Research Topics
| Rohit BakshiSummaryAffiliation: University at Buffalo Country: USA Publications
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Detail Information
Publications
Neuroimaging curriculum for neurology trainees: report from the Neuroimaging Section of the AANRohit Bakshi
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
J Neuroimaging 13:215-7. 2003....- Fatigue associated with multiple sclerosis: diagnosis, impact and managementRohit Bakshi
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
Mult Scler 9:219-27. 2003.... - Bicaudate ratio as a magnetic resonance imaging marker of brain atrophy in multiple sclerosisRobert A Bermel
Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High St, Buffalo, NY 14203, USA
Arch Neurol 59:275-80. 2002..Brain atrophy has emerged as a useful surrogate marker of disease involvement in multiple sclerosis (MS). The relationship between whole-brain or regional atrophy and cognitive dysfunction is poorly understood... - T2 hypointensity in the deep gray matter of patients with multiple sclerosis: a quantitative magnetic resonance imaging studyRohit Bakshi
Department of Neurology, University at Buffalo, State University of New York, USA
Arch Neurol 59:62-8. 2002..While gray matter T2 hypointensity in multiple sclerosis (MS) has been associated with physical disability and clinical course, previous studies have relied on visual magnetic resonance imaging (MRI) assessments... - Fluid-attenuated inversion recovery magnetic resonance imaging detects cortical and juxtacortical multiple sclerosis lesionsR Bakshi
Neuroscience Center, E 2, Buffalo General Hospital, 100 High St, Buffalo, NY 14203
Arch Neurol 58:742-8. 2001..Fluid-attenuated inversion recovery (FLAIR) is an advanced magnetic resonance imaging sequence that reveals tissue T2 prolongation with cerebrospinal fluid suppression, allowing detection of superficial brain lesions... - Neuroimaging of HIV and AIDS related illnesses: a reviewRohit Bakshi
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
Front Biosci 9:632-46. 2004..In addition, through a wide breadth of imaging techniques, the pathology, neurochemistry and metabolism of lesions can be studied to clarify the differential diagnosis, such as discriminating infection vs. neoplasia... - Regional brain atrophy is associated with physical disability in multiple sclerosis: semiquantitative magnetic resonance imaging and relationship to clinical findingsR Bakshi
Imaging Services, Kaleida Health, State University of New York at Buffalo, USA
J Neuroimaging 11:129-36. 2001..The authors conclude that brain atrophy is closely associated with physical disability and clinical course in MS patients and can be appreciated using a semiquantitative MRI regional rating system... - Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patientsR Bakshi
Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
J Neurol Sci 185:19-26. 2001..Further study is warranted to determine if T2 hypointensity is predictive of disease course in MS and is a useful surrogate outcome measure in therapeutic trials... - Fatigue in multiple sclerosis: cross-sectional correlation with brain MRI findings in 71 patientsR Bakshi
Dent Neurologic Institute, Kaleida Health Millard Fillmore Hospital, Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, USA
Neurology 53:1151-3. 1999..We suggest that brain MRI disease topography or severity does not explain fatigue in MS and that fatigue is likely due to mechanisms poorly characterized by conventional MRI... - MRI in cerebral intraventricular hemorrhage: analysis of 50 consecutive casesR Bakshi
Dent Neurologic Institute, Lucy Dent Imaging Center, Kaleida Health, State University of NY at Buffalo, 14203, USA
Neuroradiology 41:401-9. 1999..Further study is necessary to determine if MRI characteristics of IVH are helpful in excluding other intraventricular diseases such as neoplasia and pyocephalus... - MRI findings in lumbar puncture headache syndrome: abnormal dural-meningeal and dural venous sinus enhancementR Bakshi
University at Buffalo SUNY School of Medicine and Biomedical Sciences, USA
Clin Imaging 23:73-6. 1999..MRI also showed abnormal dural venous sinus enhancement, a new finding in LPHA, suggesting compensatory venous expansion. Thus, IH and venodilatation may play a role in the development of LPHA... - The cerebral intravascular enhancement sign is not specific: a contrast-enhanced MRI studyR Bakshi
Millard Fillmore Health System, Department of Neurology, University at Buffalo, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, NY 14209, USA
Neuroradiology 41:80-5. 1999.... 
