Z Baloch

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review
    Kathleen T Montone
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Pathol Lab Med 132:1241-50. 2008
  2. pmc A cytohistologic correlation of mucoepidermoid carcinoma: emphasizing the rare oncocytic variant
    Timothy V Wade
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Patholog Res Int 2011:135796. 2011
  3. ncbi Follicular-patterned afflictions of the thyroid gland: reappraisal of the most discussed entity in endocrine pathology
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, UPENN Medical Center, 3400 Spruce Street, 6 Founders Pavilion, Philadelphia, PA, 19104, USA
    Endocr Pathol 25:12-20. 2014
  4. doi Aggressive variants of follicular cell derived thyroid carcinoma; the so called 'real thyroid carcinomas'
    Zubair Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Clin Pathol 66:733-43. 2013
  5. ncbi Cytoplasmic accumulation of alpha-catenin in thyroid neoplasms
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Head Neck 23:573-8. 2001
  6. doi Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference
    Zubair W Baloch
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 36:425-37. 2008
  7. ncbi Intraoperative assessment of thyroid and parathyroid lesions
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Semin Diagn Pathol 19:219-26. 2002
  8. ncbi Encapsulated follicular variant of papillary thyroid carcinoma with bone metastases
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, USA
    Mod Pathol 13:861-5. 2000
  9. ncbi Etiology and significance of the optically clear nucleus
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, PA 19104, USA
    Endocr Pathol 13:289-99. 2002
  10. ncbi Pathologic diagnosis of papillary thyroid carcinoma: today and tomorrow
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Expert Rev Mol Diagn 5:573-84. 2005

Collaborators

Detail Information

Publications77

  1. doi The thyroid Hürthle (oncocytic) cell and its associated pathologic conditions: a surgical pathology and cytopathology review
    Kathleen T Montone
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Arch Pathol Lab Med 132:1241-50. 2008
    ..Hürthle cells are eosinophilic, follicular-derived cells that are associated with a variety of nonneoplastic and neoplastic thyroid lesions. The differential diagnosis of Hürthle cell lesions is quite broad...
  2. pmc A cytohistologic correlation of mucoepidermoid carcinoma: emphasizing the rare oncocytic variant
    Timothy V Wade
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Patholog Res Int 2011:135796. 2011
    ..Presence of mucous cells, cells with foamy/clear cytoplasm, intermediate cells and lymphocytes in a mucinous background are diagnostic indicators of MEC; presence of oncocytes should not refrain from diagnosing MEC in FNA specimens...
  3. ncbi Follicular-patterned afflictions of the thyroid gland: reappraisal of the most discussed entity in endocrine pathology
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, Perelman School of Medicine, UPENN Medical Center, 3400 Spruce Street, 6 Founders Pavilion, Philadelphia, PA, 19104, USA
    Endocr Pathol 25:12-20. 2014
    ....
  4. doi Aggressive variants of follicular cell derived thyroid carcinoma; the so called 'real thyroid carcinomas'
    Zubair Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Clin Pathol 66:733-43. 2013
    ..This paper describes these important but rare lesions, their pathological features, important clinicopathological correlations, molecular correlates and prognostic implications. ..
  5. ncbi Cytoplasmic accumulation of alpha-catenin in thyroid neoplasms
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Head Neck 23:573-8. 2001
    ..In this study, we evaluated the expression of alpha-cat in various thyroid tumors by immunohistochemical analysis...
  6. doi Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference
    Zubair W Baloch
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 36:425-37. 2008
    ..http://thyroidfna.cancer.gov/pages/info/agenda/)...
  7. ncbi Intraoperative assessment of thyroid and parathyroid lesions
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Semin Diagn Pathol 19:219-26. 2002
    ..This articles reviews the use of frozen section diagnosis in the evaluation of thyroid and parathyroid lesions, presents the current literature and the author's experiences, and proposes a practical approach to these cases...
