Shannon Bailey

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Mitochondrial proteomics in free radical research
    Shannon M Bailey
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Ryals Building, Room 623, Birmingham, AL 35294, USA
    Free Radic Biol Med 38:175-88. 2005
  2. ncbi request reprint A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction
    Shannon M Bailey
    Department of Environmental Health Sciences and Center for Free Radical Biology, School of Public Health, The University of Alabama at Birmingham, 1530 3rd Avenue South, Ryals Building, Room 623, Birmingham, AL 35294, USA
    Free Radic Res 37:585-96. 2003
  3. ncbi request reprint S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver
    Shannon M Bailey
    Department of Environmental Health Sciences, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Am J Physiol Gastrointest Liver Physiol 291:G857-67. 2006
  4. pmc Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE(-/-) mouse: implications for a "multihit" hypothesis of fatty liver disease
    Shannon M Bailey
    Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 46:928-38. 2009
  5. ncbi request reprint Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity
    Aparna Venkatraman
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 279:22092-101. 2004
  6. pmc High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo
    Sudheer K Mantena
    Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem J 417:183-93. 2009
  7. ncbi request reprint Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis
    Yavuz Cakir
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 43:1279-88. 2007
  8. doi request reprint Detection of protein thiols in mitochondrial oxidative phosphorylation complexes and associated proteins
    Kelly K Andringa
    Department of Environmental Health Sciences, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Methods Enzymol 474:83-108. 2010
  9. ncbi request reprint Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide
    Aparna Venkatraman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hepatology 38:141-7. 2003
  10. pmc Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
    Sudheer K Mantena
    Center for Free Radical Biology, Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 44:1259-72. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Mitochondrial proteomics in free radical research
    Shannon M Bailey
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, 1530 3rd Avenue South, Ryals Building, Room 623, Birmingham, AL 35294, USA
    Free Radic Biol Med 38:175-88. 2005
    ....
  2. ncbi request reprint A review of the role of reactive oxygen and nitrogen species in alcohol-induced mitochondrial dysfunction
    Shannon M Bailey
    Department of Environmental Health Sciences and Center for Free Radical Biology, School of Public Health, The University of Alabama at Birmingham, 1530 3rd Avenue South, Ryals Building, Room 623, Birmingham, AL 35294, USA
    Free Radic Res 37:585-96. 2003
    ....
  3. ncbi request reprint S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver
    Shannon M Bailey
    Department of Environmental Health Sciences, School of Public Health, University of Alabama, Birmingham, AL 35294, USA
    Am J Physiol Gastrointest Liver Physiol 291:G857-67. 2006
    ..These findings reveal new molecular targets through which SAM may work to alleviate one critical component of alcohol-induced liver injury: mitochondria dysfunction...
  4. pmc Ethanol and tobacco smoke increase hepatic steatosis and hypoxia in the hypercholesterolemic apoE(-/-) mouse: implications for a "multihit" hypothesis of fatty liver disease
    Shannon M Bailey
    Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 46:928-38. 2009
    ..These studies demonstrate that ETS increases alcohol-dependent steatosis and hypoxic stress. Therefore, ETS may be a key environmental "hit" that accelerates and exacerbates alcoholic liver disease in hypercholesterolemic apoE(-/-) mice...
  5. ncbi request reprint Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity
    Aparna Venkatraman
    Department of Pathology, University of Alabama, Birmingham, Alabama 35294, USA
    J Biol Chem 279:22092-101. 2004
    ..These data also suggest that the response of mitochondria to stress may not involve non-discriminate changes in the proteome but is restricted to those metabolic pathways that have a direct role in a specific pathology...
  6. pmc High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo
    Sudheer K Mantena
    Department of Environmental Health Sciences, Center for Free Radical Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem J 417:183-93. 2009
    ..These findings indicate that chronic exposure to a HFD negatively affects the bioenergetics of liver mitochondria and this probably contributes to hypoxic stress and deleterious NO-dependent modification of mitochondrial proteins...
  7. ncbi request reprint Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis
    Yavuz Cakir
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 43:1279-88. 2007
    ....
  8. doi request reprint Detection of protein thiols in mitochondrial oxidative phosphorylation complexes and associated proteins
    Kelly K Andringa
    Department of Environmental Health Sciences, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Methods Enzymol 474:83-108. 2010
    ....
  9. ncbi request reprint Chronic alcohol consumption increases the sensitivity of rat liver mitochondrial respiration to inhibition by nitric oxide
    Aparna Venkatraman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hepatology 38:141-7. 2003
