Research Topics
Genomes and Genes
| Rashmi BansalSummaryAffiliation: University of Connecticut Health Center Country: USA Publications
Research Grants
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Detail Information
Publications
Fibroblast growth factors and their receptors in oligodendrocyte development: implications for demyelination and remyelinationRashmi Bansal
Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030 3401, USA
Dev Neurosci 24:35-46. 2002..This review focuses on the fibroblast growth factors signaling in oligodendrocyte development, function and discusses implications for demyelination/remyelination...- S-phase entry of oligodendrocyte lineage cells is associated with increased levels of p21Cip1Rashmi Bansal
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
J Neurosci Res 80:360-8. 2005..Therefore, we propose that p21Cip1 is acting as a positive regulator, rather than an inhibitor, of cell cycle entry by favoring the assembly of active cyclin D1/CDK4 complexes... - Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cellsRashmi Bansal
Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, USA
J Neurosci Res 74:486-93. 2003..Thus, PD173704 is an excellent tool for investigating the role of FGF signaling in vivo in the context of combinatorial interactions of other signals... - Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte developmentRashmi Bansal
Department of Neuroscience, University of Connecticut Medical School, Farmington, Conn 06030 3401, USA
Dev Neurosci 25:83-95. 2003..These data provide further insights into role of FgfRs in OL development, and they emphasize that these receptors are positioned both spatially and temporally to impact OL generation in vivo... 
Myelin protein composition is altered in mice lacking either sulfated or both sulfated and non-sulfated galactolipidsSimon Ngamli Fewou
Departments of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA
J Neurochem 112:599-610. 2010....
ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelinationAkihiro Ishii
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut, USA
J Neurosci 32:8855-64. 2012..These studies suggest that the predominant role of ERK1/ERK2 signaling in vivo is in promoting rapid myelin growth to increase its thickness, subsequent to oligodendrocyte differentiation and the initiation of myelination...- Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrainMiki Furusho
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
J Neurosci 31:5055-66. 2011..Overall, our results reveal for the first time an essential role of FGF signaling in vivo, where the three Fgfrs differentially control the normal generation of OLPs from the embryonic ventral forebrain... - Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiationLuke Y S Oh
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
J Neurosci 23:883-94. 2003.... - Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thicknessMiki Furusho
Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030, USA
J Neurosci 32:6631-41. 2012.... - Disruption of fibroblast growth factor receptor signaling in nonmyelinating Schwann cells causes sensory axonal neuropathy and impairment of thermal pain sensitivityMiki Furusho
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
J Neurosci 29:1608-14. 2009..This study provides a novel molecular mechanism for nociception with possible implications for pain sensitivity in peripheral sensory neuropathies... - Oligodendrocyte development and myelin biogenesis: parsing out the roles of glycosphingolipidsNicole Jackman
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut, USA
Physiology (Bethesda) 24:290-7. 2009..Here, we review the involvement of glycosphingolipids in myelin/OL functions, including the regulation of OL differentiation, lipid raft-mediated trafficking and signaling, and neuron-glia interactions... - Role for Rab3a in oligodendrocyte morphological differentiationMihaela Anitei
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
J Neurosci Res 87:342-52. 2009..Together, these findings indicate that Rab3a specifically stimulates morphological differentiation of mature oligodendrocytes and thus may be part of the necessary machinery for myelin membrane biogenesis... - Distinct fibroblast growth factor (FGF)/FGF receptor signaling pairs initiate diverse cellular responses in the oligodendrocyte lineageDale Fortin
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
J Neurosci 25:7470-9. 2005.... - Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?Dorothy P Schafer
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
J Neurosci 24:3176-85. 2004..Together, these results suggest that trans interactions between oligodendroglial NF-155 and axonal ligands result in cross-linking, stabilization, and formation of paranodal lipid raft assemblies... - Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrixSusan Winkler
Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030 3401, USA
J Neurosci Res 69:477-87. 2002.... - Signaling cascades activated upon antibody cross-linking of myelin oligodendrocyte glycoprotein: potential implications for multiple sclerosisCecilia B Marta
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
J Biol Chem 280:8985-93. 2005..Oligodendrocyte survival is not compromised by these treatments. We discuss the possible significance of the anti-MOG-induced signaling cascade in relation to the initial steps of MOG-mediated demyelination... - CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNSMatthew N Rasband
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
Glia 50:86-90. 2005..We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice... - Sustained activation of ERK1/2 MAPK in oligodendrocytes and schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansionAkihiro Ishii
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
J Neurosci 33:175-86. 2013..Furthermore, Schwann cells with activated ERK1/2 hypermyelinate PNS axons, suggesting that ERK1/2 signaling is a conserved mechanism that promotes both CNS and PNS developmental myelination... - Microglial Fc receptors mediate physiological changes resulting from antibody cross-linking of myelin oligodendrocyte glycoproteinCecilia B Marta
Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, United States
J Neuroimmunol 196:35-40. 2008..These results indicate that FcRs are endogenous antigen/antibody cross-linkers in vitro, suggesting that FcRs could be physiologically relevant in vivo and possible targets for therapy in Multiple Sclerosis... - Human myelin proteome and comparative analysis with mouse myelinAkihiro Ishii
Departments of Neuroscience and Cell Biology and Center for Vascular Biology, University of Connecticut Medical School, Farmington, CT 06030, USA
Proc Natl Acad Sci U S A 106:14605-10. 2009.... - The myelin-axolemmal complex: biochemical dissection and the role of galactosphingolipidsKrishna Menon
Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030-3401, USA
J Neurochem 87:995-1009. 2003..These results suggest a paradigm for identification of proteins involved in neuroglial signaling... - Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axonsMatthew N Rasband
Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
Glia 44:173-82. 2003..6 clusters. Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density... - A role for Sec8 in oligodendrocyte morphological differentiationMihaela Anitei
Program of Molecular Biology and Biochemistry, University of Connecticut Medical School, Farmington, CT 06030, USA
J Cell Sci 119:807-18. 2006..These results suggest that Sec8 plays a central role in oligodendrocyte membrane formation by regulating the recruitment of vesicles that transport myelin proteins such as OSP/Claudin11 to sites of membrane growth... - Sulfatide is a negative regulator of oligodendrocyte differentiation: development in sulfatide-null miceYukie Hirahara
Research Institute, Osaka Medical Center for Maternal and Child Health, Osaka, Japan
Glia 45:269-77. 2004..We conclude that primarily sulfatide, rather than GalC, is a key molecule for the negative regulation of oligodendrocyte terminal differentiation... - Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2Masae Naruse
Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies, Hayama, Miura, Kanagawa 240-0193, Japan
Dev Biol 297:262-73. 2006..These results demonstrate that the dorsal embryonic forebrain in vivo has the potential to generate OLPs in the presence of normal positional cues and that this can be driven by FGF-2 independent of Shh signaling...
Research Grants
- FGF Receptor in Myelin Function and DiseaseRashmi Bansal; Fiscal Year: 2010..Clarification of the role of FGF signaling in these processes can be expected to contribute to an informed clinical intervention to encourage remyelination and/or discourage demyelination. ..
- PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINSRashmi Bansal; Fiscal Year: 2009....
- Fibroblast Growth Factor Receptors in Myelin Function and DiseaseRashmi Bansal; Fiscal Year: 2007....
- PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINSRashmi Bansal; Fiscal Year: 2007....
- FGF Receptor in Myelin Function and DiseaseRashmi Bansal; Fiscal Year: 2009..Clarification of the role of FGF signaling in these processes can be expected to contribute to an informed clinical intervention to encourage remyelination and/or discourage demyelination. ..