  8. ncbi Encapsulated follicular variant of papillary thyroid carcinoma with bone metastases
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, USA
    Mod Pathol 13:861-5. 2000
    ..We wish to bring attention to these innocuous-appearing lesions, which, although sharing nuclear features of papillary cancer, behave clinically in an unexpectedly malignant fashion...
  9. ncbi Etiology and significance of the optically clear nucleus
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, PA 19104, USA
    Endocr Pathol 13:289-99. 2002
    ..Recent studies have suggested that RET/PTC may be the cause of this specific nuclear change in PTC; however, the role of RET/PTC in tumor progression still needs to be defined...
  10. ncbi Pathologic diagnosis of papillary thyroid carcinoma: today and tomorrow
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Expert Rev Mol Diagn 5:573-84. 2005
    ..In addition, these involved genes may also serve as targets for cancer chemotherapy in patients where standard thyroid cancer treatment is not effective...
  11. ncbi Microcarcinoma of the thyroid
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Adv Anat Pathol 13:69-75. 2006
    ..However, when found as sporadic tumors, their implications are still unknown. The histologic features, pathologic mimics, and molecular facets of these microscopic neoplasms are discussed in this review...
  12. ncbi Role of repeat fine-needle aspiration biopsy (FNAB) in the management of thyroid nodules
    Zubair Baloch
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 29:203-6. 2003
    ....
  13. ncbi Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Mod Pathol 13:802-7. 2000
    ..All cases of MEC were positive for thyroglobulin, whereas all cases of SMECE were negative. The immunohistochemical findings suggest that both MEC and SMECE have different histogenesis...
  14. ncbi Papillary formations in metastatic melanoma
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Diagn Cytopathol 20:148-51. 1999
    ..An awareness of this cytomorphologic variation of papillary formations in cytology preparations from metastatic melanoma is important and can prevent potential inaccurate interpretation...
  15. ncbi Ultrasound-guided fine-needle aspiration biopsy of the thyroid: role of on-site assessment and multiple cytologic preparations
    Z W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 23:425-9. 2000
    ..We conclude that ultrasound-guided FNA combined with on-site evaluation and different cytologic preparations can significantly improve the diagnostic accuracy of thyroid FNA specimens...
  16. ncbi Diagnosis of "follicular neoplasm": a gray zone in thyroid fine-needle aspiration cytology
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 26:41-4. 2002
    ..However, clinical features, including gender, nodule size, and age, can be a part of the decision analysis in selecting patients for surgery...
  17. ncbi Combined tall cell carcinoma and Hürthle cell carcinoma (collision tumor) of the thyroid
    Z W Baloch
    Department of Pathology and Laboratory Medicine, 6 Founders Pavilion, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Arch Pathol Lab Med 125:541-3. 2001
    ..The coexistence of these tumor types is rare and sheds light on the histogenesis of Hürthle cell tumors and the metastatic behavior of combined tumors...
  18. doi Unique growth pattern in papillary carcinoma of the thyroid gland mimicking adenoid cystic carcinoma
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Endocr Pathol 22:200-5. 2011
    ..It is important to be aware of this unusual growth pattern in thyroid carcinomas; immunohistochemistry is warranted for rendering accurate cytopathologic and histopathologic diagnosis...
  19. ncbi Ultrasound-guided fine-needle aspiration diagnosis of adenocarcinoma of esophagus with signet-ring cell features arising in Barrett's esophagus: a case report
    Z Baloch
    Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Diagn Cytopathol 19:51-4. 1998
    ..These findings represented an adenocarcinoma with signet-ring cell features arise in Barrett's esophagus...
  20. doi Encapsulated classic and follicular variants of papillary thyroid carcinoma: comparative clinicopathologic study
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA, USA
    Endocr Pract 16:952-9. 2010
    ..To compare the clinicopathologic features of papillary thyroid carcinoma classic variant (PTC-CV) and papillary thyroid carcinoma follicular variant (PTCFV), with a focus on the encapsulated form...
