Research Topics
| J M BaetenSummaryAffiliation: University of Washington Country: USA Publications
| Collaborators
|
Detail Information
Publications
Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2C Celum
Department of Global Health, University of Washington, Harborview Medical Center, 325 Ninth Ave, Box 359927, Seattle, WA 98104, USA
N Engl J Med 362:427-39. 2010..Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV-1...- Risk Factors for HSV-2 Infection among Sexual Partners of HSV-2/HIV-1 Co-Infected PersonsAndrew Mujugira
Department of Global Health, University of Washington, Seattle, WA, USA
BMC Res Notes 4:64. 2011..abstract:.. 
Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective studySusan M Graham
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
BMC Infect Dis 7:63. 2007..However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression...
Trends in HIV-1 incidence in a cohort of prostitutes in Kenya: implications for HIV-1 vaccine efficacy trialsJ M Baeten
Departments of Epidemiology, Biostatistics, and Medicine, University of Washington, Seattle, Washington, USA
J Acquir Immune Defic Syndr 24:458-64. 2000..Little information is available on the estimated incidence of HIV-1 in such populations, especially information on incidence over time and incidence while participating in risk-reduction programs...- Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couplesJared M Baeten
University of Washington, WA, USA
AIDS 24:737-44. 2010.... - Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan womenJared M Baeten
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Int J STD AIDS 18:202-6. 2007.... - Prospective study of correlates of vaginal Lactobacillus colonisation among high-risk HIV-1 seronegative womenJ M Baeten
Department of Global Health, University of Washington, Seattle, Washington 98104, USA
Sex Transm Infect 85:348-53. 2009..Identification of factors associated with vaginal Lactobacillus colonisation may suggest interventions to improve vaginal health... - Herpes simplex virus (HSV)-suppressive therapy decreases plasma and genital HIV-1 levels in HSV-2/HIV-1 coinfected women: a randomized, placebo-controlled, cross-over trialJared M Baeten
Department of Global Health, University of Washington, Seattle, WA 98104, USA
J Infect Dis 198:1804-8. 2008..001]), as was cervical HIV-1 level (-0.35 log10 copies/swab, a 55% decrease [P < .001]). Suppressive HSV-2 therapy has the potential to reduce HIV-1 infectiousness and slow HIV-1 disease progression... - The influence of hormonal contraceptive use on HIV-1 transmission and disease progressionJared M Baeten
Department of Medicine, University of Washington, Seattle, WA, USA
Clin Infect Dis 45:360-9. 2007..Safe and effective contraceptive choices are essential for women with and at risk for HIV-1 infection. Thus, understanding the effect, if any, of hormonal contraception on HIV-1 disease among women is a public health priority... - Female-to-male infectivity of HIV-1 among circumcised and uncircumcised Kenyan menJared M Baeten
Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
J Infect Dis 191:546-53. 2005..e., infectivity) for circumcised and uncircumcised men, by use of detailed accounts of sexual behavior in a population with multiple partnerships... - Measuring the infectiousness of persons with HIV-1: opportunities for preventing sexual HIV-1 transmissionJared M Baeten
Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
Curr HIV Res 1:69-86. 2003..Unresolved issues related to optimal measurement techniques for genital HIV-1, promises and limitations of antiretroviral therapy and vaccines to reduce infectiousness, and other intervention strategies still in development are reviewed... - Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase responseJared M Baeten
Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
Am J Clin Nutr 79:218-25. 2004..The performance of RBP in the context of infection or protein malnutrition, however, has not been evaluated... - HIV-1 infection alters the retinol-binding protein:transthyretin ratio even in the absence of the acute phase responseJared M Baeten
Department of Epidemiology, University of Washington, Seattle, WA, USA
J Nutr 136:1624-9. 2006..Our results raise questions about the utility of this measurement given the high prevalence of HIV-1 infection in areas where vitamin A deficiency is common... - Vitamin A deficiency and the acute phase response among HIV-1-infected and -uninfected women in KenyaJared M Baeten
Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
J Acquir Immune Defic Syndr 31:243-9. 2002..These results provide possible explanations for the disparity between observational studies and randomized trials of vitamin A for HIV-1 infection... - Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmissionJared M Baeten
Department of Global Health, University of Washington, Seattle, WA 98195, USA
Sci Transl Med 3:77ra29. 2011..These data suggest that HIV-1 RNA in genital secretions could be used as a marker of HIV-1 sexual transmission risk... - Vitamin A supplementation and human immunodeficiency virus type 1 shedding in women: results of a randomized clinical trialJared M Baeten
Department of Epidemiology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
