VYTAS BANKAITIS

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. doi request reprint Golgi membrane dynamics and lipid metabolism
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Curr Biol 22:R414-24. 2012
  2. ncbi request reprint Phosphatidylinositol transfer protein function in the yeast Saccharomyces cerevisiae
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Adv Enzyme Regul 45:155-70. 2005
  3. pmc The Cirque du Soleil of Golgi membrane dynamics
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Cell Biol 186:169-71. 2009
  4. ncbi request reprint Phosphatidylinositol transfer protein function in the mouse
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Adv Enzyme Regul 44:201-18. 2004
  5. ncbi request reprint Lipids and the exocytotic machinery of eukaryotic cells
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Curr Opin Cell Biol 15:389-95. 2003
  6. pmc Phosphatidylinositol transfer proteins and functional specification of lipid signaling pools
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Adv Enzyme Regul 47:27-40. 2007
  7. doi request reprint Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
    Gabriel Schaaf
    Department of Cell and Developmental Biology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Mol Cell 29:191-206. 2008
  8. pmc Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast
    Carl J Mousley
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Mol Biol Cell 19:4785-803. 2008
  9. ncbi request reprint Nonclassical PITPs activate PLD via the Stt4p PtdIns-4-kinase and modulate function of late stages of exocytosis in vegetative yeast
    Sheri M Routt
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Traffic 6:1157-72. 2005
  10. pmc Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells
    James G Alb
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Mol Biol Cell 13:739-54. 2002

