Rohit Bakshi

Summary

Affiliation: University at Buffalo
Country: USA

Publications

  1. ncbi request reprint Neuroimaging curriculum for neurology trainees: report from the Neuroimaging Section of the AAN
    Rohit Bakshi
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 13:215-7. 2003
  2. ncbi request reprint Fatigue associated with multiple sclerosis: diagnosis, impact and management
    Rohit Bakshi
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Mult Scler 9:219-27. 2003
  3. ncbi request reprint Bicaudate ratio as a magnetic resonance imaging marker of brain atrophy in multiple sclerosis
    Robert A Bermel
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High St, Buffalo, NY 14203, USA
    Arch Neurol 59:275-80. 2002
  4. ncbi request reprint T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study
    Rohit Bakshi
    Department of Neurology, University at Buffalo, State University of New York, USA
    Arch Neurol 59:62-8. 2002
  5. ncbi request reprint Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions
    R Bakshi
    Neuroscience Center, E 2, Buffalo General Hospital, 100 High St, Buffalo, NY 14203
    Arch Neurol 58:742-8. 2001
  6. ncbi request reprint Neuroimaging of HIV and AIDS related illnesses: a review
    Rohit Bakshi
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Front Biosci 9:632-46. 2004
  7. ncbi request reprint Regional brain atrophy is associated with physical disability in multiple sclerosis: semiquantitative magnetic resonance imaging and relationship to clinical findings
    R Bakshi
    Imaging Services, Kaleida Health, State University of New York at Buffalo, USA
    J Neuroimaging 11:129-36. 2001
  8. ncbi request reprint Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients
    R Bakshi
    Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Neurol Sci 185:19-26. 2001
  9. ncbi request reprint Fatigue in multiple sclerosis: cross-sectional correlation with brain MRI findings in 71 patients
    R Bakshi
    Dent Neurologic Institute, Kaleida Health Millard Fillmore Hospital, Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, USA
    Neurology 53:1151-3. 1999
  10. ncbi request reprint MRI in cerebral intraventricular hemorrhage: analysis of 50 consecutive cases
    R Bakshi
    Dent Neurologic Institute, Lucy Dent Imaging Center, Kaleida Health, State University of NY at Buffalo, 14203, USA
    Neuroradiology 41:401-9. 1999

Detail Information

Publications95

  1. ncbi request reprint Neuroimaging curriculum for neurology trainees: report from the Neuroimaging Section of the AAN
    Rohit Bakshi
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 13:215-7. 2003
    ....
  2. ncbi request reprint Fatigue associated with multiple sclerosis: diagnosis, impact and management
    Rohit Bakshi
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
    Mult Scler 9:219-27. 2003
    ....
  3. ncbi request reprint Bicaudate ratio as a magnetic resonance imaging marker of brain atrophy in multiple sclerosis
    Robert A Bermel
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High St, Buffalo, NY 14203, USA
    Arch Neurol 59:275-80. 2002
    ..Brain atrophy has emerged as a useful surrogate marker of disease involvement in multiple sclerosis (MS). The relationship between whole-brain or regional atrophy and cognitive dysfunction is poorly understood...
  4. ncbi request reprint T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging study
    Rohit Bakshi
    Department of Neurology, University at Buffalo, State University of New York, USA
    Arch Neurol 59:62-8. 2002
    ..While gray matter T2 hypointensity in multiple sclerosis (MS) has been associated with physical disability and clinical course, previous studies have relied on visual magnetic resonance imaging (MRI) assessments...
  5. ncbi request reprint Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesions
    R Bakshi
    Neuroscience Center, E 2, Buffalo General Hospital, 100 High St, Buffalo, NY 14203
    Arch Neurol 58:742-8. 2001
    ..Fluid-attenuated inversion recovery (FLAIR) is an advanced magnetic resonance imaging sequence that reveals tissue T2 prolongation with cerebrospinal fluid suppression, allowing detection of superficial brain lesions...
