Affiliation: University of Illinois
- Transcriptome sequencing of the blind subterranean mole rat, Spalax galili: utility and potential for the discovery of novel evolutionary patternsAssaf Malik
Institute of Evolution, University of Haifa, Haifa, Israel
PLoS ONE 6:e21227. 2011..The results presented here will serve as a valuable resource for future studies aimed at identifying genes and gene regions evolved during the adaptive radiation associated with underground life of the blind mole rat...
- Hypoxia-induced BNIP3 expression and mitophagy: in vivo comparison of the rat and the hypoxia-tolerant mole rat, Spalax ehrenbergiMark Band
W M Keck Center for Comparative and Functional Genomics, University of Illinois, Urbana, Illinois 61801, USA
FASEB J 23:2327-35. 2009..Understanding the molecular basis of such adaptations may enhance development of new therapeutic modalities...
- Transcriptome analysis of the spalax hypoxia survival response includes suppression of apoptosis and tight control of angiogenesisAssaf Malik
Institute of Evolution, University of Haifa, Israel
BMC Genomics 13:615. 2012..The blind subterranean mole rat Spalax is a hypoxia tolerant rodent, which exhibits unique longevity and therefore has invaluable potential in hypoxia and cancer research...
- The muscle ankyrin repeat proteins are hypoxia-sensitive: in vivo mRNA expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergiMark Band
WM Keck Center for Comparative and Functional Genomics, University of Illinois, Urbana, IL 61801, USA
J Mol Evol 70:1-12. 2010..Understanding the differences in MARP expression further elucidates mechanisms of hypoxia tolerance with relevance to human ischemic disease...
- Hypoxia associated NMDA receptor 2 subunit composition: developmental comparison between the hypoxia-tolerant subterranean mole-rat, Spalax, and the hypoxia-sensitive ratMark Band
The W M Keck Center for Comparative and Functional Genomics, University of Illinois, Urbana, IL 61801, USA
J Comp Physiol B 182:961-9. 2012..We suggest that indeed the proportional combinations of NMDAR-2 subunits contribute to the ability of the Spalax brain to cope with hypoxic environments...
- Transcription pattern of p53-targeted DNA repair genes in the hypoxia-tolerant subterranean mole rat SpalaxImad Shams
Institute of Evolution, University of Haifa, Haifa 31905, Israel
J Mol Biol 425:1111-8. 2013..These results suggest that critical repair functions, which are known to be inhibited under hypoxia in mice, remain active in Spalax, as part of its unique hypoxia tolerance mechanisms...
- Diversity and strain specificity of plant cell wall degrading enzymes revealed by the draft genome of Ruminococcus flavefaciens FD-1Margret E Berg Miller
Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, Illinois, USA
PLoS ONE 4:e6650. 2009....
- Pronounced cancer resistance in a subterranean rodent, the blind mole-rat, Spalax: in vivo and in vitro evidenceIrena Manov
Institute of Evolution, University of Haifa, Haifa 31095, Israel
BMC Biol 11:91. 2013..Here we addressed the questions of (1) whether Spalax is resistant to chemically-induced tumorigenesis, and (2) whether normal fibroblasts isolated from Spalax possess tumor-suppressive activity...
- Transcriptional regulation of brain gene expression in response to a territorial intrusionYibayiri O Sanogo
Integrative Biology, University of Illinois, Urbana Champaign, IL, USA
Proc Biol Sci 279:4929-38. 2012..Finally, we found a remarkably close association between gene expression and aggressive behaviour at the individual level. This study sheds light on the molecular mechanisms in the brain that underlie the response to social challenges...
- Adaptive features of skeletal muscles of mole rats (Spalax ehrenbergi) to intensive activity under subterranean hypoxic conditionsAaron Avivi
Laboratory of Molecular Evolution of Animals, Institute of Evolution, Haifa University, Mount Carmel, Haifa 31905, Israel
Acta Histochem 111:415-9. 2009..Our results indicate that skeletal muscle in the mole rats appears to have evolved in response to specific environmental demands to permit intensive endurance burrowing activities under conditions of severe or chronic hypoxia...
- Cloning and in vivo expression of vascular endothelial growth factor receptor 2 (Flk1) in the naturally hypoxia-tolerant subterranean mole ratMark Band
W M Keck Center for Comparative and Functional Genomics, University of Illinois, Urbana, Illinois, USA
FASEB J 22:105-12. 2008....
- They live in the land down under: thyroid function and basal metabolic rate in the Blind Mole Rat, SpalaxAaron Avivi
Institute of Evolution, University of Haifa, Haifa, Israel
Endocr Res 39:79-84. 2014....
- The expression of p53-target genes in the hypoxia-tolerant subterranean mole-rat is hypoxia-dependent and similar to expression patterns in solid tumorsMark Band
The W M Keck Center for Comparative and Functional Genomics, University of Illinois at Urbana Champaign, Urbana, IL, USA
Cell Cycle 9:3347-52. 2010....
- The Songbird Neurogenomics (SoNG) Initiative: community-based tools and strategies for study of brain gene function and evolutionKirstin Replogle
Cell and Developmental Biology, Univ, of Illinois, Urbana, IL, USA
BMC Genomics 9:131. 2008..In response, we developed a core set of genomic tools and a novel collaborative strategy to probe gene expression in diverse songbird species and natural contexts...
- Gene expression profiling reveals the heterogeneous transcriptional activity of Oct3/4 and its possible interaction with Gli2 in mouse embryonic stem cellsYanzhen Li
Department of Animal Sciences, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
Genomics 102:456-67. 2013..Finally, forced activation of Gli2 in mESCs increased their proliferation rate. Collectively, it is suggested with these results that Gli2 may play a novel role in the self-renewal of pluripotent stem cells...
- Brain transcriptomic response of threespine sticklebacks to cues of a predatorYibayiri O Sanogo
University of Illinois at Urbana Champaign, Urbana, Ill 61801, USA
Brain Behav Evol 77:270-85. 2011....