H H Balfour

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students
    Henry H Balfour
    Department of Laboratory Medicine and Pathology, School of Public Health, University of Minnesota Medical School, Minneapolis 55455, USA
    J Infect Dis 207:80-8. 2013
  2. ncbi request reprint A virologic pilot study of valacyclovir in infectious mononucleosis
    Henry H Balfour
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN, USA
    J Clin Virol 39:16-21. 2007
  3. ncbi request reprint Controlled trial of acyclovir for chickenpox evaluating time of initiation and duration of therapy and viral resistance
    H H Balfour
    University of Minnesota Medical School, Minneapolis 55455 0392, USA
    Pediatr Infect Dis J 20:919-26. 2001
  4. ncbi request reprint A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis
    Henry H Balfour
    Department of Laboratory Medicine and Pathology, University of Minnesota, Fairview Clinical Virology Laboratory, Minneapolis 55455 0392, USA
    J Infect Dis 192:1505-12. 2005
  5. pmc Human immunodeficiency virus type 1 detected in all seropositive symptomatic and asymptomatic individuals
    J B Jackson
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455
    J Clin Microbiol 28:16-9. 1990
  6. pmc Effect of foscarnet on quantities of cytomegalovirus and human immunodeficiency virus in blood of persons with AIDS
    H H Balfour
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA
    Antimicrob Agents Chemother 40:2721-6. 1996
  7. ncbi request reprint Ganciclovir susceptibilities and analysis of UL97 region in cytomegalovirus (CMV) isolates from bone marrow recipients with CMV disease after antiviral prophylaxis
    A Erice
    Department of Laboratory Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    J Infect Dis 178:531-4. 1998
  8. pmc Rapid and sensitive viral culture method for human immunodeficiency virus type 1
    J B Jackson
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455
    J Clin Microbiol 26:1416-8. 1988
  9. ncbi request reprint Prevalence of cytomegalovirus antibody in hemophiliacs and homosexuals infected with human immunodeficiency virus type 1
    J B Jackson
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis
    Transfusion 28:187-9. 1988
  10. ncbi request reprint Concentration-controlled zidovudine therapy
    C V Fletcher
    Division of Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, USA
    Clin Pharmacol Ther 64:331-8. 1998

Research Grants

  1. ADULT AIDS CLINICAL TRIALS UNIT
    HENRY BALFOUR; Fiscal Year: 2004
  2. ADULT AIDS CLINICAL TRIALS UNIT
    HENRY BALFOUR; Fiscal Year: 2007

