Michael E Baker

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint What are the physiological estrogens?
    Michael E Baker
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0693, USA
    Steroids 78:337-40. 2013
  2. pmc 3D models of MBP, a biologically active metabolite of bisphenol A, in human estrogen receptor α and estrogen receptor β
    Michael E Baker
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e46078. 2012
  3. doi request reprint 3D models of human ERα and ERβ complexed with 5-androsten-3β,17β-diol
    Michael E Baker
    Department of Medicine, 0693 University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Steroids 77:1192-7. 2012
  4. doi request reprint Evolutionary analysis of the segment from helix 3 through helix 5 in vertebrate progesterone receptors
    Michael E Baker
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0693, United States
    J Steroid Biochem Mol Biol 132:32-40. 2012
  5. ncbi request reprint Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action
    M E Baker
    Department of Medicine, 0823 University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0823, USA
    Mol Cell Endocrinol 171:211-5. 2001
  6. ncbi request reprint Evolution of glucocorticoid and mineralocorticoid responses: go fish
    Michael E Baker
    Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0693, USA
    Endocrinology 144:4223-5. 2003
  7. ncbi request reprint Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors
    Michael E Baker
    Department of Medicine, University of California, 0693 San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Mol Cell Endocrinol 215:55-62. 2004
  8. ncbi request reprint Evolutionary analysis of 11beta-hydroxysteroid dehydrogenase-type 1, -type 2, -type 3 and 17beta-hydroxysteroid dehydrogenase-type 2 in fish
    Michael E Baker
    Department of Medicine 0693, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    FEBS Lett 574:167-70. 2004
  9. doi request reprint 3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone
    Michael E Baker
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Steroids 76:1451-7. 2011
  10. doi request reprint Insights from the structure of estrogen receptor into the evolution of estrogens: implications for endocrine disruption
    Michael E Baker
    Department of Medicine, University of California, San Diego, La Jolla, United States
    Biochem Pharmacol 82:1-8. 2011

Collaborators

Detail Information

Publications48

  1. doi request reprint What are the physiological estrogens?
    Michael E Baker
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0693, USA
    Steroids 78:337-40. 2013
    ..Further studies of the role of these steroids and SERMs in regulating responses mediated by ERα and ERβ a variety of tissues, during different stages of development, are likely to uncover additional estrogenic activities...
  2. pmc 3D models of MBP, a biologically active metabolite of bisphenol A, in human estrogen receptor α and estrogen receptor β
    Michael E Baker
    Department of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e46078. 2012
    ..This analysis also may be useful in designing novel chemicals for regulating the actions of human ERα and ERβ...
  3. doi request reprint 3D models of human ERα and ERβ complexed with 5-androsten-3β,17β-diol
    Michael E Baker
    Department of Medicine, 0693 University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Steroids 77:1192-7. 2012
    ..This conformational flexibility may be relevant for binding of other Δ(5)-steroids with C19 methyl substituents, such as 25-hydroxycholesterol and 27-hydroxycholesterol, to ERs...
  4. doi request reprint Evolutionary analysis of the segment from helix 3 through helix 5 in vertebrate progesterone receptors
    Michael E Baker
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0693, United States
    J Steroid Biochem Mol Biol 132:32-40. 2012
    ....
  5. ncbi request reprint Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action
    M E Baker
    Department of Medicine, 0823 University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0823, USA
    Mol Cell Endocrinol 171:211-5. 2001
    ..This coincided with the origin of nuclear receptors for androgens and estrogens suggesting that expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens...
  6. ncbi request reprint Evolution of glucocorticoid and mineralocorticoid responses: go fish
    Michael E Baker
    Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0693, USA
    Endocrinology 144:4223-5. 2003
  7. ncbi request reprint Co-evolution of steroidogenic and steroid-inactivating enzymes and adrenal and sex steroid receptors
    Michael E Baker
    Department of Medicine, University of California, 0693 San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Mol Cell Endocrinol 215:55-62. 2004
    ..Understanding the actions of Delta 5 steroids in amphioxus and lamprey may shed light on adrenarche and neurosteroid actions in humans...
  8. ncbi request reprint Evolutionary analysis of 11beta-hydroxysteroid dehydrogenase-type 1, -type 2, -type 3 and 17beta-hydroxysteroid dehydrogenase-type 2 in fish
    Michael E Baker
    Department of Medicine 0693, University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    FEBS Lett 574:167-70. 2004
    ..Also unexpectedly, searches with 11beta-HSD1 only identified several fish 11beta-HSD3s, as well as an ortholog in Ciona, indicating that 11beta-HSD3 is the ancestor of 11beta-HSD1...
