Bryan A Ballif

Summary

Affiliation: University of Vermont
Country: USA

Publications

  1. pmc Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
    Lionel Arnaud
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Mol Cell Biol 23:9293-302. 2003
  2. pmc Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells
    Devina Purmessur
    Leni and Peter W, May Department of Orthopaedics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1188, New York, NY 10029 6574, USA
    Arthritis Res Ther 13:R81. 2011
  3. ncbi request reprint Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain
    Bryan A Ballif
    Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
    J Proteome Res 7:311-8. 2008
  4. pmc Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila
    Mark S Miller
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    Biophys J 95:2391-401. 2008
  5. pmc Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587
    Bior K Bior
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    FEBS Lett 587:60-6. 2013
  6. pmc Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL
    Tyler M Aten
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    FEBS Lett 587:2313-8. 2013
  7. pmc Disruption of SMIM1 causes the Vel- blood type
    Bryan A Ballif
    Department of Biology, University of Vermont, Burlington, VT, USA
    EMBO Mol Med 5:751-61. 2013
  8. pmc Proteomic analysis of the cilia membrane of Paramecium tetraurelia
    Junji Yano
    Department of Biology, University of Vermont, Burlington, VT 05405, USA Electronic
    J Proteomics 78:113-22. 2013
  9. pmc RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation
    Madhurima Saha
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    Biochem J 447:159-66. 2012
  10. ncbi request reprint Homeostatic regulation of Kv1.2 potassium channel trafficking by cyclic AMP
    Emilee C Connors
    Department of Pharmacology, College of Medicine, University of Vermont, Burlington 05405, USA
    J Biol Chem 283:3445-53. 2008

Collaborators

  • Mark S Miller
  • David W Maughan
  • Gerrie P Farman
  • David M Warshaw
  • Lionel Arnaud
  • Shamil R Sunyaev
  • Thierry Peyrard
  • Jonathan A Cooper
  • Philippe P Roux
  • Steven P Gygi
  • Madhurima Saha
  • John Blenis
  • Tyler M Aten
  • Bior K Bior
  • Junji Yano
  • Devina Purmessur
  • Aoife T Heaslip
  • Sang Oh Yoon
  • Emilee C Connors
  • Shuhei Matsuoka
  • William M Brieher
  • Marina K Holz
  • Jian Li
  • Rana Anjum
  • Celeste J Richardson
  • Karen L Hinkle
  • Sheila O Weaver
  • Megan S Valentine
  • Anbazhagan Rajendran
  • Judith L Van Houten
  • Aliya S Lapp
  • Miranda M Redmond
  • Collin C Love
  • Osvaldo D Rivera
  • Ryan M Joy
  • Xiaocui Zhang
  • Mujeeburahiman Cheerathodi
  • John Rush
  • Geneviève Lavoie
  • Audrey Carriere
  • Rachel M Schek
  • Karolyn E Godburn
  • James C Iatridis
  • Rosalyn D Abbott
  • Nicholas J Westwood
  • Gary E Ward
  • Federica Catti
  • Kimberly L Carey
  • Jacqueline M Leung
  • Michele S Woo
  • Anthony D Morielli
  • Sejeong Shin
  • Yuzhen Liu
  • Zhenming Zhao
  • Nicole Solimini
  • Stephen J Elledge
  • Corey E Bakalarski
  • Yosef Shiloh
  • E Robert McDonald
  • Kristen E Hurov
  • Agata Smogorzewska
  • Ji Luo
  • Yaniv Lerenthal
  • Timothy J Mitchison
  • Hao Yuan Kueh
  • Victor W Hsu
  • Jun Dai
  • Aimee M Powelka
  • Diane C Fingar
  • Mark Broenstrup
  • Kristina Jülich
  • Steven Gygi