Prediction of longitudinal brain atrophy in multiple sclerosis by gray matter magnetic resonance imaging T2 hypointensityRobert A Bermel
Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, USA
Arch Neurol 62:1371-6. 2005..We hypothesize that interferon beta may exert its effect on brain atrophy in part by reducing a cascade of events that involve iron deposition as a mediator of neurotoxicity or as a disease epiphenomenon...- Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scaleRohit Bakshi
Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
Arch Neurol 65:1449-53. 2008..Individual magnetic resonance imaging (MRI) disease severity measures, such as atrophy or lesions, show weak relationships to clinical status in patients with multiple sclerosis (MS)... - Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior changeRalph H B Benedict
Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
J Neurol Sci 231:29-34. 2005..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment... 
Rate of brain atrophy in benign vs early multiple sclerosisSusan A Gauthier
Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arch Neurol 66:234-7. 2009..Benign multiple sclerosis (MS) is defined by minimal or no disability after many years of observation, therefore a less degenerative disease process is suspected to be present in this subset of patients...- Approaches to normalization of spinal cord volume: application to multiple sclerosisBrian C Healy
Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Massachusetts, USA
J Neuroimaging 22:e12-9. 2012..To determine the proper method for the normalization of spinal cord volume... - Regional lobar atrophy predicts memory impairment in multiple sclerosisRalph H B Benedict
Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
AJNR Am J Neuroradiol 26:1824-31. 2005..42-0.64). CONCLUSION: Regional atrophy accounts for more variance than lesion burden, whole brain atrophy, or lateral ventricle volume in predicting multiple sclerosis-associated memory dysfunction... - Prediction of neuropsychological impairment in multiple sclerosis: comparison of conventional magnetic resonance imaging measures of atrophy and lesion burdenRalph H B Benedict
Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo General Hospital, NY 14203, USA
Arch Neurol 61:226-30. 2004..Furthermore, few studies accounted for the influence of age, premorbid intelligence, or depression... - The association between cognitive impairment and quality of life in patients with early multiple sclerosisBonnie I Glanz
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Neurol Sci 290:75-9. 2010..Our results suggest that cognitive remediation programs aimed at improving cognitive skills may also improve quality of life for patients with early MS... - A semiautomated measure of whole-brain atrophy in multiple sclerosisRobert A Bermel
University at Buffalo, State University of New York, USA
J Neurol Sci 208:57-65. 2003..We conclude that whole-brain atrophy in MS can be reliably and readily quantified by a semiautomated approach. Longitudinal studies are warranted to determine if this method provides a sensitive biologic marker of the MS disease process... - Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosisJames M Stankiewicz
Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Brookline, Massachusetts 02445, USA
J Neuroimaging 21:e50-6. 2011..To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI)... - Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: a longitudinal studyJennifer Moodie
Department of Neurology, University of Massachusetts, Boston, MA, USA
J Neurol Sci 315:49-54. 2012..We previously described a composite MRI scale combining T1-lesions, T2-lesions and whole brain atrophy in multiple sclerosis (MS): the magnetic resonance disease severity scale (MRDSS)... - Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosisAyda Tekok Kilic
Department of Neurology, University at Buffalo, State University of New York, USA
Neuroimage 36:1294-300. 2007..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy... - Accounting for disease modifying therapy in models of clinical progression in multiple sclerosisBrian C Healy
Department of Neurology, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Brookline, MA 02115, USA
J Neurol Sci 303:109-13. 2011..DMT modeling choice had a modest impact on the variables classified as predictors of EDSS score change. Importantly, however, interpretation of these predictors is dependent upon modeling choice... - Gray and white matter brain atrophy and neuropsychological impairment in multiple sclerosisMichael P Sanfilipo
Department of Neurology, SUNY-University, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
Neurology 66:685-92. 2006..CONCLUSION: Both gray and white brain matter atrophy contribute to neuropsychological deficits in multiple sclerosis... - Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosisMohit Neema
Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neuroimaging 19:3-8. 2009..Conventional brain MRI lesion measures have unreliable associations with clinical progression in multiple sclerosis (MS). Gray matter imaging may improve clinical-MRI correlations... - The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correctionMichael P Sanfilipo
Department of Neurology, SUNY-University at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
Neuroimage 26:1068-77. 2005..These findings suggest that gray matter loss is related to other aspects of brain pathology and has more clinical relevance than white matter atrophy in MS... - Multiple sclerosis: hyperintense lesions in the brain on nonenhanced T1-weighted MR images evidenced as areas of T1 shorteningVallabh Janardhan
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
Radiology 244:823-31. 2007.... - Genomic effects of once-weekly, intramuscular interferon-beta1a treatment after the first dose and on chronic dosing: Relationships to 5-year clinical outcomes in multiple sclerosis patientsBianca Weinstock-Guttman
Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
J Neuroimmunol 205:113-25. 2008.... - Selective caudate atrophy in multiple sclerosis: a 3D MRI parcellation studyRobert A Bermel
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, 100 High St, Buffalo, NY 14203, USA
Neuroreport 14:335-9. 2003..05). We conclude that selective caudate atrophy is associated with MS and may occur through direct mechanisms... - Functional imaging during covert auditory attention in multiple sclerosisMichael P Santa Maria
Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D-6 Buffalo, 100 High Street, 14203, USA
J Neurol Sci 218:9-15. 2004..This study demonstrates cingulate hypoactivity and cerebral reorganization during auditory attention in MS... - Magnetic resonance imaging in multiple sclerosisSalvatore Q Napoli
Partners, Multiple Sclerosis Center, and Center for Neurological Imaging, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Rev Neurol Dis 2:109-16. 2005..In this review, we will focus on the role of MRI in the diagnosis and management of MS. We will also review how advanced MRI techniques contribute to our understanding of MS... - Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual methodMichael P Sanfilipo
Department of Neurology, SUNY-University at Buffalo School of Medicine and Biomedical Sciences, NY 14203, USA
Neuroimage 22:1732-43. 2004..Our findings suggest that head size correction of brain regions with the residual method generally may provide advantages over the proportion method... - Whole-brain atrophy in multiple sclerosis measured by automated versus semiautomated MR imaging segmentationJitendra Sharma
Buffalo Neuroimaging Analysis Center, University at Buffalo, State University of New York, Buffalo, NY, USA
AJNR Am J Neuroradiol 25:985-96. 2004..They discriminated MS from healthy individuals and showed similar relationships to established disease variables... - A magnetization transfer MRI study of deep gray matter involvement in multiple sclerosisJitendra Sharma
Center for Neurological Imaging, Partners MS Center, Department of Neurology, Brigham/Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neuroimaging 16:302-10. 2006..It remains to be determined if other MRI techniques are more sensitive than MTI for detecting pathology in these areas... - 3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosisMohit Neema
Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, MA 02445, USA
Neuroimage 46:633-41. 2009..Such findings may represent demyelination, inflammation, glial proliferation and axonal loss... - Construct validity and frequency of euphoria sclerotica in multiple sclerosisInna Fishman
State University of New York (SUNY) Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York, USA
J Neuropsychiatry Clin Neurosci 16:350-6. 2004..Thus, we used the NPI to validate the euphoria syndrome in multiple sclerosis (MS) and determined its frequency, and its neurological and psychological correlates... - MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosisMilena Stosic
Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14203, USA
J Neurol 257:63-71. 2010..MRI reveals more profound injury in patients with MS versus PAPLS. APLA mediates heterogeneous cerebral pathology that remains to be further investigated... - Measurement of brain and spinal cord atrophy by magnetic resonance imaging as a tool to monitor multiple sclerosisRohit Bakshi
Center for Neurological Imaging, Partners Multiple Sclerosis Center, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Neuroimaging 15:30S-45S. 2005..Future research to clarify the etiology and pathophysiology of brain and spinal cord atrophy should provide new targets for therapeutic development... - Iron in chronic brain disorders: imaging and neurotherapeutic implicationsJames Stankiewicz
