Research Topics
Genomes and Genes | E BancalariSummaryAffiliation: University of Miami Country: USA Publications
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Publications
Effects of volume-guaranteed synchronized intermittent mandatory ventilation in preterm infants recovering from respiratory failureCarmen M Herrera
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101, USA
Pediatrics 110:529-33. 2002....
Control of oxygenation during mechanical ventilation in the premature infantEduardo Bancalari
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, University of Miami, Miami, Florida, USA
Clin Perinatol 39:563-72. 2012..Automated control systems can also improve target maintenance, and this is achieved mainly by reducing exposure to hyperoxemia. The long-term benefits and safety of this strategy are yet to be determined in clinical trials...
Management of infants with bronchopulmonary dysplasia in North AmericaEduardo Bancalari
Division of Newborn Medicine, Dept of Pediatrics R131, University of Miami School of Medicine, PO Box 016960, 1611 N W 12 Avenue, Miami, FL 33136, USA
Early Hum Dev 81:171-9. 2005..Immunizations and RSV prevention are also important to prevent infections in these vulnerable immunocompromised patients...
Non-invasive ventilation of the preterm infantEduardo Bancalari
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida, USA
Early Hum Dev 84:815-9. 2008..Long term improvements in respiratory outcome have also been reported but need to be confirmed in larger trials...
Patent ductus arteriosus and respiratory outcome in premature infantsEduardo Bancalari
Division of Newborn Medicine, Department of Pediatrics, University Miami Miller School of Medicine, Miami, Florida 33101, USA
Biol Neonate 88:192-201. 2005..This, plus the need for longer and more aggressive mechanical ventilation, can explain the association between patent ductus arteriosus and an increased risk for bronchopulmonary dysplasia in extremely premature infants...
Apnea is not prolonged by acid gastroesophageal reflux in preterm infantsEduardo Bancalari
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, PO Box 016960, Miami, FL 33101, USA
Pediatrics 116:1217-8. 2005
Continuous positive airway pressure: early, late, or stay with synchronized intermittent mandatory ventilation?E Bancalari
Division of Newborn Medicine, Department of Pediatrics, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
J Perinatol 26:S33-7; discussion S43-5. 2006..Despite this, there is no evidence that these beneficial short-term effects translate into lower rates of long-term morbidity such as bronchopulmonary dysplasia and neurologic sequelae or mortality rates...
Bronchopulmonary dysplasia: changes in pathogenesis, epidemiology and definitionEduardo Bancalari
Division of Neonatology, Department of Pediatrics, Jackson Memorial Medical Center, University of Miami School of Medicine, 33101, Miami, FL, USA
Semin Neonatol 8:63-71. 2003..Some of the limitations of the criteria most commonly used to diagnose BPD are discussed in this article...
Definitions and diagnostic criteria for bronchopulmonary dysplasiaEduardo Bancalari
Division of Newborn Medicine, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
Semin Perinatol 30:164-70. 2006..In view of all these shortcomings, it is essential to develop more objective physiologic tools to define the degree of lung damage and improve the prediction for long-term outcome in these infants...
Weaning preterm infants from mechanical ventilationEduardo Bancalari
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Neonatology 94:197-202. 2008..Therefore, it is recommended to avoid or limit the exposure to ventilatory support. This is a review of existing practices and novel strategies to achieve weaning of ventilatory support in this population...
Bronchopulmonary dysplasia and surfactantE Bancalari
Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine, Miami, Fla, 33101, USA
Biol Neonate 80:7-13. 2001..The lack of consistency in the results with surfactant replacement may reflect the changing pathogenesis of BPD and the multiplicity of factors involved among which surfactant deficiency is only one...
Closed-loop controlled inspired oxygen concentration for mechanically ventilated very low birth weight infants with frequent episodes of hypoxemiaN Claure
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101, USA
Pediatrics 107:1120-4. 2001....