  6. ncbi request reprint Neuroimaging of HIV and AIDS related illnesses: a review
    Rohit Bakshi
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Front Biosci 9:632-46. 2004
    ..In addition, through a wide breadth of imaging techniques, the pathology, neurochemistry and metabolism of lesions can be studied to clarify the differential diagnosis, such as discriminating infection vs. neoplasia...
  7. ncbi request reprint Regional brain atrophy is associated with physical disability in multiple sclerosis: semiquantitative magnetic resonance imaging and relationship to clinical findings
    R Bakshi
    Imaging Services, Kaleida Health, State University of New York at Buffalo, USA
    J Neuroimaging 11:129-36. 2001
    ..The authors conclude that brain atrophy is closely associated with physical disability and clinical course in MS patients and can be appreciated using a semiquantitative MRI regional rating system...
  8. ncbi request reprint Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients
    R Bakshi
    Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Neurol Sci 185:19-26. 2001
    ..Further study is warranted to determine if T2 hypointensity is predictive of disease course in MS and is a useful surrogate outcome measure in therapeutic trials...
  9. ncbi request reprint Fatigue in multiple sclerosis: cross-sectional correlation with brain MRI findings in 71 patients
    R Bakshi
    Dent Neurologic Institute, Kaleida Health Millard Fillmore Hospital, Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, USA
    Neurology 53:1151-3. 1999
    ..We suggest that brain MRI disease topography or severity does not explain fatigue in MS and that fatigue is likely due to mechanisms poorly characterized by conventional MRI...
  10. ncbi request reprint MRI in cerebral intraventricular hemorrhage: analysis of 50 consecutive cases
    R Bakshi
    Dent Neurologic Institute, Lucy Dent Imaging Center, Kaleida Health, State University of NY at Buffalo, 14203, USA
    Neuroradiology 41:401-9. 1999
    ..Further study is necessary to determine if MRI characteristics of IVH are helpful in excluding other intraventricular diseases such as neoplasia and pyocephalus...
  11. ncbi request reprint MRI findings in lumbar puncture headache syndrome: abnormal dural-meningeal and dural venous sinus enhancement
    R Bakshi
    University at Buffalo SUNY School of Medicine and Biomedical Sciences, USA
    Clin Imaging 23:73-6. 1999
    ..MRI also showed abnormal dural venous sinus enhancement, a new finding in LPHA, suggesting compensatory venous expansion. Thus, IH and venodilatation may play a role in the development of LPHA...
  12. ncbi request reprint The cerebral intravascular enhancement sign is not specific: a contrast-enhanced MRI study
    R Bakshi
    Millard Fillmore Health System, Department of Neurology, University at Buffalo, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, NY 14209, USA
    Neuroradiology 41:80-5. 1999
    ....
  13. pmc Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensity
    Robert A Bermel
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, USA
    Arch Neurol 62:1371-6. 2005
    ..Treatment with intramuscular interferon beta-1a limits brain atrophy in the second year of treatment...
  14. pmc Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale
    Rohit Bakshi
    Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Neurol 65:1449-53. 2008
    ..Individual magnetic resonance imaging (MRI) disease severity measures, such as atrophy or lesions, show weak relationships to clinical status in patients with multiple sclerosis (MS)...
  15. ncbi request reprint Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change
    Ralph H B Benedict
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
    J Neurol Sci 231:29-34. 2005
    ..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment...
  16. doi request reprint Rate of brain atrophy in benign vs early multiple sclerosis
    Susan A Gauthier
    Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 66:234-7. 2009
    ..Benign multiple sclerosis (MS) is defined by minimal or no disability after many years of observation, therefore a less degenerative disease process is suspected to be present in this subset of patients...
  17. ncbi request reprint Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis
    Ayda Tekok-Kilic
    Department of Neurology, University at Buffalo, State University of New York, USA
    Neuroimage 36:1294-300. 2007
    ..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy...
  18. pmc Approaches to normalization of spinal cord volume: application to multiple sclerosis
    Brian C Healy
    Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Massachusetts, USA
    J Neuroimaging 22:e12-9. 2012
    ..To determine the proper method for the normalization of spinal cord volume...