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Neurotherapeutics 4:371-86. 2007..We conclude with a discussion of the potential implications of iron-related toxicity to neurotherapeutic development... - MRI in multiple sclerosis: what's inside the toolbox?Mohit Neema
Department of Neurology, Center for Neurological Imaging, Partners MS Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Neurotherapeutics 4:602-17. 2007..We review the most recent data regarding the role of conventional and advanced MRI techniques in the assessment of MS. We focus on the most relevant pathologic and clinical correlation studies relevant to these measures... - New error type and recall consistency indices for the Brief Visuospatial Memory Test - Revised: performance in healthy adults and multiple sclerosis patientsJeffrey J Gaines
Department of Neurology, State University of New York at Buffalo School of Medicine, NY, USA
Clin Neuropsychol 22:851-63. 2008..Findings suggest these error types and inconsistent learning contribute to poorer recall of visual material in MS... - Neuroimaging of toxic and metabolic disordersAshish Arora
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Semin Neurol 28:495-510. 2008..We hope this article will prove useful to trainees and practitioners in the clinical and imaging fields of the neurosciences... - Central nervous system atrophy and clinical status in multiple sclerosisRobert Zivadinov
Department of Neurology, University at Buffalo, SUNY School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
J Neuroimaging 14:27S-35S. 2004..The authors conclude that measurement of atrophy of the CNS is emerging as a clinically relevant biomarker of the MS disease process... - Thalamic involvement in multiple sclerosis: a diffusion-weighted magnetic resonance imaging studyAndrew J Fabiano
Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
J Neuroimaging 13:307-14. 2003..Both indirect and direct mechanisms of gray matter injury may play a role in the pathophysiology of MS... - Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosisRalph H B Benedict
State University of New York Buffalo School of Medicine, Jacobs Neurological Institute, Department of Neurology, Buffalo General Hospital, New York 14203, USA
J Neuroimaging 14:36S-45S. 2004..Continuing research focuses on the possible relationship between measures of regional brain atrophy and cognitive and emotional impairment... - MRI in multiple sclerosis: a review of the current literatureAntonia Ceccarelli
Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners MS Center, Harvard Medical School, Boston, Massachusetts, USA
Curr Opin Neurol 25:402-9. 2012..This review summarizes the recent data pertaining to the use of magnetic resonance imaging (MRI) in assessing brain and spinal cord involvement in multiple sclerosis (MS)... - Smoking and disease progression in multiple sclerosisBrian C Healy
Department of Neurology, Partners MS Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Arch Neurol 66:858-64. 2009..Although cigarette smokers are at increased risk of developing multiple sclerosis (MS), the effect of smoking on the progression of MS remains uncertain... - T1- and T2-based MRI measures of diffuse gray matter and white matter damage in patients with multiple sclerosisMohit Neema
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Neuroimaging 17:16S-21S. 2007..For example, T2 mapping may allow an assessment of myelin content in NAWM. In this review, we will focus on MRI advances in the last 10 years pertaining to T1 and T2 measures of diffuse GM and WM damage... - Acute hemorrhagic leukoencephalitis vs ADEM: FLAIR MRI and neuropathology findingsSharmeela Kuperan
Department of Medicine, University at Buffalo, State University of New York, USA
Neurology 60:721-2. 2003 - Unbiased treatment effect estimates by modeling the disease process of multiple sclerosisBrian C Healy
Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Boston, MA 02115, USA
J Neurol Sci 278:54-9. 2009..The implications of these results are discussed in terms of efficacy and safety... - Frontal cortex atrophy predicts cognitive impairment in multiple sclerosisRalph H B Benedict
Department of Neurology, State University of New York at Buffalo School of Medicine, Buffalo, USA
J Neuropsychiatry Clin Neurosci 14:44-51. 2002..The authors conclude that cerebral atrophy predicts NP impairment while accounting for the influence of TLA or 3VW. Regions of cortex most susceptible to atrophic and cognitive changes in MS are the right and left superior frontal lobes... - Study of mitoxantrone for the treatment of recurrent neuromyelitis optica (Devic disease)Bianca Weinstock-Guttman
The William C Baird Multiple Sclerosis Center, Jacobs Neurological Institute, State University of New York, Buffalo, NY 14203, USA