  21. doi Fine-needle aspiration of the thyroid: today and tomorrow
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, 6 Founders Pavilion, 3400 Spruce Street, University of Pennsylvania Medical Center, Philadelphia, PA, 19104, USA
    Best Pract Res Clin Endocrinol Metab 22:929-39. 2008
    ..Finally, an assessment of modern techniques such as immunohistochemistry and molecular analyses is given with emphasis on their validity for FNA samples as well as the pitfalls that are encountered in their use...
  22. ncbi Parathyromatosis as cause of recurrent secondary hyperparathyroidism: a cytologic diagnosis
    Z W Baloch
    Department of Pathology and Laboratory Medicine, 6 Founders Pavilion, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 25:403-5. 2001
    ..We present a case of parathyromatosis occurring in a patient with recurrent secondary hyperparathyroidism 4 yr after parathyroidectomy. The diagnosis was confirmed preoperatively by fine-needle aspiration of one of several neck masses...
  23. ncbi Evaluation of the CD34 and CD10 immunostains using a two-color staining protocol in liver fine-needle aspiration biopsies
    Robert L Zimmerman
    Department of Pathology and Lab Medicine, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 32:88-91. 2005
    ..Two-color immunostaining with CD10 and CD34 may prove useful in distinguishing HCC from metastases...
  24. doi E-cadherin/beta-catenin and CD10: a limited immunohistochemical panel to distinguish pancreatic endocrine neoplasm from solid pseudopapillary neoplasm of the pancreas on endoscopic ultrasound-guided fine-needle aspirates of the pancreas
    Holly Burford
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
    Am J Clin Pathol 132:831-9. 2009
    ..On limited FNA samples, the characteristic expression of E-cadherin/beta-catenin and the expression of CD10 can be used to distinguish PEN from SPN...
  25. ncbi Ectopic parathyroid adenoma initially suspected to be a thyroid lesion
    S A Pitsilos
    Department of Anatomic Pathology and Laboratory Medicine, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    Arch Pathol Lab Med 126:1541-2. 2002
    ..We present a case of an ectopic parathyroid adenoma for which misleading localization prompted cytologic misdiagnosis and intraoperative suspicion of thyroid carcinoma...
  26. ncbi Histiocytic aggregates in benign nodular goiters mimicking cytologic features of papillary thyroid carcinoma (PTC)
    Aziza Nassar
    Department of Pathology and Laboratory Medicine, Division of Cytopathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Diagn Cytopathol 29:243-5. 2003
    ..Immunostaining for CD68 may be of value in differentiating between benign cystic thyroid nodules with histiocytic aggregates that mimic cytologic features of papillary carcinoma, and PTC with cystic change...
  27. ncbi Does the fine-needle aspiration diagnosis of "Hürthle-cell neoplasm/follicular neoplasm with oncocytic features" denote increased risk of malignancy?
    Tamar Giorgadze
    Departments of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 31:307-12. 2004
    ..Clinical features including size of the nodule, age, and possibly sex of the patient can be a part of the decision analysis in selecting a patient for surgery...
  28. ncbi Morbidity following central compartment reoperation for recurrent or persistent thyroid cancer
    Michael K Kim
    Fair Grounds Medical Center, Allentown, PA, USA
    Arch Otolaryngol Head Neck Surg 130:1214-6. 2004
    ..To determine the incidence of recurrent laryngeal nerve injury and hypoparathyroidism, we reviewed our experience with central compartment reoperation...
  29. ncbi Cervical chordoma masquerading as a thyroid neoplasm: a case report
    Anjali Saqi
    Department of Pathology, New York Presbyterian Hospital, Columbia Presbyterian Medial Center, New York, 10032, USA
    Diagn Cytopathol 32:296-8. 2005
    ....