  19. ncbi request reprint Regional lobar atrophy predicts memory impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
    AJNR Am J Neuroradiol 26:1824-31. 2005
    ..The relationship between regional lobar atrophy and cognitive impairment is yet to be examined. We endeavored to assess the clinical significance of regional lobar atrophy in multiple sclerosis...
  20. ncbi request reprint Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burden
    Ralph H B Benedict
    Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
    Arch Neurol 61:226-30. 2004
    ..Furthermore, few studies accounted for the influence of age, premorbid intelligence, or depression...
  21. doi request reprint The association between cognitive impairment and quality of life in patients with early multiple sclerosis
    Bonnie I Glanz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Neurol Sci 290:75-9. 2010
    ..Our results suggest that cognitive remediation programs aimed at improving cognitive skills may also improve quality of life for patients with early MS...
  22. ncbi request reprint A semiautomated measure of whole-brain atrophy in multiple sclerosis
    Robert A Bermel
    University at Buffalo, State University of New York, USA
    J Neurol Sci 208:57-65. 2003
    ..We conclude that whole-brain atrophy in MS can be reliably and readily quantified by a semiautomated approach. Longitudinal studies are warranted to determine if this method provides a sensitive biologic marker of the MS disease process...
  23. pmc Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis
    James M Stankiewicz
    Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Brookline, Massachusetts 02445, USA
    J Neuroimaging 21:e50-6. 2011
    ..To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI)...
  24. pmc Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal study
    Jennifer Moodie
    Department of Neurology, University of Massachusetts, Boston, MA, USA
    J Neurol Sci 315:49-54. 2012
    ..We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS)...
  25. doi request reprint Accounting for disease modifying therapy in models of clinical progression in multiple sclerosis
    Brian C Healy
    Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Brookline, MA 02115, USA
    J Neurol Sci 303:109-13. 2011
    ..DMT modeling choice had a modest impact on the variables classified as predictors of EDSS score change. Importantly, however, interpretation of these predictors is dependent upon modeling choice...
  26. ncbi request reprint Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosis
    Michael P Sanfilipo
    Department of Neurology, SUNY University, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
    Neurology 66:685-92. 2006
    ..The relationship of gray and white matter atrophy in multiple sclerosis (MS) to neuropsychological and neuropsychiatric impairment has not been examined...
  27. pmc Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis
    Mohit Neema
    Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 19:3-8. 2009
    ..Conventional brain MRI lesion measures have unreliable associations with clinical progression in multiple sclerosis (MS). Gray matter imaging may improve clinical-MRI correlations...
  28. ncbi request reprint The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction
    Michael P Sanfilipo
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
    Neuroimage 26:1068-77. 2005
    ..These findings suggest that gray matter loss is related to other aspects of brain pathology and has more clinical relevance than white matter atrophy in MS...
  29. ncbi request reprint Multiple sclerosis: hyperintense lesions in the brain on nonenhanced T1-weighted MR images evidenced as areas of T1 shortening
    Vallabh Janardhan
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
    Radiology 244:823-31. 2007
    ....
  30. doi request reprint Genomic effects of once-weekly, intramuscular interferon-beta1a treatment after the first dose and on chronic dosing: Relationships to 5-year clinical outcomes in multiple sclerosis patients
    Bianca Weinstock-Guttman
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
    J Neuroimmunol 205:113-25. 2008
    ....
  31. ncbi request reprint Selective caudate atrophy in multiple sclerosis: a 3D MRI parcellation study
    Robert A Bermel
    Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High St, Buffalo, NY 14203, USA
    Neuroreport 14:335-9. 2003
    ..05). We conclude that selective caudate atrophy is associated with MS and may occur through direct mechanisms...
  32. ncbi request reprint Functional imaging during covert auditory attention in multiple sclerosis
    Michael P Santa Maria
    Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6 Buffalo, 100 High Street, 14203, USA
    J Neurol Sci 218:9-15. 2004
    ..This study demonstrates cingulate hypoactivity and cerebral reorganization during auditory attention in MS...
  33. ncbi request reprint Magnetic resonance imaging in multiple sclerosis
    Salvatore Q Napoli
    Partners, Multiple Sclerosis Center, and Center for Neurological Imaging, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 2:109-16. 2005
    ..In this review, we will focus on the role of MRI in the diagnosis and management of MS. We will also review how advanced MRI techniques contribute to our understanding of MS...
