H Bagavant

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes
    Harini Bagavant
    Department of Internal Medicine, Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 177:8258-65. 2006
  2. pmc Novel therapeutic approaches to lupus glomerulonephritis: translating animal models to clinical practice
    Harini Bagavant
    Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Kidney Dis 57:498-507. 2011
  3. ncbi request reprint Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis
    Harini Bagavant
    Department of Pathology and University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 175:944-50. 2005
  4. pmc Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease
    Harini Bagavant
    Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Pathol 179:651-60. 2011
  5. ncbi request reprint Differential effect of neonatal thymectomy on systemic and organ-specific autoimmune disease
    Harini Bagavant
    Health Sciences Center, Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Int Immunol 14:1397-406. 2002
  6. pmc Induction and immunohistology of autoimmune ovarian disease in cynomolgus macaques (Macaca fascicularis)
    Harini Bagavant
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Pathol 160:141-9. 2002
  7. ncbi request reprint Autoimmune ovarian inflammation triggered by proinflammatory (Th1) T cells is compatible with normal ovarian function in mice
    H Bagavant
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 61:635-42. 1999
  8. ncbi request reprint Autoimmune ovarian disease: mechanism of induction and prevention
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Soc Gynecol Investig 8:S49-51. 2001
  9. pmc Genetic complementation results in augmented autoantibody responses to lupus-associated antigens
    Davis L Sim
    Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 183:3505-11. 2009
  10. doi request reprint Autoimmune ovarian disease induced by immunization with zona pellucida (ZP3) peptide
    Kenneth Tung
    University of Virginia, Charlottesville, Virginia, USA
    Curr Protoc Immunol . 2002

Research Grants

  1. Regulatory T cells in Systemic Lupus Erythematosus
    Harini Bagavant; Fiscal Year: 2007
  2. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2006
  3. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2007
  4. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2009
  5. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2010
  6. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2009

