Research Topics
| KEVIN S BAKERSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Quality of life and recovery after graft-versus-host diseaseK Scott Baker
Department of Pediatrics, Division of Pediatric Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota, 420 Delaware Street SE, Mayo Building Room D557, Mayo Mail Code 484, Minneapolis, MN 55455, USA
Best Pract Res Clin Haematol 21:333-41. 2008....
Outcome of ethnic minorities with acute or chronic leukemia treated with hematopoietic stem-cell transplantation in the United StatesK Scott Baker
Pediatric Blood and Marrow Transplant Program, University of Minnesota, Mayo Mail Code 484, Minneapolis, MN 55455, USA
J Clin Oncol 23:7032-42. 2005..The purpose of this study was to examine the relationship between ethnicity and post-transplantation events and determine their net effect on survival...- Late effects in survivors of chronic myeloid leukemia treated with hematopoietic cell transplantation: results from the Bone Marrow Transplant Survivor StudyK Scott Baker
University of Minnesota Cancer Center, Blood and Marrow Transplant Program, Department of Internal Medicine, University of Minnesota, Minneapolis, USA
Blood 104:1898-906. 2004..However, adverse medical late effects with significant morbidity were uncommon. Chronic GVHD is the most important predictor of adverse medical late effects and poor overall health... 
Diabetes, hypertension, and cardiovascular events in survivors of hematopoietic cell transplantation: a report from the bone marrow transplantation survivor studyK Scott Baker
Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
Blood 109:1765-72. 2007..42; 95% CI, 1.55-7.52). Thus, HCT survivors have a higher age- and BMI-adjusted risk of diabetes and hypertension, potentially leading to a higher than expected risk of CV events with age...- Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: analysis of graft sources and long-term outcomeMichael B Tomblyn
Department of Therapeutic Radiology and Radiation Oncology, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Oncol 27:3634-41. 2009..Analysis of hematopoietic cell transplantation (HCT) for high-risk or recurrent acute lymphoblastic leukemia (ALL) using different donor sources is confounded by variable conditioning and supportive care... - Allogeneic hematopoietic cell transplantation in children with relapsed acute lymphoblastic leukemia isolated to the central nervous systemPaul D Harker-Murray
Pediatric Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 14:685-92. 2008..These data support the use of allogeneic HCT in the treatment of children with poor prognosis isolated CNS relapse... - Trends in survival rates after allogeneic hematopoietic stem-cell transplantation for acute and chronic leukemia by ethnicity in the United States and CanadaDerek S Serna
Department of Internal Medicine, Health Policy Institute, Medical College of Wisconsin Milwaukee, WI 53226, USA
J Clin Oncol 21:3754-60. 2003..Factors not accounted for in this analysis, such as comorbid disease, socioeconomic status, healthcare access and delivery, and psychosocial and cultural variables, require further prospective study... - Performance limitations and participation restrictions among childhood cancer survivors treated with hematopoietic stem cell transplantation: the bone marrow transplant survivor studyKirsten K Ness
Department of Pediatrics, University of Minnesota, Minneapolis, USA
Arch Pediatr Adolesc Med 159:706-13. 2005..9-4.2). CONCLUSION: This study demonstrated that persons treated with HCT as children were at increased risk for performance limitations that restricted participation in routine daily activities and interpersonal relationships... - Long-term medical effects of childhood and adolescent rhabdomyosarcoma: a report from the childhood cancer survivor studyJudith A Punyko
Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 44:643-53. 2005..8, 1.9-7.5). CONCLUSIONS: Survivors are at risk for developing sequelae many years after their initial diagnosis and treatment. Continued medical surveillance is necessary to ensure the long-term health and well-being of RMS survivors... - Prevalence of the metabolic syndrome in relation to self-reported cancer historyKirsten K Ness
Division of Epidemiology and Clinical Research, Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
Ann Epidemiol 15:202-6. 2005..CONCLUSION: These results add to the emerging concern that metabolic syndrome and associated risks for cardiovascular disease and type 2 diabetes may be an adverse late effect of cancer and/or its treatment... - Late effects in survivors of Hodgkin and non-Hodgkin lymphoma treated with autologous hematopoietic cell transplantation: a report from the bone marrow transplant survivor studyNavneet S Majhail
