William A Banks

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Minimal penetration of lipopolysaccharide across the murine blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, St Louis, MO 63106, USA
    Brain Behav Immun 24:102-9. 2010
  2. pmc Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier
    Shinya Dohgu
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    PLoS ONE 7:e39565. 2012
  3. pmc Insulin detemir is not transported across the blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Puget Sound Health Care System, United States
    Peptides 31:2284-8. 2010
  4. doi request reprint Measurement of phosphorothioate oligodeoxynucleotide antisense transport across the blood-brain barrier
    William A Banks
    Geriatrics Research, Education, and Clinical Center, Puget Sound Health Care System, Seattle, WA, USA
    Methods Mol Biol 789:337-42. 2011
  5. pmc Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice
    William A Banks
    Division of Gerontology and Geriatric Medicine, Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Proc Natl Acad Sci U S A 107:22272-7. 2010
  6. doi request reprint Opiate modulation of IL-1alpha, IL-2, and TNF-alpha transport across the blood-brain barrier
    Jessica L Lynch
    GRECC, Veterns Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of Medicine, C O Dr William Banks Laboratory, 915 N, Grand Boulevard, St Louis, MO 63106, USA
    Brain Behav Immun 22:1096-102. 2008
  7. pmc Transport across the blood-brain barrier of pluronic leptin
    Tulin O Price
    Geriatric Research, Education, and Clinical Center, VA Medical Center, John Cochran Division, 915 N Grand Blvd, St Louis, MO 63106, USA
    J Pharmacol Exp Ther 333:253-63. 2010
  8. doi request reprint Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain
    Michelle A Erickson
    GRECC, Veterans Affairs Puget Sound Health Care System and University of Washington School of Medicine, Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, Seattle, WA, USA
    J Alzheimers Dis 28:951-60. 2012
  9. pmc Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 North Grand Boulevard, St Louis, MO 63106, United States
    Peptides 29:2061-5. 2008
  10. pmc Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells
    Michelle A Erickson
    University of Pennsylvania, Department of Pathology, School of Dental Medicine, Philadelphia, Pennsylvania M A E Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington M A E, Y M, J B O, W A B Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, Washington M A E, Y M, J B O, W A B Department of Chemistry, University of Kentucky, Lexington, Kentucky J B O and Department of Neurosurgery, University of Nagasaki, Nagasaki, Japan Y M
    J Pharmacol Exp Ther 349:497-507. 2014

Detail Information

Publications57

  1. pmc Minimal penetration of lipopolysaccharide across the murine blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, St Louis, MO 63106, USA
    Brain Behav Immun 24:102-9. 2010
    ..In conclusion, brain uptake of circulating I-LPS is so low that most effects of peripherally administered LPS are likely mediated through LPS receptors located outside the BBB...
  2. pmc Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier
    Shinya Dohgu
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    PLoS ONE 7:e39565. 2012
    ..We conclude that M6PR is an important receptor used by HIV-1 to cross the BBB...
  3. pmc Insulin detemir is not transported across the blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Puget Sound Health Care System, United States
    Peptides 31:2284-8. 2010
    ..The altered CNS profile of insulin detemir may be caused by its poor access to CNS receptors and by a block of human insulin from crossing the BBB...
  4. doi request reprint Measurement of phosphorothioate oligodeoxynucleotide antisense transport across the blood-brain barrier
    William A Banks
    Geriatrics Research, Education, and Clinical Center, Puget Sound Health Care System, Seattle, WA, USA
    Methods Mol Biol 789:337-42. 2011
    ....
  5. pmc Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice
    William A Banks
    Division of Gerontology and Geriatric Medicine, Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Proc Natl Acad Sci U S A 107:22272-7. 2010
    ..7%. These results show that treatment with a GHRH antagonist has positive effects on some aspects of aging, including an increase in telomerase activity...
  6. doi request reprint Opiate modulation of IL-1alpha, IL-2, and TNF-alpha transport across the blood-brain barrier
    Jessica L Lynch
    GRECC, Veterns Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of Medicine, C O Dr William Banks Laboratory, 915 N, Grand Boulevard, St Louis, MO 63106, USA
    Brain Behav Immun 22:1096-102. 2008
    ..Whereas IL-1alpha, IL-2, and TNF-alpha are all proinflammatory cytokines, morphine exposure has individualized effects on their blood-to-brain transport...