  30. doi Value of P63 and CK5/6 in distinguishing squamous cell carcinoma from adenocarcinoma in lung fine-needle aspiration specimens
    Said Khayyata
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 37:178-83. 2009
    ..Cytomorphology alone may not be able to stratify all cases of nonsmall cell lung carcinoma into ADC and SQCC in FNA specimens. The immune-panel of TTF-1, CK7, CK20, P63, and CK5/6 is useful in differentiating SQCC from ADC...
  31. ncbi A novel microdissection and genotyping of follicular-derived thyroid tumors to predict aggressiveness
    Jennifer L Hunt
    University of Pittsburgh Medical Center, Pittsburgh, PA and University of Pennsylvania Medical Center, Philadelphia, PA 15213, USA
    Hum Pathol 34:375-80. 2003
    ....
  32. ncbi Cytologic and architectural mimics of papillary thyroid carcinoma. Diagnostic challenges in fine-needle aspiration and surgical pathology specimens
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Am J Clin Pathol 125:S135-44. 2006
    ..Both the cytologic and histopathologic preparations containing these changes are reviewed and illustrated; guidelines for distinctions among these entities are provided...
  33. ncbi Use and abuse of frozen section in the diagnosis of follicular thyroid lesions
    Virginia A LiVolsi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Endocr Pathol 16:285-93. 2005
    ....
  34. ncbi Granular cell tumor of the thyroid: a case report
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Int J Surg Pathol 13:291-4. 2005
    ..The classic histomorphologic features and immunohistochemistry are helpful in arriving at the correct diagnosis...
  35. ncbi Is fine-needle aspiration (FNA) of multiple thyroid nodules justified?
    Julieta E Barroeta
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 6 Founders, 3400 Spruce Street, Philadelphia, 19104, USA
    Endocr Pathol 17:61-5. 2006
    ..The aim of this study was to assess if there is a correlation between the risk of malignancy and number of thyroid nodules...
  36. pmc Our approach to follicular-patterned lesions of the thyroid
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Pathol 60:244-50. 2007
    ..In this review, we present our diagnostic approach based on our experience with the histological diagnosis of these tumours, which can help in appropriate clinical management...
  37. ncbi Fine needle aspiration cytology of lipomatous lesions of the thyroid
    Theresa Scognamiglio
    Diagn Cytopathol 34:787-9. 2006
  38. pmc Endoscopic ultrasound guided fine needle aspiration of non-pancreatic lesions: an institutional experience
    Dipti Anand
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Pathol 60:1254-62. 2007
    ..In recent years EUS-FNA has also been used to diagnose lesions of non-pancreatic sites such as structures in close proximity to the gut wall within the mediastinum, abdomen, pelvis and retro-peritoneum...
  39. ncbi Concordance between thyroid nodule sizes measured by ultrasound and gross pathology examination: effect on patient management
    M Salih Deveci
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 35:579-83. 2007
    ..0 cm size range (78.5%). This may lead to an increase in the number of patients undergoing FNA and subsequent surgical excision...
  40. ncbi Differential expression of miRNAs in papillary thyroid carcinoma compared to multinodular goiter using formalin fixed paraffin embedded tissues
    Michael T Tetzlaff
    Department of Pathology and Laboratory Medicine, Hospital for the University of Pennsylvania, 3400 Spruce Street, 7 Founders Pavilion, Philadelphia, PA 19040, USA
    Endocr Pathol 18:163-73. 2007
    ..The ability to utilize FFPE tissue in the molecular characterization of human malignancy will unlock a rich resource for future cancer studies...
  41. ncbi Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Surg Pathol 31:1683-94. 2007
    ..ACC-high-grade transformation is a highly aggressive salivary gland tumor with a variety of histologic patterns. The high propensity for lymph node metastases suggests a role for neck dissection in patients with this rare tumor...
  42. doi Unusual tumors of the thyroid gland
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, 6 Founders Pavilion, Philadelphia, PA 19104, USA
    Endocrinol Metab Clin North Am 37:297-310, vii. 2008
    ..In this article, the authors review the unusual tumors of the thyroid, their morphologic features, and clinical and prognostic implications...