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Role for nephritogenic T cells in lupus glomerulonephritis: progression to renal failure is accompanied by T cell activation and expansion in regional lymph nodes
    Harini Bagavant
    Department of Internal Medicine, Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 177:8258-65. 2006
    ..This T cell activation and infiltration are influenced by gender-dependent end-organ factors and may determine the progression of acute GN to chronic GN and renal failure...
  2. pmc Novel therapeutic approaches to lupus glomerulonephritis: translating animal models to clinical practice
    Harini Bagavant
    Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Am J Kidney Dis 57:498-507. 2011
    ..This review describes recently developed targeted drug delivery technologies and potential targets that can regulate glomerular cell responses, offering a novel therapeutic approach for lupus nephritis...
  3. ncbi request reprint Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and sialoadenitis
    Harini Bagavant
    Department of Pathology and University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 175:944-50. 2005
    ..After d3tx, the proliferative GN of female mice progressed to fatal GN, but largely regressed in the male, thereby revealing a checkpoint in lupus GN progression that depends on gender...
  4. pmc Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein E-deficient mice: a model linking hyperlipidemia and renal disease
    Harini Bagavant
    Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Pathol 179:651-60. 2011
    ..Our study shows that some of these factors are regulated by ID3. Thus, ID3 is a novel risk factor linking cardiovascular and renal disease...
  5. ncbi request reprint Differential effect of neonatal thymectomy on systemic and organ-specific autoimmune disease
    Harini Bagavant
    Health Sciences Center, Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Int Immunol 14:1397-406. 2002
    ..Therefore, d3tx paradoxically protects SNF1 mice from genetically prone lupus-like GN, yet promotes de novo organ-specific autoimmunity...
  6. pmc Induction and immunohistology of autoimmune ovarian disease in cynomolgus macaques (Macaca fascicularis)
    Harini Bagavant
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Pathol 160:141-9. 2002
    ..The results are discussed in the context of complications of ZP-based human immunocontraceptive vaccines and case reports of human autoimmune oophoritis...
  7. ncbi request reprint Autoimmune ovarian inflammation triggered by proinflammatory (Th1) T cells is compatible with normal ovarian function in mice
    H Bagavant
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    Biol Reprod 61:635-42. 1999
    ..Despite these changes, fertility rates and gonadotropin-induced follicular development remained essentially normal. Therefore, normal ovarian function is compatible with severe ovarian inflammation mediated by autoreactive T cells...
  8. ncbi request reprint Autoimmune ovarian disease: mechanism of induction and prevention
    K S Tung
    Department of Pathology, University of Virginia, Charlottesville, Virginia 22908, USA
    J Soc Gynecol Investig 8:S49-51. 2001
    ..Future studies should determine the applicability of these findings to human ovarian autoimmunity...
  9. pmc Genetic complementation results in augmented autoantibody responses to lupus-associated antigens
    Davis L Sim
    Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 183:3505-11. 2009
    ..In NZM/NOD F(1) mouse, genetic complementation between NZM and NOD genes leads to expression of phenotypes similar to those seen in certain lupus patients...
  10. doi request reprint Autoimmune ovarian disease induced by immunization with zona pellucida (ZP3) peptide
    Kenneth Tung
    University of Virginia, Charlottesville, Virginia, USA
    Curr Protoc Immunol . 2002
    ..Surgical procedures are included for adult oophrectomy, neonatal ovariectomy, and implantation of ovarian grafts into mice without endogenous ovaries...
  11. pmc Type I interferon receptor deficiency prevents murine Sjogren's syndrome
    B M Szczerba
    Division of Nephrology, Center for Immunity Inflammation and Regenerative Medicine, University of Florida, Gainesville, FL, USA
    J Dent Res 92:444-9. 2013
    ..Our study suggests that, in genetically susceptible individuals, the type I IFN pathway can instigate certain features of SS...
  12. ncbi request reprint Immunogenicity and contraceptive potential of a human zona pellucida 3 peptide vaccine
    H Bagavant
    Department of Pathology, University of Virginia, Charlottesville 22908, USA
    Biol Reprod 56:764-70. 1997
    ....
  13. pmc Pathogenesis of kidney disease in systemic lupus erythematosus
    Harini Bagavant
    Division of Nephrology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    Curr Opin Rheumatol 21:489-94. 2009
    ..A combination of systemic autoimmunity and tissue response to immune injury underlie renal involvement in lupus erythematosus. In this review, we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis...
  14. pmc Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antigens
    Chao Jiang
    Division of Rheumatology and Immunology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Immunol 184:1085-91. 2010
    ..In addition, our findings provide insights into the origin of the anti-dsDNA Abs often detected in patients with systemic lupus erythematosus...
  15. pmc Breaking tolerance to double stranded DNA, nucleosome, and other nuclear antigens is not required for the pathogenesis of lupus glomerulonephritis
    Samuel T Waters
    The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Exp Med 199:255-64. 2004
    ..These results reaffirm that anti-dsDNA and related Ab production and chronic glomerulonephritis are under independent genetic control. These findings have significant implications in the pathogenesis of systemic lupus erythematosus...
  16. ncbi request reprint Role of anti-DNA antibodies in the pathogenesis of lupus nephritis
