Rashmi Bansal

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Fibroblast growth factors and their receptors in oligodendrocyte development: implications for demyelination and remyelination
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030 3401, USA
    Dev Neurosci 24:35-46. 2002
  2. ncbi request reprint Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, USA
    J Neurosci Res 74:486-93. 2003
  3. ncbi request reprint Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Conn 06030 3401, USA
    Dev Neurosci 25:83-95. 2003
  4. ncbi request reprint S-phase entry of oligodendrocyte lineage cells is associated with increased levels of p21Cip1
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci Res 80:360-8. 2005
  5. doi request reprint Myelin protein composition is altered in mice lacking either sulfated or both sulfated and non-sulfated galactolipids
    Simon Ngamli Fewou
    Departments of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Neurochem 112:599-610. 2010
  6. pmc ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination
    Akihiro Ishii
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut, USA
    J Neurosci 32:8855-64. 2012
  7. pmc Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain
    Miki Furusho
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci 31:5055-66. 2011
  8. ncbi request reprint Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation
    Luke Y S Oh
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurosci 23:883-94. 2003
  9. pmc Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness
    Miki Furusho
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030, USA
    J Neurosci 32:6631-41. 2012
  10. pmc Disruption of fibroblast growth factor receptor signaling in nonmyelinating Schwann cells causes sensory axonal neuropathy and impairment of thermal pain sensitivity
    Miki Furusho
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurosci 29:1608-14. 2009