  43. ncbi Assessing the utility of a mutational assay for B-RAF as an adjunct to conventional fine needle aspiration of the thyroid gland
    Michael T Tetzlaff
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    Adv Anat Pathol 13:228-37. 2006
    ..would a test enhance our ability to distinguish benign from malignant, would a test unveil a risk factor not otherwise known, and would detecting a mutation enable a therapeutic option specific to those patients who carry the mutation?..
  44. ncbi Lymphatic and blood vessel density in the follicular patterned lesions of thyroid
    Tamar A Giorgadze
    Department of Pathology, East Tennessee State University, Johnson City, TN 37604, USA
    Mod Pathol 18:1424-31. 2005
    ..63, 15.04, and 0.11 respectively; P<0.0001). The results of the study show that intratumoral lymphatic vessel density may serve as a useful tool in the differential diagnosis of follicular patterned lesions of thyroid...
  45. ncbi Follicular-patterned lesions of the thyroid: the bane of the pathologist
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19103, USA
    Am J Clin Pathol 117:143-50. 2002
    ..The cytologic and histologic characteristics are described, and criteria for diagnosing the major follicular lesions are reviewed...
  46. ncbi Microscopic papillary thyroid carcinoma compared with clinical carcinomas by loss of heterozygosity mutational profile
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania, USA
    Am J Surg Pathol 27:159-66. 2003
    ..These data are further evidence that microscopic and clinically sized PTCa are pathogenetically related...
  47. ncbi Can we rely on pathologic parameters to define conservative treatment of papillary thyroid carcinoma?
    Michele Paessler
    Department of Pathology, University of Pennsylvania Medical Center, Philadelphia, PA 19103, USA
    Int J Surg Pathol 10:267-72. 2002
    ..Hence, pathologic parameters such as lack of vascular invasion and lack of multifocality may be used to identify patients who can benefit from conservative therapy alone...
  48. ncbi Sentinel lymph node evaluation for tumor metastasis
    Jennifer L Hunt
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Semin Diagn Pathol 19:263-77. 2002
    ..The history, technical details, and histopathologic work-up for sentinel lymph node biopsy are reviewed. Particular attention is paid to the intraoperative consultation and a protocol for optimal histopathologic management is presented...
  49. ncbi Intraoperative and on-site cytopathology consultation: utilization, limitations, and value
    Prabodh K Gupta
    Department of Pathology, University of Pennsylvania School of Medicine, University of Pennsylvania Health System, Philadelphia, PA 19104, USA
    Semin Diagn Pathol 19:227-36. 2002
    ....
  50. ncbi Intraoperative consultation: an historical perspective
    Geza Acs
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Semin Diagn Pathol 19:190-1. 2002
  51. ncbi Distinguishing tall cell variant of papillary thyroid carcinoma from usual variant of papillary thyroid carcinoma in cytologic specimens
    Alyson Solomon
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Diagn Cytopathol 27:143-8. 2002
    ..This feature was seen in almost all cases of TCV and was rarely seen in usual PTC. On the basis of the above-mentioned cytologic features, TCV can be distinguished from usual PTC in FNA specimens...
  52. ncbi The quest for a magic tumor marker: continuing saga in the diagnosis of the follicular lesions of thyroid
    Zubair W Baloch
    Am J Clin Pathol 118:165-6. 2002
  53. ncbi Diagnostic value and cost-effectiveness of on-site evaluation of fine-needle aspiration specimens: review of 5,688 cases
    Joseph F Nasuti
    University of Pennsylvania Medical Center, Department of Pathology and Laboratory Medicine, Cytopathology and Cytometry Section, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 27:1-4. 2002
    ..Based on this study, on-site cytopathologic evaluation of FNA specimens is accurate, cost-effective, and has improved patient care at our institution...