Proportional assist ventilation decreases thoracoabdominal asynchrony and chest wall distortion in preterm infantsG Musante
Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine, Miami, Florida, USA
Pediatr Res 49:175-80. 2001..We conclude that proportional assist ventilation reduces TAA and CWD by generating a small increase in airway pressure that occurs in synchrony and in proportion to each inspiratory effort...
Mechanisms of hypoxemia episodes in spontaneously breathing preterm infants after mechanical ventilationCristian Esquer
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Fla 33101, USA
Neonatology 94:100-4. 2008..Preterm infants often present with recurrent episodes of hypoxemia after mechanical ventilation...
Brainstem amino acid neurotransmitters and ventilatory response to hypoxia in pigletsDorothy A Hehre
Department of Pediatrics, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
Pediatr Res 63:46-50. 2008..These data suggest that the larger depression in the ventilatory response to hypoxia observed in younger piglets is mediated by predominance of the inhibitory AA neurotransmitters, GABA, glycine, and taurine, in the NTS...
Mechanical ventilatory support in preterm infantsN Claure
Division of Neonatology, Department of Pediatrics, University of Miami Miller Schoolof Medicine, Miami, FL, USA
Minerva Pediatr 60:177-82. 2008..This is a review of the different modes of invasive and noninvasive mechanical ventilation used to support premature infants with respiratory failure...
Changes in the pathogenesis and prevention of chronic lung disease of prematurityE Bancalari
Department of Pediatrics, University of Miami School of Medicine, FL 33101, USA
Am J Perinatol 18:1-9. 2001..For this reason, efforts to prevent CLD in extremely low birth weight infants should include an aggressive approach to the prevention and treatment of prenatal and neonatal infections and an early closure of the PDA...
Methods and evidence on volume-targeted ventilation in preterm infantsNelson Claure
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Curr Opin Pediatr 20:125-31. 2008..The article describes these modalities, their clinical application in preterm infants and reviews the evidence for the possible beneficial effects in this population...
A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infantsFernando R Moya
Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
Pediatrics 115:1018-29. 2005....
Role of abdominal muscles activity on duration and severity of hypoxemia episodes in mechanically ventilated preterm infantsCristian Esquer
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Neonatology 92:182-6. 2007..Episodes of hypoxemia are often observed in ventilated preterm infants. The factors that determine their duration, severity and the failure of the mechanical breaths to maintain ventilation have not been fully defined...
The effect of a nebulized NO donor, DPTA/NO, on acute hypoxic pulmonary hypertension in newborn pigletsKaren C Young
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA
Biol Neonate 85:195-202. 2004..We speculate that NONOates may have clinical application in the treatment of persistent pulmonary hypertension of the newborn...
Protective effect of pentoxifylline on volume-induced lung injury in newborn pigletsWilliam E Smalling
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA
Biol Neonate 86:15-21. 2004..These results suggest that PTXF may be effective in modulating lung inflammation associated with mechanical ventilation in neonates...
Acute effects of inhaled nitric oxide on pulmonary and cardiac function in preterm infants with evolving bronchopulmonary dysplasiaKamlesh Athavale
Department of Pediatrics, University of Miami School of Medicine, Miami, FL 33101, USA
J Perinatol 24:769-74. 2004..Mean SpO(2) remained unchanged, but the duration of spontaneous hypoxemic episodes increased during iNO. CONCLUSION: Low-dose iNO had no acute effects on lung function, cardiac function and oxygenation in evolving BPD...
Effects of a nebulized NONOate, DPTA/NO, on group B streptococcus-induced pulmonary hypertension in newborn pigletsKatarzyna Dabrowska
Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine Miami, FL 33101, USA
Pediatr Res 57:378-83. 2005..Therefore, NONOates may have clinical application in the management of pulmonary hypertension secondary to sepsis in neonates...