Arch Neurol 63:957-63. 2006..Mitoxantrone hydrochloride, a synthetic anthracenedione approved for worsening relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis, has been shown to primarily suppress the humoral response... - The measurement and clinical relevance of brain atrophy in multiple sclerosisRobert A Bermel
Department of Neurology, Cleveland Clinic Foundation, Cleveland, OH, USA
Lancet Neurol 5:158-70. 2006..Based on a review of current information, we will summarise the rate of atrophy among phenotypes for multiple sclerosis, the clinical relevance of brain atrophy, and the effect of disease-modifying treatments on its progression... - Quality of life in patients with multiple sclerosis: the impact of fatigue and depressionVallabh Janardhan
Department of Neurology, Boston University Medical Center, Boston, MA, USA
J Neurol Sci 205:51-8. 2002..03). This study demonstrates that fatigue and depression are independently associated with impaired QOL in MS, after accounting for physical disability, suggesting that their recognition and treatment can potentially improve QOL... - The use of magnetic resonance imaging in the diagnosis and long-term management of multiple sclerosisRohit Bakshi
Department of Neurology, Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, RF396, Boston, MA 02115, USA
Neurology 63:S3-11. 2004..The use of conventional MRI in the diagnosis and longitudinal management of patients with MS is the focus of this review... - Lymphomatosis cerebri presenting as a rapidly progressive dementia: clinical, neuroimaging and pathologic findingsR Bakshi
Department of Neurology, UCLA School of Medicine and UCLA Medical Center, Reed Neurological Research Center, Los Angeles, CA, USA
Dement Geriatr Cogn Disord 10:152-7. 1999..We refer to this entity as 'lymphomatosis cerebri' and add it to the differential diagnosis of a rapidly progressive dementia... - Cerebral ventricular empyema associated with severe adult pyogenic meningitis: computed tomography findingsR Bakshi
Millard Fillmore Health System, Dent Neurologic Institute, Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, USA
Clin Neurol Neurosurg 99:252-5. 1997..Frank neutrophilic pus was taken from the subarachnoid space. After antibiotic treatment, the pyocephalus resolved. CVE may be visualized on CT with pus layering in the ventricular CSF, creating a fluid level of intermediate hypodensity... - Guillain-Barré syndrome after combined tetanus-diphtheria toxoid vaccinationR Bakshi
Department of Neurology, UCLA School of Medicine 90024, USA
J Neurol Sci 147:201-2. 1997..The first case of GBS following a vaccination with combined tetanus-diphtheria toxoid is reported... - MRI T2 hypointensity of the dentate nucleus is related to ambulatory impairment in multiple sclerosisC W Tjoa
Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
J Neurol Sci 234:17-24. 2005..This study adds more weight to the notion that T2 hypointensity is a clinically relevant marker of tissue damage in MS... - Interhemispheric asymmetry of brain diffusivity in normal individuals: a diffusion-weighted MR imaging studyAndrew J Fabiano
Department of Neurosurgery, State University of New York, Buffalo, NY, USA
AJNR Am J Neuroradiol 26:1089-94. 2005..Analysis of deep gray matter lesions requires caution, as statistically significant interhemispheric differences may not always be indicative of disease... - Role of fluid-attenuated inversion recovery in the diagnosis of meningitis: comparison with contrast-enhanced magnetic resonance imagingSaadat Kamran
The Lucy Dent Imaging Research Center, Millard Filmore Hospital, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, USA
J Comput Assist Tomogr 28:68-72. 2004..We describe hyperintense sulci (HS) on FLAIR sequence in meningitis in relation to cerebrospinal fluid (CSF) protein and effective echo time (TE)... - Advances in neuroimaging technology: state of the artRohit Bakshi
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Rev Neurol Dis 4:97-9. 2007..Highlights from the 30th Annual Meeting of the American Society of Neuroimaging, January 17-21, 2007, Miami, FL... - Role of MRI in multiple sclerosis II: brain and spinal cord atrophyRobert Zivadinov
Buffalo Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
Front Biosci 9:647-64. 2004..This should in turn lead to better long term neurologic functioning and a better quality of life for patients with MS... - Acute disseminated encephalomyelitis in childrenS N Krishna Murthy
Department of Neurology, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York, USA
Pediatrics 110:e21. 2002..Prognosis for survival and outcome was excellent. Recurrent episodes of ADEM must be differentiated from multiple sclerosis... - Diffuse dural gadolinium MRI enhancement associated with bilateral chronic subdural hematomasSvetlana Blitshteyn
Department of Neurology, Mayo Clinic Jacksonville, Mayo College of Medicine, Jacksonville, FL, USA
