Laura Balcer

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Clinical practice. Optic neuritis
    Laura J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 354:1273-80. 2006
  2. doi request reprint Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity
    Laura J Balcer
    Department of Neurology, 3 East Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 74:S16-23. 2010
  3. doi request reprint Low-contrast acuity measures visual improvement in phase 3 trial of natalizumab in relapsing MS
    Laura J Balcer
    Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Neurol Sci 318:119-24. 2012
  4. pmc Residency training: the King-Devick test and sleep deprivation: study in pre- and post-call neurology residents
    Emma C Davies
    Departments of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 78:e103-6. 2012
  5. ncbi request reprint Idiopathic intracranial hypertension: relation of age and obesity in children
    L J Balcer
    Department of Neurology, Hospital of the University of Pennsylvania, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 52:870-2. 1999
  6. ncbi request reprint Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 61:1367-73. 2003
  7. ncbi request reprint Natalizumab reduces visual loss in patients with relapsing multiple sclerosis
    L J Balcer
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurology 68:1299-304. 2007
  8. ncbi request reprint Clinical outcome measures for research in multiple sclerosis
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuroophthalmol 21:296-301. 2001
  9. ncbi request reprint Evidence-based neuro-ophthalmology: advances in treatment
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Ophthalmol 12:387-92. 2001
  10. ncbi request reprint Visual loss in children with neurofibromatosis type 1 and optic pathway gliomas: relation to tumor location by magnetic resonance imaging
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Ophthalmol 131:442-5. 2001

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Clinical practice. Optic neuritis
    Laura J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    N Engl J Med 354:1273-80. 2006
  2. doi request reprint Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity
    Laura J Balcer
    Department of Neurology, 3 East Gates Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 74:S16-23. 2010
    ..Lesions associated with these impairments frequently involve the afferent visual pathway...
  3. doi request reprint Low-contrast acuity measures visual improvement in phase 3 trial of natalizumab in relapsing MS
    Laura J Balcer
    Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA
    J Neurol Sci 318:119-24. 2012
    ..We determined the effects of natalizumab on the frequency and cumulative probability of visual improvement using low-contrast letter acuity a prespecified tertiary outcome measure in AFFIRM...
  4. pmc Residency training: the King-Devick test and sleep deprivation: study in pre- and post-call neurology residents
    Emma C Davies
    Departments of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 78:e103-6. 2012
    ..The current study investigates the effect of sleep deprivation on the speed and accuracy of eye movements as measured by the King-Devick (K-D) test, a <1-minute test that involves rapid number naming...
  5. ncbi request reprint Idiopathic intracranial hypertension: relation of age and obesity in children
    L J Balcer
    Department of Neurology, Hospital of the University of Pennsylvania, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Neurology 52:870-2. 1999
    ..01). Younger children with idiopathic intracranial hypertension are less likely to be obese than are older children or adults...
  6. ncbi request reprint Contrast letter acuity as a visual component for the Multiple Sclerosis Functional Composite
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurology 61:1367-73. 2003
    ..Visual dysfunction is one of the most common causes of disability in multiple sclerosis (MS). The Multiple Sclerosis Functional Composite (MSFC), a new clinical trial outcome measure, does not currently include a test of visual function...
  7. ncbi request reprint Natalizumab reduces visual loss in patients with relapsing multiple sclerosis
    L J Balcer
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurology 68:1299-304. 2007
    ....
  8. ncbi request reprint Clinical outcome measures for research in multiple sclerosis
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuroophthalmol 21:296-301. 2001
    ..Measures of visual function and HRQOL should also be incorporated to capture the broad scope of neurologic impairment and disability in MS populations...
  9. ncbi request reprint Evidence-based neuro-ophthalmology: advances in treatment
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Curr Opin Ophthalmol 12:387-92. 2001
    ....
  10. ncbi request reprint Visual loss in children with neurofibromatosis type 1 and optic pathway gliomas: relation to tumor location by magnetic resonance imaging
    L J Balcer
    Division of Neuro ophthalmology, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Ophthalmol 131:442-5. 2001
    ..To examine the potential for visual acuity loss, and its relation to extent and location of optic pathway gliomas in a cohort of children with neurofibromatosis type 1 studied with magnetic resonance imaging...
  11. pmc Damage to the optic radiation in multiple sclerosis is associated with retinal injury and visual disability
    Daniel S Reich
    Department of Neurology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, Phipps Bldg, Room B 112, Baltimore, MD 21287, USA
    Arch Neurol 66:998-1006. 2009
    ..To determine whether damage to the optic radiation (OR) in multiple sclerosis (MS) is associated with optic nerve injury and visual dysfunction...
  12. pmc Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
    Lauren S Talman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 67:749-60. 2010
    ..We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON)...
  13. ncbi request reprint Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis
    Jennifer B Fisher
    Division of Neuro ophthalmology, Departments of Neurology, Ophthalmology, and Biostatistics, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania, USA
    Ophthalmology 113:324-32. 2006
    ....
