A Bansal

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. pmc An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranes
    P A Goepfert
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    J Virol 73:7210-7. 1999
  2. pmc Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 205:1009-17. 2008
  3. ncbi request reprint Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers
    Paul A Goepfert
    University of Alabama at Birmingham, 908 20th Street South, CCB 328, Birmingham, AL 35294, USA
    Vaccine 25:510-8. 2007
  4. ncbi request reprint High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2050, USA
    J Infect Dis 192:1249-59. 2005
  5. pmc Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    J Infect Dis 203:610-9. 2011
  6. pmc A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon
    P A Goepfert
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    J Virol 74:10249-55. 2000
  7. pmc Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Alabama, USA
    AIDS 21:2387-97. 2007
  8. pmc Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma
    Bradley H Edwards
    Department of Medicine, University of Alabama, 845 19th Street South, BBRB 226, Birmingham, AL 35294, USA
    J Virol 76:2298-305. 2002
  9. ncbi request reprint Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    Jie Yu
    Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Med Virol 78:1147-57. 2006
  10. ncbi request reprint CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
    AIDS 19:241-50. 2005

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranes
    P A Goepfert
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    J Virol 73:7210-7. 1999
    ..We conclude that the dilysine motif of HFV imposes a partial restriction on the site of viral maturation but is not necessary for viral infectivity...
  2. pmc Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 205:1009-17. 2008
    ..In addition to their direct implications for HIV-1 vaccine design, these data suggest that CTL-induced viral polymorphisms and their associated in vivo viral fitness costs could have a significant impact on HIV-1 pathogenesis...
  3. ncbi request reprint Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers
    Paul A Goepfert
    University of Alabama at Birmingham, 908 20th Street South, CCB 328, Birmingham, AL 35294, USA
    Vaccine 25:510-8. 2007
    ..Use of the recombinant proteins NefTat and gp120(W61D) formulated with the AS02A adjuvant system was previously shown to protect against AIDS in a rhesus macaque SHIV animal model system...
  4. ncbi request reprint High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2050, USA
    J Infect Dis 192:1249-59. 2005
    ..0) TCID50 (60 participants) than when given at the regular dose, 10(7.26) TCID50 (40 participants); as a control, a placebo vaccine preparation also was administered (10 participants)...
  5. pmc Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles
    Paul A Goepfert
    Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
    J Infect Dis 203:610-9. 2011
    ..This Phase 1 clinical trial compared the safety and immunogenicity of a rMVA vaccine administered with and without DNA vaccine priming..
  6. pmc A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon
    P A Goepfert
    Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    J Virol 74:10249-55. 2000
    ..The implications of this CTL assay comparison and the possibility of phenotypic differences in HIV-specific CD8(+) T lymphocytes are discussed...
  7. pmc Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescents
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Alabama, USA
    AIDS 21:2387-97. 2007
    ..Differential protein targeting by HIV-specific CD8 T cells is associated with disparate plasma viral loads; however, it is unclear if the quality of these responses differs depending upon the specificity of the targeted epitopes...
  8. pmc Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasma
    Bradley H Edwards
    Department of Medicine, University of Alabama, 845 19th Street South, BBRB 226, Birmingham, AL 35294, USA
    J Virol 76:2298-305. 2002
    ..These data serve as strong evidence that major histocompatibility complex class I presentation of Gag peptides is an essential feature for any HIV-1 vaccine designed to elicit optimal CD8+ T-cell responses...
  9. ncbi request reprint Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
    Jie Yu
    Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Med Virol 78:1147-57. 2006
    ..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo...
  10. ncbi request reprint CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptides
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
    AIDS 19:241-50. 2005
    ..To understand the mechanisms underlying the differential targeting of T-cell responses during HIV-1 disease progression...
  11. doi request reprint CD8 T-cell proliferative capacity is compromised in primary HIV-1 infection
    Sonya L Heath
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Acquir Immune Defic Syndr 56:213-21. 2011
    ..Furthermore, the heterogeneity of this population suggests that a simple measure of an effective vaccine response remains elusive...
  12. pmc CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcription
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Exp Med 207:51-9. 2010
    ..These findings indicate that the HIV-1 genome might encode and deploy a large potential repertoire of unconventional epitopes to enhance vaccine-induced antiviral immunity...
  13. doi request reprint Treatment response in acute/early infection versus advanced AIDS: equivalent first and second phases of HIV RNA decline
    J Michael Kilby
    Division of Infectious Diseases and 1917 HIV Research Clinic, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294 2050, USA
    AIDS 22:957-62. 2008
    ..Compare the initial phases of virologic decay when acute/early and advanced HIV-infected adults are administered the same treatment regimen...
  14. ncbi request reprint T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I alleles
    Anju Bansal
    Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    AIDS Res Hum Retroviruses 19:1017-26. 2003
    ..Hence host genetic variation among different racial groups may have less impact on the utility of candidate HIV-1 vaccines than previously suspected...
  15. ncbi request reprint Cross-reactive CD8+ T cell epitopes identified in US adolescent minorities
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Acquir Immune Defic Syndr 33:426-38. 2003
    ..Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine...
  16. ncbi request reprint Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatment
    Steffanie Sabbaj
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
    J Infect Dis 195:108-17. 2007
    ..These studies show that functionally competent subsets of antigen-specific memory CD8+ T cells in HIV-infected individuals are maintained but only if control of viremia is attained early during the course of infection...
  17. ncbi request reprint Group M-based HIV-1 Gag peptides are frequently targeted by T cells in chronically infected US and Zambian patients
    Anju Bansal
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    AIDS 20:353-60. 2006
    ..Hence these sequences may be promising candidates for HIV vaccines or serve as a universal reagent set for evaluating Gag-specific responses...
  18. pmc Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administration
    Anju Bansal
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Virol 82:6458-69. 2008
    ..These findings demonstrate that the route and dose of DNA vaccines significantly impact the quality of immune responses, yielding important information for future vaccine design...
  19. pmc Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllers
    Latonya D Williams
    University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
    J Virol 85:2316-24. 2011
    ..Our results demonstrate that HIV-1-specific IL-21-producing CD8 T cells are induced following primary infection and enriched in elite controllers, suggesting a critical role for these cells in the maintenance of viremia control...

Research Grants9

  1. CD8+ T cell cytokine production in HIV-1 infection
    Paul Goepfert; Fiscal Year: 2005
    ..An HIV-1 vaccine would also be enhanced by identifying CD8+ T cell epitopes that portend a favorable prognosis and are difficult for the virus to mutate (specific aims 2 and 3). ..
  2. HIV-1 Suppression by MHC class I restricted CD8 T Cells
    Paul Goepfert; Fiscal Year: 2007
    ..Our findings will have important implications fro HIV immunopathogenesis and vaccine design by supplying an HIV-1 specific CD8 T cell phenotype that results in efficient HIV-1 control. ..
  3. ALABAMA/ZAMBIA HIV VACCINE CLINICAL TRIALS UNIT (HVTU)
    Paul Goepfert; Fiscal Year: 2006
    ..Recently, the Alabama clinic enrolled 125 higher-risk gay men in <5 months in the first US phase III trial. Plans for utilizing these cohorts and others are described. ..
  4. HIV-1 Cryptic Epitopes: Implications for Vaccine Design
    Paul A Goepfert; Fiscal Year: 2010
    ..This information will be highly relevant and directly applicable to the design of an HIV-1 vaccine. ..