  9. doi request reprint 3D models of lamprey corticoid receptor complexed with 11-deoxycortisol and deoxycorticosterone
    Michael E Baker
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Steroids 76:1451-7. 2011
    ..We propose that this interaction was present in the CR and lost during the evolution of the MR and GR, leading to changes in their response to progesterone and corticosteroids, respectively...
  10. doi request reprint Insights from the structure of estrogen receptor into the evolution of estrogens: implications for endocrine disruption
    Michael E Baker
    Department of Medicine, University of California, San Diego, La Jolla, United States
    Biochem Pharmacol 82:1-8. 2011
    ....
  11. doi request reprint Origin and diversification of steroids: co-evolution of enzymes and nuclear receptors
    Michael E Baker
    Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, United States
    Mol Cell Endocrinol 334:14-20. 2011
    ..CYP450 metabolism of hydrophobic xenobiotics may have been a key event in the origin of ligand-activated steroid receptors from constitutively active nuclear receptors...
  12. doi request reprint 11Beta-hydroxysteroid dehydrogenase-type 2 evolved from an ancestral 17beta-hydroxysteroid dehydrogenase-type 2
    Michael E Baker
    Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, United States
    Biochem Biophys Res Commun 399:215-20. 2010
    ..Sequence analyses indicate that 17beta-HSD2 in sea urchin may have a non-enzymatic activity. Evolutionary analyses indicate that if acorn worm 17beta-HSD2 is catalytically active, then it metabolizes novel substrate(s)...
  13. pmc Structural analysis of the evolution of steroid specificity in the mineralocorticoid and glucocorticoid receptors
    Michael E Baker
    Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    BMC Evol Biol 7:24. 2007
    ..Still not completely understood is how specificity for glucocorticoids (e.g. cortisol) and mineralocorticoids (e.g. aldosterone) evolved in these receptors...
  14. doi request reprint Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3
    Michael E Baker
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0693, USA
    FEBS Lett 584:2279-84. 2010
    ....
  15. pmc 3D model of lamprey estrogen receptor with estradiol and 15alpha-hydroxy-estradiol
    Michael E Baker
    Department of Medicine, University of California San Diego, La Jolla, CA, USA
    PLoS ONE 4:e6038. 2009
    ..For example, 15alpha-hydroxy-estradiol [15alpha-OH-E2] is the estrogen, instead of estradiol [E2]. To investigate how 15alpha-OH-E2 binds lamprey ER, we constructed a 3D model of the lamprey ER with E2 and 15alpha-OH-E2...
  16. doi request reprint Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors: toward a better understanding of estrogen receptor evolution
    Michael E Baker
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Biochem Biophys Res Commun 371:724-8. 2008
    ..This suggests unusual ligand recognition in amphioxus ER...
  17. doi request reprint Trichoplax, the simplest known animal, contains an estrogen-related receptor but no estrogen receptor: Implications for estrogen receptor evolution
    Michael E Baker
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Biochem Biophys Res Commun 375:623-7. 2008
    ..Our database searches and phylogenetic analysis indicate that invertebrate ERs evolved in a lophotrochozoan and steroid-binding ERs evolved in a deuterostome...
  18. ncbi request reprint Analysis of 3D models of octopus estrogen receptor with estradiol: evidence for steric clashes that prevent estrogen binding
    Michael E Baker
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Biochem Biophys Res Commun 361:782-8. 2007
    ..Like ERR, octopus ER also may have the activation function 2 domain (AF2) in a configuration that can bind to coactivators in the absence of estrogens, which would explain constitutive activity of octopus ER...
  19. ncbi request reprint Evolution of adrenal and sex steroid action in vertebrates: a ligand-based mechanism for complexity
    Michael E Baker
    Department of Medicine 0693, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Bioessays 25:396-400. 2003
    ....
  20. ncbi request reprint Steroid receptor phylogeny and vertebrate origins
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Mol Cell Endocrinol 135:101-7. 1997
    ....
  21. doi request reprint 3D models of lamprey progesterone receptor complexed with progesterone, 7α-hydroxy-progesterone and 15α-hydroxy-progesterone
    Michael E Baker
    Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Steroids 76:169-76. 2011
    ..BLAST searches reveal that Met-277 on lamprey PR is unique among vertebrate PRs. This unique site on lamprey PR could be a target for compounds to control reproduction in sea lamprey, an environmental pest in Lake Michigan...
  22. doi request reprint 3D model of amphioxus steroid receptor complexed with estradiol
    Michael E Baker
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0693, USA
    Biochem Biophys Res Commun 386:516-20. 2009
    ..The 3D model predicts that mutation of Glu-346 to Gln will increase the affinity of testosterone for amphioxus SR and elucidate the evolution of steroid-binding to nuclear receptors...