    Umesh S Deshmukh
    Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Autoimmun Rev 5:414-8. 2006
    ..Thus, reactivity to dsDNA should be considered as one of the characteristic of polyreactive autoantibodies and not a primary requisite for the pathogenesis of lupus nephritis...
  17. pmc Activation of innate immune responses through Toll-like receptor 3 causes a rapid loss of salivary gland function
    Umesh S Deshmukh
    Division of Rheumatology, Center for Immunity, Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Oral Pathol Med 38:42-7. 2009
    ..As viral infections are considered to be a trigger for SS, in this study we investigated whether in vivo engagement of TLR3 affects salivary gland function...
  18. ncbi request reprint Epitope spreading within lupus-associated ribonucleoprotein antigens
    Umesh S Deshmukh
    Division of Rheumatology and Immunology, Specialized Center of Research on Systemic Lupus Erythematosus, Department of Internal Medicine, HSC Box 800412, University of Virginia, Charlottesville, VA 22908, USA
    Clin Immunol 117:112-20. 2005
    ..This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis...
  19. ncbi request reprint A SmD peptide induces better antibody responses to other proteins within the small nuclear ribonucleoprotein complex than to SmD protein via intermolecular epitope spreading
    Umesh S Deshmukh
    Specialized Center of Research on Systemic Lupus Erythematosus, Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:2565-71. 2007
    ..Thus caution must be taken in the identification of Ags responsible for initiating autoimmune responses based solely on serological analysis of patients and animals with systemic autoimmune disorders...
  20. pmc Alum, an aluminum-based adjuvant, induces Sjögren's syndrome-like disorder in mice
    H Bagavant
    Division of Nephrology, University of Virginia, Charlottesville, VA and Arthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Clin Exp Rheumatol 32:251-5. 2014
    ..This study investigates the role of alum, an aluminum-based adjuvant in the induction of Sjögren's syndrome-like disorder in mice...
  21. pmc Activation of innate immunity accelerates sialoadenitis in a mouse model for Sjögren's syndrome-like disease
    S R Nandula
    Division of Nephrology, Center for Immunity Inflammation and Regenerative Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Oral Dis 17:801-7. 2011
    ..This study was undertaken to investigate the effects of innate immunity activation on sialoadenitis in a mouse strain genetically susceptible for development of SS-like disease...
  22. ncbi request reprint Lupus glomerulonephritis revisited 2004: autoimmunity and end-organ damage
    H Bagavant
    The University of Virginia Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Scand J Immunol 60:52-63. 2004
    ..The data discussed in this review call for a re-evaluation of the current paradigms for pathogenesis of SLE. An interactive model separating autoimmunity from end-organ susceptibility for the pathogenesis of SLE is proposed...
  23. pmc Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+ CD25+ regulatory T cells
    Yulius Y Setiady
    Department of Pathology, University of Virginia, Charlottesville, VA 22908, USA
    Blood 107:1056-62. 2006
    ..We conclude that the physiologic autoAg quickly and continuously enhances disease-specific polyclonal Treg function to maintain self-tolerance...
  24. pmc Anti-alpha8 integrin immunoliposomes in glomeruli of lupus-susceptible mice: a novel system for delivery of therapeutic agents to the renal glomerulus in systemic lupus erythematosus
    Yogesh Scindia
    University of Virginia, Charlottesville, VA 22908, USA
    Arthritis Rheum 58:3884-91. 2008
    ..This study was undertaken in a mouse model of lupus GN to identify mesangial markers and to develop a system for targeted drug delivery to the glomerulus...
  25. ncbi request reprint New insights from murine lupus: disassociation of autoimmunity and end organ damage and the role of T cells
    Harini Bagavant
    Specialized Center of Research on Systemic Lupus Erythematosus, University of Virginia, Charlottesville, 22908, USA
    Curr Opin Rheumatol 17:523-8. 2005
    ..Recent findings conflicting with the current paradigm that loss of tolerance to chromatin is the critical step for end-organ injury are discussed...
  26. pmc Inflammatory stimuli accelerate Sjögren's syndrome-like disease in (NZB x NZW)F1 mice
    Umesh S Deshmukh
    University of Virginia, Charlottesville, VA 22908, USA
    Arthritis Rheum 58:1318-23. 2008
    ..This study was undertaken to determine whether induction of systemic inflammation accelerates the development of Sjögren's syndrome (SS) in genetically susceptible mice...
  27. ncbi request reprint The role of Fas in the immune system biology of IL-2R alpha knockout mice: interplay among regulatory T cells, inflammation, hemopoiesis, and apoptosis
    Rahul Sharma
    Division of Rheumatology and Immunology, Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908 0412, USA
    J Immunol 175:1965-73. 2005
    ....

Research Grants7

  1. Regulatory T cells in Systemic Lupus Erythematosus
    Harini Bagavant; Fiscal Year: 2007
    ..This award will help to overcome the lag period in my career induced by my leave of absence and return to a new field of study, and will facilitate my aim of becoming an independent scientist. ..
  2. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2006
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  3. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2007
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  4. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2009
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  5. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2010
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..
  6. Autoimmunity and Pathogenesis of Glomerulonephritis
    Harini Bagavant; Fiscal Year: 2009
    ..These studies will provide insights into pathogenesis of lupus nephritis and identify checkpoints for intervention in patients. ..