Detail Information

Publications25

  1. pmc Regulation of protein tyrosine kinase signaling by substrate degradation during brain development
    Lionel Arnaud
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, WA 98109, USA
    Mol Cell Biol 23:9293-302. 2003
    ..Our data provide the first evidence for how Reelin down-regulates Dab1 protein expression in vivo. Dab1 degradation may be important for ensuring a transient Reelin response and may play a role in normal brain development...
  2. pmc Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells
    Devina Purmessur
    Leni and Peter W, May Department of Orthopaedics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1188, New York, NY 10029 6574, USA
    Arthritis Res Ther 13:R81. 2011
    ..The goal of this study was to use soluble factors from NCs in alginate and NCs in their native tissue to differentiate human MSCs to a young nucleus pulposus (NP) phenotype...
  3. ncbi request reprint Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain
    Bryan A Ballif
    Department of Biology, University of Vermont, Burlington, Vermont 05405, USA
    J Proteome Res 7:311-8. 2008
    ..To measure the conservation of phosphorylated tyrosines and their surrounding residues, we constructed a computational pipeline and identified patterns of conservation within the signature of phosphotyrosine...
  4. pmc Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila
    Mark S Miller
    Department of Molecular Physiology and Biophysics, University of Vermont, Burlington, Vermont 05405, USA
    Biophys J 95:2391-401. 2008
    ..We also speculate that a lack of MgATP due to damaged mitochondria accounts for the decreased flight performance...
  5. pmc Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587
    Bior K Bior
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    FEBS Lett 587:60-6. 2013
    ..These data provide an early glimpse into how Cin85 phosphorylation might alter the composition of its scaffolding partners to regulate its diverse roles including vesicular trafficking, receptor endocytosis and actin remodeling...
  6. pmc Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL
    Tyler M Aten
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    FEBS Lett 587:2313-8. 2013
    ..SFK activity was shown to be sufficient, but not required for the interaction between ESDN and the CrkL-SH2 domain. Finally, antibody-mediated ESDN clustering induces ESDN tyrosine phosphorylation and CrkL-SH2 binding. ..
  7. pmc Disruption of SMIM1 causes the Vel- blood type
    Bryan A Ballif
    Department of Biology, University of Vermont, Burlington, VT, USA
    EMBO Mol Med 5:751-61. 2013
    ..These results answer a 60-year-old riddle and provide tools of immediate assistance to all clinicians involved in the care of Vel- patients...
  8. pmc Proteomic analysis of the cilia membrane of Paramecium tetraurelia
    Junji Yano
    Department of Biology, University of Vermont, Burlington, VT 05405, USA Electronic
    J Proteomics 78:113-22. 2013
    ..Of 267 proteins unique to the DP, 147 were novel, i.e. not found in other proteomic and genomic studies of cilia...
  9. pmc RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation
    Madhurima Saha
    Department of Biology, University of Vermont, Burlington, VT 05405, USA
    Biochem J 447:159-66. 2012
    ..Together these data suggest that one mechanism whereby RSK negatively regulates MAPK activation is via site-specific SOS1 phosphorylation...
  10. ncbi request reprint Homeostatic regulation of Kv1.2 potassium channel trafficking by cyclic AMP
    Emilee C Connors
    Department of Pharmacology, College of Medicine, University of Vermont, Burlington 05405, USA
    J Biol Chem 283:3445-53. 2008
    ..2 at the cell surface. This effect is not blocked by PKA inhibitors, but is blocked by inhibition of Kv1.2 endocytosis. We conclude that Kv1.2 levels at the cell surface are kept in dynamic balance by opposing effects of cAMP...
  11. pmc A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity
    Aoife T Heaslip
    Department of Microbiology and Molecular Genetics, University of Vermont, Burlington, Vermont, USA
    PLoS Pathog 6:e1000720. 2010
    ....
  12. ncbi request reprint ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    Shuhei Matsuoka
    Department of Genetics and Center for Genetics and Genomics, Brigham and Women s Hospital, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 316:1160-6. 2007