Clin Imaging 28:90-2. 2004..CSDH should be considered in the differential diagnosis of diffuse dural enhancement, especially when supported by appropriate clinical findings... - Combination therapy for multiple sclerosis: the treatment strategy of the future?Bianca Weinstock-Guttman
Baird MS Research Center of The Jacobs Neurological Institute, Buffalo, New York 14203, USA
CNS Drugs 18:777-92. 2004..Ultimately, the optimal therapies will likely include strategies that promote repair and limit tissue destruction in combination with anti-inflammatory interventions... - Syncope and head CT scans in the emergency departmentPierre Giglio
Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
Emerg Radiol 12:44-6. 2005..Abnormal findings pertinent to the syncope were observed in only 1 patient. A prospective study examining yield in a larger series of patients may help define the utility of this neuroimaging modality in syncope... - Cognitive impairment is associated with subcortical magnetic resonance imaging grey matter T2 hypointensity in multiple sclerosisS D Brass
Department of Neurology, Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Mult Scler 12:437-44. 2006..These data implicate a role for basal ganglia iron deposition in neuropsychological dysfunction... - Thalamic atrophy and cognition in multiple sclerosisM K Houtchens
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
Neurology 69:1213-23. 2007..In this study, we tested the hypothesis that thalamic volume is lower in MS than in normal subjects, and that thalamic atrophy in MS correlates with cognitive function... - Role of fluorodeoxyglucose positron emission tomography in the diagnosis of neurosarcoidosisNeeraj Dubey
Dent Neurologic Institute, Buffalo, NY, USA
J Neurol Sci 205:77-81. 2002..In patients with perplexing neurologic presentations, whole body FDG-PET can help secure a timely and minimally invasive diagnosis of neurosarcoidosis... - Early computed tomography hypodensity predicts hemorrhage after intravenous tissue plasminogen activator in acute ischemic strokeN Dubey
Department of Neurology, University of Texas at Houston, Texas, USA
J Neuroimaging 11:184-8. 2001..The authors conclude that basal ganglia hypodensity quantified by CT may be a useful method of risk stratification to select acute MCA stroke patients for thrombolytic therapy... - Spinal cord lesions and clinical status in multiple sclerosis: A 1.5 T and 3 T MRI studyJ M Stankiewicz
Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Brookline, MA 02445, USA
J Neurol Sci 279:99-105. 2009..Assess the relationship between spinal cord T2 hyperintense lesions and clinical status in multiple sclerosis (MS) with 1.5 and 3 T MRI... - Magnetic resonance imaging of iron deposition in neurological disordersSteven D Brass
Center for Neurological Imaging, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Top Magn Reson Imaging 17:31-40. 2006..The potential role of iron deposition and its assessment by MRI provides exciting potential applications to the diagnosis, longitudinal monitoring, and therapeutic development for disorders of the brain... - Gray matter involvement in multiple sclerosisIstvan Pirko
Department of Neurology, University of Cincinnati, OH, USA
Neurology 68:634-42. 2007..However, continued studies of GM pathology as well as neuronal and axonal involvement in MS and related experimental models are necessary to better understand the etiology and pathogenesis of the degenerative components... - Neuroimaging of stroke: a reviewAndrew R Xavier
Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
South Med J 96:367-79. 2003..We outline the specific role of each modality in clinical practice... - Role of MRI in multiple sclerosis I: inflammation and lesionsRobert Zivadinov
Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
Front Biosci 9:665-83. 2004..In particular, the use of these techniques is promising in elucidating mechanisms underlying the accumulation of tissue damage, repair and functional reorganization of neural pathways in patients with MS... - Acute demyelinating optic neuritis: a reviewSteven David Brass
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Boston, MA, USA
Front Biosci 13:2376-90. 2008.... - Multiple sclerosis characteristics in African American patients in the New York State Multiple Sclerosis ConsortiumB Weinstock-Guttman
William C Baird Multiple Sclerosis Research Center, The Jacobs Neurological Institute, Buffalo, NY 14203, USA
Mult Scler 9:293-8. 2003..Our findings suggest a racial influence in MS. Further genetic studies that consider race differences are warranted to elucidate mechanisms of disease susceptibility... - Sample size requirements for treatment effects using gray matter, white matter and whole brain volume in relapsing-remitting multiple sclerosisB Healy
Department of Neurology, Brigham and Women s Hospital, Partners MS Center, Harvard Medical School, Boston, Massachusetts, USA
