NED BALLATORI

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Pleiotropic functions of the organic solute transporter Ostα-Ostβ
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, N Y, USA
    Dig Dis 29:13-7. 2011
  2. pmc Glutathione dysregulation and the etiology and progression of human diseases
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Biol Chem 390:191-214. 2009
  3. pmc Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Avenue, Box EHSC, Rochester, NY 14642, USA
    Mol Aspects Med 30:13-28. 2009
  4. pmc Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 295:G179-G186. 2008
  5. ncbi Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis
    Nazzareno Ballatori
    Department of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, Rochester, NY 14642, United States
    Comp Biochem Physiol B Biochem Mol Biol 144:167-79. 2006
  6. ncbi OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, NY 14642, USA
    Hepatology 42:1270-9. 2005
  7. ncbi Biology of a novel organic solute and steroid transporter, OSTalpha-OSTbeta
    Nazzareno Ballatori
    Department of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Biol Med (Maywood) 230:689-98. 2005
  8. ncbi Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Toxicol Appl Pharmacol 204:238-55. 2005
  9. pmc Transport of toxic metals by molecular mimicry
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Environ Health Perspect 110:689-94. 2002
  10. pmc OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Front Biosci 14:2829-44. 2009

Research Grants

  1. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
  2. Training in Environment Toxicology
    Nazzareno Ballatori; Fiscal Year: 2007
  3. FUNCTIONS OF THE HEPATIC GAMMA-GLUTAMYL CYCLE
    Nazzareno Ballatori; Fiscal Year: 2007
  4. Functions of the Human OST-alpha and OST-beta Proteins
    Nazzareno Ballatori; Fiscal Year: 2009
  5. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2000
  6. FUNCTIONS OF THE HEPATIC GAMMA-GLUTAMYL CYCLE
    Nazzareno Ballatori; Fiscal Year: 2002
  7. Functions of the Human OST-alpha and OST-beta Proteins
    Nazzareno Ballatori; Fiscal Year: 2010