  14. ncbi request reprint Self-reported visual dysfunction in multiple sclerosis: new data from the VFQ-25 and development of an MS-specific vision questionnaire
    Siu Ling Ma
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Ophthalmol 133:686-92. 2002
    ....
  15. doi request reprint Retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis
    Maulik S Zaveri
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Arch Neurol 65:924-8. 2008
    ....
  16. ncbi request reprint Multiple sclerosis and the ophthalmologist
    Ellen M Mowry
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Compr Ophthalmol Update 8:39-49. 2007
    ..A summary presents the appropriate evaluation and management of patients with optic neuritis and other first demyelinating events (also referred to as clinically isolated syndromes)...
  17. doi request reprint Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    J Neurol Sci 282:96-105. 2009
    ..Measurement of retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) is gaining increasing attention...
  18. ncbi request reprint Contrast letter acuity as a measure of visual dysfunction in patients with Friedreich ataxia
    David R Lynch
    Department of Neurology, University of Pennsylvania and The Children s Hospital of Philadelphia, 19104, USA
    J Neuroophthalmol 22:270-4. 2002
    ..We sought to identify a simple, reliable method for assessing clinical and subclinical visual dysfunction in patients with Friedreich ataxia...
  19. pmc Measuring the rate of progression in Friedreich ataxia: implications for clinical trial design
    Lisa S Friedman
    Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 25:426-32. 2010
    ..These results help to establish norms for progression in FRDA that can be useful in measuring the long-term success of therapeutic agents and defining sample-size calculations for double-blind clinical trials...
  20. doi request reprint Approach to optic neuropathies: clinical update
    Sashank Prasad
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neurologist 16:23-34. 2010
    ....
  21. ncbi request reprint Friedreich ataxia: effects of genetic understanding on clinical evaluation and therapy
    David R Lynch
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, USA
    Arch Neurol 59:743-7. 2002
    ..Although no proven therapy is yet available, antioxidants are a potential method for therapeutic intervention...
  22. ncbi request reprint Near infrared muscle spectroscopy in patients with Friedreich's ataxia
    David R Lynch
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Muscle Nerve 25:664-73. 2002
    ..These results suggest that NIRS may be an effective tool for monitoring the biochemical and functional features of Friedreich's ataxia in parallel...
  23. ncbi request reprint Lack of effect of polymorphisms in dopamine metabolism related genes on imaging of TRODAT-1 in striatum of asymptomatic volunteers and patients with Parkinson's disease
    David R Lynch
    Department of Neurology, University of Pennsylvania and The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 18:804-12. 2003
    ..These results demonstrate that these specific genetic variations do not alter the fidelity of (99)Tc-TRODAT-1 as a measure of dopaminergic function in asymptomatic volunteer individuals or patients with PD...
  24. ncbi request reprint Validation and test characteristics of a 10-item neuro-ophthalmic supplement to the NEI-VFQ-25
    Brian A Raphael
    Department of Neurology, Division of Neuro ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Ophthalmol 142:1026-35. 2006
    ....
  25. ncbi request reprint Occult thyroid eye disease in patients with unexplained ocular misalignment identified by standardized orbital echography
    Nicholas J Volpe
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Am J Ophthalmol 142:75-81. 2006
    ....
  26. ncbi request reprint Performance measures in Friedreich ataxia: potential utility as clinical outcome tools
    David R Lynch
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4318, USA
    Mov Disord 20:777-82. 2005
    ..Thus, a composite scale derived from these performance measures may provide the best overall measure for assessing disease progression throughout the illness...
  27. doi request reprint Pupil-involving third nerve palsy as a manifestation of anti-myelin-associated glycoprotein neuropathy
    Madhura A Tamhankar
    Department of Ophthalmology, Scheie Eye Institute, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neuroophthalmol 31:29-33. 2011
    ..The patient improved with prednisone and rituximab treatment. Anti-MAG neuropathy should be considered when evaluating a patient with an undiagnosed cranial neuropathy, especially in the setting of a sensory neuropathy...
  28. ncbi request reprint Optical coherence tomography in multiple sclerosis
    Elliot Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
    Lancet Neurol 5:853-63. 2006
    ..In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis...
  29. pmc Optical coherence tomography: a window into the mechanisms of multiple sclerosis
    Elliot M Frohman
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
    Nat Clin Pract Neurol 4:664-75. 2008
    ....
  30. doi request reprint Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis
    Bryn M Burkholder
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Arch Neurol 66:1366-72. 2009
    ..Inner (area adjacent to the fovea) and outer regions of the macula differ with respect to relative thicknesses of the ganglion cell layer (neurons) vs retinal nerve fiber layer (RNFL; axons)...
  31. doi request reprint Functional visual loss in idiopathic intracranial hypertension
    Joshua J Ney
    Departments of Neurology and Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, 51 North 39th Street, Philadelphia, PA 19104, USA
    Ophthalmology 116:1808-1813.e1. 2009
    ..To identify and describe patients with idiopathic intracranial hypertension (IIH) with concurrent functional visual loss (FVL)...