  34. ncbi request reprint Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual method
    Michael P Sanfilipo
    Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical Sciences, NY 14203, USA
    Neuroimage 22:1732-43. 2004
    ..Our findings suggest that head size correction of brain regions with the residual method generally may provide advantages over the proportion method...
  35. ncbi request reprint Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentation
    Jitendra Sharma
    Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, NY, USA
    AJNR Am J Neuroradiol 25:985-96. 2004
    ..Semiautomated and automated methods are used to measure whole-brain atrophy in multiple sclerosis (MS), but their comparative reliability, sensitivity, and validity are unknown...
  36. ncbi request reprint A magnetization transfer MRI study of deep gray matter involvement in multiple sclerosis
    Jitendra Sharma
    Center for Neurological Imaging, Partners MS Center, Department of Neurology, Brigham Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 16:302-10. 2006
    ..Magnetization transfer imaging (MTI), an advanced MRI technique, is sensitive to disease in normal appearing white matter (NAWM) in patients with MS...
  37. pmc 3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis
    Mohit Neema
    Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA 02445, USA
    Neuroimage 46:633-41. 2009
    ..Such findings may represent demyelination, inflammation, glial proliferation and axonal loss...
  38. ncbi request reprint Construct validity and frequency of euphoria sclerotica in multiple sclerosis
    Inna Fishman
    State University of New York SUNY Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York, USA
    J Neuropsychiatry Clin Neurosci 16:350-6. 2004
    ..Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates...
  39. doi request reprint MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosis
    Milena Stosic
    Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14203, USA
    J Neurol 257:63-71. 2010
    ..MRI reveals more profound injury in patients with MS versus PAPLS. APLA mediates heterogeneous cerebral pathology that remains to be further investigated...
  40. ncbi request reprint Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosis
    Rohit Bakshi
    Center for Neurological Imaging, Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Neuroimaging 15:30S-45S. 2005
    ..Future research to clarify the etiology and pathophysiology of brain and spinal cord atrophy should provide new targets for therapeutic development...
  41. pmc Iron in chronic brain disorders: imaging and neurotherapeutic implications
    James Stankiewicz
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 4:371-86. 2007
    ..We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development...
  42. ncbi request reprint MRI in multiple sclerosis: what's inside the toolbox?
    Mohit Neema
    Department of Neurology, Center for Neurological Imaging, Partners MS Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neurotherapeutics 4:602-17. 2007
    ..We review the most recent data regarding the role of conventional and advanced MRI techniques in the assessment of MS. We focus on the most relevant pathologic and clinical correlation studies relevant to these measures...
  43. ncbi request reprint New error type and recall consistency indices for the Brief Visuospatial Memory Test - Revised: performance in healthy adults and multiple sclerosis patients
    Jeffrey J Gaines
    Department of Neurology, State University of New York at Buffalo School of Medicine, NY, USA
    Clin Neuropsychol 22:851-63. 2008
    ..Findings suggest these error types and inconsistent learning contribute to poorer recall of visual material in MS...
  44. doi request reprint Neuroimaging of toxic and metabolic disorders
    Ashish Arora
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Semin Neurol 28:495-510. 2008
    ..We hope this article will prove useful to trainees and practitioners in the clinical and imaging fields of the neurosciences...
  45. ncbi request reprint Central nervous system atrophy and clinical status in multiple sclerosis
    Robert Zivadinov
    Department of Neurology, University at Buffalo, SUNY School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 14:27S-35S. 2004
    ..The authors conclude that measurement of atrophy of the CNS is emerging as a clinically relevant biomarker of the MS disease process...
  46. ncbi request reprint Thalamic involvement in multiple sclerosis: a diffusion-weighted magnetic resonance imaging study
    Andrew J Fabiano
    Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
    J Neuroimaging 13:307-14. 2003
    ..Diffusion-weighted magnetic resonance imaging (MRI) can assess tissue damage with greater sensitivity than conventional MRI. The authors' objective was to assess thalamic gray matter damage by diffusion-weighted imaging in MS patients...
