Research Topics
| A BansalSummaryAffiliation: University of Alabama at Birmingham Country: USA Publications
Research Grants
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Detail Information
Publications
An endoplasmic reticulum retrieval signal partitions human foamy virus maturation to intracytoplasmic membranesP A Goepfert
Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
J Virol 73:7210-7. 1999..We conclude that the dilysine motif of HFV imposes a partial restriction on the site of viral maturation but is not necessary for viral infectivity...- Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipientsPaul A Goepfert
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 205:1009-17. 2008..In addition to their direct implications for HIV-1 vaccine design, these data suggest that CTL-induced viral polymorphisms and their associated in vivo viral fitness costs could have a significant impact on HIV-1 pathogenesis... 
Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteersPaul A Goepfert
University of Alabama at Birmingham, 908 20th Street South, CCB 328, Birmingham, AL 35294, USA
Vaccine 25:510-8. 2007..Use of the recombinant proteins NefTat and gp120(W61D) formulated with the AS02A adjuvant system was previously shown to protect against AIDS in a rhesus macaque SHIV animal model system...- High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjectsPaul A Goepfert
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2050, USA
J Infect Dis 192:1249-59. 2005..0) TCID50 (60 participants) than when given at the regular dose, 10(7.26) TCID50 (40 participants); as a control, a placebo vaccine preparation also was administered (10 participants)... - Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particlesPaul A Goepfert
Department of Medicine, University of Alabama at Birmingham, AL 35294, USA
J Infect Dis 203:610-9. 2011..This Phase 1 clinical trial compared the safety and immunogenicity of a rMVA vaccine administered with and without DNA vaccine priming.. - A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferonP A Goepfert
Departments of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
J Virol 74:10249-55. 2000..The implications of this CTL assay comparison and the possibility of phenotypic differences in HIV-specific CD8(+) T lymphocytes are discussed... - Immunological control of chronic HIV-1 infection: HLA-mediated immune function and viral evolution in adolescentsAnju Bansal
Department of Medicine, University of Alabama at Birmingham, Alabama, USA
AIDS 21:2387-97. 2007..Differential protein targeting by HIV-specific CD8 T cells is associated with disparate plasma viral loads; however, it is unclear if the quality of these responses differs depending upon the specificity of the targeted epitopes... - Magnitude of functional CD8+ T-cell responses to the gag protein of human immunodeficiency virus type 1 correlates inversely with viral load in plasmaBradley H Edwards
Department of Medicine, University of Alabama, 845 19th Street South, BBRB 226, Birmingham, AL 35294, USA
J Virol 76:2298-305. 2002..These data serve as strong evidence that major histocompatibility complex class I presentation of Gag peptides is an essential feature for any HIV-1 vaccine designed to elicit optimal CD8+ T-cell responses... - Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infectionJie Yu
Department of Medicine, Infectious Diseases Unit, University of Rochester School of Medicine and Dentistry, New York 14642, USA
J Med Virol 78:1147-57. 2006..These defective proliferative responses of HIV- and CMV-specific CD8+ T cells were restored by the addition of IL-2 at the time of stimulation. These results may have implications for the design of immune modulation strategies in vivo... - CD8 T-cell responses in early HIV-1 infection are skewed towards high entropy peptidesAnju Bansal
Department of Medicine, University of Alabama at Birmingham, 20th Street South, Birmingham, AL 35294, USA
AIDS 19:241-50. 2005.... 