  32. ncbi request reprint Pituitary apoplexy causing optic neuropathy and horner syndrome without ophthalmoplegia
    Robert K Shin
    Department of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neuroophthalmol 23:208-10. 2003
    ..The combination of headache, acute visual loss, and ipsilateral Horner syndrome without ophthalmoplegia, which may suggest carotid artery dissection, is evidently an unusual manifestation of pituitary apoplexy...
  33. doi request reprint Reproducibility of high-resolution optical coherence tomography in multiple sclerosis
    Stephanie B Syc
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Mult Scler 16:829-39. 2010
    ..Specific procedures for OCT acquisition and analysis of retinal imaging metrics using SD-OCT technology may improve the application of this novel technology in multiple sclerosis...
  34. doi request reprint Combined optic neuropathy and myelopathy secondary to copper deficiency
    Stacy L Pineles
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Surv Ophthalmol 55:386-92. 2010
    ..It is crucial to elicit a history of gastric surgery or other risk factors for hypocupremia in those patients undergoing an evaluation for subacute or chronically progressive optic neuropathy or myelopathy...
  35. doi request reprint Health related quality of life measures in Friedreich Ataxia
    Elizabeth Epstein
    Department of Neurology, University of Pennsylvania School of Medicine, USA
    J Neurol Sci 272:123-8. 2008
    ..Findings of this study are consistent with the phenotypic characteristics of FA, and suggest that HRQOL measures are potentially useful as clinical markers of disease status in FA...
  36. ncbi request reprint Treatment of acute demyelinating optic neuritis
    Laura J Balcer
    Division of Neuro ophthalmology, Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Semin Ophthalmol 17:4-10. 2002
    ..Oral prednisone alone, without prior treatment with IV methylprednisolone, may increase the risk for recurrent optic neuritis and should be avoided...
  37. pmc The King-Devick test as a determinant of head trauma and concussion in boxers and MMA fighters
    K M Galetta
    Department of Neurology, University of Pennsylvania School of Medicine, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurology 76:1456-62. 2011
    ..We investigated the K-D test as a potential rapid sideline screening for concussion in a cohort of boxers and mixed martial arts fighters...
  38. ncbi request reprint Tension pneumocephalus after endoscopic sinus surgery: case report of repair and management in absence of obvious skull base defect
    Robert G Whitmore
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    Ear Nose Throat J 87:96-9. 2008
    ..We discuss management of this complication and preventive measures for avoiding pneumocephalus after functional endoscopic sinus surgery...
  39. pmc Antioxidant use in Friedreich ataxia
    Lauren Myers
    Department of Neurology, University of Pennsylvania School of Medicine, USA
    J Neurol Sci 267:174-6. 2008
    ..This confirms that non-prescription antioxidant use represents a major confounder to formal trials of existing and novel agents for Friedreich ataxia...
  40. ncbi request reprint The role of unilateral temporal artery biopsy
    Jennifer K Hall
    Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania School of Medicine, 51 North 39th Street, Philadelphia, PA 19104, USA
    Ophthalmology 110:543-8; discussion 548. 2003
    ..To examine the role of unilateral temporal artery biopsy (TAB) in suspected giant cell arteritis (GCA)...
  41. doi request reprint Reproducibility of optical coherence tomography in multiple sclerosis
    Deanna Cettomai
    Pathology Bldg, Ste 627, The Johns Hopkins Hospital, 600 N Wolfe St, Baltimore, MD 21287, USA
    Arch Neurol 65:1218-22. 2008
    ..Optical coherence tomography is being considered as a potential outcome measure in multiple sclerosis (MS) clinical trials, but no data exist on the reproducibility of this technique in MS centers...
  42. ncbi request reprint Laser pointer visual field screening
    Michael S Lee
    Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Neuroophthalmol 23:260-3. 2003
    ..We compared the sensitivity of laser pointer visual field screening (LVF) with conventional CVF for identifying eyes with abnormal automated perimetry...

Research Grants14

  1. Novel visual outcome measures in optic neuritis and multiple sclerosis
    Laura Balcer; Fiscal Year: 2007
    ..S. This work will provide support for additional research and for mentoring of beginning clinician scientists in the development of improved testing methods for vision in these conditions. ..
  2. Longitudinal Assessment of Visual Function in MS
    Laura Balcer; Fiscal Year: 2007
    ....
  3. Visual Dysfunction and Quality of Life in MS
    Laura Balcer; Fiscal Year: 2003
    ..This proposal will provide a crucial foundation for future studies of vision in MS that will involve longitudinal assessment. ..
  4. Novel Clinical and Ocular Imaging Outcomes with Long-Term Follow-Up in MS
    Laura Balcer; Fiscal Year: 2010
    ..Aim 3: Determine how low-contrast letter acuity, RNFL thickness, and total macular volume impact vision specific and overall health-related quality of life (HRQOL) in longitudinal studies of MS and ON. ..