  47. ncbi request reprint Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis
    Ralph H B Benedict
    State University of New York Buffalo School of Medicine, Jacobs Neurological Institute, Department of Neurology, Buffalo General Hospital, New York 14203, USA
    J Neuroimaging 14:36S-45S. 2004
    ..Continuing research focuses on the possible relationship between measures of regional brain atrophy and cognitive and emotional impairment...
  48. doi request reprint MRI in multiple sclerosis: a review of the current literature
    Antonia Ceccarelli
    Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Neurol 25:402-9. 2012
    ..This review summarizes the recent data pertaining to the use of magnetic resonance imaging (MRI) in assessing brain and spinal cord involvement in multiple sclerosis (MS)...
  49. pmc Smoking and disease progression in multiple sclerosis
    Brian C Healy
    Department of Neurology, Partners MS Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 66:858-64. 2009
    ..Although cigarette smokers are at increased risk of developing multiple sclerosis (MS), the effect of smoking on the progression of MS remains uncertain...
  50. ncbi request reprint T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosis
    Mohit Neema
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Neuroimaging 17:16S-21S. 2007
    ..For example, T2 mapping may allow an assessment of myelin content in NAWM. In this review, we will focus on MRI advances in the last 10 years pertaining to T1 and T2 measures of diffuse GM and WM damage...
  51. ncbi request reprint Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findings
    Sharmeela Kuperan
    Department of Medicine, University at Buffalo, State University of New York, USA
    Neurology 60:721-2. 2003
  52. doi request reprint Unbiased treatment effect estimates by modeling the disease process of multiple sclerosis
    Brian C Healy
    Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Boston, MA 02115, USA
    J Neurol Sci 278:54-9. 2009
    ..The implications of these results are discussed in terms of efficacy and safety...
  53. ncbi request reprint Frontal cortex atrophy predicts cognitive impairment in multiple sclerosis
    Ralph H B Benedict
    Department of Neurology, State University of New York at Buffalo School of Medicine, Buffalo, USA
    J Neuropsychiatry Clin Neurosci 14:44-51. 2002
    ..The authors conclude that cerebral atrophy predicts NP impairment while accounting for the influence of TLA or 3VW. Regions of cortex most susceptible to atrophic and cognitive changes in MS are the right and left superior frontal lobes...
  54. ncbi request reprint Study of mitoxantrone for the treatment of recurrent neuromyelitis optica (Devic disease)
    Bianca Weinstock-Guttman
    The William C Baird Multiple Sclerosis Center, Jacobs Neurological Institute, State University of New York, Buffalo, NY 14203, USA
    Arch Neurol 63:957-63. 2006
    ..Mitoxantrone hydrochloride, a synthetic anthracenedione approved for worsening relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis, has been shown to primarily suppress the humoral response...
  55. ncbi request reprint The measurement and clinical relevance of brain atrophy in multiple sclerosis
    Robert A Bermel
    Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH, USA
    Lancet Neurol 5:158-70. 2006
    ..Based on a review of current information, we will summarise the rate of atrophy among phenotypes for multiple sclerosis, the clinical relevance of brain atrophy, and the effect of disease-modifying treatments on its progression...
  56. ncbi request reprint Quality of life in patients with multiple sclerosis: the impact of fatigue and depression
    Vallabh Janardhan
    Department of Neurology, Boston University Medical Center, Boston, MA, USA
    J Neurol Sci 205:51-8. 2002
    ..03). This study demonstrates that fatigue and depression are independently associated with impaired QOL in MS, after accounting for physical disability, suggesting that their recognition and treatment can potentially improve QOL...
  57. ncbi request reprint The use of magnetic resonance imaging in the diagnosis and long-term management of multiple sclerosis
    Rohit Bakshi
    Department of Neurology, Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, RF396, Boston, MA 02115, USA
    Neurology 63:S3-11. 2004
    ..The use of conventional MRI in the diagnosis and longitudinal management of patients with MS is the focus of this review...