  7. pmc Transport across the blood-brain barrier of pluronic leptin
    Tulin O Price
    Geriatric Research, Education, and Clinical Center, VA Medical Center, John Cochran Division, 915 N Grand Blvd, St Louis, MO 63106, USA
    J Pharmacol Exp Ther 333:253-63. 2010
    ..0005; 0-2 h, p < 0.001]. These studies show that the structure based Pluronic modification of leptin increased metabolic stability, reduced food intake, and allowed BBB penetration by a mechanism-independent BBB leptin transporter...
  8. doi request reprint Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain
    Michelle A Erickson
    GRECC, Veterans Affairs Puget Sound Health Care System and University of Washington School of Medicine, Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, Seattle, WA, USA
    J Alzheimers Dis 28:951-60. 2012
    ..Antisense also caused improvements in memory (p < 0.001). Together, these data support the therapeutic potential of AβPP antisense and show a unique association between AβPP and LRP-1 expression in the SAMP8 mouse...
  9. pmc Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 North Grand Boulevard, St Louis, MO 63106, United States
    Peptides 29:2061-5. 2008
    ..Overall, these results show that serum factors and physiological states influence the rate at which ghrelin is transported across the blood-brain barrier...
  10. pmc Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells
    Michelle A Erickson
    University of Pennsylvania, Department of Pathology, School of Dental Medicine, Philadelphia, Pennsylvania M A E Geriatric Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington M A E, Y M, J B O, W A B Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington School of Medicine, Seattle, Washington M A E, Y M, J B O, W A B Department of Chemistry, University of Kentucky, Lexington, Kentucky J B O and Department of Neurosurgery, University of Nagasaki, Nagasaki, Japan Y M
    J Pharmacol Exp Ther 349:497-507. 2014
    ..This suggests that blood-borne CCL11 may have important physiologic functions in the CNS and implicates the BBB as an important regulator of physiologic versus pathologic effects of this chemokine. ..
  11. pmc Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated mice
    William A Banks
    GRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Neuroinflammation 9:231. 2012
    ..Immune cell trafficking into the CNS and other tissues plays important roles in health and disease. Rapid quantitative methods are not available that could be used to study many of the dynamic aspects of immune cell-tissue interactions...
  12. pmc Role of the blood-brain barrier in the evolution of feeding and cognition
    William A Banks
    GRECC, Veterans Affairs Puget Sound Health Care System and Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98108, USA
    Ann N Y Acad Sci 1264:13-9. 2012
    ..The relation between triglycerides and cognition may be partially mediated through triglyceride's ability to regulate the BBB transport of cognitively active gastrointestinal hormones such as leptin, insulin, and ghrelin...
  13. doi request reprint Impairments in brain-to-blood transport of amyloid-β and reabsorption of cerebrospinal fluid in an animal model of Alzheimer's disease are reversed by antisense directed against amyloid-β protein precursor
    William A Banks
    GRECC, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    J Alzheimers Dis 23:599-605. 2011
    ..These findings suggest that AβPP/Aβ itself contributes to the impairments in bulk flow and saturable efflux of Aβ and that reduction of AβPP/Aβ levels can restore normal function of the BBB...
  14. pmc Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration
    Nicole Ducharme
    Geriatrics Research Education and Clinical Center, Veterans Affairs Medical Center St Louis, St Louis, MO, USA
    Eur J Pharmacol 641:128-34. 2010
    ..These results show that either the i.v. or intranasal routes of administration can deliver neurosteroids to blood and brain, but that the two routes have significant differences with intranasal administration favoring some brain regions...
  15. ncbi request reprint Passage of erythropoietic agents across the blood-brain barrier: a comparison of human and murine erythropoietin and the analog darbepoetin alfa
    William A Banks
    Geriatrics Research, Education, and Clinical Center, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, USA
    Eur J Pharmacol 505:93-101. 2004
    ..We conclude that erythropoietic agents cross the blood-brain barrier by way of the extracellular pathways in amounts that are likely sufficient to explain their neuroprotective effects...