Collaborators

Detail Information

Publications31

  1. doi request reprint Golgi membrane dynamics and lipid metabolism
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Curr Biol 22:R414-24. 2012
    ..We review the growing body of evidence for how lipid metabolism is integrally written into the engineering of the Golgi system and highlight questions for future study...
  2. ncbi request reprint Phosphatidylinositol transfer protein function in the yeast Saccharomyces cerevisiae
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Adv Enzyme Regul 45:155-70. 2005
    ....
  3. pmc The Cirque du Soleil of Golgi membrane dynamics
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Cell Biol 186:169-71. 2009
    ..Now, in this issue, Schmidt and Brown (2009. J. Cell Biol. doi:10.1083/jcb.200904147) report that lysophosphatidic acid-specific acyltransferase, LPAAT3, contributes to Golgi membrane dynamics by suppressing tubule formation...
  4. ncbi request reprint Phosphatidylinositol transfer protein function in the mouse
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Adv Enzyme Regul 44:201-18. 2004
  5. ncbi request reprint Lipids and the exocytotic machinery of eukaryotic cells
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Curr Opin Cell Biol 15:389-95. 2003
    ....
  6. pmc Phosphatidylinositol transfer proteins and functional specification of lipid signaling pools
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Adv Enzyme Regul 47:27-40. 2007
  7. doi request reprint Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
    Gabriel Schaaf
    Department of Cell and Developmental Biology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Mol Cell 29:191-206. 2008
    ..Collectively, these findings outline functional mechanisms for the Sec14 superfamily and reveal additional layers of complexity for regulating phosphoinositide homeostasis in eukaryotes...
  8. pmc Trans-Golgi network and endosome dynamics connect ceramide homeostasis with regulation of the unfolded protein response and TOR signaling in yeast
    Carl J Mousley
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Mol Biol Cell 19:4785-803. 2008
    ..These results provide new insight into Sec14 function, and they emphasize the TGN/endosomal system as a central hub for homeostatic regulation in eukaryotes...
  9. ncbi request reprint Nonclassical PITPs activate PLD via the Stt4p PtdIns-4-kinase and modulate function of late stages of exocytosis in vegetative yeast
    Sheri M Routt
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Traffic 6:1157-72. 2005
    ..The collective in vivo and biochemical data suggest SFH-mediated stimulation of Stt4p activity is indirect, most likely via a substrate delivery mechanism...
  10. pmc Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells
    James G Alb
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Mol Biol Cell 13:739-54. 2002
    ..We suggest that PITP beta is an essential housekeeping PITP in murine cells, whereas PITP alpha plays a far more specialized function in mammals than that indicated by in vitro systems that show PITP dependence...
  11. ncbi request reprint Biological functions of phosphatidylinositol transfer proteins
    Sheri M Routt
    Department of Cell and Developmental Biology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 27599 7090, USA
    Biochem Cell Biol 82:254-62. 2004
    ..Herein, we review recent advances in PITP biology and discuss as yet unresolved issues in this field...
  12. ncbi request reprint Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia
    James G Alb
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599 7090, USA
    J Biol Chem 278:33501-18. 2003
    ..Taken together, the data suggest an unanticipated role for PITP alpha in with glucose homeostasis and in mammalian endoplasmic reticulum functions that interface with transport of specific luminal lipid cargoes...
  13. pmc Local control of phosphatidylinositol 4-phosphate signaling in the Golgi apparatus by Vps74 and Sac1 phosphoinositide phosphatase
    Christopher S Wood
    Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6058, USA
    Mol Biol Cell 23:2527-36. 2012
    ..The results establish additive roles of Vps74-mediated and sphingolipid-dependent sorting of Golgi residents...
  14. pmc The Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signaling
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill Chapel Hill, North Carolina 27599 7090, USA
    Trends Biochem Sci 35:150-60. 2010
    ..Mechanisms of crosstalk, by which non-enzymatic proteins integrate metabolic cues with the action of interfacial enzymes, represent unappreciated regulatory themes in lipid signaling...
  15. pmc The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking
    Carl J Mousley
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    Biochim Biophys Acta 1771:727-36. 2007
    ....
  16. pmc Conformational dynamics of the major yeast phosphatidylinositol transfer protein sec14p: insight into the mechanisms of phospholipid exchange and diseases of sec14p-like protein deficiencies
    Margaret M Ryan
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Research Center, University of North Carolina at Chapel Hill, NC 27599 7090, USA
    Mol Biol Cell 18:1928-42. 2007
    ..These conformational transitions further suggest structural rationales for known disease missense mutations that functionally compromise mammalian members of the Sec14-protein superfamily...
  17. pmc Crystallization and preliminary X-ray diffraction analysis of phospholipid-bound Sfh1p, a member of the Saccharomyces cerevisiae Sec14p-like phosphatidylinositol transfer protein family
    Gabriel Schaaf
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1156-60. 2006
    ..This information will significantly extend our current understanding of how Sec14p-like proteins catalyze phospholipid exchange...
  18. ncbi request reprint Cell biology. Slick recruitment to the Golgi
    Vytas A Bankaitis
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Science 295:290-1. 2002
  19. pmc A Sec14p-nodulin domain phosphatidylinositol transfer protein polarizes membrane growth of Arabidopsis thaliana root hairs
    Patrick Vincent
    Department of Cell and Developmental Biology, Michael Hooker Microscopy Facility, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
    J Cell Biol 168:801-12. 2005
    ..We further suggest that Sec14p-nodulin domain proteins represent a family of regulators of polarized membrane growth in plants...
  20. ncbi request reprint The diverse biological functions of phosphatidylinositol transfer proteins in eukaryotes
    Scott E Phillips
    Department of Cell and Developmental Biology, School of Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Crit Rev Biochem Mol Biol 41:21-49. 2006
    ..Herein, we review recent progress in deciphering the biological functions of PITPs, and discuss some of the open questions that remain...
  21. pmc Specific and nonspecific membrane-binding determinants cooperate in targeting phosphatidylinositol transfer protein beta-isoform to the mammalian trans-Golgi network
    Scott E Phillips
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Mol Biol Cell 17:2498-512. 2006
    ..These latter findings are at odds with a previous report that conventional PKC-mediated phosphorylation of residue Ser262 is required for PITPbeta targeting to Golgi membranes...
  22. ncbi request reprint Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling
    Kristina E Ile
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7090, USA
    Nat Chem Biol 2:576-83. 2006
    ..Recent studies suggest such integration is linked to the action of phosphatidylinositol transfer proteins that operate at the interface of the metabolism, trafficking and organization of specific lipids...
  23. pmc Phosphoinositide phosphatases in cell biology and disease
    Yang Liu
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Prog Lipid Res 49:201-17. 2010
    ....
  24. pmc The Sac1 phosphoinositide phosphatase regulates Golgi membrane morphology and mitotic spindle organization in mammals
    Yang Liu
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 7090, USA
    Mol Biol Cell 19:3080-96. 2008
    ....
  25. ncbi request reprint The pathologies associated with functional titration of phosphatidylinositol transfer protein alpha activity in mice
    James G Alb
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7090, USA
    J Lipid Res 48:1857-72. 2007
    ..Finally, the data also demonstrate intrinsic neuronal deficits in PITPalpha-deficient mice that are independent of intestinal lipid transport defects and hypoglycemia...
  26. ncbi request reprint Activation of the phosphatidylinositol 3-kinase Vps34 by a G protein alpha subunit at the endosome
    Janna E Slessareva
    Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell 126:191-203. 2006
    ..These findings reveal two new components of the pheromone signaling pathway. More remarkably, these proteins appear to comprise a preformed effector-G beta subunit assembly and function at the endosome rather than at the plasma membrane...
  27. pmc Regulation of phosphoinositide levels by the phospholipid transfer protein Sec14p controls Cdc42p/p21-activated kinase-mediated cell cycle progression at cytokinesis
    Alicia G Howe
    Atlantic Research Centre, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Eukaryot Cell 6:1814-23. 2007
    ..Sec14p regulation of phosphoinositide levels affects cytokinesis at the level of the Cdc42p/Cla4p/Ste20p signaling cascade...
  28. pmc Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast
    Lora L Yanagisawa
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Mol Biol Cell 13:2193-206. 2002
    ....
  29. ncbi request reprint The chemistry of phospholipid binding by the Saccharomyces cerevisiae phosphatidylinositol transfer protein Sec14p as determined by EPR spectroscopy
    Tatyana I Smirnova
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695, USA
    J Biol Chem 281:34897-908. 2006
    ..The data further suggest that the Sec14p phospholipid binding pocket provides a polarity gradient that we propose is a primary thermodynamic factor that powers the ability of Sec14p to abstract a phospholipid from a membrane bilayer...
  30. pmc Analysis of oxysterol binding protein homologue Kes1p function in regulation of Sec14p-dependent protein transport from the yeast Golgi complex
    Xinmin Li
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Cell Biol 157:63-77. 2002
    ....
  31. pmc Local polarity and hydrogen bonding inside the Sec14p phospholipid-binding cavity: high-field multi-frequency electron paramagnetic resonance studies
    Tatyana I Smirnova
    Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695 8204, USA
    Biophys J 92:3686-95. 2007
    ....

