Silvana Balzar

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program
    Silvana Balzar
    University of Pittsburgh Asthma Institute at UPMC University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 183:299-309. 2011
  2. pmc IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes
    Silvana Balzar
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, UPMC Montefiore, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:855-62. 2007
  3. pmc MAPK regulation of IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-β1 and IL-13 in human airway fibroblasts
    XiuXia Zhou
    University of Pittsburgh Asthma Institute, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 188:6046-54. 2012
  4. pmc 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Asthma Institute, University of Pittsburgh Medical Center University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 108:14246-51. 2011
  5. pmc Role of insulin-like growth factor binding protein-3 in allergic airway remodeling
    Kristen L Veraldi
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 180:611-7. 2009
  6. pmc Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 179:782-90. 2009
  7. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
  8. ncbi Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts
    XiuXia Zhou
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:1388-97. 2007
  9. ncbi Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:1345-52. 2003
  10. ncbi Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptoms
    Silvana Balzar
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int Arch Allergy Immunol 140:96-102. 2006

Detail Information

Publications17

  1. pmc Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program
    Silvana Balzar
    University of Pittsburgh Asthma Institute at UPMC University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 183:299-309. 2011
    ..Severe asthma (SA) remains poorly understood. Mast cells (MC) are implicated in asthma pathogenesis, but it remains unknown how their phenotype, location, and activation relate to asthma severity...
  2. pmc IgE expression pattern in lung: relation to systemic IgE and asthma phenotypes
    Silvana Balzar
    Division of Pulmonary, Allergy, and Critical Care Medicine, School of Medicine, University of Pittsburgh, UPMC Montefiore, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:855-62. 2007
    ..IgE-mediated responses contribute to allergy and asthma. Little is understood regarding the relationship of tissue IgE to systemic IgE, inflammation or clinical outcomes...
  3. pmc MAPK regulation of IL-4/IL-13 receptors contributes to the synergistic increase in CCL11/eotaxin-1 in response to TGF-β1 and IL-13 in human airway fibroblasts
    XiuXia Zhou
    University of Pittsburgh Asthma Institute, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 188:6046-54. 2012
    ..Thus, TGF-β1, a pleiotropic cytokine upregulated in asthmatic airways, can augment eosinophilic inflammation by interfering with IL-13's negative feedback autoregulatory loop under MEK/ERK-dependent conditions...
  4. pmc 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh Asthma Institute, University of Pittsburgh Medical Center University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 108:14246-51. 2011
    ..The results confirm a previously unknown signaling role for 15LO1 and its PE-conjugated eicosanoid product in human airway epithelial cells. This pathway enhances critical inflammatory pathways integral to asthma pathogenesis...
  5. pmc Role of insulin-like growth factor binding protein-3 in allergic airway remodeling
    Kristen L Veraldi
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 180:611-7. 2009
    ....
  6. pmc Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells
    Jinming Zhao
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Respir Crit Care Med 179:782-90. 2009
    ..IL-13 is known to induce 15LO1 and MUC5AC in human airway epithelial cells in vitro. Whether 15LO1 and/or its product 15-HETE modulate MUC5AC expression is unknown...
  7. pmc IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression
    Sally E Wenzel
    University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Respir Crit Care Med 175:570-6. 2007
    ..However, an effect on exacerbations and tissue inflammation has not been shown...
  8. ncbi Mechanisms of tissue inhibitor of metalloproteinase 1 augmentation by IL-13 on TGF-beta 1-stimulated primary human fibroblasts
    XiuXia Zhou
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Allergy Clin Immunol 119:1388-97. 2007
    ..Although these interactions have implications for remodeling in asthma, little is understood regarding the mechanisms controlling TIMP-1 product...
  9. ncbi Subepithelial basement membrane immunoreactivity for matrix metalloproteinase 9: association with asthma severity, neutrophilic inflammation, and wound repair
    Sally E Wenzel
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    J Allergy Clin Immunol 111:1345-52. 2003
    ..Although MMP-9 is increased in lavage fluid and sputum in patients with asthma, controversy exists as to the role of tissue MMP-9...
  10. ncbi Subtle immunodeficiency in severe asthma: IgA and IgG2 correlate with lung function and symptoms
    Silvana Balzar
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int Arch Allergy Immunol 140:96-102. 2006
    ....
  11. ncbi Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation
    Christina Miranda
    National Jewish Medical and Research Center and the University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    J Allergy Clin Immunol 113:101-8. 2004
    ..Asthma is a heterogeneous process, yet little is understood regarding phenotypes...
  12. ncbi Relationship of small airway chymase-positive mast cells and lung function in severe asthma
    Silvana Balzar
    Department of Medicine and Division of Biostatistics, National Jewish Medical and Research Center, 1400 Jackson St, J 226, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:431-9. 2005
    ..89; p </= 0.001 for all correlations). These data suggest that induction of chymase-positive mast cells, particularly in the small airway outer wall/alveolar attachments region, may be protective for lung function in severe asthma...
  13. pmc Transforming growth factor-beta2 induces bronchial epithelial mucin expression in asthma
    Hong Wei Chu
    Department of Medicine, National Jewish Medical and Research Center, D104, 1400 Jackson St, Denver, CO 80206, USA
    Am J Pathol 165:1097-106. 2004
    ..These data suggest that TGF-beta2 production by asthmatic bronchial epithelial cells may increase airway mucin expression. IL-13-induced mucin expression may occur in part through TGF-beta2 up-regulation...
  14. ncbi Increased TGF-beta2 in severe asthma with eosinophilia
    Silvana Balzar
    Department of Medicine, National Jewish Medical and Research Center and University of Colorado Health Sciences Center, Denver 80206, USA
    J Allergy Clin Immunol 115:110-7. 2005
    ..However, little is known regarding the expression of specific TGF-beta isoforms (TGF-beta1, TGF-beta2, and TGF-beta3) in asthma, despite recent evidence suggesting that isoforms may have differing biologic activities...
  15. doi Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways
    Weimin Liu
    Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 121:893-902.e2. 2008
    ..Many airway cells manifest signs of chronic activation in asthma. The mechanism of this chronic activation is unknown...
  16. ncbi Exhaled nitric oxide identifies the persistent eosinophilic phenotype in severe refractory asthma
    Philip E Silkoff
    National Jewish Medical and Research Center, Narbeth, PA 19072, USA
    J Allergy Clin Immunol 116:1249-55. 2005
    ..The fractional concentration of exhaled nitric oxide (FENO) is increased in asthma, correlates with eosinophilic inflammation, and decreases after steroid therapy...
  17. ncbi Myofibroblast or smooth muscle: do in vitro systems adequately replicate tissue smooth muscle?
    Sally E Wenzel
    Am J Respir Crit Care Med 174:364-5. 2006