Research Grants

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Fibroblast growth factors and their receptors in oligodendrocyte development: implications for demyelination and remyelination
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030 3401, USA
    Dev Neurosci 24:35-46. 2002
    ..This review focuses on the fibroblast growth factors signaling in oligodendrocyte development, function and discusses implications for demyelination/remyelination...
  2. ncbi request reprint Specific inhibitor of FGF receptor signaling: FGF-2-mediated effects on proliferation, differentiation, and MAPK activation are inhibited by PD173074 in oligodendrocyte-lineage cells
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, USA
    J Neurosci Res 74:486-93. 2003
    ..Thus, PD173704 is an excellent tool for investigating the role of FGF signaling in vivo in the context of combinatorial interactions of other signals...
  3. ncbi request reprint Expression of FGF receptors 1, 2, 3 in the embryonic and postnatal mouse brain compared with Pdgfralpha, Olig2 and Plp/dm20: implications for oligodendrocyte development
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Conn 06030 3401, USA
    Dev Neurosci 25:83-95. 2003
    ..These data provide further insights into role of FgfRs in OL development, and they emphasize that these receptors are positioned both spatially and temporally to impact OL generation in vivo...
  4. ncbi request reprint S-phase entry of oligodendrocyte lineage cells is associated with increased levels of p21Cip1
    Rashmi Bansal
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci Res 80:360-8. 2005
    ..Therefore, we propose that p21Cip1 is acting as a positive regulator, rather than an inhibitor, of cell cycle entry by favoring the assembly of active cyclin D1/CDK4 complexes...
  5. doi request reprint Myelin protein composition is altered in mice lacking either sulfated or both sulfated and non-sulfated galactolipids
    Simon Ngamli Fewou
    Departments of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, USA
    J Neurochem 112:599-610. 2010
    ....
  6. pmc ERK1/ERK2 MAPK signaling is required to increase myelin thickness independent of oligodendrocyte differentiation and initiation of myelination
    Akihiro Ishii
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut, USA
    J Neurosci 32:8855-64. 2012
    ..These studies suggest that the predominant role of ERK1/ERK2 signaling in vivo is in promoting rapid myelin growth to increase its thickness, subsequent to oligodendrocyte differentiation and the initiation of myelination...
  7. pmc Fibroblast growth factor signaling is required for the generation of oligodendrocyte progenitors from the embryonic forebrain
    Miki Furusho
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci 31:5055-66. 2011
    ..Overall, our results reveal for the first time an essential role of FGF signaling in vivo, where the three Fgfrs differentially control the normal generation of OLPs from the embryonic ventral forebrain...
  8. ncbi request reprint Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation
    Luke Y S Oh
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurosci 23:883-94. 2003
    ....
  9. pmc Fibroblast growth factor receptor signaling in oligodendrocytes regulates myelin sheath thickness
    Miki Furusho
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030, USA
    J Neurosci 32:6631-41. 2012
    ....
  10. pmc Disruption of fibroblast growth factor receptor signaling in nonmyelinating Schwann cells causes sensory axonal neuropathy and impairment of thermal pain sensitivity
    Miki Furusho
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurosci 29:1608-14. 2009
    ..This study provides a novel molecular mechanism for nociception with possible implications for pain sensitivity in peripheral sensory neuropathies...
  11. pmc Sustained activation of ERK1/2 MAPK in oligodendrocytes and schwann cells enhances myelin growth and stimulates oligodendrocyte progenitor expansion
    Akihiro Ishii
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci 33:175-86. 2013
    ..Furthermore, Schwann cells with activated ERK1/2 hypermyelinate PNS axons, suggesting that ERK1/2 signaling is a conserved mechanism that promotes both CNS and PNS developmental myelination...
  12. ncbi request reprint Distinct fibroblast growth factor (FGF)/FGF receptor signaling pairs initiate diverse cellular responses in the oligodendrocyte lineage
    Dale Fortin
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030, USA
    J Neurosci 25:7470-9. 2005
    ....
  13. ncbi request reprint Signaling cascades activated upon antibody cross-linking of myelin oligodendrocyte glycoprotein: potential implications for multiple sclerosis
    Cecilia B Marta
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Biol Chem 280:8985-93. 2005
    ..Oligodendrocyte survival is not compromised by these treatments. We discuss the possible significance of the anti-MOG-induced signaling cascade in relation to the initial steps of MOG-mediated demyelination...
  14. ncbi request reprint Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrix
    Susan Winkler
    Department of Neuroscience, University of Connecticut School of Medicine, Farmington 06030 3401, USA
    J Neurosci Res 69:477-87. 2002
    ....
  15. pmc Oligodendrocyte development and myelin biogenesis: parsing out the roles of glycosphingolipids
    Nicole Jackman
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut, USA
    Physiology (Bethesda) 24:290-7. 2009
    ..Here, we review the involvement of glycosphingolipids in myelin/OL functions, including the regulation of OL differentiation, lipid raft-mediated trafficking and signaling, and neuron-glia interactions...
  16. doi request reprint Role for Rab3a in oligodendrocyte morphological differentiation
    Mihaela Anitei
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurosci Res 87:342-52. 2009
    ..Together, these findings indicate that Rab3a specifically stimulates morphological differentiation of mature oligodendrocytes and thus may be part of the necessary machinery for myelin membrane biogenesis...
  17. ncbi request reprint Does paranode formation and maintenance require partitioning of neurofascin 155 into lipid rafts?
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    J Neurosci 24:3176-85. 2004
    ..Together, these results suggest that trans interactions between oligodendroglial NF-155 and axonal ligands result in cross-linking, stabilization, and formation of paranodal lipid raft assemblies...
  18. ncbi request reprint CNP is required for maintenance of axon-glia interactions at nodes of Ranvier in the CNS
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06032, USA
    Glia 50:86-90. 2005
    ..We suggest that CNP is a glial protein required for maintaining the integrity of paranodes and that disrupted axoglial signaling at this site underlies progressive axonal degeneration, observed later in the CNS of Cnp1-null mice...
  19. pmc Microglial Fc receptors mediate physiological changes resulting from antibody cross-linking of myelin oligodendrocyte glycoprotein
    Cecilia B Marta
    Department of Neuroscience, University of Connecticut Medical School, Farmington, CT 06030 3401, United States
    J Neuroimmunol 196:35-40. 2008
    ..These results indicate that FcRs are endogenous antigen/antibody cross-linkers in vitro, suggesting that FcRs could be physiologically relevant in vivo and possible targets for therapy in Multiple Sclerosis...
  20. ncbi request reprint The myelin-axolemmal complex: biochemical dissection and the role of galactosphingolipids
    Krishna Menon
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurochem 87:995-1009. 2003
    ..These results suggest a paradigm for identification of proteins involved in neuroglial signaling...
  21. ncbi request reprint Paranodal transverse bands are required for maintenance but not initiation of Nav1.6 sodium channel clustering in CNS optic nerve axons
    Matthew N Rasband
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    Glia 44:173-82. 2003
    ..6 clusters. Thus, transverse bands are not required for Nav1.6 clustering and localization at nodes or for exclusion of Nav1.2 from myelinated nerve fibers, but are required for the maintenance of nodal Nav1.6 cluster size and density...
  22. ncbi request reprint A role for Sec8 in oligodendrocyte morphological differentiation
    Mihaela Anitei
    Program of Molecular Biology and Biochemistry, University of Connecticut Medical School, Farmington, CT 06030, USA
    J Cell Sci 119:807-18. 2006
    ..These results suggest that Sec8 plays a central role in oligodendrocyte membrane formation by regulating the recruitment of vesicles that transport myelin proteins such as OSP/Claudin11 to sites of membrane growth...
  23. pmc Human myelin proteome and comparative analysis with mouse myelin
    Akihiro Ishii
    Departments of Neuroscience and Cell Biology and Center for Vascular Biology, University of Connecticut Medical School, Farmington, CT 06030, USA
    Proc Natl Acad Sci U S A 106:14605-10. 2009
    ....
  24. ncbi request reprint Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2
    Masae Naruse
    Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies, Hayama, Miura, Kanagawa 240 0193, Japan
    Dev Biol 297:262-73. 2006
    ..These results demonstrate that the dorsal embryonic forebrain in vivo has the potential to generate OLPs in the presence of normal positional cues and that this can be driven by FGF-2 independent of Shh signaling...
  25. ncbi request reprint Sulfatide is a negative regulator of oligodendrocyte differentiation: development in sulfatide-null mice
    Yukie Hirahara
    Research Institute, Osaka Medical Center for Maternal and Child Health, Osaka, Japan
    Glia 45:269-77. 2004
    ..We conclude that primarily sulfatide, rather than GalC, is a key molecule for the negative regulation of oligodendrocyte terminal differentiation...

Research Grants17

  1. FGF Receptor in Myelin Function and Disease
    Rashmi Bansal; Fiscal Year: 2010
    ..Clarification of the role of FGF signaling in these processes can be expected to contribute to an informed clinical intervention to encourage remyelination and/or discourage demyelination. ..
  2. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ....
  3. Fibroblast Growth Factor Receptors in Myelin Function and Disease
    Rashmi Bansal; Fiscal Year: 2007
    ....
  4. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2007
    ....
  5. FGF Receptor in Myelin Function and Disease
    Rashmi Bansal; Fiscal Year: 2009
    ..Clarification of the role of FGF signaling in these processes can be expected to contribute to an informed clinical intervention to encourage remyelination and/or discourage demyelination. ..