Research Topics
Species | Bryan A BallifSummaryAffiliation: University of Vermont Country: USA Publications
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Detail Information
Publications
Regulation of protein tyrosine kinase signaling by substrate degradation during brain developmentLionel Arnaud
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
Mol Cell Biol 23:9293-302. 2003..Our data provide the first evidence for how Reelin down-regulates Dab1 protein expression in vivo. Dab1 degradation may be important for ensuring a transient Reelin response and may play a role in normal brain development...- Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cellsDevina Purmessur
Leni and Peter W, May Department of Orthopaedics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1188, New York, NY 10029 6574, USA
Arthritis Res Ther 13:R81. 2011..The goal of this study was to use soluble factors from NCs in alginate and NCs in their native tissue to differentiate human MSCs to a young nucleus pulposus (NP) phenotype... 
Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brainBryan A Ballif
Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
J Proteome Res 7:311-8. 2008..To measure the conservation of phosphorylated tyrosines and their surrounding residues, we constructed a computational pipeline and identified patterns of conservation within the signature of phosphotyrosine...- Aging enhances indirect flight muscle fiber performance yet decreases flight ability in DrosophilaMark S Miller
Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
Biophys J 95:2391-401. 2008..We also speculate that a lack of MgATP due to damaged mitochondria accounts for the decreased flight performance... 
RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activationMadhurima Saha
Department of Biology, University of Vermont, Burlington, VT 05405, USA
Biochem J 447:159-66. 2012..Together these data suggest that one mechanism whereby RSK negatively regulates MAPK activation is via site-specific SOS1 phosphorylation...- A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activityAoife T Heaslip
Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA
PLoS Pathog 6:e1000720. 2010.... - Homeostatic regulation of Kv1.2 potassium channel trafficking by cyclic AMPEmilee C Connors
Department of Pharmacology, College of Medicine, University of Vermont, Burlington 05405, USA
J Biol Chem 283:3445-53. 2008..2 at the cell surface. This effect is not blocked by PKA inhibitors, but is blocked by inhibition of Kv1.2 endocytosis. We conclude that Kv1.2 levels at the cell surface are kept in dynamic balance by opposing effects of cAMP... - ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damageShuhei Matsuoka
Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Science 316:1160-6. 2007..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals... - Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transportSang Oh Yoon
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Mol Cell 29:362-75. 2008..Our findings highlight an important link between two major cell-fate determinants: nuclear transport and the Ras/ERK/RSK and PI3K/Akt signaling pathways... - Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1William M Brieher
Department of Systems Biology and 2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 175:315-24. 2006..The cooperative activities of cofilin, coronin, and Aip1 should provide a biochemical basis for understanding how actin filaments can grow in some places in the cell while shrinking in others... - Identification of 14-3-3epsilon substrates from embryonic murine brainBryan A Ballif
Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
J Proteome Res 5:2372-9. 2006..Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol... - mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation eventsMarina K Holz
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Cell 123:569-80. 2005..Thus, the eIF3 preinitiation complex acts as a scaffold to coordinate a dynamic sequence of events in response to stimuli that promote efficient protein synthesis... - Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migrationJian Li
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Dev Cell 9:663-73. 2005..These findings advance an understanding of how integrin recycling is achieved during cell migration, and also address a basic issue of how intracellular signaling can interface with transport to achieve regulated recycling... - Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinasesBryan A Ballif
Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Brain Res Mol Brain Res 117:152-9. 2003.... - Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neuronsBryan A Ballif
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
Curr Biol 14:606-10. 2004..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development... - SKAR is a specific target of S6 kinase 1 in cell growth controlCeleste J Richardson
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Curr Biol 14:1540-9. 2004..Interestingly, genetic experiments predict that a substrate that is specific to S6K1 but not S6K2 regulates cell growth... - Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinasePhilippe P Roux
Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:13489-94. 2004..Together, our data unveil a regulatory mechanism by which the Ras/MAPK and PI3K pathways converge on the tumor suppressor tuberin to inhibit its function... - Phosphoproteomic analysis of the developing mouse brainBryan A Ballif
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Mol Cell Proteomics 3:1093-101. 2004.... - Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressorsBryan A Ballif
Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 102:667-72. 2005.... - The tumor suppressor DAP kinase is a target of RSK-mediated survival signalingRana Anjum
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Biol 15:1762-7. 2005..Our results suggest that RSK-mediated phosphorylation of DAPK is a unique mechanism for suppressing the proapoptotic function of this death kinase in healthy cells as well as Ras/Raf-transformed cells... - Fyn tyrosine kinase is a critical regulator of disabled-1 during brain developmentLionel Arnaud
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
Curr Biol 13:9-17. 2003..Mutations in Dab1, its phosphorylation sites, Reelin, or the Reelin receptors cause a common phenotype. However, the molecular mechanism whereby Reelin regulates Dab1 tyrosine phosphorylation is poorly understood...