Collaborators

Detail Information

Publications29

  1. pmc Behavioral, virologic, and immunologic factors associated with acquisition and severity of primary Epstein-Barr virus infection in university students
    Henry H Balfour
    Department of Laboratory Medicine and Pathology, School of Public Health, University of Minnesota Medical School, Minneapolis 55455, USA
    J Infect Dis 207:80-8. 2013
    ..University students were studied prospectively to determine the incidence of and risk factors for acquisition of primary Epstein-Barr virus (EBV) infection and the virologic and immune correlates of disease severity...
  2. ncbi request reprint A virologic pilot study of valacyclovir in infectious mononucleosis
    Henry H Balfour
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center, Minneapolis, MN, USA
    J Clin Virol 39:16-21. 2007
    ..Infectious mononucleosis decreases the productivity of many college students and Epstein-Barr virus (EBV) infection may result in long-term immune damage...
  3. ncbi request reprint Controlled trial of acyclovir for chickenpox evaluating time of initiation and duration of therapy and viral resistance
    H H Balfour
    University of Minnesota Medical School, Minneapolis 55455 0392, USA
    Pediatr Infect Dis J 20:919-26. 2001
    ..Chickenpox is prevalent in the US despite the availability of an effective vaccine. Acyclovir treatment is limited by concerns about efficacy if given after the first day of rash and by concerns about induction of viral resistance...
  4. ncbi request reprint A prospective clinical study of Epstein-Barr virus and host interactions during acute infectious mononucleosis
    Henry H Balfour
    Department of Laboratory Medicine and Pathology, University of Minnesota, Fairview Clinical Virology Laboratory, Minneapolis 55455 0392, USA
    J Infect Dis 192:1505-12. 2005
    ....
  5. pmc Human immunodeficiency virus type 1 detected in all seropositive symptomatic and asymptomatic individuals
    J B Jackson
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455
    J Clin Microbiol 28:16-9. 1990
    ..Moreover, the sensitivities and specificities of PCR and culture for the detection of HIV-1 appear to be equivalent, and both methods are superior to testing for HIV-1 antigen in serum for the direct detection of HIV-1...
  6. pmc Effect of foscarnet on quantities of cytomegalovirus and human immunodeficiency virus in blood of persons with AIDS
    H H Balfour
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, USA
    Antimicrob Agents Chemother 40:2721-6. 1996
    ..The dual antiviral activity of foscarnet shown in this trial encourages investigation of its use in combination with other antiretroviral therapies for persons with AIDS...
  7. ncbi request reprint Ganciclovir susceptibilities and analysis of UL97 region in cytomegalovirus (CMV) isolates from bone marrow recipients with CMV disease after antiviral prophylaxis
    A Erice
    Department of Laboratory Medicine, University of Minnesota Medical School, Minneapolis 55455, USA
    J Infect Dis 178:531-4. 1998
    ..Ganciclovir-resistant CMV isolates may emerge rapidly in bone marrow transplant recipients who are treated with ganciclovir after receiving prophylaxis with acyclovir...
  8. pmc Rapid and sensitive viral culture method for human immunodeficiency virus type 1
    J B Jackson
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455
    J Clin Microbiol 26:1416-8. 1988
    ..All 72 patients with symptoms of HIV-1 infection were culture positive, as were 69 of 70 asymptomatic patients. Of the 142 patients, 132 (93%) were culture positive within 10 days after initiation of the culture...
  9. ncbi request reprint Prevalence of cytomegalovirus antibody in hemophiliacs and homosexuals infected with human immunodeficiency virus type 1
    J B Jackson
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis
    Transfusion 28:187-9. 1988
    ....
  10. ncbi request reprint Concentration-controlled zidovudine therapy
    C V Fletcher
    Division of Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, USA
    Clin Pharmacol Ther 64:331-8. 1998
    ..The active moiety of nucleoside anti-HIV drugs is the intracellular anabolite. Therefore the heterogeneity in response to nucleoside agents may arise as a result of pharmacologic variability at both the systemic and cellular level...
  11. pmc Practical diagnostic testing for human immunodeficiency virus
    J B Jackson
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis 55455
    Clin Microbiol Rev 1:124-38. 1988
    ..While the other assays are more tedious, they are valuable confirmatory tests and are suitable for reference laboratories. The biohazards of performing HIV testing can be minimized with proper biosafety measures...
  12. ncbi request reprint Lymphocyte mitochondrial biomarkers in asymptomatic HIV-1-infected individuals treated with nucleoside reverse transcriptase inhibitors
    Keith Henry
    HIV Program Regions Hospital, St Paul, MN, USA
    AIDS 16:2485-7. 2002
  13. pmc Emergence of antiviral resistance during oral valganciclovir treatment of an infant with congenital cytomegalovirus (CMV) infection
    K Yeon Choi
    Division of Pediatric Infectious Diseases and Immunology, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    J Clin Virol 57:356-60. 2013
    ..DNAemia resolved after the discontinuation of VAL-GCV. Long-term VAL-GCV therapy in congenitally infected infants can select for resistant viral variants, and anticipatory virological monitoring may be warranted. ..
  14. pmc Anti-human immunodeficiency virus type 1 activity of an anti-CD4 immunoconjugate containing pokeweed antiviral protein
    A Erice
    Department of Laboratory Medicine, University of Minnesota Health Sciences Center, Minneapolis 55455, USA
    Antimicrob Agents Chemother 37:835-8. 1993
    ....
  15. ncbi request reprint Valacyclovir pharmacokinetics and exploratory pharmacodynamics in young adults with Epstein-Barr virus infectious mononucleosis
    Heather E Vezina
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
    J Clin Pharmacol 50:734-42. 2010
    ..Acyclovir pharmacokinetic parameters do not correlate with response metrics. These results support further studies of valacyclovir for EBV infectious mononucleosis...
  16. ncbi request reprint A randomized crossover study to determine bioequivalence of generic and brand name nevirapine, zidovudine, and lamivudine in HIV-negative women in India