    ..We propose that this results in a greater vulnerability to hypoxia and the development of alcohol-induced hepatotoxicity...
  10. pmc Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases
    Sudheer K Mantena
    Center for Free Radical Biology, Department of Environmental Health Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 44:1259-72. 2008
    ....
  11. ncbi request reprint Nitroxia: the pathological consequence of dysfunction in the nitric oxide-cytochrome c oxidase signaling pathway
    Sruti Shiva
    Department of Pathology, University of Alabama at Birmingham, BMR II, 901 19th Street South, Birmingham, AL 35294, USA
    Free Radic Biol Med 38:297-306. 2005
    ..We term this unique pathological condition Nitroxia and describe how it may contribute to the pathology of chronic inflammatory diseases using ethanol-dependent hepatotoxicity as an example...
  12. pmc Proteomic approaches to identify and characterize alterations to the mitochondrial proteome in alcoholic liver disease
    Shannon M Bailey
    University of Alabama, Birmingham, AL, USA
    Methods Mol Biol 447:369-80. 2008
    ..These proteomic data can then be integrated into a logical and mechanistic framework to further our understanding of the role of mitochondrial dysfunction in the pathogenesis of alcohol-induced liver disease...
  13. ncbi request reprint Contribution of mitochondria to oxidative stress associated with alcoholic liver disease
    Shannon M Bailey
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, 1530 3rd Ave South, RPHB 317, Birmingham, AL 35294, USA
    Free Radic Biol Med 32:11-6. 2002
    ....
  14. ncbi request reprint Novel interactions of mitochondria and reactive oxygen/nitrogen species in alcohol mediated liver disease
    Sudheer K Mantena
    Department of Environmental Health Sciences, Center for Free Radical Biology, University of Alabama at Birmingham, Ryals Building, Room 623, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    World J Gastroenterol 13:4967-73. 2007
    ....
  15. ncbi request reprint The role of iNOS in alcohol-dependent hepatotoxicity and mitochondrial dysfunction in mice
    Aparna Venkatraman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hepatology 40:565-73. 2004
    ..In conclusion, the hepatic response to chronic alcohol-dependent cytotoxicity involves a change in mitochondrial function dependent on the induction of iNOS...
  16. ncbi request reprint Oxidative modification of hepatic mitochondria protein thiols: effect of chronic alcohol consumption
    Aparna Venkatraman
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Gastrointest Liver Physiol 286:G521-7. 2004
    ....
  17. pmc Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: effect on HMG-CoA synthase
    Kelly K Andringa
    Department of Environmental Health Sciences and The Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Toxicol Lett 177:188-97. 2008
    ..The pathophysiological relevance of these limited changes in protein thiols remains to be investigated...
  18. pmc Chronic ethanol consumption enhances sensitivity to Ca(2+)-mediated opening of the mitochondrial permeability transition pore and increases cyclophilin D in liver
    Adrienne L King
    Dept of Environmental Health Sciences, Center for Free Radical Biology, Univ of Alabama at Birmingham, AL 35294, USA
    Am J Physiol Gastrointest Liver Physiol 299:G954-66. 2010
    ..Therefore, therapeutic strategies aimed at normalizing Cyp D levels may be beneficial in preventing ethanol-dependent mitochondrial dysfunction and liver injury...
  19. doi request reprint Blue native-gel electrophoresis proteomics
    Kelly Andringa
    Department of Environmental Health Sciences, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Methods Mol Biol 519:241-58. 2009
    ..In this short overview the concepts and methods of BN-PAGE are presented, which demonstrate the power of using this complementary proteomics approach to identify alterations in the mitochondrial proteome that contribute to disease...
  20. pmc What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology
    Bradford G Hill
    Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2180, USA
    J Biol Chem 285:19699-704. 2010
    ..In this minireview, we emphasize the current understanding of the biochemistry of NO and place it in a biological context...

Research Grants13

  1. Chronic Alcohol and Liver Oxidative Stress
    Shannon Bailey; Fiscal Year: 2003
    ..This investigation should thus provide information on ethanol-elicited alterations that contribute to oxidative damage in the liver. ..
  2. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2010
    ....
  3. Mitochondrial Mechanisms of Hydrogen Sulfide Induced Suspended Animation
    SHANNON MARIE BAILEY; Fiscal Year: 2010
    ....
  4. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    Shannon Bailey; Fiscal Year: 2009
    ....
  5. Redox Modification of Thiols in Alcohol Hepatotoxicity
    Shannon Bailey; Fiscal Year: 2007
    ..New information on the molecular targets of SAM will also be achieved, which will enable the design of effective therapeutic strategies to treat liver diseases. ..
  6. Proteomics of Oxidant-Induced Mitochondrial Damage in an Animal Model of NASH
    Shannon Bailey; Fiscal Year: 2007
    ..The studies in this application are important as they will identify the underlying factors responsible for obesity-related liver diseases, which will lead to the discovery of new treatments. ..
  7. Alcoholic Liver Dysfunction Potentiation by Hyperlipidemia and Cigarette Smoke
    SHANNON MARIE BAILEY; Fiscal Year: 2010
    ....