  58. ncbi request reprint Lymphomatosis cerebri presenting as a rapidly progressive dementia: clinical, neuroimaging and pathologic findings
    R Bakshi
    Department of Neurology, UCLA School of Medicine and UCLA Medical Center, Reed Neurological Research Center, Los Angeles, CA, USA
    Dement Geriatr Cogn Disord 10:152-7. 1999
    ..We refer to this entity as 'lymphomatosis cerebri' and add it to the differential diagnosis of a rapidly progressive dementia...
  59. ncbi request reprint Cerebral ventricular empyema associated with severe adult pyogenic meningitis: computed tomography findings
    R Bakshi
    Millard Fillmore Health System, Dent Neurologic Institute, Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, USA
    Clin Neurol Neurosurg 99:252-5. 1997
    ..Frank neutrophilic pus was taken from the subarachnoid space. After antibiotic treatment, the pyocephalus resolved. CVE may be visualized on CT with pus layering in the ventricular CSF, creating a fluid level of intermediate hypodensity...
  60. ncbi request reprint Guillain-Barré syndrome after combined tetanus-diphtheria toxoid vaccination
    R Bakshi
    Department of Neurology, UCLA School of Medicine 90024, USA
    J Neurol Sci 147:201-2. 1997
    ..The first case of GBS following a vaccination with combined tetanus-diphtheria toxoid is reported...
  61. ncbi request reprint MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosis
    C W Tjoa
    Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    J Neurol Sci 234:17-24. 2005
    ..Ambulatory dysfunction limits quality of life; however correlation with conventional MRI remains poor...
  62. ncbi request reprint Interhemispheric asymmetry of brain diffusivity in normal individuals: a diffusion-weighted MR imaging study
    Andrew J Fabiano
    Department of Neurosurgery, State University of New York, Buffalo, NY, USA
    AJNR Am J Neuroradiol 26:1089-94. 2005
    ..The purpose of this study was to assess whether water diffusivity in deep gray matter structures shown by diffusion-weighted (DW) imaging differs between the right and left cerebral hemispheres in normal individuals...
  63. ncbi request reprint Role of fluid-attenuated inversion recovery in the diagnosis of meningitis: comparison with contrast-enhanced magnetic resonance imaging
    Saadat Kamran
    The Lucy Dent Imaging Research Center, Millard Filmore Hospital, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA
    J Comput Assist Tomogr 28:68-72. 2004
    ..We describe hyperintense sulci (HS) on FLAIR sequence in meningitis in relation to cerebrospinal fluid (CSF) protein and effective echo time (TE)...
  64. ncbi request reprint Advances in neuroimaging technology: state of the art
    Rohit Bakshi
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Rev Neurol Dis 4:97-9. 2007
    ..Highlights from the 30th Annual Meeting of the American Society of Neuroimaging, January 17-21, 2007, Miami, FL...
  65. ncbi request reprint Role of MRI in multiple sclerosis II: brain and spinal cord atrophy
    Robert Zivadinov
    Buffalo Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Front Biosci 9:647-64. 2004
    ..This should in turn lead to better long term neurologic functioning and a better quality of life for patients with MS...
  66. ncbi request reprint Acute disseminated encephalomyelitis in children
    S N Krishna Murthy
    Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA
    Pediatrics 110:e21. 2002
    ..To describe the epidemiologic, clinical, neuroimaging, and laboratory features; treatment; and outcome in a cohort of children with acute disseminated encephalomyelitis (ADEM)...
  67. ncbi request reprint Diffuse dural gadolinium MRI enhancement associated with bilateral chronic subdural hematomas
    Svetlana Blitshteyn
    Department of Neurology, Mayo Clinic Jacksonville, Mayo College of Medicine, Jacksonville, FL, USA
    Clin Imaging 28:90-2. 2004
    ..CSDH should be considered in the differential diagnosis of diffuse dural enhancement, especially when supported by appropriate clinical findings...
  68. ncbi request reprint Combination therapy for multiple sclerosis: the treatment strategy of the future?
    Bianca Weinstock-Guttman
    Baird MS Research Center of The Jacobs Neurological Institute, Buffalo, New York 14203, USA
    CNS Drugs 18:777-92. 2004
    ..Ultimately, the optimal therapies will likely include strategies that promote repair and limit tissue destruction in combination with anti-inflammatory interventions...