J Neurol Neurosurg Psychiatry 80:1218-23. 2009.... - Normal findings on brain fluid-attenuated inversion recovery MR images at 3TM Neema
Department of Neurology, Brigham and Women s Hospital, Laboratory for Neuroimaging Research, Partners Multiple Sclerosis Center, Harvard Medical School, Boston, MA, USA
AJNR Am J Neuroradiol 30:911-6. 2009..The purpose of this study was to evaluate the frequency and topography of cerebral hyperintensities seen with FLAIR MR imaging of the brain at 3T in a normal population and compare those findings to 1.5T... - Validity of the Beck Depression Inventory-Fast Screen in multiple sclerosisR H B Benedict
Department of Neurology, State University of New York SUNY, Buffalo School of Medicine and Biomedical Sciences, Buffalo General Hospital, Buffalo, New York 14203, USA
Mult Scler 9:393-6. 2003..The BDI-FS may be useful in this regard although, to date, its validity in MS patients has not been assessed... - A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon betaD R Smith
Department of Neurology, Brigham and Women's Hospital, Boston, MA, USA
Mult Scler 11:573-82. 2005..75; P =0.011). CY/MP treatment was well tolerated. CONCLUSION: Combination therapy with CY/MP and IFNbeta-Ia decreased the number of Gd+ lesions and slowed clinical activity in patients with previously active disease on IFNbeta alone... - Imaging of multiple sclerosis: role in neurotherapeuticsRohit Bakshi
Department of Neurology and Radiology, Partners MS Center, Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
NeuroRx 2:277-303. 2005..However, these advanced methods are limited by their cost, availability, complexity, and lack of validation. In this article, we review the role of conventional and advanced imaging techniques with an emphasis on neurotherapeutics... - Magnetic resonance imaging advances in multiple sclerosisRohit Bakshi
Center for Neurological Imaging, Partners Multiple Sclerosis Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neuroimaging 15:5S-9S. 2005.... - Short-term brain atrophy changes in relapsing-remitting multiple sclerosisRobert Zivadinov
Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy
J Neurol Sci 223:185-93. 2004.... - Multiple sclerosis medical image analysis and information managementLifeng Liu
Center for Neurological Imaging, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neuroimaging 15:103S-117S. 2005..The authors' system can be extended to general applications in clinical trials and to routine processing for image-based clinical research... - Neuroimaging: anything to do with neurotherapeutics?Jose C Masdeu
NeuroRx 2:163-6. 2005 - IM interferon beta-1a delays definite multiple sclerosis 5 years after a first demyelinating eventR Philip Kinkel
Neurology 66:678-84. 2006..CONCLUSIONS: These results support the use of IM interferon beta-1a after a first clinical demyelinating event and indicate that there may be modest beneficial effects of immediate treatment compared with delayed initiation of treatment... - Special populations: the management of seizures in HIV-positive patientsPaul Mullin
Columbia University Comprehensive Epilepsy Center, New York Neurological Institute, 710 West 168th Street, New York, NY 10032, USA
Curr Neurol Neurosci Rep 4:308-14. 2004..Lastly, optimal choice of an AED should reflect commonly encountered neurologic and psychiatric comorbidities... - Incorporating domain knowledge into the fuzzy connectedness framework: application to brain lesion volume estimation in multiple sclerosisMark A Horsfield
Department of Cardiovascular Sciences, University of Leicester, Leicester LE1 5WW, UK
IEEE Trans Med Imaging 26:1670-80. 2007..The operator interaction time required to evaluate one subject was reduced from an average of 111 min with contouring to 16 min with the FC method... - Cerebral venous thrombosis: analysis of a multicenter cohort from the United StatesMohammad Wasay
Aga Khan University, Karachi, Pakistan
J Stroke Cerebrovasc Dis 17:49-54. 2008..The data regarding diagnosis, prognosis, management, and outcome of patients with cerebral venous thrombosis are limited from the United States... - MRI in multiple sclerosis: current status and future prospectsRohit Bakshi
Center for Neurological Imaging, Partners Multiple Sclerosis Center, Departments of Neurology and Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Lancet Neurol 7:615-25. 2008..Advances in MRI should improve our ability to diagnose, monitor, and understand the pathophysiology of MS... - Brain CT and MRI findings in 100 consecutive patients with intracranial tuberculomaMohammad Wasay
Department of Neurology, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
J Neuroimaging 13:240-7. 2003..The authors reviewed the features of tuberculoma on CT scans and MRI. The authors also correlated the MRI characteristics on various pulse sequences with neuropathological findings...