  16. ncbi request reprint Effects of a behaviorally active antibody on the brain uptake and clearance of amyloid beta proteins
    William A Banks
    GRECC, Veterans Affairs Medical Center, 915 N Grand Blvd, St Louis, MO 63106, USA
    Peptides 26:287-94. 2005
    ....
  17. ncbi request reprint Evidence that the species barrier of human immunodeficiency virus-1 does not extend to uptake by the blood--brain barrier: comparison of mouse and human brain microvessels
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, St Louis, MO 63106, USA
    Life Sci 77:2361-8. 2005
    ..These results show that the mouse can be used to study the initial phases of HIV-1 uptake by the BBB...
  18. ncbi request reprint Delivery of testosterone to the brain by intranasal administration: comparison to intravenous testosterone
    William A Banks
    Geriatrics Research Education and Clinical Center, Veterans Affairs Medical Center St Louis, MO 63106, USA
    J Drug Target 17:91-7. 2009
    ..We conclude that the i.n. administration route delivers testosterone systemically and can target the brain, especially the olfactory bulb, hypothalamus, striatum, and hippocampus...
  19. ncbi request reprint Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1
    Tulin O Price
    Geriatric Research, Education, and Clinical Center GRECC, Veteran Affairs Medical Center, St Louis, MO 63106, USA
    Peptides 28:2372-81. 2007
    ..Efflux of labeled nesfatin-1 from brain back into blood was by way of bulk flow. These findings demonstrate that nesfatin-1 crosses the BBB in both the blood-to-brain and brain-to-blood directions by nonsaturable mechanisms...
  20. pmc Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease
    Michelle A Erickson
    1 GRECC, Veterans Affairs Puget Sound Health Care System, Seattle, Washington, USA 2 Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington, USA 3 Department of Pathology, School of Dental Medicine, University of Pennsylvania, Seattle, Washington, USA
    J Cereb Blood Flow Metab 33:1500-13. 2013
    ..From the results discussed herein, we conclude that BBB dysfunction contributes to AD through a number of mechanisms that could be initiated in the presence or absence of Aβ pathology. ..
  21. pmc Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide
    Andrej Kovac
    Division of Gerontology and Geriatric Medicine, Department of Internal Medicine, University of Washington, Seattle, Washington, USA
    J Neuroinflammation 8:139. 2011
    ....
  22. doi request reprint Blood-brain barrier as a regulatory interface
    William A Banks
    GRECC, Veterans Affairs Medical Center, St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, St Louis, MO, USA
    Forum Nutr 63:102-10. 2010
    ..Finally, the implications of these views for drug development targeted at obesity or anorexia is explored. Overall, these views show the BBB is an integral part of the physiology of eating...
  23. ncbi request reprint Triglycerides induce leptin resistance at the blood-brain barrier
    William A Banks
    Department of Internal Medicine, Division of Geriatrics, Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, St Louis University School of Medicine, 915 N Grand Boulevard, St Louis, MO 631056, USA
    Diabetes 53:1253-60. 2004
    ..Decreasing triglycerides may potentiate the anorectic effect of leptin by enhancing leptin transport across the BBB...
  24. ncbi request reprint The blood-brain barrier as a regulatory interface in the gut-brain axes
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, MO, United States
    Physiol Behav 89:472-6. 2006
    ..For example, it appears that adiponectin can inhibit release of interleukin-6 from brain endothelial cells. Overall, the BBB represents an important interface in mediating gut-brain axes...
  25. pmc The blood-brain barrier: connecting the gut and the brain
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N Grand Blvd, St Louis, MO 63106, USA
    Regul Pept 149:11-4. 2008
    ..By these and other mechanisms, the BBB regulates communications between the CNS and GI tract...
  26. ncbi request reprint Blood-brain barrier and energy balance
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis, Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N Grand Boulevard, St Louis, MO, USA
    Obesity (Silver Spring) 14:234S-237S. 2006
    ..Additionally, BBB secretions can be modulated by substances that affect feeding, such as adiponectin and lipopolysaccharide...