CD8 T-cell proliferative capacity is compromised in primary HIV-1 infectionSonya L Heath
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Acquir Immune Defic Syndr 56:213-21. 2011..Furthermore, the heterogeneity of this population suggests that a simple measure of an effective vaccine response remains elusive...- CD8 T cell response and evolutionary pressure to HIV-1 cryptic epitopes derived from antisense transcriptionAnju Bansal
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Exp Med 207:51-9. 2010..These findings indicate that the HIV-1 genome might encode and deploy a large potential repertoire of unconventional epitopes to enhance vaccine-induced antiviral immunity... - Treatment response in acute/early infection versus advanced AIDS: equivalent first and second phases of HIV RNA declineJ Michael Kilby
Division of Infectious Diseases and 1917 HIV Research Clinic, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294 2050, USA
AIDS 22:957-62. 2008..Compare the initial phases of virologic decay when acute/early and advanced HIV-infected adults are administered the same treatment regimen... - T cell responses in HIV type 1-infected adolescent minorities share similar epitope specificities with whites despite significant differences in HLA class I allelesAnju Bansal
Department of Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
AIDS Res Hum Retroviruses 19:1017-26. 2003..Hence host genetic variation among different racial groups may have less impact on the utility of candidate HIV-1 vaccines than previously suspected... - Cross-reactive CD8+ T cell epitopes identified in US adolescent minoritiesSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Acquir Immune Defic Syndr 33:426-38. 2003..Frequent recognition of several of these CTL epitopes in persons of diverse racial backgrounds bodes well for the development of a broadly reactive HIV-1 vaccine... - Functionally competent antigen-specific CD127(hi) memory CD8+ T cells are preserved only in HIV-infected individuals receiving early treatmentSteffanie Sabbaj
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
J Infect Dis 195:108-17. 2007..These studies show that functionally competent subsets of antigen-specific memory CD8+ T cells in HIV-infected individuals are maintained but only if control of viremia is attained early during the course of infection... - Group M-based HIV-1 Gag peptides are frequently targeted by T cells in chronically infected US and Zambian patientsAnju Bansal
Department of Medicine, Emory University, Atlanta, Georgia, USA
AIDS 20:353-60. 2006..CONCLUSION: Our data demonstrate that peptide pools based on consensus or ancestral M-based sequences can be used to evaluate Gag-specific responses elicited by subtype B or subtype C-based immunogens... - Multifunctional T-cell characteristics induced by a polyvalent DNA prime/protein boost human immunodeficiency virus type 1 vaccine regimen given to healthy adults are dependent on the route and dose of administrationAnju Bansal
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Virol 82:6458-69. 2008..These findings demonstrate that the route and dose of DNA vaccines significantly impact the quality of immune responses, yielding important information for future vaccine design... - Interleukin-21-producing HIV-1-specific CD8 T cells are preferentially seen in elite controllersLatonya D Williams
University of Alabama at Birmingham, Department of Medicine, Birmingham, AL 35294, USA
J Virol 85:2316-24. 2011..Our results demonstrate that HIV-1-specific IL-21-producing CD8 T cells are induced following primary infection and enriched in elite controllers, suggesting a critical role for these cells in the maintenance of viremia control...
Research Grants
- CD8+ T cell cytokine production in HIV-1 infectionPaul Goepfert; Fiscal Year: 2005..An HIV-1 vaccine would also be enhanced by identifying CD8+ T cell epitopes that portend a favorable prognosis and are difficult for the virus to mutate (specific aims 2 and 3). ..
- HIV-1 Suppression by MHC class I restricted CD8 T CellsPaul Goepfert; Fiscal Year: 2007..Our findings will have important implications fro HIV immunopathogenesis and vaccine design by supplying an HIV-1 specific CD8 T cell phenotype that results in efficient HIV-1 control. ..
- ALABAMA/ZAMBIA HIV VACCINE CLINICAL TRIALS UNIT (HVTU)Paul Goepfert; Fiscal Year: 2006..Recently, the Alabama clinic enrolled 125 higher-risk gay men in <5 months in the first US phase III trial. Plans for utilizing these cohorts and others are described. ..
- HIV-1 Cryptic Epitopes: Implications for Vaccine DesignPaul A Goepfert; Fiscal Year: 2010..This information will be highly relevant and directly applicable to the design of an HIV-1 vaccine. ..