  54. ncbi Thyroid microcarcinoma: fine-needle aspiration diagnosis and histologic follow-up
    Grace C H Yang
    Department of Pathology, New York University Medical Center, New York, USA
    Int J Surg Pathol 10:133-9. 2002
    ..Ultrasound-guided FNA is effective in the sampling of thyroid cancers that are 1.0 cm or less. The present study shows that some of these lesions can be clinically significant...
  55. ncbi Immunohistochemical expression of galectin-3 in benign and malignant thyroid lesions
    Marille E Herrmann
    Department of Pathology, University of Pennsylvania, Philadelphia, USA
    Arch Pathol Lab Med 126:710-3. 2002
    ..The expression of galectin-3, a human lectin, has been shown to be highly associated with malignant behavior of thyroid lesions...
  56. ncbi Spindle cell metaplasia of the thyroid arising in association with papillary carcinoma and follicular adenoma
    JoAnne Vergilio
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Am J Clin Pathol 117:199-204. 2002
    ..Immunostains showed reactivity with thyroglobulin, indicating their follicular origin. We believe it is important to recognize these metaplastic proliferations and distinguish them from aggressive malignant neoplasms...
  57. ncbi Loss of heterozygosity mutations of tumor suppressor genes in cytologically atypical areas in chronic lymphocytic thyroiditis
    Jennifer L Hunt
    University of Pittsburgh, Medical Center, Pittsburgh, PA 15213, USA
    Endocr Pathol 13:321-30. 2002
    ..These genetic mutations are evidence of clonal preneoplastic or neoplastic changes in the follicular cells of CLT. The clinical malignant potential of these minute foci is likely to be very small but remains to be determined...
  58. ncbi Cytokeratin 19 immunolocalization in cell block preparation of thyroid aspirates. An adjunct to fine-needle aspiration diagnosis of papillary thyroid carcinoma
    Kamal K Khurana
    Department of Pathology, State University of New York Upstate Medical University Hospital, Syracuse 13210, USA
    Arch Pathol Lab Med 127:579-83. 2003
    ....
  59. ncbi Peroxisome proliferator-activated receptor gamma expression in follicular-patterned thyroid lesions. Caveats for the use of immunohistochemical studies
    Karen S Gustafson
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA
    Am J Clin Pathol 120:175-81. 2003
    ..PPAR gamma expression is not a specific marker for FCs, and its detection in nonlesional thyroid tissue suggests limited usefulness as a diagnostic marker for follicular-patterned lesions in general...
  60. ncbi c-Met expression in tall cell variant papillary carcinoma of the thyroid
    Heather C Nardone
    Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Cancer 98:1386-93. 2003
    ..This current study examined c-Met expression in tall cell variant tumors compared with other types of papillary thyroid carcinoma and benign thyroid disease...
  61. ncbi The diagnostic dilemma of follicular variant of papillary thyroid carcinoma
    Susan B Kesmodel
    Department of Surgery, Division of Endocrinology, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Surgery 134:1005-12; discussion 1012. 2003
    ....
  62. ncbi Unsuspected systemic amyloidosis diagnosed by fine-needle aspiration of the salivary gland: case report
    Tamar Giorgadze
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, 19104, USA
    Diagn Cytopathol 31:57-9. 2004
    ..Further workup of the patient revealed generalized amyloidosis with multiorgan involvement by the disease. This case demonstrates that FNA can be a useful technique in the diagnosis of unsuspected amyloidosis...
  63. ncbi Can cytomorphology differentiate between benign nodules and tumors arising in Graves' disease?
    Scott R Anderson
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Diagn Cytopathol 31:64-7. 2004
    ..However, adherence to strict diagnostic criteria (nuclear elongation, pale powdery chromatin, intranuclear grooves, and small eccentric nucleoli) can enable the diagnosis of PTC arising in GD...
  64. ncbi Oncocytic parathyroid adenoma: problem in cytological diagnosis
    Tamar Giorgadze
    Department of Pathology and Laboratory Medicine University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 31:276-80. 2004
    ..We report two cases of this type of clinically "silent" parathyroid adenomas that on FNA were diagnosed as Hurthle cell thyroid neoplasm...