  69. ncbi request reprint Syncope and head CT scans in the emergency department
    Pierre Giglio
    Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
    Emerg Radiol 12:44-6. 2005
    ..Patients presenting with syncope to the emergency department (ED) of a community hospital were evaluated...
  70. ncbi request reprint Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosis
    S D Brass
    Department of Neurology, Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mult Scler 12:437-44. 2006
    ..These data implicate a role for basal ganglia iron deposition in neuropsychological dysfunction...
  71. ncbi request reprint Thalamic atrophy and cognition in multiple sclerosis
    M K Houtchens
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
    Neurology 69:1213-23. 2007
    ..In this study, we tested the hypothesis that thalamic volume is lower in MS than in normal subjects, and that thalamic atrophy in MS correlates with cognitive function...
  72. ncbi request reprint Role of fluorodeoxyglucose positron emission tomography in the diagnosis of neurosarcoidosis
    Neeraj Dubey
    Dent Neurologic Institute, Buffalo, NY, USA
    J Neurol Sci 205:77-81. 2002
    ..In patients with perplexing neurologic presentations, whole body FDG-PET can help secure a timely and minimally invasive diagnosis of neurosarcoidosis...
  73. ncbi request reprint Early computed tomography hypodensity predicts hemorrhage after intravenous tissue plasminogen activator in acute ischemic stroke
    N Dubey
    Department of Neurology, University of Texas at Houston, Texas, USA
    J Neuroimaging 11:184-8. 2001
    ..The authors conclude that basal ganglia hypodensity quantified by CT may be a useful method of risk stratification to select acute MCA stroke patients for thrombolytic therapy...
  74. pmc Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI study
    J M Stankiewicz
    Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Brookline, MA 02445, USA
    J Neurol Sci 279:99-105. 2009
    ..Assess the relationship between spinal cord T2 hyperintense lesions and clinical status in multiple sclerosis (MS) with 1.5 and 3 T MRI...
  75. ncbi request reprint Magnetic resonance imaging of iron deposition in neurological disorders
    Steven D Brass
    Center for Neurological Imaging, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Top Magn Reson Imaging 17:31-40. 2006
    ..The potential role of iron deposition and its assessment by MRI provides exciting potential applications to the diagnosis, longitudinal monitoring, and therapeutic development for disorders of the brain...
  76. ncbi request reprint Gray matter involvement in multiple sclerosis
    Istvan Pirko
    Department of Neurology, University of Cincinnati, OH, USA
    Neurology 68:634-42. 2007
    ..However, continued studies of GM pathology as well as neuronal and axonal involvement in MS and related experimental models are necessary to better understand the etiology and pathogenesis of the degenerative components...
  77. ncbi request reprint Neuroimaging of stroke: a review
    Andrew R Xavier
    Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
    South Med J 96:367-79. 2003
    ..We outline the specific role of each modality in clinical practice...
  78. ncbi request reprint Role of MRI in multiple sclerosis I: inflammation and lesions
    Robert Zivadinov
    Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
    Front Biosci 9:665-83. 2004
    ..In particular, the use of these techniques is promising in elucidating mechanisms underlying the accumulation of tissue damage, repair and functional reorganization of neural pathways in patients with MS...
  79. ncbi request reprint Acute demyelinating optic neuritis: a review
    Steven David Brass
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Boston, MA, USA
    Front Biosci 13:2376-90. 2008
    ....
  80. ncbi request reprint Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis Consortium
    B Weinstock-Guttman
    William C Baird Multiple Sclerosis Research Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA
    Mult Scler 9:293-8. 2003
    ..Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility...
  81. pmc Sample size requirements for treatment effects using gray matter, white matter and whole brain volume in relapsing-remitting multiple sclerosis
    B Healy
    Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Boston, Massachusetts, USA
    J Neurol Neurosurg Psychiatry 80:1218-23. 2009
    ....