Research Grants28

  1. Role of Mammalian PITP Beta in Neurodegenerative Disease
    VYTAS BANKAITIS; Fiscal Year: 2005
    ..The Bankaitis laboratory is in a unique position to undertake this line of research as it has developed the requisite genetic and biochemical systems for such comprehensive analyses. ..
  2. PHOSPHOLIPIDS IN GOLGI SECRETORY FUNCTION
    VYTAS BANKAITIS; Fiscal Year: 2007
    ....
  3. PTDINS TRANSFER PROTEIN FUNCTION AND NEURODEGENERATION
    VYTAS BANKAITIS; Fiscal Year: 2007
    ..The Bankaitis laboratory is uniquely poised to address questions of mechanism of PITPalpha function as it has developed unique experimental systems for analysis. ..
  4. Multi-Domain Sec14 Proteins and Developmentally Regulated Membrane Morphogenesis
    VYTAS BANKAITIS; Fiscal Year: 2009
    ....
  5. Multi-Domain Sec14 Proteins and Developmentally Regulated Membrane Morphogenesis
    Vytas A Bankaitis; Fiscal Year: 2010
    ....
  6. PHOSPHOLIPIDS IN GOLGI SECRETORY FUNCTION
    VYTAS BANKAITIS; Fiscal Year: 2003
    ..abstract_text> ..
  7. PTDINS TRANSFER PROTEIN FUNCTION AND NEURODEGENERATION
    VYTAS BANKAITIS; Fiscal Year: 2001
    ....
  8. PHOSPHOLIPIDS IN GOLGI SECRETORY FUNCTION
    Vytas A Bankaitis; Fiscal Year: 2010
    ....