  23. ncbi request reprint Evolution of mammalian 11beta- and 17beta-hydroxysteroid dehydrogenases-type 2 and retinol dehydrogenases from ancestors in Caenorhabditis elegans and evidence for horizontal transfer of a eukaryote dehydrogenase to E. coli
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    J Steroid Biochem Mol Biol 66:355-63. 1998
    ..Sequence comparisons and phylogenetic analysis indicate that the E. coli protein may be an example of horizontal transfer from a eukaryote ancestor...
  24. ncbi request reprint Albumin's role in steroid hormone action and the origins of vertebrates: is albumin an essential protein?
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    FEBS Lett 439:9-12. 1998
    ....
  25. ncbi request reprint A common ancestor for a subunit in the mitochondrial proton-translocating NADH:ubiquinone oxidoreductase (complex I) and short-chain dehydrogenases/reductases
    M E Baker
    Department of Medicine, University of California, San Diego 92093 0823, USA
    Cell Mol Life Sci 55:450-5. 1999
    ....
  26. ncbi request reprint Three-dimensional model of human TIP30, a coactivator for HIV-1 Tat-activated transcription, and CC3, a protein associated with metastasis suppression
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0823, USA
    Cell Mol Life Sci 57:851-8. 2000
    ..Our structural model points to this alpha-helix and the SDR-like part of TIP30/CC3 for mutagenesis experiments to elucidate its role in HIV-1 Tat-activated transcription, metastasis suppression, and other cellular functions...
  27. ncbi request reprint Adrenal and sex steroid receptor evolution: environmental implications
    M E Baker
    Department of Medicine, 0823, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0823, USA
    J Mol Endocrinol 26:119-25. 2001
    ..Moreover, unliganded adrenal and sex steroid receptors form complexes with heat shock protein 90. Thus, the evolution of adrenal and sex steroid receptors involved changes in protein-protein interactions as well as ligand recognition...
  28. ncbi request reprint Hydroxysteroid dehydrogenases: ancient and modern regulators of adrenal and sex steroid action
    M E Baker
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0823, USA
    Mol Cell Endocrinol 175:1-4. 2001
    ..Hydroxysteroid dehydrogenases in fish, amphibia and mammals are likely have different affinities for some xenobiotics, which needs to be considered in evaluating their hazards as endocrine disruptors...
  29. ncbi request reprint Recent insights into the origins of adrenal and sex steroid receptors
    M E Baker
    Department of Medicine, 0823, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0823, USA
    J Mol Endocrinol 28:149-52. 2002
    ..Thornton proposed that estradiol was the earliest of the steroids to activate a steroid receptor. An alternative hypothesis is that a steroid in the Delta(5) pathway activated the ancestral estrogen receptor...
  30. ncbi request reprint Albumin, steroid hormones and the origin of vertebrates
    M E Baker
    Department of Medicine, 0823B, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0823, USA
    J Endocrinol 175:121-7. 2002
    ..Thus, animals in which albumin expression was high had a selective advantage in regulating the steroid response and avoiding endocrine disruption by xenobiotics...
  31. pmc Analysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family members
    Wei Wu
    Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093 0693, USA
    Physiol Genomics 38:116-24. 2009
    ..One Ust amplification in mouse appears to be recent. This cluster may be coordinately regulated and under selective pressure in a species-specific manner...
  32. ncbi request reprint Characterization of Ke 6, a new 17beta-hydroxysteroid dehydrogenase, and its expression in gonadal tissues
    J Fomitcheva
    Nephrology Division, Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 273:22664-71. 1998
    ....
  33. ncbi request reprint Meta-MEME: motif-based hidden Markov models of protein families
    W N Grundy
    Department of Computer Science and Engineering, University of California, San Diego, La Jolla 92093, USA
    Comput Appl Biosci 13:397-406. 1997
    ..For families in which there are few known sequences, a standard linear HMM contains too many parameters to be trained adequately...
  34. ncbi request reprint Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093
    Mol Endocrinol 3:881-4. 1989
    ..We propose that the steroid recognition site on 17 beta-OH-steroid dehydrogenase evolved from an ancestral recognition site for polyols such as ribitol and glucitol-6-phosphate...
  35. ncbi request reprint Amphioxus, a primitive chordate, is on steroids: evidence for sex steroids and steroidogenic enzymes
    Michael E Baker
    Department of Medicine, 0693, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0693, USA
    Endocrinology 148:3551-3. 2007
  36. ncbi request reprint Licorice and enzymes other than 11 beta-hydroxysteroid dehydrogenase: an evolutionary perspective
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623
    Steroids 59:136-41. 1994
    ..Other oxidoreductases in bacteria, plants, and animals that are inhibited by licorice-derived compounds are likely to be discovered in the future...