Effect of maturation on the extrathoracic airway stability of infantsS Duara
Department of Pediatrics, University of Miami School of Medicine, Florida 33101
J Appl Physiol 73:2368-72. 1992..l-1.s). These data reveal that ETA instability is present in preterm infants at birth and decreases with increasing postnatal age. Full-term neonates, by comparison, display markedly greater ETA stability in the immediate neonatal period...
Randomized, controlled trial comparing synchronized intermittent mandatory ventilation and synchronized intermittent mandatory ventilation plus pressure support in preterm infantsZenaida C Reyes
Division of Newborn Medicine, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Pediatrics 118:1409-17. 2006....
Acute effects of PEEP on tidal volume and respiratory center output during synchronized ventilation in preterm infantsXimena Alegria
Department of Pediatrics, Division of Newborn Medicine, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Pediatr Pulmonol 41:759-64. 2006..An acute increase in PEEP can affect lung mechanics and tidal volume, but it is unknown if these effects elicit compensatory changes in respiratory center output...
Effect of cyclooxygenase and lipoxygenase products on pulmonary function in group B streptococcal sepsisC Suguihara
Department of Pediatrics, University of Miami School of Medicine, Florida 33101
Pediatr Res 22:478-82. 1987..10 to 1.28 +/- 0.14 ml/cm H2O/kg, p less than 0.01) over the study period. Total pulmonary resistance decreased significantly (18.7 +/- 1.8 to 15.7 +/- 1.5 cm H2O/liter/s, p less than 0.02) only at 60 min.(ABSTRACT TRUNCATED AT 250 WORDS)..
Conditional overexpression of connective tissue growth factor disrupts postnatal lung developmentShu Wu
Department of Pediatrics, Division of Neonatology, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Am J Respir Cell Mol Biol 42:552-63. 2010..These histologic changes are similar to those observed in lungs of infants with bronchopulmonary dysplasia...
Inhibition of JNK enhances TGF-beta1-activated Smad2 signaling in mouse embryonic lungShu Wu
Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Pediatr Res 65:381-6. 2009..These data suggest that the JNK pathway may antagonize TGF-beta1 dependent Smad2 signaling during mouse embryonic lung development...
High tidal volume ventilation activates Smad2 and upregulates expression of connective tissue growth factor in newborn rat lungShu Wu
Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine, Miami, Florida 33101, USA
Pediatr Res 63:245-50. 2008..These data suggest that high V(t) ventilation activates the Smad2 pathway, which may be responsible for downstream induction of CTGF expression in newborn rat lungs...
Multicenter crossover study of automated control of inspired oxygen in ventilated preterm infantsNelson Claure
University of Miami, Miller School of Medicine, Department of Pediatrics, Division of Neonatology, PO Box 016960, R 131, Miami, FL 33101, USA
Pediatrics 127:e76-83. 2011....
Targeted minute ventilation and tidal volume in an animal model of acute changes in lung mechanics and episodes of hypoxemiaNelson Claure
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Fla 33101, USA
Neonatology 95:132-40. 2009....
Automated respiratory support in newborn infantsNelson Claure
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, P O Box 016960 R 131, Miami, FL 33101, USA
Semin Fetal Neonatal Med 14:35-41. 2009..This article describes the preliminary evidence on the application of these new techniques in preterm infants and animal models...
Automated adjustment of inspired oxygen in preterm infants with frequent fluctuations in oxygenation: a pilot clinical trialNelson Claure
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
J Pediatr 155:640-5.e1-2. 2009..To assess the efficacy of a system for automated fraction of inspired oxygen (FiO(2)) adjustment in maintaining oxygen saturation (SpO(2)) within an intended range in preterm infants with spontaneous fluctuations in SpO(2)...
Effects of pressure support during an acute reduction of synchronized intermittent mandatory ventilation in preterm infantsWaldo Osorio
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, FL, USA
J Perinatol 25:412-6. 2005..CONCLUSION: Assistance of the spontaneous breaths with pressure support maintained gas exchange. PS of 6 cm H(2)O prevented an increase in breathing effort during an acute 50% reduction in SIMV rate...