Collaborators

Detail Information

Publications44

  1. pmc Pleiotropic functions of the organic solute transporter Ostα-Ostβ
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, N Y, USA
    Dig Dis 29:13-7. 2011
    ..The present report summarizes the evidence for a pleiotropic role of Ostα-Ostβ in different tissues...
  2. pmc Glutathione dysregulation and the etiology and progression of human diseases
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Biol Chem 390:191-214. 2009
    ..The present report highlights and integrates the growing connections between imbalances in GSH homeostasis and a multitude of human diseases...
  3. pmc Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Avenue, Box EHSC, Rochester, NY 14642, USA
    Mol Aspects Med 30:13-28. 2009
    ..This report summarizes the evidence that Mrps contribute to the regulation of cellular GSH levels and the thiol-redox state, and thus to the many biochemical processes that are influenced by this tripeptide...
  4. pmc Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Ave, Rochester, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 295:G179-G186. 2008
    ..Overall, these findings provide direct support for the hypothesis that Ostalpha-Ostbeta is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver...
  5. ncbi Retention of structural and functional polarity in cultured skate hepatocytes undergoing in vitro morphogenesis
    Nazzareno Ballatori
    Department of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, Rochester, NY 14642, United States
    Comp Biochem Physiol B Biochem Mol Biol 144:167-79. 2006
    ....
  6. ncbi OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, NY 14642, USA
    Hepatology 42:1270-9. 2005
    ....
  7. ncbi Biology of a novel organic solute and steroid transporter, OSTalpha-OSTbeta
    Nazzareno Ballatori
    Department of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Exp Biol Med (Maywood) 230:689-98. 2005
    ..If confirmed, this model would have important implications for the body's handling of various steroid-derived molecules and may provide a new pharmacologic target for altering sterol homeostasis...
  8. ncbi Molecular mechanisms of reduced glutathione transport: role of the MRP/CFTR/ABCC and OATP/SLC21A families of membrane proteins
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Toxicol Appl Pharmacol 204:238-55. 2005
    ..Because transport is a key step in GSH homeostasis and is intimately linked to its biological functions, GSH export proteins are likely to modulate essential cellular functions...
  9. pmc Transport of toxic metals by molecular mimicry
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Environ Health Perspect 110:689-94. 2002
    ..Because other toxic metals also form complexes with endogenous molecules, comparable mechanisms may be involved in their membrane transport and disposition...
  10. pmc OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Front Biosci 14:2829-44. 2009
    ..Collectively, the data indicate that Ost alpha-Ost beta is essential for bile acid and sterol disposition, and suggest that the carrier may be involved in human conditions related to imbalances in bile acid or lipid homeostasis...
  11. ncbi Defining the molecular and cellular basis of toxicity using comparative models
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, New York 14642, USA
    Toxicol Appl Pharmacol 183:207-220. 2002
    ....
  12. ncbi Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta
    David J Seward
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Biol Chem 278:27473-82. 2003
    ..Interestingly, OSTalpha and OSTbeta mRNAs were highly expressed and widely distributed in human tissues, with the highest levels occurring in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland...
  13. pmc Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter
    Na Li
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Biochem J 407:363-72. 2007
    ....
  14. ncbi N-glycosylation controls functional activity of Oatp1, an organic anion transporter
    Thomas K Lee
    Dept of Environmental Medicine, Univ of Rochester School of Medicine, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 285:G371-81. 2003
    ..These results demonstrate that both membrane targeting and functional activity of Oatp1 are controlled by the extent of N-glycosylation...
  15. ncbi Accelerated urinary excretion of methylmercury following administration of its antidote N-acetylcysteine requires Mrp2/Abcc2, the apical multidrug resistance-associated protein
    Michael S Madejczyk
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Avenue, Box EHSC, Rochester, NY 14642, USA
    J Pharmacol Exp Ther 322:378-84. 2007
    ..These results indicate that Mrp2 is involved in urinary MeHg excretion after NAC administration and suggest that the transported molecule is most likely the MeHg-NAC complex...
  16. ncbi Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion: transport by the renal organic anion transporter-1
    Albert S Koh
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Mol Pharmacol 62:921-6. 2002
    ..This is the first molecular identification of a transport mechanism by which these antidotes may enhance urinary excretion of toxic metals...
  17. pmc N-acetylcysteine as a potential antidote and biomonitoring agent of methylmercury exposure
    David A Aremu
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Environ Health Perspect 116:26-31. 2008
    ..The only way to prevent or ameliorate MeHg toxicity is to enhance its elimination from the body...
  18. ncbi Activation of plasma membrane reduced glutathione transport in death receptor apoptosis of HepG2 cells
    Christine L Hammond
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Toxicol Appl Pharmacol 195:12-22. 2004
    ..These findings suggest that an organic anion transporter is involved in GSH release during apoptosis, and that maintenance of intracellular GSH levels during apoptosis provides protection for the cell...
  19. ncbi The editosome for cytidine to uridine mRNA editing has a native complexity of 27S: identification of intracellular domains containing active and inactive editing factors
    Mark P Sowden
    Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Cell Sci 115:1027-39. 2002
    ..It is proposed that the heterogeneity in size of complexes containing editing factors is functionally significant and reflects functionally engaged editosomes in the nucleus and an inactive cytoplasmic pool of factors...
  20. pmc Neurosteroid transport by the organic solute transporter OSTα-OSTβ
    Fang Fang
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurochem 115:220-33. 2010
    ..These results demonstrate that OSTα-OSTβ is localized to steroidogenic cells of the brain and adrenal gland, and that it modulates DHEA/DHEAS homeostasis, suggesting that it may contribute to neurosteroid action...
  21. ncbi Glutathione export during apoptosis requires functional multidrug resistance-associated proteins
    Christine L Hammond
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Biol Chem 282:14337-47. 2007
    ..Furthermore, when MRP1 expression was decreased with RNA interference, GSH release was lower under both basal and apoptotic conditions, providing direct evidence that MRP1 is involved in GSH export...
  22. ncbi Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2
    James F Rebbeor
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Ave, Box EHSC, Rochester, NY 14642, USA
    Biochim Biophys Acta 1559:171-8. 2002
    ..When this inhibition was partially relieved, ATP-dependent GSH transport was detected in rat liver canalicular plasma membranes, indicating that both Mrp2 and Ycf1p are able to transport GSH by an ATP-dependent mechanism...
  23. pmc Identification of human gene products containing Pro-Pro-x-Tyr (PY) motifs that enhance glutathione and endocytotic marker uptake in yeast
    Shujie Shi
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY, USA
    Cell Physiol Biochem 25:293-306. 2010
    ..In summary, although the results do not reveal novel GSH transporters, they identify five PY-containing human gene products that may influence plasma membrane transport activity...
  24. ncbi Human organic anion transporter 1B1 and 1B3 function as bidirectional carriers and do not mediate GSH-bile acid cotransport