Blood and Marrow Transplant Program, Departments of Medicine and Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Biol Blood Marrow Transplant 13:1153-9. 2007..4, 95% CI 1.0-5.5). HL and NHL survivors of autologous HCT have a high prevalence of long-term health-related complications and require continued monitoring for late effects of transplantation... - Body composition, muscle strength deficits and mobility limitations in adult survivors of childhood acute lymphoblastic leukemiaKirsten K Ness
Department of Pediatrics, Division of Epidemiology and Clinical Research, University of Minnesota, Minneapolis, Minnesota 55455, USA
Pediatr Blood Cancer 49:975-81. 2007..We compared body composition, muscle strength, and mobility between 75 adult survivors of childhood acute lymphoblastic leukemia (ALL) and expected values based on population normative data... - Poor adherence to dietary guidelines among adult survivors of childhood acute lymphoblastic leukemiaKim Robien
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second St, 300 WBOB, Minneapolis, MN 55454, USA
J Pediatr Hematol Oncol 30:815-22. 2008.... - First report of donor cell-derived acute leukemia as a complication of umbilical cord blood transplantationChristopher J Fraser
Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN 55455, USA
Blood 106:4377-80. 2005..This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients... - Prospective study of changes in bone mineral density and turnover in children after hematopoietic cell transplantationAnna Petryk
Department of Pediatrics, University of Minnesota, 13 124 PWB, MMC 404, 516 Delaware Street SE, Minneapolis, Minnesota 55455, USA
J Clin Endocrinol Metab 91:899-905. 2006..Osteoporosis is common in adults after hematopoietic cell transplantation (HCT). The data on bone mineral density (BMD) in children after HCT are limited... - Long-term follow-up of children who underwent hematopoeitic cell transplant (HCT) for AML or ALL at less than 3 years of ageJoanna L Perkins
Department of Pediatric Hematology Oncology, Children s Hospitals and Clinics, Minneapolis, Minnesota 55404, USA
Pediatr Blood Cancer 49:958-63. 2007..Hematopoeitic cell transplantation (HCT) in childhood has been associated with late complications including endocrine, neurocognitive, and cardiopulmonary abnormalities. Little is known about the complications of transplantation in infants... - Novel conditioning regimens and nonmyeloablative stem cell transplantsK Scott Baker
Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
Curr Opin Pediatr 14:17-22. 2002..The potential to use this nonmyeloablative approach in nonmalignant disorders in which regimen-related toxicity must be minimized is of particular interest in children... - Transplantation of unrelated donor umbilical cord blood in 102 patients with malignant and nonmalignant diseases: influence of CD34 cell dose and HLA disparity on treatment-related mortality and survivalJohn E Wagner
Blood and Marrow Transplant Program of the Department of Pediatrics, University of Minnesota Cancer Center and School of Medicine, Minneapolis 55455, USA
Blood 100:1611-8. 2002..7 x 10(5) CD34(+) cells per kilogram of recipient's body weight. Therefore, graft selection should be based principally on CD34 cell dose when multiple UCB units exist with an HLA disparity of 2 or less... - Children from ethnic minorities have benefited equally as other children from contemporary therapy for rhabdomyosarcoma: a report from the Intergroup Rhabdomyosarcoma Study GroupK Scott Baker
University of Minnesota, Minneapolis, MN, USA
J Clin Oncol 20:4428-33. 2002..To define the clinical characteristics of rhabdomyosarcoma (RMS) occurring in children from ethnic minorities and determine whether these children have benefited equally from advances in therapy... - Hypertension and diabetes mellitus in adult and pediatric survivors of allogeneic hematopoietic cell transplantationNavneet S Majhail
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 15:1100-7. 2009..Continued monitoring and treatment of hypertension and diabetes is necessary in allogeneic HCT survivors, especially in those exposed to high doses of corticosteroids... - New malignancies after blood or marrow stem-cell transplantation in children and adults: incidence and risk factorsK Scott Baker
Department of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota, Minneapolis 55455, USA
J Clin Oncol 21:1352-8. 2003..To determine the incidence and risk factors for the development of new malignancies occurring after stem-cell transplantation (SCT)... - Impact of chronic graft-versus-host disease on the health status of hematopoietic cell transplantation survivors: a report from the Bone Marrow Transplant Survivor StudyChristopher J Fraser
Pediatric Blood and Marrow Transplant Program, Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 108:2867-73. 2006..We conclude that active cGVHD has a significant impact on many aspects of the overall health status of HCT survivors and that, most importantly, those successfully treated for cGVHD do not appear to have long-term impairments... - Hematopoietic cell transplantation for children with acute lymphoblastic leukemia in second complete remission: similar outcomes in recipients of unrelated marrow and umbilical cord blood versus marrow from HLA matched sibling donorsAngela R Smith
