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Genomes and Genes | Robert BalohSummaryAffiliation: University of California Country: USA Publications
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Publications
Episodic ataxias 1 and 2Robert W Baloh
Department of Neurology, University of California, Los Angeles, CA 90095 1769, USA
Handb Clin Neurol 103:595-602. 2012..Acetazolamide can be dramatic in controlling episodes of ataxia with EA2 but is typically less beneficial with EA1...- The history and future of neuro-otologyRobert W Baloh
David Geffen School of Medicine at UCLA, P O Box 951769, Los Angeles, CA 90095, USA
Continuum (Minneap Minn) 18:1001-15. 2012..Since that time, scientific discovery has advanced our knowledge of the physiology and the pathophysiology of the vestibular system. This article describes where we have been, where we are now, and where we need to go from here... 
Dizziness: neurological emergenciesR W Baloh
Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
Neurol Clin 16:305-21. 1998..Antivertiginous and anti-emetic drugs can provide relief of acute vertigo and nausea, but medications should be rapidly tapered to allow compensation to occur...- A longitudinal study of gait and balance dysfunction in normal older peopleRobert W Baloh
Department of Neurology, University of California, Los Angeles 90095, USA
Arch Neurol 60:835-9. 2003..To identify the causes of deteriorating gait and balance in normal older people... - Clinical practice. Vestibular neuritisRobert W Baloh
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1769, USA
N Engl J Med 348:1027-32. 2003 - Genes and migraineRobert W Baloh
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Drugs Today (Barc) 40:577-88. 2004..However, none of the numerous studies performed to date provide convincing evidence for a gene responsible for the common varieties of migraine... - Genetics of familial episodic vertigo and ataxiaRobert W Baloh
Department of Neurology and Division of Surgery Head and Neck, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Ann N Y Acad Sci 956:338-45. 2002..An ion channel mutation shared by brain and inner ear could explain the combined central and peripheral features of the syndrome... - Robert Bárány and the controversy surrounding his discovery of the caloric reactionRobert W Baloh
Department of Neurology, Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neurology 58:1094-9. 2002..However, in the aftermath of the First World War and the controversy surrounding his selection for the Nobel Prize, Bárány left Vienna for Uppsala, Sweden, where he spent the last 20 years of his life in relative isolation... - Episodic vertigo: central nervous system causesRobert W Baloh
Department of Neurology, Division of Surgery Head and Neck, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Curr Opin Neurol 15:17-21. 2002..Small infarcts in the cerebellum and lateral medulla can present with vertigo without other localizing symptoms... - Static and dynamic posturography in patients with vestibular and cerebellar lesionsR W Baloh
Department of Neurology, University of California Los Angeles School of Medicine, 90095 1769, USA
Arch Neurol 55:649-54. 1998..To assess the diagnostic usefulness of posturography in 2 well-defined patient groups with impaired balance... - VertigoR W Baloh
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Lancet 352:1841-6. 1998..These drugs are generally not indicated for long-term daily use, however, since they may interfere with the normal compensation process... - The dizzy patientR W Baloh
Department of Neurology and Head and Neck Surgery, University of California, Los Angeles, UCLA School of Medicine 90095 1769, USA
Postgrad Med 105:161-4, 167-72. 1999..Initiation of a vestibular exercise program as soon as possible after injury helps ensure the best compensation possible... - Charles Skinner Hallpike and the beginnings of neurotologyR W Baloh
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
Neurology 54:2138-46. 2000..His bithermal caloric test and positional tests are still routinely used in evaluation of the vertiginous patient... - Prosper Ménière and his diseaseR W Baloh
Department of Neurology, Division of Head and Neck Surgery, University of California School of Medicine, Los Angeles, CA, USA
Arch Neurol 58:1151-6. 2001..Confusion regarding the clinical and pathologic features of Ménière disease persisted well into the 20th century... - Age-related changes in vestibular function: a longitudinal studyR W Baloh
Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
Ann N Y Acad Sci 942:210-9. 2001..These patients likely had an underlying disease even though in most cases the disease process could not be identified... - A novel mutation in KCNA1 causes episodic ataxia without myokymiaHane Lee
Department of Human Genetics, University of California, Los Angeles, California, USA
Hum Mutat 24:536. 2004..This mutation leads to a distinct clinical phenotype without myokymia broadening the scope of clinical characteristics of EA1 and highlighting the heterogeneity of phenotypic effects from distinct missense mutations... - Unbiased quantification of Scarpa's ganglion neurons in aminoglycoside ototoxicityGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
J Vestib Res 15:197-202. 2005..109). These findings may be consistent with either retrograde degeneration or a direct neurotoxic effect of the aminoglycosides on the vestibular ganglion neuron... - Regional estimates of hair cells and supporting cells in the human crista ampullarisIvan Lopez
Surgery Department, Division of Head and Neck, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
J Neurosci Res 82:421-31. 2005..34+/-0.10, and HC density was 0.63 cells/100 microm2. A significant decline in type I, type II, and total HC number and density was found in groups 2 and 3, with individuals exceeding the average human life span... - Histopathology of the vestibular end organs after intratympanic gentamicin failure for Meniere's diseaseGail Ishiyama
Department of Neurology, University of California School of Medicine, Los Angeles, CA 90095, USA
Acta Otolaryngol 127:34-40. 2007..Objective: To describe the histopathology and morphometry of the vestibular end organs from a 59-year-old Meniere's patient who underwent transmastoid labyrinthectomy for recurrent vertigo after failed intratympanic gentamicin... - Association of progesterone receptor with migraine-associated vertigoHane Lee
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA
Neurogenetics 8:195-200. 2007..0007). Two SNPs (rs2228480 and rs1801132) within ESR1 demonstrated no significant association. No synergistic effect between ESR1 variants and PGR variants was identified... 
