Jason V Baker
Affiliation: University of Minnesota
- Circulating levels of tissue factor microparticle procoagulant activity are reduced with antiretroviral therapy and are associated with persistent inflammation and coagulation activation among HIV-positive patientsJason V Baker
Department of Medicine, University of Minnesota, Minneapolis, MN, USA
J Acquir Immune Defic Syndr 63:367-71. 2013..001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non-AIDS-defining complications...
- Angiotensin converting enzyme inhibitor and HMG-CoA reductase inhibitor as adjunct treatment for persons with HIV infection: a feasibility randomized trialJason V Baker
Department of Medicine, Hennepin County Medical Center HCMC, Minneapolis, Minnesota, USA
PLoS ONE 7:e46894. 2012..Treatments that reduce inflammation and cardiovascular disease (CVD) risk among individuals with HIV infection receiving effective antiretroviral therapy (ART) are needed...
- HIV replication, inflammation, and the effect of starting antiretroviral therapy on plasma asymmetric dimethylarginine, a novel marker of endothelial dysfunctionJason V Baker
Department of Medicine, University of Minnesota, Minneapolis, MN 55415, USA
J Acquir Immune Defic Syndr 60:128-34. 2012..Understanding the effects of HIV replication on endothelial dysfunction and platelet activation may identify treatment targets to reduce cardiovascular disease risk...
- Inflammation predicts changes in high-density lipoprotein particles and apolipoprotein A1 following initiation of antiretroviral therapyJason V Baker
University of Minnesota, Minneapolis, USA
AIDS 25:2133-42. 2011..The effects of initiating versus deferring ART on high-density and low-density lipoprotein particle (HDL-P and LDL-P, respectively) concentrations and apolipoprotein (Apo) levels are not well described...
- Cardiovascular implications from untreated human immunodeficiency virus infectionJason V Baker
Department of Medicine, Hennepin County Medical Center, University of Minnesota, 701 Park Ave, MC G5, Minneapolis, MN 55415, USA
Eur Heart J 32:945-51. 2011..Ultimately, additional adjunctive treatment will be needed to mitigate premature CVD risk among contemporary HIV-infected patients with access to ART...
- Changes in inflammatory and coagulation biomarkers: a randomized comparison of immediate versus deferred antiretroviral therapy in patients with HIV infectionJason V Baker
University of Minnesota, Minneapolis, MN, USA
J Acquir Immune Defic Syndr 56:36-43. 2011..Changes in these biomarkers have been described after stopping ART, but not after starting ART in SMART...
- Biomarkers and HIV-associated cardiovascular diseaseJason V Baker
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55415, USA
Curr Opin HIV AIDS 5:511-6. 2010..Our goal is to summarize recent literature on biomarkers of cardiovascular disease (CVD) in the setting of HIV infection with an emphasis on those associated with clinical events...
- Untreated HIV infection and large and small artery elasticityJason V Baker
Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415, USA
J Acquir Immune Defic Syndr 52:25-31. 2009..Untreated HIV infection may increase risk for cardiovascular disease, and arterial elasticity is a marker of cardiovascular risk and early disease...
- The consequences of HIV infection and antiretroviral therapy use for cardiovascular disease risk: shifting paradigmsJason V Baker
University of Minnesota, Hennepin County Medical Center, Minneapolis, Minnesota, USA
Curr Opin HIV AIDS 4:176-82. 2009..e. at higher CD4 cell counts than currently recommended by guidelines)...
- Poor initial CD4+ recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseasesJason V Baker
Department of Biostatistics, University of Minnesota, Minneapolis, MN, USA
J Acquir Immune Defic Syndr 48:541-6. 2008..Low CD4+ increases risk for both AIDS- and non-AIDS-related morbidity and mortality. The magnitude of CD4+ recovery early after initial antiretroviral therapy (ART) is important in the ultimate duration of immune depletion...
- CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infectionJason V Baker
University of Minnesota, Minneapolis, USA
AIDS 22:841-8. 2008..Reductions in AIDS-related morbidity and mortality following the advent of combination antiretroviral therapy have coincided with relative increases in chronic non-AIDS end-organ diseases among HIV+ patients...
- Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infectionJacqueline Neuhaus
University of Minnesota, Minneapolis, Minnesota 55414, USA
J Infect Dis 201:1788-95. 2010..Human immunodeficiency virus (HIV) replication and immune activation may increase inflammation and coagulation biomarkers. Limited data exist comparing such biomarkers in persons with and without HIV infection...
- Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or deathDavid R Boulware
University of Minnesota, Minneapolis, Minnesota, USA
J Infect Dis 203:1637-46. 2011..Substantial morbidity occurs during the first year of antiretroviral therapy (ART) in persons with advanced human immunodeficiency virus (HIV) disease despite HIV suppression. Biomarkers may identify high-risk groups...
- Biomarkers and bacterial pneumonia risk in patients with treated HIV infection: a case-control studySonja M Bjerk
Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America
PLoS ONE 8:e56249. 2013..Studies of biomarker associations with bacterial pneumonia risk in treated HIV-infected patients do not currently exist...
- HIV Replication Alters the Composition of Extrinsic Pathway Coagulation Factors and Increases Thrombin GenerationJason V Baker
Hennepin County Medical Center, Minneapolis, MN
J Am Heart Assoc 2:e000264. 2013..We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors...
- Collagen deposition limits immune reconstitution in the gutJacob Estes
Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Infect Dis 198:456-64. 2008....
- Progression of carotid intima-media thickness in a contemporary human immunodeficiency virus cohortJason V Baker
Department of Medicine, Hennepin County Medical Center, University of Minnesota, Minneapolis, USA
Clin Infect Dis 53:826-35. 2011..Persons with human immunodeficiency virus (HIV) infection are at risk for premature cardiovascular disease (CVD). Predictors of atherosclerotic disease progression in contemporary patients have not been well described...
- Inguinal lymph node biopsy in patients infected with the human immunodeficiency virus is safeDavid E Skarda
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
Surg Infect (Larchmt) 8:173-8. 2007..Additionally, we monitored the rates of other complications, namely, hematoma, dorsal vein thrombosis, epididymitis, lymphocele, and suture extrusion...
- A case for treating high hepatitis B DNA levels before starting HIV therapyJason V Baker
AIDS 20:2402-3. 2006