  65. ncbi Chronic granulomatous lesions after thyroidectomy: imaging findings
    Jill E Langer
    Department of Radiology, University of Pennsylvania Medical Center, 3400 Spruce St, Philadelphia, PA 19104, USA
    AJR Am J Roentgenol 185:1350-4. 2005
    ..These lesions may appear as complex cystic masses on CT and MRI and may have increased activity on PET. Percutaneous biopsy can establish the diagnosis of an inflammatory lesion and can exclude underlying active infection and malignancy...
  66. ncbi Follicular neoplasms of the thyroid: view, biases, and experiences
    Virginia A LiVolsi
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Adv Anat Pathol 11:279-87. 2004
    ..The authors present their views based on their experience with the cytologic and histologic diagnosis of these tumors and propose a scheme to assist in their classification and appropriate clinical management...
  67. ncbi Comparison of p63 and p73 expression in benign and malignant salivary gland lesions
    Raja R Seethala
    University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Head Neck 27:696-702. 2005
    ..In this study, we examined the expression of p63 and p73 in 50 various benign salivary gland lesions and 45 malignant salivary gland tumors...
  68. ncbi Improved detection of amyloid in fat pad aspiration: an evaluation of Congo red stain by fluorescent microscopy
    Tamar A Giorgadze
    Department of Pathology and Laboratory Medicine, Cytopathology and Cytometry Section, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
    Diagn Cytopathol 31:300-6. 2004
    ..Minimally weak fluorescence in the adipose tissue was observed in the control cases. The use of FM in Congo red-stained fat pad smears can improve the detection of amyloid in cytology preparations...
  69. ncbi Utility of cytomorphologic criteria and p53 immunolocalization in distinguishing benign from malignant cystic squamous-lined lesions of the neck on fine-needle aspiration
    Joseph F Nasuti
    University of Pennsylvania Medical Center, Department of Pathology and Laboratory Medicine, Cytopathology and Cytometry Section, Philadelphia, Pennsylvania 19104, USA
    Diagn Cytopathol 27:10-4. 2002
    ..Application of the above-mentioned cytomorphologic criteria and the use of p53 immunostain could effectively distinguish between benign and malignant cystic lesions of the head and neck...
  70. ncbi Diagnostic utility of mucin profile in fine-needle aspiration specimens of the pancreas: an immunohistochemical study with surgical pathology correlation
    Tamar A Giorgadze
    Department of Pathology, East Tennessee State University, Johnson City, Tennessee 19104, USA
    Cancer 108:186-97. 2006
    ....
  71. ncbi Predicting prognosis in thyroid carcinoma: can histology do it?
    Virginia A LiVolsi
    Am J Surg Pathol 26:1064-5. 2002
  72. ncbi Phyllodes tumor metastatic to thyroid Hürthle cell adenoma
    Tamar Giorgadze
    Department of Pathology, East Tennessee State University, Johnson City, USA
    Arch Pathol Lab Med 126:1233-6. 2002
    ..To the best of our knowledge, this unusual case is a first report of tumor-to-tumor metastasis of a sarcoma to a primary thyroid neoplasm...
  73. ncbi Fine-needle aspiration of thyroid nodules: past, present, and future
    Zubair W Baloch
    Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19103, USA
    Endocr Pract 10:234-41. 2004
    ..To present a review of the traditional and more recent techniques and applications of thyroid fine-needle aspiration biopsy...
  74. ncbi Relative accuracy of fine-needle aspiration and frozen section in the diagnosis of lesions of the parotid gland
    Raja R Seethala
    Department of Pathology and Laboratory Medicine, 6 Founders Pavilion, 3400 Spruce Street, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Head Neck 27:217-23. 2005
    ..Herein, we determine the relative accuracies of both FNA and FS in the diagnosis of salivary gland lesions...