Familial clustering of migraine, episodic vertigo, and Ménière's diseaseYoon Hee Cha
Department of Neurology, University of California Los Angeles, Los Angeles, California 90095, USA
Otol Neurotol 29:93-6. 2008..To evaluate the association between migraine, episodic vertigo, and Ménière's disease in families...- Gentamicin ototoxicity: clinical features and the effect on the human vestibulo-ocular reflexGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Acta Otolaryngol 126:1057-61. 2006..Sinusoidal rotational stimuli with high accelerations such as the bedside head-thrust test or rotational step changes in velocity are useful to diagnose bilateral vestibulopathy... - Increased prevalence of significant recurrent headache in preclinical familial Alzheimer's disease mutation carriersJohn M Ringman
Alzheimer s Disease Research Center, UCLA, Los Angeles, CA 90095 7226, USA
Dement Geriatr Cogn Disord 25:380-4. 2008..In our study we compared the prevalence of headaches between nondemented FAD mutation carriers (MCs) and non-mutation-carrying controls (NCs)... - Clinical features and associated syndromes of mal de debarquementYoon Hee Cha
Dept of Neurology, University of California, 710 Westwood Plaza, 951769, Los Angeles, CA 90095, USA
J Neurol 255:1038-44. 2008..To investigate the clinical features and natural history of mal de debarquement (MdD)... - Familial episodic ataxia: a model for migrainous vertigoJoanna C Jen
UCLA Neurology, Los Angeles, California, USA
Ann N Y Acad Sci 1164:252-6. 2009..Efforts are ongoing to perform genomewide association studies to identify risk alleles for migrainous vertigo, which may also be relevant to migraine in general... - Three brothers with a very-late-onset writer's crampRoongroj Bhidayasiri
Department of Neurology, UCLA Medical Center, Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
Mov Disord 20:1375-7. 2005..We describe a family of Bulgarian descent with three brothers presenting with a very-late-onset dystonic WC, compatible with linkage to chromosome 18p... - No mutations in CACNA1A and ATP1A2 in probands with common types of migraineJoanna C Jen
Department of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA
Arch Neurol 61:926-8. 2004..Mutations in CACNA1A, encoding a neuronal calcium channel subunit, and ATP1A2, encoding a catalytic subunit of a sodium-potassium-ATPase, have been found in some families with dominantly inherited hemiplegic migraine... - Canavan's leukodystrophy is associated with defects in cochlear neurodevelopment and deafnessGail Ishiyama
Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
Neurology 60:1702-4. 2003..The vestibular end organs and ganglia were normal. These findings implicate a role of aminoacylase II in the neurodevelopment of the organ of Corti... - Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesisJoanna C Jen
Department of Neurology, University of California, Los Angeles, CA 90095, USA
Science 304:1509-13. 2004..Like its murine homolog Rig1/Robo3, but unlike other Robo proteins, ROBO3 is required for hindbrain axon midline crossing... - Immunolocalization of voltage-gated calcium channel alpha1 subunits in the chinchilla cochleaIvan Lopez
Department of Surgery, Division of Head and Neck, 31 25 Rehabilitation Center, UCLA School of Medicine, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
Cell Tissue Res 313:177-86. 2003..The presence of alpha1A, the pore-forming subunit of the P/Q type channels, has not previously been demonstrated in inner and outer hair cells, and its function in the cochlear hair cell is unknown... - Genetics of episodic ataxiaJoanna C Jen
Department of Neurology, UCLA School of Medicine, Los Angeles, California, USA
Adv Neurol 89:459-61. 2002 - Chronic cough due to Thr124Met mutation in the peripheral myelin protein zero (MPZ gene)Robert H Baloh
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 62:1905-6. 2004 - Phenotypic and genetic analysis of a large family with migraine-associated vertigoHane Lee
Department of Human Genetics, University of California, Los Angeles, CA 90095, USA
Headache 48:1460-7. 2008..To describe a large multigenerational family with migraine-associated vertigo (MAV) combining a detailed phenotypic and genetic analysis... - Nonconsensus intronic mutations cause episodic ataxiaJijun Wan
Department of Neurology, University of California at Los Angeles, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA
Ann Neurol 57:131-5. 2005..The identification of these disease-causing mutations expands the spectrum of EA2 mutations and emphasizes the importance of intronic sequences in regulating gene expression... - A genome-wide linkage scan of familial benign recurrent vertigo: linkage to 22q12 with evidence of heterogeneityHane Lee
Department of Human Genetics, University of California, Los Angeles, 90095, USA
Hum Mol Genet 15:251-8. 2006..Additional family and population-based linkage and association studies will be needed to determine the causative alleles... - The Dix-Hallpike test and the canalith repositioning maneuverErik Viirre