  37. pmc Analysis of endocrine disruption in Southern California coastal fish using an aquatic multispecies microarray
    Michael E Baker
    Department of Medicine, University of California San Diego, 9500 Gilman Dr, MC 0724, La Jolla, CA 92093 USA
    Environ Health Perspect 117:223-30. 2009
    ....
  38. pmc Is vitellogenin an ancestor of apolipoprotein B-100 of human low-density lipoprotein and human lipoprotein lipase?
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093
    Biochem J 255:1057-60. 1988
    ..In addition to providing a link between invertebrates and vertebrates for proteins involved in lipid transport, these homologies suggest new functions for vitellogenin other than being a yolk food for the developing embryo...
  39. ncbi request reprint Similarity between the amino-terminal portion of mammalian 58-kD sterol carrier protein (SCPx) and Escherichia coli acetyl-CoA acyltransferase: evidence for a gene fusion in SCPx
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623
    DNA Cell Biol 10:695-8. 1991
    ..coli enzyme are 8.25 and 8.8 SD, respectively. The catalytically active cysteine of E. coli acetyl-CoA acyltransferase (cysteine 91) aligns with cysteine 93 and cysteine 94 on human and rat 58-kD sterol carrier protein, respectively...
  40. ncbi request reprint Flavonoids inhibit estrogen binding to rat alpha-fetoprotein
    M E Baker
    Department of Medicine, University of California, San Diego, La Jolla 92093 0623, USA
    Proc Soc Exp Biol Med 217:317-21. 1998
    ..Finally, bioflavonoids should be useful tools for understanding the variety of estrogen actions initiated by different structural classes of estrogens...
  41. ncbi request reprint Inhibition of 11 beta-hydroxysteroid dehydrogenase type 2 by dithiocarbamates
    Atanas G Atanasov
    Division of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Berne CH 3010, Switzerland
    Biochem Biophys Res Commun 308:257-62. 2003
    ....
  42. ncbi request reprint The 11-ketosteroid 11-ketodexamethasone is a glucocorticoid receptor agonist
    Alexandre G Rebuffat
    Department of Clinical Research, University of Berne, Freiburgstrasse 15, 3010 Berne, Switzerland
    Mol Cell Endocrinol 214:27-37. 2004
    ..The finding that 11-ketoDex is a specific GR agonist may explain the potent glucocorticoid effect of Dex in tissues expressing 11beta-HSD2 including kidney and colon and also in certain tumor cells...
  43. ncbi request reprint Glutamate-115 renders specificity of human 11beta-hydroxysteroid dehydrogenase type 2 for the cofactor NAD+
    Peter Arnold
    Division of Nephrology and Hypertension, Department of Clinical Research, University of Berne, Freiburgstrasse 15, Switzerland
    Mol Cell Endocrinol 201:177-87. 2003
    ..Thus, predictions using the 3D-model combined with analysis of mutants allowed the identification of residues critical for NAD(+)-dependent activity of 11beta-HSD2...
  44. pmc Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids
    Atanas G Atanasov
    Department of Nephrology and Hypertension, University of Berne, Berne, Switzerland
    Environ Health Perspect 113:1600-6. 2005
    ..Enhanced glucocorticoid concentrations due to disruption of 11beta-HSD2 function may contribute to the observed organotin-dependent toxicity in some glucocorticoid-sensitive tissues such as thymus and placenta...
  45. ncbi request reprint Differences in catalytic activity between rat testicular and ovarian carbonyl reductases are due to two amino acids
    Michel A Sciotti
    Institute of Clinical Chemistry, 3010 Bern, Switzerland
    FEBS Lett 580:67-71. 2006
    ..Comparisons of three-dimensional models of rCR1 and rCR2 show how Thr-235 and Glu-238 stabilize rCR2 binding of NADPH and menadione...
  46. ncbi request reprint Rat 3alpha-hydroxysteroid dehydrogenase: to oxidize or reduce, that is the question
    Michael E Baker
    Endocrinology 147:1589-90. 2006
  47. ncbi request reprint Dissecting the axoneme interactome: the mammalian orthologue of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the mammalian orthologue of Chlamydomonas PF16
    Zhibing Zhang
    Center for Research on Reproduction and Women s Health and the Department of Ophthalmology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Proteomics 4:914-23. 2005
    ..Thus, PF6, SPAG6, and PF20 form a newly identified network that links together components of the axoneme central apparatus and presumably participates in its dynamic regulation of ciliary and flagellar beat...
  48. doi request reprint Activity versus peroxisomal targeting of PerCR
    Michael E Baker
    Structure 16:331-2. 2008