  27. ncbi request reprint Aluminum complexing enhances amyloid beta protein penetration of blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N Grand Blvd, St Louis, MO 63106, USA
    Brain Res 1116:215-21. 2006
    ..Brain-to-blood transport was similar for Al-Abeta42 and Abeta42. In conclusion, complexing with aluminum affects some aspects of blood-to-brain permeability so that Al-Abeta42 would have more ready access to brain cells than Abeta42...
  28. ncbi request reprint The effects of high fat diets on the blood-brain barrier transport of leptin: failure or adaptation?
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, USA
    Physiol Behav 88:244-8. 2006
    ....
  29. ncbi request reprint Entry of blood-borne cytokines into the central nervous system: effects on cognitive processes
    William A Banks
    GRECC, Veterans Affairs Medical Center, St Louis, MO, USA
    Neuroimmunomodulation 10:319-27. 2002
    ..Furthermore, this effect at the PDS is largely mediated by circulating IL-1alpha acting directly at the PDS which, in turn, depends on the ability of IL-1alpha to cross the BBB...
  30. ncbi request reprint Permeability of the blood-brain barrier to HIV-1 Tat
    William A Banks
    Division of Geriatrics, Department of Internal Medicine, GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, 915 N Grand Boulevard, St Louis, MO 63106, USA
    Exp Neurol 193:218-27. 2005
    ..In conclusion, we found that Tat crossed the BBB bidirectionally. Such permeability could provide a mechanism by which Tat produced on one side of the BBB could affect neural or immune function on the other side...
  31. pmc Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF
    Shinya Dohgu
    Department of Pharmaceutical Care and Health Sciences, Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan
    J Neuroinflammation 8:167. 2011
    ..These cytokines, in turn, act at the luminal surface of the BMEC to enhance the transcellular transport of HIV-1 independently of actions on paracellular permeability...
  32. ncbi request reprint Human immunodeficiency virus type 1 transport across the in vitro mouse brain endothelial cell monolayer
    Ryota Nakaoke
    Geriatric Research, Educational, and Clinical Center, Veterans Affairs Medical Center, St Louis, MO 63106, USA
    Exp Neurol 193:101-9. 2005
    ..HIV-1 taken up from luminal side by monolayers of brain endothelial cells was mainly released to the luminal side. HIV-1 efflux mechanisms are different from influx mechanisms...
  33. ncbi request reprint The source of cerebral insulin
    William A Banks
    Research Service 151, GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, WAB, 915 N Grand Boulevard, St Louis, MO 63106, USA
    Eur J Pharmacol 490:5-12. 2004
    ..Insulin itself also has effects on the BBB, altering enzymatic and transporter functions. Overall, BBB transport of insulin provides a mechanism for peripheral insulin to act within the CNS as a regulatory peptide...
  34. doi request reprint Delivery of galanin-like peptide to the brain: targeting with intranasal delivery and cyclodextrins
    Naoko Nonaka
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Medical Center, John Cochran Division, 915 N Grand Blvd, St Louis, MO 63106, USA
    J Pharmacol Exp Ther 325:513-9. 2008
    ..These studies show that intranasal administration is an effective route of administration for the delivery of GALP to the brain and that targeting among brain regions may be possible with the use of various cyclodextrins...
  35. pmc Developing drugs that can cross the blood-brain barrier: applications to Alzheimer's disease
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis, and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, 915 N Grand Blvd, St Louis, MO 63106, USA
    BMC Neurosci 9:S2. 2008
    ..It then examines some examples of the delivery of drugs to the central nervous system that are relevant to Alzheimer's disease, placing emphasis on peptides, antibodies, and antisense oligonucleotides...
  36. ncbi request reprint The blood-brain barrier in psychoneuroimmunology
    William A Banks
    Geriatrics Research Education and Clinical Center, Veterans Affairs Medical Center St Louis, 915 North Grand Boulevard, St Louis, MO 63106, USA
    Neurol Clin 24:413-9. 2006
    ..All these normal functions of the BBB can be altered in an adaptive or pathologic manner by neuroimmune events. As such, the BBB is an important conduit in the communication of the immune and the central nervous systems...