  82. pmc Normal findings on brain fluid-attenuated inversion recovery MR images at 3T
    M Neema
    Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners Multiple Sclerosis Center, Harvard Medical School, Boston, MA, USA
    AJNR Am J Neuroradiol 30:911-6. 2009
    ..The purpose of this study was to evaluate the frequency and topography of cerebral hyperintensities seen with FLAIR MR imaging of the brain at 3T in a normal population and compare those findings to 1.5T...
  83. ncbi request reprint Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosis
    R H B Benedict
    Department of Neurology, State University of New York SUNY, Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York 14203, USA
    Mult Scler 9:393-6. 2003
    ..The BDI-FS may be useful in this regard although, to date, its validity in MS patients has not been assessed...
  84. ncbi request reprint A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon beta
    D R Smith
    Department of Neurology, Brigham and Women s Hospital, Boston, MA, USA
    Mult Scler 11:573-82. 2005
    ..To evaluate the efficacy and safety of combination therapy with pulse cyclophosphamide given with methylprednisolone (MP) and interferon beta (IFNbeta)-Ia in multiple sclerosis (MS) patients with active disease during IFNbeta monotherapy...
  85. pmc Imaging of multiple sclerosis: role in neurotherapeutics
    Rohit Bakshi
    Department of Neurology and Radiology, Partners MS Center, Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    NeuroRx 2:277-303. 2005
    ..However, these advanced methods are limited by their cost, availability, complexity, and lack of validation. In this article, we review the role of conventional and advanced imaging techniques with an emphasis on neurotherapeutics...
  86. ncbi request reprint Magnetic resonance imaging advances in multiple sclerosis
    Rohit Bakshi
    Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 15:5S-9S. 2005
    ....
  87. ncbi request reprint Short-term brain atrophy changes in relapsing-remitting multiple sclerosis
    Robert Zivadinov
    Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
    J Neurol Sci 223:185-93. 2004
    ....
  88. ncbi request reprint Multiple sclerosis medical image analysis and information management
    Lifeng Liu
    Center for Neurological Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuroimaging 15:103S-117S. 2005
    ..The authors' system can be extended to general applications in clinical trials and to routine processing for image-based clinical research...
  89. pmc Neuroimaging: anything to do with neurotherapeutics?
    Jose C Masdeu
    NeuroRx 2:163-6. 2005
  90. ncbi request reprint IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating event
    R Philip Kinkel
    Neurology 66:678-84. 2006
    ..This report highlights the primary results of a 5-year, open-label extension of CHAMPS (the Controlled High Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurologic Surveillance [CHAMPIONS Study])...
  91. ncbi request reprint Special populations: the management of seizures in HIV-positive patients
    Paul Mullin
    Columbia University Comprehensive Epilepsy Center, New York Neurological Institute, 710 West 168th Street, New York, NY 10032, USA
    Curr Neurol Neurosci Rep 4:308-14. 2004
    ..Lastly, optimal choice of an AED should reflect commonly encountered neurologic and psychiatric comorbidities...
  92. ncbi request reprint Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosis
    Mark A Horsfield
    Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
    IEEE Trans Med Imaging 26:1670-80. 2007
    ..The operator interaction time required to evaluate one subject was reduced from an average of 111 min with contouring to 16 min with the FC method...
  93. doi request reprint Cerebral venous thrombosis: analysis of a multicenter cohort from the United States
    Mohammad Wasay
    Aga Khan University, Karachi, Pakistan
    J Stroke Cerebrovasc Dis 17:49-54. 2008
    ..The data regarding diagnosis, prognosis, management, and outcome of patients with cerebral venous thrombosis are limited from the United States...
  94. pmc MRI in multiple sclerosis: current status and future prospects
    Rohit Bakshi
    Center for Neurological Imaging, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Lancet Neurol 7:615-25. 2008
    ..Advances in MRI should improve our ability to diagnose, monitor, and understand the pathophysiology of MS...
  95. ncbi request reprint Brain CT and MRI findings in 100 consecutive patients with intracranial tuberculoma
    Mohammad Wasay
    Department of Neurology, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    J Neuroimaging 13:240-7. 2003
    ..The authors reviewed the features of tuberculoma on CT scans and MRI. The authors also correlated the MRI characteristics on various pulse sequences with neuropathological findings...