    Chitrawina Mahagita
    Department of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Gastrointest Liver Physiol 293:G271-8. 2007
    ..Overall, these results indicate that OATP1B3/OATP-8 and OATP1B1/OATP-C most likely function as bidirectional facilitated diffusion transporters and that GSH is not a substrate or activator of their transport activity...
  25. pmc Transport of a neurotoxicant by molecular mimicry: the methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2
    Tracey A Simmons-Willis
    Department of Environmental Medicine, University of Rochester School of Medicine, 575 Elmwood Avenue, Box EHSC, Rochester, NY 14642, U S A
    Biochem J 367:239-46. 2002
    ..These transport proteins may therefore participate in metal ion homoeostasis and toxicity...
  26. ncbi Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates
    Brian K Barlow
    Department of Pathology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Neurochem 85:1075-86. 2003
    ..These results suggest that selective dithiocarbamates may alter the kinetics of different endogenous and exogenous compounds to enhance their neurotoxicity...
  27. pmc Hepatic uptake and biliary excretion of manganese in the little skate, Leucoraja erinacea
    Michael S Madejczyk
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Comp Biochem Physiol C Toxicol Pharmacol 149:566-71. 2009
    ..These data indicate that skate liver has efficient mechanisms for removing Mn from the sinusoidal circulation, whereas overall biliary excretion is low and appears to be mediated in part by an ATP-sensitive mechanism...
  28. ncbi Mechanisms of mercury disposition in the body
    Thomas W Clarkson
    Department of Environmental Medicine, Rochester School of Medicine, Rochester, New York, USA
    Am J Ind Med 50:757-64. 2007
    ..The implications of these mechanisms with regard to biological monitoring are discussed...
  29. pmc Multidrug resistance-associated protein 1 as a major mediator of basal and apoptotic glutathione release
    Rosemarie Marchan
    Department of Environmental Medicine, Box EHSC, University of Rochester School of Medicine, 575 Elmwood Avenue, Rochester, NY 14642, USA
    Biochim Biophys Acta 1778:2413-20. 2008
    ..The enhanced GSH release, with a concurrent decrease of intracellular GSH, appears to be necessary for the progression of apoptosis...
  30. ncbi Exploiting genome data to understand the function, regulation, and evolutionary origins of toxicologically relevant genes
    Nazzareno Ballatori
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, New York, USA
    EHP Toxicogenomics 111:61-5. 2003
    ....
  31. ncbi Apolipoprotein B mRNA editing and the reduction in synthesis and secretion of the atherogenic risk factor, apolipoprotein B100 can be effectively targeted through TAT-mediated protein transduction
    Yan Yang
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Mol Pharmacol 61:269-76. 2002
    ..These results suggested that apoB mRNA editing should be re-evaluated as a LDL-lowering therapeutic target in the new context of protein transduction therapy...
  32. pmc The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway
    Mei Cui
    Department of Environmental Medicine, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:8043-8. 2009
    ..These results may have far-reaching implications for our understanding of the mechanism of cell death in a wide range of neurodegenerative diseases and may open new avenues for neuroprotective intervention...
  33. pmc Transient glutathione depletion determines terminal differentiation in HL-60 cells
    Suzanne M Krance
    University of Rochester School of Medicine, Rochester, New York, USA
    Oxid Med Cell Longev 3:53-60. 2010
    ..These findings indicate that intracellular GSH levels are regulated in a complex fashion during HL-60 cell differentiation, and that transient GSH depletion using low doses of CDNB and DEM enhances the differentiation process...
  34. ncbi Lack of biliary lipid excretion in the little skate, Raja erinacea, indicates the absence of functional Mdr2, Abcg5, and Abcg8 transporters
    Ronald P J Oude Elferink
    AMC Liver Center, Academic Medical Center S1 162, Meibergdreef 69 71, 1105 BK Amsterdam
    Am J Physiol Gastrointest Liver Physiol 286:G762-8. 2004
    ..Little skate plasma membranes may be protected against bile salt micelles mainly by their high sphingomyelin content...
  35. ncbi Molecular characterization of a multidrug resistance-associated protein, Mrp2, from the little skate
    Shi Ying Cai
    Liver Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Regul Integr Comp Physiol 284:R125-30. 2003
    ..This analysis indicates that Mrp2 orthologs evolved early in vertebrate evolution and that conserved domains may be important determinants of Mrp2 substrate specificity...
  36. ncbi An evolutionarily ancient Oatp: insights into conserved functional domains of these proteins
    Shi Ying Cai
    Liver Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 282:G702-10. 2002
    ..We propose that the conserved regions of the SLC21A transporter family may be critical structural determinants of substrate specificity and function...
  37. pmc Arachidonic acid-induced expression of the organic solute and steroid transporter-beta (Ost-beta) in a cartilaginous fish cell line
    Jae Ho Hwang
    Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA
    Comp Biochem Physiol C Toxicol Pharmacol 148:39-47. 2008
    ..Although the function of this transport protein in embryo-derived cells is unknown, it may play a role in the disposition of eicosanoids or steroid-derived molecules...
  38. pmc The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter
    Paul A Dawson
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 280:6960-8. 2005
    ..These results demonstrate that the mouse Ostalpha-Ostbeta heteromeric transporter is a basolateral bile acid carrier and may be responsible for bile acid efflux in ileum and other ASBT-expressing tissues...
  39. ncbi Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents
    James L Boyer
    Liver Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1124-30. 2006
    ..These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor...
  40. ncbi The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution
    Shi Ying Cai
    Liver Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1400-9. 2007
    ..Acquisition of this property may be an example of molecular exploitation, where an older molecule is recruited for a new functional role...
  41. ncbi 4-Hydroxyacetophenone-induced choleresis in rats is mediated by the Mrp2-dependent biliary secretion of its glucuronide conjugate
    Chitrawina Mahagita
    Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Rd, Bangkok 10400, Thailand
    Pharm Res 23:2603-10. 2006
    ..The present study examined the underlying mechanism by which 4-hydroxyacetophenone (4-HA), a bioactive compound found in several medicinal herbs, exerts its potent stimulatory effects on hepatic bile secretion...
  42. pmc Bile acids induce ileal damage during experimental necrotizing enterocolitis
    Melissa D Halpern
    Department of Pediatrics, Steele Children s Research Center, University of Arizona, Tucson, 85724, USA
    Gastroenterology 130:359-72. 2006
    ..While the effect of bile acids (BAs) on intestinal mucosal injury is known, we investigated the contribution of BAs during the development of NEC in neonatal rats...
  43. ncbi Glutathione secretion into rat milk and its subsequent gamma-glutamyltranspeptidase-mediated catabolism
    Noboru Fujikake
    Development Research Laboratories, Banyu Pharmaceutical Company, Osatogun, Saitama, Japan
    Biol Neonate 82:134-8. 2002
    ..This cycle may contribute to the secretion of cysteine into milk, which is a rate-limiting amino acid for neonatal growth and development...
  44. ncbi Phloracetophenone-induced choleresis in rats is mediated through Mrp2
    Lukmanee Tradtrantip
    Department of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    Am J Physiol Gastrointest Liver Physiol 293:G66-74. 2007
    ..THA appears to stimulate BF by its osmotic effects and may attenuate the cholestatic effects of hepatotoxins undergoing biotransformation and excretion via similar pathways...