Division of Pediatric Hematology Oncology Blood and Marrow Transplantation, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 15:1086-93. 2009.... - Umbilical cord blood transplantation for myeloid malignanciesClaudio G Brunstein
Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota, USA
Curr Opin Hematol 14:162-9. 2007..To review the available data on the outcomes of pediatric and adult patients with acute myeloid leukemia, myelodysplastic syndrome and chronic myelogenous leukemia after umbilical cord blood transplantation... - Visual, auditory, sensory, and motor impairments in long-term survivors of hematopoietic stem cell transplantation performed in childhood: results from the Bone Marrow Transplant Survivor studyJames G Gurney
Department of Pediatrics, Division of General Pediatrics, 300 NIB 6E02 Box 0456, University of Michigan, 300 N Ingalls Street, Ann Arbor, MI 48109, USA
Cancer 106:1402-8. 2006..Because of treatment-related toxicity, research is increasingly being focused on long-term sequelae secondary to hematopoietic stem cell transplantation (HSCT) in survivor populations... - Homozygous alpha-thalassemia treated with intrauterine transfusions and unrelated donor hematopoietic cell transplantationJoanna S Yi
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
J Pediatr 154:766-8. 2009..We present a patient with Hemoglobin Bart's disease who was cured after failing to engraft with 1 unrelated HCT, but engrafting after a second unrelated donor HCT... - Transplant outcomes for primary immunodeficiency diseaseAngela R Smith
Department of Pediatrics, University of Minnesota Pediatric Blood and Marrow Transplant Program, Minneapolis, MN, USA
Semin Hematol 47:79-85. 2010.... - Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based evaluationJudith A Punyko
Department of Pediatrics and the University of Minnesota Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
Cancer 103:1475-83. 2005..The patterns in RMS survival noted from the current population-based evaluation did not appear to differ substantially from those previously reported by major clinical trials... - Metabolic syndrome and growth hormone deficiency in adult survivors of childhood acute lymphoblastic leukemiaJames G Gurney
Child Health Evaluation and Research CHEAR Unit, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan 48109 0456, USA
Cancer 107:1303-12. 2006.... - Atypical cells in bronchoalveolar lavage specimens from bone marrow transplant recipients. A potential pitfallH Evin Gulbahce
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA
Am J Clin Pathol 120:101-6. 2003..There was substantial overlap between the reactive atypia and carcinoma. Clinical correlation was the most important factor in making accurate diagnosis... - Glutathione S-transferase A1 genetic variants reduce busulfan clearance in children undergoing hematopoietic cell transplantationL aurelle Johnson
Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
J Clin Pharmacol 48:1052-62. 2008..Larger, prospective studies are needed to confirm these findings... - Inflammatory cytokines and the development of pulmonary complications after allogeneic hematopoietic cell transplantation in patients with inherited metabolic storage disordersSandhya Kharbanda
University of Minnesota Cancer Center and Department of Pediatrics, Division of Pediatric Hematology/Oncology and Blood and Marrow Transplant, Minneapolis, 55455, USA
Biol Blood Marrow Transplant 12:430-7. 2006..Larger studies will be required to further elucidate etiologic mechanisms and predictive factors... - Endothelial function in young adult survivors of childhood acute lymphoblastic leukemiaDonald R Dengel
School of Kinesiology, University of Minnesota, Minneapolis, MN, USA
J Pediatr Hematol Oncol 30:20-5. 2008..2+/-7.1 y) adult survivors of childhood ALL who received chemotherapy without cranial radiation (n=25) or chemotherapy combined with cranial radiation (n=50) compared with a healthy control group of similar sex, age, and weight (n=59)... - Spontaneous liver rupture in a child with graft-versus-host diseaseSean J Barnett
Department of Surgery, University of Minnesota, Minneapolis, MN, USA
J Pediatr Surg 39:e1-3. 2004..The skin, gastrointestinal tract, and the liver are the most frequently affected organs. The authors present the first reported case of a spontaneous rupture of the liver in a child with GVHD after SCT... - Bone mineral density in young adult survivors of acute lymphoblastic leukemiaInas H Thomas
Division of Pediatric Endocrinology, Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA
