Peter Baluk

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Significance of blood vessel leakiness in cancer
    Donald M McDonald
    Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Res 62:5381-5. 2002
  2. ncbi request reprint Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004
  3. ncbi request reprint Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection
    Arin B Aurora
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 175:6319-26. 2005
  4. ncbi request reprint In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin
    Kyung Eun Kim
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Arterioscler Thromb Vasc Biol 27:564-70. 2007
  5. pmc Disease-specific gene expression profiling in multiple models of lung disease
    Christina C Lewis
    Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
    Am J Respir Crit Care Med 177:376-87. 2008
  6. ncbi request reprint Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways
    Peter Baluk
    Cardiovascular Research Institute, Department of Anatomy, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California Electronic address
    Am J Pathol 184:1877-89. 2014
  7. ncbi request reprint Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation
    Peter Baluk
    Department of Anatomy, The Cardiovascular Research Institute, and the Comprehensive Cancer Center, University of California, San Francisco, California Electronic address
    Am J Pathol 184:1577-92. 2014
  8. pmc Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Pathol 182:1434-47. 2013
  9. doi request reprint Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
  10. pmc TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 119:2954-64. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Significance of blood vessel leakiness in cancer
    Donald M McDonald
    Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Res 62:5381-5. 2002
    ..New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding...
  2. ncbi request reprint Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004
    ..We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. pulmonis-induced chronic airway inflammation...
  3. ncbi request reprint Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection
    Arin B Aurora
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 175:6319-26. 2005
    ..The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology...
  4. ncbi request reprint In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin
    Kyung Eun Kim
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Arterioscler Thromb Vasc Biol 27:564-70. 2007
    ..We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature with that during wound healing...
  5. pmc Disease-specific gene expression profiling in multiple models of lung disease
    Christina C Lewis
    Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
    Am J Respir Crit Care Med 177:376-87. 2008
    ..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis...
  6. ncbi request reprint Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways
    Peter Baluk
    Cardiovascular Research Institute, Department of Anatomy, and the Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California Electronic address
    Am J Pathol 184:1877-89. 2014
    ..We conclude that neutrophil influx is required for remodeling of capillaries into venules in the airways of mice with Mycoplasma infection and that TNFα signaling is necessary but not sufficient for vascular remodeling. ..
  7. ncbi request reprint Preferential lymphatic growth in bronchus-associated lymphoid tissue in sustained lung inflammation
    Peter Baluk
    Department of Anatomy, The Cardiovascular Research Institute, and the Comprehensive Cancer Center, University of California, San Francisco, California Electronic address
    Am J Pathol 184:1577-92. 2014
    ..The lung lymphatic network can thus expand in sustained inflammation, but the expansion is not as reversible as the accompanying inflammation. ..
  8. pmc Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Pathol 182:1434-47. 2013
    ..We conclude that lymphangiogenesis triggered by IL-1β overexpression in mouse airways is driven by VEGF-C/D from macrophages, but not neutrophils, recruited by chemokines from epithelial cells that express IL1R1...
  9. doi request reprint Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
    ..Other markers, including CD31, junctional proteins, and receptors, such as VEGF-2, are shared by lymphatic and blood vessels...
  10. pmc TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 119:2954-64. 2009
    ..We conclude that TNF-alpha is a strong candidate for a mediator that drives blood vessel remodeling and lymphangiogenesis in inflammation...
  11. pmc Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation
    Jonas Fuxe
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Am J Pathol 178:2897-909. 2011
    ..The findings also show that the antileakage action of Ang1 requires PDGF-dependent actions of pericytes in maintaining endothelial stability...
  12. pmc Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways
    Li Chin Yao
    Department of Anatomy, University of California, 513 Parnassus Ave, Room S1363, San Francisco, CA 94143 0452, USA
    Am J Pathol 176:1525-41. 2010
    ..We suggest that lymphatic remodeling that persists after the initial inflammatory response has resolved may influence subsequent inflammatory episodes in clinical situations...
  13. pmc alpha5beta1 Integrin blockade inhibits lymphangiogenesis in airway inflammation
    Tatsuma Okazaki
    Department of Anatomy, S1363, University of California, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 174:2378-87. 2009
    ..pulmonis infection because expression of the integrin is selectively increased on lymphatic sprouts and plays an essential role in lymphatic growth...
  14. pmc Plasticity of button-like junctions in the endothelium of airway lymphatics in development and inflammation
    Li Chin Yao
    Department of Anatomy, Cardiovascular Research Institute, and the Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Am J Pathol 180:2561-75. 2012
    ..These findings demonstrate the plasticity of intercellular junctions in lymphatics during development and inflammation and show that button formation can be promoted by glucocorticoid receptor signaling in lymphatic endothelial cells...
  15. pmc Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    Tetsuichiro Inai
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 165:35-52. 2004
    ..Early loss of endothelial fenestrations in RIP-Tag2 tumors is a clue that vessel phenotype may be predictive of exceptional sensitivity to these inhibitors...
  16. pmc Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation
    Jonas Fuxe
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143 0452, USA
    Am J Pathol 176:2009-18. 2010
    ..pulmonis-infected mouse airways. Together, these findings suggest that blockade of the Ang/Tie2 pathway may represent a therapeutic approach in airway inflammation...