Elimination of ventilator dead space during synchronized ventilation in premature infantsNelson Claure
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101, USA
J Pediatr 143:315-20. 2003..Mainstream airflow sensors used in neonatal ventilators to synchronize mechanical breaths with spontaneous inspiration and measure ventilation increase dead space and may impair carbon dioxide (CO(2)) elimination...
The role of endothelin converting enzyme inhibition during group B streptococcus-induced pulmonary hypertension in newborn pigletsCristina T Navarrete
University of Miami School of Medicine, Department of Pediatrics R 131, PO Box 016960, Miami, FL 33101, U S A
Pediatr Res 54:387-92. 2003..All animals in the ECEI group survived the study period as opposed to 25% survival in the PL group (p < 0.001). These data suggest that the increased circulating ET-1 levels mediate, in part, the GBS-induced pulmonary hypertension...
Nonimmune hydrops fetalis in the liveborn: series of 32 autopsiesMaria M Rodriguez
Department of Pathology, Division of Pediatric Pathology, University of Miami, Jackson Memorial Medical Center, Miami, FL 33136, USA
Pediatr Dev Pathol 8:369-78. 2005..Our study shows that cardiovascular diseases that lead to heart failure or impaired venous return are more common in the liveborn (50%), whereas congenital infections are more common in the stillborn with NIHF...
ALK-5 mediates endogenous and TGF-beta1-induced expression of connective tissue growth factor in embryonic lungShu Wu
Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine, P O Box 016960, Miami, FL 33101, USA
Am J Respir Cell Mol Biol 36:552-61. 2007....
The effect of pentoxifylline on the pulmonary response to high tidal volume ventilation in ratsAndrea Lessa
Department of Pediatrics R 131, Division of Neonatology, University of Miami, Miller School of Medicine, PO Box 016960, Miami, FL 33101, USA
Pulm Pharmacol Ther 21:54-60. 2008..Volume-induced lung injury is associated with lung inflammation. Pentoxifylline inhibits cytokine release and modulates neutrophil function...
CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasiaShaoyi Chen
Department of Pediatrics, Division of Neonatology, Univ of Miami Miller School of Medicine, FL 33101, USA
Am J Physiol Lung Cell Mol Physiol 300:L330-40. 2011....
New modes of mechanical ventilation in the preterm newborn: evidence of benefitNelson Claure
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, USA
Arch Dis Child Fetal Neonatal Ed 92:F508-12. 2007
The role of angiotensin II receptor-1 blockade in the hypoxic pulmonary vasoconstriction response in newborn pigletsJosé Simon Camelo
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Fla 33101, USA
Neonatology 93:263-8. 2008..Angiotensin-converting enzyme activity is increased in newborn infants with respiratory distress syndrome and in animals with alveolar hypoxia...
Ventilatory response to hypoxia during endotoxemia in young rats: role of nitric oxideJohn Ladino
Department of Pediatrics, Division of Neonatology, Neonatal Developmental Biology Laboratory, Batchelor Children s Research Institute, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Pediatr Res 62:134-8. 2007..03). These data demonstrate that the attenuation of the early VRH during endotoxemia is in part mediated by an inhibitory effect of endothelial NO on the respiratory control mechanisms...
Effects of volume-targeted synchronized intermittent mandatory ventilation on spontaneous episodes of hypoxemia in preterm infantsValentina Polimeni
Division of Newborn Medicine, Department of Pediatrics, University of Miami School of Medicine, Miami, Fla. 3301, USA
Biol Neonate 89:50-5. 2006..Conclusion: VT-SIMV did not reduce the frequency of hypoxemic episodes, but VT-SIMV 6.0 was effective in reducing the duration of the hypoxemic episodes...