    Heather E Vezina
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    J Acquir Immune Defic Syndr 41:131-6. 2006
    ..Lack of average bioequivalence for zidovudine was found for C(max) but is not expected to be clinically significant, because the total AUC values were similar between formulations...
  17. ncbi request reprint Alterations in the C-terminal region of the HIV-1 accessory gene vpr do not confer clinical advantage to subjects receiving nucleoside antiretroviral therapy
    Winston Cavert
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Infect Dis 189:2181-4. 2004
    ..Frequency of C-terminal mutations did not correlate to any measures of disease intensity. Changes in that portion of vpr did not attenuate disease...
  18. ncbi request reprint Intermittent administration of high-dose stavudine to nucleoside-experienced individuals infected with HIV-1
    Edward P Acosta
    Department of Clinical Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Acquir Immune Defic Syndr 33:343-8. 2003
    ..A similar approach might be considered using a more potent regimen for patients in whom resistance to nucleosides is a major reason for therapeutic failure...
  19. ncbi request reprint Periodontal status of individuals in early stages of human immunodeficiency virus infection
    C R Drinkard
    School of Dentistry, University of Minnesota, Minneapolis 55455
    Community Dent Oral Epidemiol 19:281-5. 1991
    ..There were no clinically significant differences detected between ARC versus asymptomatic patients. Dental histories and oral examinations showed that two groups of patients in early stages of HIV-disease were in good periodontal health...
  20. ncbi request reprint A randomized, controlled, double-blind study comparing the survival benefit of four different reverse transcriptase inhibitor therapies (three-drug, two-drug, and alternating drug) for the treatment of advanced AIDS. AIDS Clinical Trial Group 193A Study T
    K Henry
    University of Minnesota, Minneapolis, USA
    J Acquir Immune Defic Syndr Hum Retrovirol 19:339-49. 1998
    ..The time to new HIV disease progression or death, toxicities, the change in CD4 cells, and plasma HIV-1 RNA concentrations in a subset of study subjects were evaluated...
  21. doi request reprint Simultaneous determination of acyclovir, ganciclovir, and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in human plasma using high-performance liquid chromatography
    Dennis R Weller
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, Minneapolis, MN, USA
    Biomed Chromatogr 23:822-7. 2009
    ..5 to 106.4% for four quality controls (50, 100, 1000 and 10,000 ng/mL). This assay supports pharmacokinetic and pharmacodynamic studies of candidate anti-EBV drugs in children and adults with EBV infections...
  22. ncbi request reprint Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient
    J E Julin
    Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
    Transpl Infect Dis 4:201-6. 2002
    ..Autopsy samples of brain and cerebrospinal fluid contained CMV DNA with a UL97 mutation (M460V) known to confer ganciclovir resistance. No foscarnet resistance mutations were found...
  23. ncbi request reprint Detection of antiretroviral resistance in HIV-1
    Winston Cavert
    Department of Laboratory Medicine and Pathology, University of Minnesota, 420 Delaware Street, Southwest, Minneapolis, MN 55455 0392, USA
    Clin Lab Med 23:915-28. 2003
    ..Future studies about viral fitness and other viral, host, and pharmacologic factors responsible for disease progression likely will facilitate more precise application of resistance testing to the clinical setting...
  24. ncbi request reprint An isocratic liquid chromatography method for determining HIV non-nucleoside reverse transcriptase inhibitor and protease inhibitor concentrations in human plasma
    Dennis R Weller
    Department of Laboratory Medicine and Pathology, Medical School, University of Minnesota, 420 Delaware St SE, Minneapolis, MN 55455, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 848:369-73. 2007
    ..Accuracy ranges from 91.0 to 112.8% for four quality controls (50, 100, 1000, and 10,000 ng/ml) for all drugs measured (efavirenz, nevirapine, amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, and saquinavir)...
  25. ncbi request reprint Analysis of HIV-1 reverse transcriptase and protease sequences in paired plasma and lymphoid tissue specimens from HIV-1 infected individuals
    A Erice
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, USA
    AIDS 15:831-6. 2001
    ..CONCLUSION: The genotype of plasma HIV-1 is similar to the genotype of the virus in lymphoid tissue. Resistance studies using plasma samples should provide accurate information regarding the genotype of HIV-1 in lymphoid tissues...
  26. pmc Progress and problems in understanding and managing primary Epstein-Barr virus infections
    Oludare A Odumade
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, MMC 437, 420 Delaware St SE, Minneapolis, MN 55455 0392, USA
    Clin Microbiol Rev 24:193-209. 2011
    ..We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies...
  27. ncbi request reprint Predictive value of HIV-1 viral load on risk for opportunistic infection
    Susan Swindells
    University of Nebraska Medical Center, Omaha 68198 5400, USA
    J Acquir Immune Defic Syndr 30:154-8. 2002
    ....
  28. doi request reprint Coinfection alters the playing field: herpesviruses induce acyclovir to inhibit HIV
    Jack T Stapleton
    Department of Internal Medicine, The University of Iowa and Iowa City VA Medical Center, SW54, GH, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Cell Host Microbe 4:194-5. 2008
    ..This report underscores the importance of studying HIV in the context of microbial copathogens...
  29. ncbi request reprint Epstein-Barr virus vaccine for the prevention of infectious mononucleosis--and what else?
    Henry H Balfour
    J Infect Dis 196:1724-6. 2007

Research Grants3

  1. ADULT AIDS CLINICAL TRIALS UNIT
    HENRY BALFOUR; Fiscal Year: 2004
    ..The Iowa subunit has expertise in the detection of hepatitis C and will be collaborating in studies of the pathogenesis of coinfection with HIV and hepatitis C. ..
  2. ADULT AIDS CLINICAL TRIALS UNIT
    HENRY BALFOUR; Fiscal Year: 2007
    ..The Iowa subunit has expertise in detection of hepatitis C and will be collaborating in studies of the pathogenesis of coinfection with HIV and hepatitis C. ..