associated with a malformation of cortical development first identified in humans, we will examine mechanisms contributing to seizure generation and potential avenues for treatment. ..
- Seizure resistance in zebrafishSCOTT BARABAN; Fiscal Year: 2007..The results promise to provide new information about the genetics of seizure resistance and may lead to the design of novel anticonvulsant treatments designed to prevent epilepsy. ..
- MGE Progenitor Cell Grafts and EpilepsySCOTT BARABAN; Fiscal Year: 2007..abstract_text> ..
- Genetics of Seizure Resistance: A Mutagenesis StrategySCOTT BARABAN; Fiscal Year: 2004..The results of this unique collaboration promise to provide new insights into the genetic factors that influence epilepsy, and will, perhaps, lead to a cure for this devastating neurological disorder. ..
- Epileptogenesis in the Malformed BrainSCOTT BARABAN; Fiscal Year: 2004..The results promise to provide new information about cellular mechanisms of epileptogenesis associated with malformations and may lead to the design of novel anticonvulsant treatments for these otherwise intractable forms of epilepsy. ..
- MGE Progenitor Cell Grafts and EpilepsySCOTT BARABAN; Fiscal Year: 2005..Our results promise to provide new information about the function of transplanted MGE progenitors in a host brain and may provide a direct demonstration of the potential for progenitor cells to treat intractable forms of epilepsy. ..
- An Interneuron-based Cell Therapy for EpilepsyScott C Baraban; Fiscal Year: 2010..Using mouse embryonic and stem cell derived neural progenitor cells and a common rodent model of temporal lobe epilepsy we propose to develop a novel interneuron-based cell therapy. ..