Inductance plethysmography: an alternative signal to servocontrol the airway pressure during proportional assist ventilation in small animalsA Schulze
Department of Pediatrics, Division of Neonatology, University of Miami, Miami, Florida, USA
Pediatr Res 49:169-74. 2001..We conclude that an RIP abdominal band signal can be used to generate PAV, avoiding increased dead space and endotracheal tube leak problems...
Effects of non-invasive pressure support ventilation (NI-PSV) on ventilation and respiratory effort in very low birth weight infantsNabeel Ali
Division of Neonatology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
Pediatr Pulmonol 42:704-10. 2007..Pressure support ventilation (PSV) is a mode of synchronized ventilation that can supplement the spontaneous breathing effort, but it is unknown if it is effective in non-intubated very low birth weight (VLBW) infants...
Randomized crossover comparison of proportional assist ventilation and patient-triggered ventilation in extremely low birth weight infants with evolving chronic lung diseaseAndreas Schulze
Division of Neonatology, Department of Pediatrics, University of Miami School of Medicine, Miami, FL, USA
Neonatology 92:1-7. 2007..Refinement of ventilatory techniques remains a challenge given the persistence of chronic lung disease of preterm infants...
The effect of Escherichia coli endotoxin infusion on the ventilatory response to hypoxia in unanesthetized newborn pigletsGwendolyn E McDeigan
Department of Pediatrics, University of Miami School of Medicine, Miami, Florida 33101, USA
Pediatr Res 53:950-5. 2003..These data show a significant attenuation in the ventilatory response to hypoxia during E. coli endotoxemia. This decrease in ventilation was associated with a significant decrease in the metabolic rate during hypoxia and endotoxemia...
Antenatal exposure to magnesium sulfate and the incidence of patent ductus arteriosus in extremely low birth weight infantsT del Moral
Division of Neonatology, Department of Pediatrics, University of Miami, Miller School of Medicine, Miami, FL 33101, USA
J Perinatol 27:154-7. 2007..The purpose of this study was to explore the relationship between antenatal exposure to MgSO(4) and the incidence of patent ductus arteriosus (PDA) in extremely low birth weight infants...
The association between early tracheal colonization and bronchopulmonary dysplasiaKaren C Young
Division of Newborn Medicine, Department of Pediatrics, University of Miami School of Medicine, FL 33101, USA
J Perinatol 25:403-7. 2005..42, CI 1.05 to 5.62, p < 0.05). CONCLUSION: Preterm infants exposed to chorioamnionitis have an increased incidence of early tracheal colonization. This early tracheal colonization may predispose them to develop BPD...
Can lung ultrasound scanning be a useful diagnostic tool in neonates with respiratory distress?Waldemar A Carlo
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233 7335, USA
Neonatology 91:210-1. 2007
Effect of respiratory syncytial virus on apnea in weanling ratsCarlos Sabogal
Department of Pediatrics, Division of Pediatric Pulmonology, University of Miami School of Medicine, FL 33136, USA
Pediatr Res 57:819-25. 2005....
On "A randomized, multicenter masked comparison trial of poractant alfa (Curosurf) versus beractant (Survanta) in the treatment of respiratory distress syndrome in preterm infants" (Am J Perinatol 2004;21:109-120)Eduardo Bancalari
Am J Perinatol 21:307-9. 2004
Bronchopulmonary dysplasia: old problem, new presentationEduardo Bancalari
J Pediatr (Rio J) 82:2-3. 2006
Executive summary of the workshop on oxygen in neonatal therapies: controversies and opportunities for researchRosemary D Higgins
Pregnancy and Perinatology Branch, Center for Developmental Biology and Perinatal Medicine, NICHD, NIH, 6100 Executive Blvd, Room 4B03B, MSC 7510, Bethesda, MD 20892, USA
Pediatrics 119:790-6. 2007..This article provides a summary of the discussions, focusing on major knowledge gaps, with prioritized suggestions for studies in this area...
Caffeine for apnea of prematurityEduardo Bancalari
N Engl J Med 354:2179-81. 2006