  17. pmc Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors
    Patricia Parsons-Wingerter
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Pathol 167:193-211. 2005
    ..This strategy of injecting antibodies revealed the uniform overexpression and rapid accessibility of alpha5beta1 integrin on tumor vessels and may prove useful in assessing other potential therapeutic targets in cancer...
  18. doi request reprint Pulmonary lymphangiectasia resulting from vascular endothelial growth factor-C overexpression during a critical period
    Li Chin Yao
    From the Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco L C Y, P B, D M M Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden C T, L C W Wihuri Research Institute and Translational Cancer Biology Program, Biomedicum Helsinki and University of Helsinki, Helsinki, Finland D T, A A, K A Department of Pathology, Boston Children s Hospital, Harvard University, MA S O V, and Department of Cell Biology, ImClone Systems, Eli Lilly and Company, New York B P
    Circ Res 114:806-22. 2014
    ....
  19. pmc Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 163:1801-15. 2003
    ..These findings indicate that basement membrane covers most tumor vessels but has profound structural abnormalities, consistent with the dynamic nature of endothelial cells and pericytes in tumors...
  20. pmc Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143 0130, USA
    Am J Pathol 165:1071-85. 2004
    ..Blood vessels can respond to VEGF by sprouting angiogenesis within a few days, but regress more slowly after VEGF withdrawal, and leave a historical record of their previous extent in the form of empty basement membrane sleeves...
  21. pmc Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice
    Tatsuma Okazaki
    Department of Anatomy, S1363, University of California, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 174:2388-99. 2009
    ..We conclude that defective pericyte coverage causes capillary defects, abundant endothelial sprouts, and thick capillary diameters in EphA2-deficient mice, indicating that these animals have exaggerated responses to airway inflammation...
  22. pmc Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California, USA
    Proc Am Thorac Soc 8:504-7. 2011
    ..Whatever the mechanisms, the dynamic nature of airway blood vessels and lymphatics during perinatal development foretells the extraordinary vascular plasticity found in many diseases...
  23. pmc Rapid remodeling of airway vascular architecture at birth
    Amy Ni
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA
    Dev Dyn 239:2354-66. 2010
    ..These findings reveal the plasticity of airway vasculature after birth and show that these vessels can be used to elucidate factors that promote postnatal vascular remodeling and maturation...
  24. ncbi request reprint Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels
    Anette Magnussen
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
    Cancer Res 65:2712-21. 2005
    ..Together, these findings indicate that the rapid accessibility of alpha(5)beta(1) integrin in RIP-Tag2 tumors results from overexpression of the integrin on the luminal surface of tumor vessels...
  25. ncbi request reprint Cellular abnormalities of blood vessels as targets in cancer
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Curr Opin Genet Dev 15:102-11. 2005
    ..Rapid vascular regrowth reflects the ongoing drive for angiogenesis and bizarre microenvironment in tumors that promote vascular abnormalities and thereby create therapeutic targets...
  26. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases...
  27. pmc Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning
    Trung H M Pham
    Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 207:17-27. 2010
    ..Our data provide evidence that lymphatic endothelial cells are an in vivo source of S1P required for lymphocyte egress from LNs and Peyer's patches, and suggest a role for S1P in lymphatic vessel maturation...
  28. ncbi request reprint Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Chest 128:602S-608S. 2005
  29. pmc Functionally specialized junctions between endothelial cells of lymphatic vessels
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2349-62. 2007
    ..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
  30. pmc Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth
    Hiroya Hashizume
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0452, USA
    Cancer Res 70:2213-23. 2010
    ....
  31. ncbi request reprint Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung
    Cecile J Favre
    Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 285:H1917-38. 2003
    ..This approach can readily be used to profile genes expressed in blood vessels in tumors, chronic inflammation, and other sites in which endothelial cells avidly take up cationic liposomes...
  32. pmc Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    Shunichi Morikawa
    Department of Anatomy and Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California 94143 0130, USA
    Am J Pathol 160:985-1000. 2002
    ..The association of pericytes with endothelial sprouts raises the possibility of an involvement in sprout growth or retraction in tumors...
  33. pmc Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401 B, New Haven, CT 06520 8057, USA
    Proc Natl Acad Sci U S A 103:11021-6. 2006
    ..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling...
  34. pmc Mast cells protect mice from Mycoplasma pneumonia
    Xiang Xu
    Pulmonary and Critical Care Medicine, Mailstop 111 D, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121
    Am J Respir Crit Care Med 173:219-25. 2006
    ..Mice infected with Mycoplasma pulmonis can develop localized, life-long airway infection accompanied by persistent inflammation and remodeling...
  35. ncbi request reprint Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Circ Res 97:86-94. 2005
    ..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow...
  36. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    ..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders...
  37. ncbi request reprint The biologic basis of in vivo angiogenesis imaging
    Iclal Ocak
    Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
    Front Biosci 12:3601-16. 2007
    ..Serial analysis of gene expression or in vivo phage display may help identify new, more selective, markers that can be utilized for the targeted imaging and treatment of angiogenesis...