Research Topics
| T L Baker-HermanSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
Episodic but not continuous hypoxia elicits long-term facilitation of phrenic motor output in ratsT L Baker
Center for Neuroscience and Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
J Physiol 529:215-9. 2000..3 and 5.1 +/- 2 bursts min-1 60 min post-hypoxia, respectively; P > 0.05). 4. The results indicate that hypoxia-induced long-term facilitation of phrenic motor output is sensitive to the pattern of hypoxic exposure in anaesthetized rats...
Differential expression of respiratory long-term facilitation among inbred rat strainsT L Baker-Herman
Department of Comparative Biosciences, University of Wisconsin, 2015 Linden Drive, Madison, WI 53706, USA
Respir Physiol Neurobiol 170:260-7. 2010..BN had higher 5-HT(7) and TrkB mRNA versus F344; BN and Lewis had higher BDNF mRNA levels versus F344. Genetic variations in serotonergic function may underlie strain differences in AIH-induced pLTF...
Similarities and differences in mechanisms of phrenic and hypoglossal motor facilitationTracy L Baker-Herman
Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
Respir Physiol Neurobiol 179:48-56. 2011....
Phrenic long-term facilitation requires spinal serotonin receptor activation and protein synthesisTracy L Baker-Herman
Department of Comparative Biosciences and Center for Neuroscience, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 22:6239-46. 2002..We conclude that phrenic LTF requires spinal serotonin receptor activation and protein synthesis. Serotonin receptors on phrenic motoneuron dendrites may induce new protein synthesis, thereby giving rise to phrenic LTF...
Respiratory plasticity: differential actions of continuous and episodic hypoxia and hypercapniaT L Baker
Center for Neuroscience, University of Wisconsin, 2015 Linden Drive West, Madison, WI 53706, USA
Respir Physiol 129:25-35. 2001..We hypothesize that the response of respiratory motoneurons to serotonergic and noradrenergic modulation may contribute to pattern sensitivity to hypoxia and hypercapnia...
Ventilatory impairment in the dysmyelinated Long Evans shaker ratR A Johnson
Department of Surgical Sciences, University of Wisconsin, Madison, WI 53706, USA
Neuroscience 169:1105-14. 2010..This study is the first reporting age-related breathing abnormalities in a rodent dysmyelination model, and provides the foundation for mechanistic studies of respiratory insufficiency and therapeutic interventions...
BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxiaTracy L Baker-Herman
Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
Nat Neurosci 7:48-55. 2004..These experiments also illustrate the potential use of RNAi to investigate functional consequences of gene expression in the mammalian nervous system in vivo...
Okadaic acid-sensitive protein phosphatases constrain phrenic long-term facilitation after sustained hypoxiaJulia E R Wilkerson
Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 28:2949-58. 2008..The specific okadaic acid-sensitive phosphatase(s) constraining pLTF and their spatiotemporal dynamics during and/or after IH and SH remain to be determined...
Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptorsDavid D Fuller
Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin, USA
J Neurotrauma 22:203-13. 2005..05). Our data are consistent with the hypothesis that spontaneous increase in 5-HT2A receptor expression on or near phrenic motoneurons contributes to strengthened crossed-spinal synaptic pathways to phrenic motoneurons following C2HS...
Determinants of frequency long-term facilitation following acute intermittent hypoxia in vagotomized ratsTracy L Baker-Herman
Department of Comparative Biosciences, University of Wisconsin, Madison, WI 53706, USA
Respir Physiol Neurobiol 162:8-17. 2008..Variations in baseline burst frequency may contribute to variation in frequency LTF and may underlie the apparent effects of some drug treatments...
Spinal adenosine A2a receptor activation elicits long-lasting phrenic motor facilitationFrancis J Golder
Department of Comparative Biosciences, University of Wisconsin, Madison, Wisconsin 53706, USA
J Neurosci 28:2033-42. 2008....