Cancer 113:3248-56. 2008..The purpose of the current study was to determine the prevalence of low bone mineral density (BMD) (ie, osteopenia) and identify factors associated with low BMD in young adult survivors of childhood acute lymphoblastic leukemia (ALL)... - Pulmonary nodular lesions in bone marrow transplant recipients: impact of histologic diagnosis on patient management and prognosisH Evin Gulbahce
Department of Laboratory Medicine and Pathology, University of Minnesota, Fairview University Medical Center, Minneapolis 55455, USA
Am J Clin Pathol 121:205-10. 2004..Histologic examination is accurate in determining the cause of PNLs and identifying lesions that have a favorable outcome and those that require a change in treatment... - Diagnostic peritoneal lavage for assessing acute abdomen in pediatric oncology and stem cell transplantation patientsAshish Kumar
Division of Pediatric Hematology, Oncology, and Bone Marrow Transplantation, University of Minnesota, 420 Delaware Street, Minneapolis, MN 55455, USA
J Pediatr Hematol Oncol 26:824-6. 2004..DPL was uneventfully performed at the bedside in both patients. The authors suggest DPL be considered as an alternative to laparotomy in critically ill pediatric oncology and stem cell transplantation patients... - Health knowledge about symptoms of heart attack and stroke in adult survivors of childhood acute lymphoblastic leukemiaJames G Gurney
Child Health Evaluation and Research Unit, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Ann Epidemiol 17:778-81. 2007..Long-term survivors of childhood ALL, however, carry an elevated risk of early mortality from cardiac events and stroke and a disproportionately high prevalence of dyslipidemia and obesity, presumably as an adverse effect of treatment... - Late mortality in survivors of autologous hematopoietic-cell transplantation: report from the Bone Marrow Transplant Survivor StudySmita Bhatia
City of Hope Cancer Center, 1500 E Duarte Rd, Duarte, CA 91010 3000, USA
Blood 105:4215-22. 2005..4) when compared with siblings. Although mortality rates approach that of the general population after 10 years in certain subgroups, long-term survivors of autologous HCT continue to face challenges affecting their health and well-being... - Outcome of unrelated donor stem cell transplantation for children with severe aplastic anemiaEvelio D Perez-Albuerne
Division of Stem Cell Transplantation and Immunology, Children s National Medical Center, Washington, DC, USA
Br J Haematol 141:216-23. 2008..008). The data suggest that unrelated donor transplantation is an acceptable alternative for children; early referral for transplantation and identification of an HLA-matched (allele-level) donor offers the best outcome... - Pulmonary cytolytic thrombi after allogeneic hematopoietic cell transplantation: a further histologic descriptionAntoinette Peters
Biol Blood Marrow Transplant 11:484-5. 2005 - Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: report from the Bone Marrow Transplant Survivor StudySmita Bhatia
Population Sciences, City of Hope National Medical Center, Duarte, CA 91010 3000, USA
Blood 110:3784-92. 2007..This study demonstrates that mortality rates remain twice as high as that of the general population among 15-year survivors of HCT, and that the survivors face challenges affecting their health and well-being... - Unrelated cord blood transplantation in children with sickle cell disease: review of four-center experienceTom V Adamkiewicz
Department of Family Medicine, Morehouse School of Medicine, Atlanta, East Point, GA 30344, USA
Pediatr Transplant 11:641-4. 2007..Four patients (57%) developed viral infections. Engraftment, GVHD, and infection remain challenges... - Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IVJohn C Breneman
Children s Hospital Medical Center, Division of Radiation Oncology, Cincinnati, OH 45219 0757, USA
J Clin Oncol 21:78-84. 2003..To identify risk factors associated with outcomes in children with metastatic rhabdomyosarcoma (RMS) treated on the fourth Intergroup Rhabdomyosarcoma Study (IRS-IV)... - Health care utilization by adult long-term survivors of hematopoietic cell transplant: report from the Bone Marrow Transplant Survivor StudySadhna M Shankar
Vanderbilt Ingram Cancer Center, Nashville, Tennessee, USA
Cancer Epidemiol Biomarkers Prev 16:834-9. 2007..Primary care physicians provide health care for an increasing number of adult long-term survivors of HCT, emphasizing the need for increased awareness of the long-term follow-up needs of the HCT survivors by the health care providers...
Research Grants
- LATE EFFECTS IN SURVIVORS OF STEM CELL TRANSPLANTATIONKevin Baker; Fiscal Year: 2006..Robison is Principal Investigator) for a comparative analysis of patients in that cohort receiving standard chemotherapy versus those who have undergone SCT as part of their therapy. ..
- Gene Therapy for Purine Nucleoside Phosphorylase Deficiency (PNP)Kevin Baker; Fiscal Year: 2007....
- Metabolic Syndrome Following Transplant for LeukemiaKevin Baker; Fiscal Year: 2007....