    ..This database paints a much broader landscape for the DDR than was previously appreciated and opens new avenues of investigation into the responses to DNA damage in mammals...
  13. pmc Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport
    Sang Oh Yoon
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 29:362-75. 2008
    ..Our findings highlight an important link between two major cell-fate determinants: nuclear transport and the Ras/ERK/RSK and PI3K/Akt signaling pathways...
  14. pmc Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1
    William M Brieher
    Department of Systems Biology and 2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 175:315-24. 2006
    ..The cooperative activities of cofilin, coronin, and Aip1 should provide a biochemical basis for understanding how actin filaments can grow in some places in the cell while shrinking in others...
  15. ncbi request reprint Identification of 14-3-3epsilon substrates from embryonic murine brain
    Bryan A Ballif
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Proteome Res 5:2372-9. 2006
    ..Phosphorylation of the deubiquitinating enzyme USP8 at serine 680 was found essential for its interaction with 14-3-3epsilon and for maintaining USP8 in the cytosol...
  16. ncbi request reprint Tyrosine phosphorylation of Disabled-1 is essential for Reelin-stimulated activation of Akt and Src family kinases
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Brain Res Mol Brain Res 117:152-9. 2003
    ....
  17. ncbi request reprint Activation of a Dab1/CrkL/C3G/Rap1 pathway in Reelin-stimulated neurons
    Bryan A Ballif
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Curr Biol 14:606-10. 2004
    ..C3G and Rap1 regulate adhesion of fibroblasts and other cell types. Regulation of Crk/CrkL, C3G, and Rap1 by Reelin may be involved in coordinating neuron migrations during brain development...
  18. ncbi request reprint SKAR is a specific target of S6 kinase 1 in cell growth control
    Celeste J Richardson
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 14:1540-9. 2004
    ..Interestingly, genetic experiments predict that a substrate that is specific to S6K1 but not S6K2 regulates cell growth...
  19. pmc Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
    Philippe P Roux
    Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:13489-94. 2004
    ..Together, our data unveil a regulatory mechanism by which the Ras/MAPK and PI3K pathways converge on the tumor suppressor tuberin to inhibit its function...
  20. ncbi request reprint Phosphoproteomic analysis of the developing mouse brain
    Bryan A Ballif
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell Proteomics 3:1093-101. 2004
    ....
  21. pmc Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
    Bryan A Ballif
    Department of Cell Biology and Taplin Biological Mass Spectrometry Facility, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:667-72. 2005
    ....
  22. ncbi request reprint The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling
    Rana Anjum
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Biol 15:1762-7. 2005
    ..Our results suggest that RSK-mediated phosphorylation of DAPK is a unique mechanism for suppressing the proapoptotic function of this death kinase in healthy cells as well as Ras/Raf-transformed cells...
  23. ncbi request reprint Phosphorylation of ACAP1 by Akt regulates the stimulation-dependent recycling of integrin beta1 to control cell migration
    Jian Li
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 9:663-73. 2005
    ..These findings advance an understanding of how integrin recycling is achieved during cell migration, and also address a basic issue of how intracellular signaling can interface with transport to achieve regulated recycling...
  24. ncbi request reprint mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
    Marina K Holz
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 123:569-80. 2005
    ..Thus, the eIF3 preinitiation complex acts as a scaffold to coordinate a dynamic sequence of events in response to stimuli that promote efficient protein synthesis...
  25. ncbi request reprint Fyn tyrosine kinase is a critical regulator of disabled-1 during brain development
    Lionel Arnaud
    Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, 98109, Seattle, WA, USA
    Curr Biol 13:9-17. 2003
    ..Mutations in Dab1, its phosphorylation sites, Reelin, or the Reelin receptors cause a common phenotype. However, the molecular mechanism whereby Reelin regulates Dab1 tyrosine phosphorylation is poorly understood...