  37. pmc Drug delivery to the brain in Alzheimer's disease: consideration of the blood-brain barrier
    William A Banks
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    Adv Drug Deliv Rev 64:629-39. 2012
    ..In this case, those differences can complicate the treatment of CNS diseases such as depression, delirium, psychoses, and pain control in the AD population...
  38. ncbi request reprint Insulin in the brain: there and back again
    William A Banks
    Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care Center, Seattle, WA, USA
    Pharmacol Ther 136:82-93. 2012
    ..These aspects of CNS insulin action and the control of its entry by the BBB are likely only a small part of the story of insulin within the brain...
  39. ncbi request reprint Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Department of Internal Medicine, WAB, 915 N Grand Blvd, St Louis, MO 63106, USA
    Curr Pharm Des 9:801-9. 2003
    ..Evolutionary pressures would not have selected against such impairments if leptin levels were lower than those typically seen in Western society. A model that could explain how leptin transporter resistance can be acquired is presented...
  40. ncbi request reprint The many lives of leptin
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis, Department of Internal Medicine, Division of Geriatrics, Saint Louis University School of Medicine, 915 N Grand Boulevard, St Louis, MO 63106, USA
    Peptides 25:331-8. 2004
    ....
  41. ncbi request reprint Influence of ethanol dependence and methionine enkephalin antisense on serum endomorphin-1 and methionine enkephalin levels
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, St Louis, Missouri, USA
    Alcohol Clin Exp Res 28:792-6. 2004
    ..Levels of methionine enkephalin (MEnk), for example, are affected by ethanol. No study on the effect of ethanol on endomorphin, the endogenous ligand for the mu-opiate receptor, has yet been conducted...
  42. ncbi request reprint Permeability of the mouse blood-brain barrier to murine interleukin-2: predominance of a saturable efflux system
    William A Banks
    Division of Geriatrics, Department of Internal Medicine, GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, 915 N Grand Blvd, St Louis, MO 63106, USA
    Brain Behav Immun 18:434-42. 2004
    ..This is the first description of a saturable CNS-to-blood efflux system for a cytokine. We postulate that this efflux system may protect the brain from circulating IL-2...
  43. doi request reprint Delivery of peptides to the brain: emphasis on therapeutic development
    William A Banks
    Geriatrics Research, Educational, and Clincal Center, Veterans Affairs Medical Center St Louis, St Louis, MO, USA
    Biopolymers 90:589-94. 2008
    ..This provides both a therapeutic opportunity and the potential for disease to arise from BBB dysfunctions. In the last case, the BBB itself is a therapeutic target...
  44. pmc Mouse models of neurological disorders: a view from the blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, 915 N Grand Blvd, St Louis, MO 63106, USA
    Biochim Biophys Acta 1802:881-8. 2010
    ..An increasing number of diseases are so categorized in which BBB dysfunction or dysregulation plays a major role; this review highlights such roles for the BBB including those proposed for Alzheimer's disease and obesity...
  45. ncbi request reprint Lipids and cognition
    John E Morley
    GRECC, VA Medical Center and Saint Louis University School of Medicine, St Louis, MO, USA
    J Alzheimers Dis 20:737-47. 2010
    ..Overall, these studies strongly suggest that some lipids affect cognition in AD, the elderly, and obesity through a variety of mechanisms yet to be fully defined...
  46. ncbi request reprint Blood-brain barrier transport of cytokines: a mechanism for neuropathology
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, Division of Geriatrics, Department of Internal Medicine, 915 North Grand Blvd, St Louis, MO 63106, USA
    Curr Pharm Des 11:973-84. 2005
    ..Here we address some of the major principles and concepts relating to cytokine transport and BBB function which have emerged as important to neuroimmunology and neuropathology...
  47. ncbi request reprint Passage of amyloid beta protein antibody across the blood-brain barrier in a mouse model of Alzheimer's disease
    William A Banks
    GRECC, Division of Geriatrics, Department of Internal Medicine, Veterans Affairs Medical Center St Louis and Saint Louis University School of Medicine, St Louis, MO 63106, USA
    Peptides 23:2223-6. 2002
    ..This ability to enter and exit the brain even in the presence of increased brain ligand supports the use of antibody in the treatment of Alzheimer's and other diseases of the brain...