Research Grants32

  1. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2005
    ..Evaluate the molecular mechanism by which NAC stimulates renal excretion of MeHg. IV. Test the hypothesis that urinary excretion of MeHg following an NAC oral challenge may be used as a new biomarker of MeHg exposure. ..
  2. Training in Environment Toxicology
    Nazzareno Ballatori; Fiscal Year: 2007
    ..D. trainees starting in August 2002, and 23 postdoctoral fellows currently in training. The present application requests an additional five years of funding for 18 predoctoral and 3 postdoctoral trainees per year. ..
  3. FUNCTIONS OF THE HEPATIC GAMMA-GLUTAMYL CYCLE
    Nazzareno Ballatori; Fiscal Year: 2007
    ....
  4. Functions of the Human OST-alpha and OST-beta Proteins
    Nazzareno Ballatori; Fiscal Year: 2009
    ..Overall, these studies should provide fundamental information on the mechanisms by which this novel transporter regulates bile acid and steroid homeostasis in mammals. ..
  5. METHYLMERCURY TRANSPORT ACROSS CELL MEMBRANES
    Nazzareno Ballatori; Fiscal Year: 2000
    ....
  6. FUNCTIONS OF THE HEPATIC GAMMA-GLUTAMYL CYCLE
    Nazzareno Ballatori; Fiscal Year: 2002
    ....
  7. Functions of the Human OST-alpha and OST-beta Proteins
    Nazzareno Ballatori; Fiscal Year: 2010
    ..Such therapeutics could be of benefit in many human conditions related to imbalances in bile acid or lipid homeostasis. ..