Anju Bansal

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:51-9. 2010
  2. ncbi request reprint T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I alleles
    Anju Bansal
    Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    AIDS Res Hum Retroviruses 19:1017-26. 2003
  3. pmc Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Alabama, USA
    AIDS 21:2387-97. 2007
  4. ncbi request reprint CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
    AIDS 19:241-50. 2005
  5. pmc Treatment response in acute/early infection versus advanced AIDS: equivalent first and second phases of HIV RNA decline
    J Michael Kilby
    Division of Infectious Diseases and 1917 HIV Research Clinic, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294 2050, USA
    AIDS 22:957-62. 2008
  6. pmc Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 205:1009-17. 2008
  7. ncbi request reprint Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Acquir Immune Defic Syndr 33:426-38. 2003
  8. pmc Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
    Latonya D Williams
    University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
    J Virol 85:2316-24. 2011
  9. pmc Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression
    Olusimidele T Akinsiku
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 58:132-40. 2011
  10. ncbi request reprint Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    Jie Yu
    Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Med Virol 78:1147-57. 2006

Collaborators

Detail Information

Publications20

  1. pmc CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:51-9. 2010
    ..These findings indicate that the HIV-1 genome might encode and deploy a large potential repertoire of unconventional epitopes to enhance vaccine-induced antiviral immunity...
  2. ncbi request reprint T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I alleles
    Anju Bansal
    Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    AIDS Res Hum Retroviruses 19:1017-26. 2003
    ..Hence host genetic variation among different racial groups may have less impact on the utility of candidate HIV-1 vaccines than previously suspected...
  3. pmc Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Alabama, USA
    AIDS 21:2387-97. 2007
    ..Differential protein targeting by HIV-specific CD8 T cells is associated with disparate plasma viral loads; however, it is unclear if the quality of these responses differs depending upon the specificity of the targeted epitopes...
  4. ncbi request reprint CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
    AIDS 19:241-50. 2005
    ..To understand the mechanisms underlying the differential targeting of T-cell responses during HIV-1 disease progression...
  5. pmc Treatment response in acute/early infection versus advanced AIDS: equivalent first and second phases of HIV RNA decline
    J Michael Kilby
    Division of Infectious Diseases and 1917 HIV Research Clinic, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294 2050, USA
    AIDS 22:957-62. 2008
    ..Compare the initial phases of virologic decay when acute/early and advanced HIV-infected adults are administered the same treatment regimen...
  6. pmc Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 205:1009-17. 2008
    ..In addition to their direct implications for HIV-1 vaccine design, these data suggest that CTL-induced viral polymorphisms and their associated in vivo viral fitness costs could have a significant impact on HIV-1 pathogenesis...
  7. ncbi request reprint Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Acquir Immune Defic Syndr 33:426-38. 2003
    ..Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine...
  8. pmc Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
    Latonya D Williams
    University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
    J Virol 85:2316-24. 2011
    ..Our results demonstrate that HIV-1-specific IL-21-producing CD8 T cells are induced following primary infection and enriched in elite controllers, suggesting a critical role for these cells in the maintenance of viremia control...
  9. pmc Interleukin-2 production by polyfunctional HIV-1-specific CD8 T cells is associated with enhanced viral suppression
    Olusimidele T Akinsiku
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 58:132-40. 2011
    ..To further investigate this, we measured the capacity of virus-specific CD8 T cells to inhibit HIV-1 replication in an in vitro suppression assay...
  10. ncbi request reprint Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    Jie Yu
    Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Med Virol 78:1147-57. 2006
    ..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
  11. ncbi request reprint Group M-based HIV-1 Gag peptides are frequently targeted by T cells in chronically infected US and Zambian patients
    Anju Bansal
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    AIDS 20:353-60. 2006
    ..Hence these sequences may be promising candidates for HIV vaccines or serve as a universal reagent set for evaluating Gag-specific responses...
  12. pmc Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma
    Bradley H Edwards
    Department of Medicine, University of Alabama, 845 19th Street South, BBRB 226, Birmingham, AL 35294, USA
    J Virol 76:2298-305. 2002
    ..These data serve as strong evidence that major histocompatibility complex class I presentation of Gag peptides is an essential feature for any HIV-1 vaccine designed to elicit optimal CD8+ T-cell responses...
  13. pmc HIV-specific CD8+ T cells from elite controllers are primed for survival
    Jiyu Yan
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 87:5170-81. 2013
    ..Furthermore, a better understanding of cellular markers that can be utilized to predict response durability in disease- or vaccine-elicited responses will advance the field...
  14. ncbi request reprint Immune Activation Is Associated with CD8 T Cell Interleukin-21 Production in HIV-1-Infected Individuals
    Latonya D Williams
    Department of Microbiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Virol 88:10259-63. 2014
    ..Instead, IL-21 production by CD8 T cells was associated with high levels of activation, suggesting that these cells emerge as a consequence of excessive chronic immune activation rather than CD4 lymphopenia. ..
  15. pmc CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection
    Sonya L Heath
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 56:213-21. 2011
    ..Furthermore, the heterogeneity of this population suggests that a simple measure of an effective vaccine response remains elusive...
  16. ncbi request reprint Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Infect Dis 195:108-17. 2007
    ..These studies show that functionally competent subsets of antigen-specific memory CD8+ T cells in HIV-infected individuals are maintained but only if control of viremia is attained early during the course of infection...
  17. pmc Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Virol 82:6458-69. 2008
    ..These findings demonstrate that the route and dose of DNA vaccines significantly impact the quality of immune responses, yielding important information for future vaccine design...
  18. pmc Characterization of T-Cell Responses to Cryptic Epitopes in Recipients of a Noncodon-Optimized HIV-1 Vaccine
    Anne Bet
    Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL Statistical Center for HIV AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA and Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL
    J Acquir Immune Defic Syndr 65:142-50. 2014
    ..Although CE responses are commonly detected during HIV-1 infection, it is not known whether these responses are induced after vaccination...
  19. doi request reprint Protocol for analyzing human leukocyte antigen variants and sexually transmitted infections: from genotyping to immunoassays
    Jianming Tang
    Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA
    Methods Mol Biol 903:359-80. 2012
    ..Proper application of these mature and robust techniques should help establish the importance of individual HLA alleles, haplotypes, and supertypes to host-pathogen interactions...
  20. pmc Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection
    Michael R Betts
    Laboratory of Immunology, Human Immunology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 40 Convent Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:4512-7. 2005
    ..These data suggest that control of HIV by vaccine-elicited HIV-specific T cell responses may be difficult, even when the T cell response has those characteristics predicted to provide optimal protection...