  48. pmc Brain meets body: the blood-brain barrier as an endocrine interface
    William A Banks
    Veterans Affairs Puget Sound Health Care System and Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Endocrinology 153:4111-9. 2012
    ..In summary, the BBB acts as a regulatory interface in an endocrine-like, humoral-based communication between the CNS and peripheral tissues...
  49. pmc Cytokine and chemokine responses in serum and brain after single and repeated injections of lipopolysaccharide: multiplex quantification with path analysis
    Michelle A Erickson
    Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, United States
    Brain Behav Immun 25:1637-48. 2011
    ....
  50. ncbi request reprint Effects of chronic ethanol on brain and serum level of methionine enkephalin
    William A Banks
    GRECC, Department of Internal Medicine, Saint Louis University School of Medicine, Veterans Affairs Medical Center at St Louis, Division of Geriatrics, 915 N Grand Blvd, St Louis, MO 63106, USA
    Peptides 24:1935-40. 2003
    ..These results support the hypothesis that exposure to ethanol alters brain Met-Enk in a way consistent with the reinforcement of physical dependence...
  51. doi request reprint The blood-brain barrier in psychoneuroimmunology
    William A Banks
    Geriatrics Research Education and Clinical Center, Veterans Affairs Medical Center St Louis, 915 North Grand Boulevard, St Louis, MO 63106, USA
    Immunol Allergy Clin North Am 29:223-8. 2009
    ..These normal functions of the BBB can be altered by neuroimmune events. As such, the BBB is an important conduit in the communication between the immune system and the CNS...
  52. ncbi request reprint Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible
    William A Banks
    Geriatrics Research, Educational, and Clinical Center, Veterans Affairs Medical Center St Louis, 63106, USA
    Am J Physiol Endocrinol Metab 285:E10-5. 2003
    ..These results show that, in obese CD-1 mice, the impaired transport of leptin across the BBB develops in tandem with obesity and is reversible with even modest weight reduction...
  53. pmc Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier
    Michelle A Erickson
    Department of Pharmacology and Physiology, Saint Louis University, 1402 South Grand Blvd, St Louis, MO 63104, USA
    J Neuroinflammation 9:150. 2012
    ..Here, our aim is to determine which physiological routes of Aβ clearance are affected following systemic inflammation, including those relying on LRP-1 and Pgp function at the blood-brain barrier...
  54. pmc Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier
    Michelle A Erickson
    Geriatrics Research Education and Clinical Center, Puget Sound Health Care System, Seattle, Wash, USA
    Neuroimmunomodulation 19:121-30. 2012
    ..In summary, the BBB is an interactive interface that regulates and defines many of the ways that the CNS and the immune system communicate with one another...
  55. ncbi request reprint Passage of murine scrapie prion protein across the mouse vascular blood-brain barrier
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis and Division of Geriatrics, Department of Internal Medicine, Saint Louis University School of Medicine, 915 N Grand Blvd, St Louis, MO 63106, USA
    Biochem Biophys Res Commun 318:125-30. 2004
    ..PrP(SC) also entered the cerebrospinal fluid (CSF) compartment. These results show that a prion protein can cross the intact BBB to enter both the parenchymal and CSF compartments of the brain...
  56. ncbi request reprint Are the extracellular [correction of extracelluar] pathways a conduit for the delivery of therapeutics to the brain?
    William A Banks
    GRECC, Veterans Affairs Medical Center St Louis, USA
    Curr Pharm Des 10:1365-70. 2004
    ..These examples suggest that the extracellular pathways are an option for the delivery of certain therapeutics to the brain...
  57. ncbi request reprint Neuroimmune networks and communication pathways: the importance of location
    William A Banks
    Division of Geriatrics, Department of Internal Medicine, GRECC, Veterans Affairs Medical Center, St Louis University School of Medicine, St Louis, MO 63106, USA
    Brain Behav Immun 18:120-2. 2004

Research Grants1