Division of Otolaryngology, Head and Neck Surgery, University of California, San Diego, School of Medicine, San Diego, CA, USA
Laryngoscope 115:184-7. 2005..If, during any of this testing, a movement elicits vertigo or nystagmus, the appropriate CRM is then carried out... - Drop attacks and vertigo secondary to a non-meniere otologic causeGail Ishiyama
Department of Neurology, University of California, Los Angeles, UCLA School of Medicine, Los Angeles, CA 90095, USA
Arch Neurol 60:71-5. 2003..The clinical description of the falls is similar to those associated with Meniere syndrome. Further studies are needed to understand the etiology of Tumarkin falls in these patients with normal hearing... - A new episodic ataxia syndrome with linkage to chromosome 19q13Kevin A Kerber
Department of Neurology, UCLA, Los Angeles, California 90095 1769, USA
Arch Neurol 64:749-52. 2007..Multiple episodic ataxia phenotypes and genotypes have been described... - Dejerine-Sottas syndrome and vestibular loss due to a point mutation in the PMP22 geneJoanna Jen
Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095-1769, United States
J Neurol Sci 237:21-4. 2005..It is important to recognize this combination of peripheral nerve and vestibular deficits since rehabilitation strategies and prognosis are different... - Unbiased stereologic type I and type II hair cell counts in human utricular maculaQuinton Gopen
Division of Head and Neck Surgery, Medical Center, University of California-Los Angeles School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Laryngoscope 113:1132-8. 2003..The current data represent the first total type I and type II hair cell counts in human utricular neuroepithelium... - Late-onset pure cerebellar ataxia: differentiating those with and without identifiable mutationsKevin A Kerber
Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
J Neurol Sci 238:41-5. 2005..Although only a third of these idiopathic late onset ataxia patients had a positive family history, this homogeneous syndrome probably represents a yet to be identified genetic disorder... - A longitudinal study of oculomotor function in normal older peopleKevin A Kerber
Department of Neurology, Reed Neurological Research Center, 710 Westwood Plaza, Box 951769, UCLA School of Medicine, Los Angeles, CA, USA
Neurobiol Aging 27:1346-53. 2006..The significant correlation between decline in oculomotor measures and gait and balance measures (even after controlling for age) suggests a common mechanism for the decline in both measures... - Recurrent vertigo attacks cured by stenting a basilar artery stenosisKevin A Kerber
Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
Neurology 65:962. 2005 - Estimation of the number of nerve fibers in the human vestibular endorgans using unbiased stereology and immunohistochemistryIvan Lopez
Division of Head and Neck Surgery, CHS 62-132, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
J Neurosci Methods 145:37-46. 2005..These methods can be applied for studies of normal aging and pathological conditions of the vestibular periphery... - Hearing symptoms in migrainous infarctionHyung Lee
Department of Neurology, Keimyung University, School of Medicine, Daegu, Korea
Arch Neurol 60:113-6. 2003..We speculate that these symptoms may have resulted from migraine-associated vasospasm. Migrainous infarction should be considered in the differential diagnosis of acute auditory symptoms, including sudden, bilateral hearing loss... - Increased risk of death in community-dwelling older people with white matter hyperintensities on MRIKevin A Kerber
Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0322, USA
J Neurol Sci 250:33-8. 2006..CONCLUSIONS: Severe WMH increase the risk of death, even in community-dwelling elderly without stroke or other neurological disease, independent of other covariates including hypertension, age, and coronary artery disease... - Sigmund Freud and the VIIIth Cranial NerveGerald Wiest
Department of Neurology, School of Medicine, University of Vienna, Vienna, Austria
Otol Neurotol 23:228-32. 2002
Research Grants
- Diseases of the Vestibular SystemRobert Baloh; Fiscal Year: 2006..abstract_text> ..
- DIZZINESS IN OLDER PEOPLERobert Baloh; Fiscal Year: 2000..By continuing this longitudinal study of carefully studied older patients and controls, our multidisciplinary research team is in a good position to achieve our goals. ..
- DIZZINESS IN OLDER PEOPLERobert Baloh; Fiscal Year: 1993..This multidisciplinary study can overcome these limitations and thereby improve the diagnosis and management of elderly persons complaining of dizziness...
- DIZZINESS IN OLDER PEOPLERobert Baloh; Fiscal Year: 2006..By continuing this longitudinal study of carefully studied older patients and controls, our multidisciplinary research team is in a good position to achieve our goals. ..