J Infect Dis 185:1187-91. 2002..Vitamin A supplementation is unlikely to decrease the infectivity of women infected with HIV-1... - Hormonal contraception and risk of sexually transmitted disease acquisition: results from a prospective studyJ M Baeten
Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
Am J Obstet Gynecol 185:380-5. 2001..To examine the relationship between use of oral contraceptive pills or depot medroxyprogesterone acetate and sexually transmitted disease acquisition... - Selenium deficiency is associated with shedding of HIV-1--infected cells in the female genital tractJ M Baeten
Department of Epidemiology, University of Washington, Seattle, 98104 2499, USA
J Acquir Immune Defic Syndr 26:360-4. 2001..To assess the relation between selenium deficiency and vaginal or cervical shedding of HIV-1-infected cells... - Pregnancy complications and outcomes among overweight and obese nulliparous womenJ M Baeten
Department of Epidemiology, University of Washington, 325 Ninth Ave, Box 359909, Seattle, WA 98104 2499, USA
Am J Public Health 91:436-40. 2001..This study examined the associations between prepregnancy weight and the risk of pregnancy complications and adverse outcomes among nulliparous women... - Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan womenJared M Baeten
Seattle HIV Prevention Trials Unit, Department of Medicine, University of Washington, 9012 Boren Avenue, Seattle, WA 98104, USA
AIDS 21:1771-7. 2007..A recent study from Uganda and Zimbabwe found that women using hormonal contraception were at increased risk for HIV-1 if they were seronegative for herpes simplex virus type 2 (HSV-2), but not if they were HSV-2 seropositive... - Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trialJared M Baeten
Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
J Infect Dis 189:1466-71. 2004..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity... - Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan womenLudo Lavreys
Departments of Epidemiology and Medicine, University of Washington, Seattle 98104 2499, USA
AIDS 18:2179-84. 2004..To evaluate the relationship between hormonal contraceptive use and the acquisition of cervical sexually transmitted infections (STI) among HIV-1-infected women... - Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progressionAnne Piantadosi
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Virol 83:10269-74. 2009..Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection... - Heterosexual HIV-1 transmission after initiation of antiretroviral therapy: a prospective cohort analysisDeborah Donnell
Statistical Center for HIV AIDS Research and Prevention and the Vaccine and Infectious Disease Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Lancet 375:2092-8. 2010..Initiation of antiretroviral therapy (ART) reduces plasma HIV-1 concentrations. We aimed to assess the effect of ART use by patients infected with HIV-1 on risk of transmission to their uninfected partners... 
High Mycoplasma genitalium organism burden is associated with shedding of HIV-1 DNA from the cervixLisa E Manhart
Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
J Infect Dis 197:733-6. 2008..genitalium-negative women (adjusted OR, 2.9 [95% confidence interval, 1.1-7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count)...- HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loadsJared M Baeten
Department of Medicine, University of Washington, Seattle, WA, USA
J Infect Dis 195:1177-80. 2007..There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads... - Quantification of genital human immunodeficiency virus type 1 (HIV-1) DNA in specimens from women with low plasma HIV-1 RNA levels typical of HIV-1 nontransmittersSarah Benki
Department of Microbiology, University of Washington, Seattle, WA 98109, USA, and Coast Provincial General Hospital, Mombasa, Kenya
J Clin Microbiol 44:4357-62. 2006..The assay described here can be utilized in future efforts to examine the role of cell-associated HIV-1 in transmission... - Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 populationManish Sagar
Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue, Seattle, WA 98109, USA
AIDS 18:615-9. 2004..CONCLUSION: The presence of genital tract infections and hormonal contraceptive use at the time of transmission were associated with the acquisition of multiple HIV-1 variants... - Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohortJared M Baeten
University of Washington, Seattle, WA, USA
J Acquir Immune Defic Syndr 38:S18-21. 2005 - Reducing HIV-1 transmission through prevention strategies targeting HIV-1-seropositive individualsR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA, USA
J Antimicrob Chemother 57:163-6. 2006..Further work is urgently needed to develop, test and implement comprehensive strategies for prevention in positives... - Efficient use of longitudinal CD4 counts and viral load measures in survival analysisS E Holte
Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Stat Med 31:2086-97. 2012..Moreover, the FPC scores are shown to be a more powerful prognostic factor than other common summaries when used in survival analysis... - High levels of cervical HIV-1 RNA during early HIV-1 infectionLudo Lavreys
Department of Epidemiology, University of Washington, Seattle, Washington, USA
AIDS 20:2389-90. 2006..43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006)... - A prospective study of risk factors for bacterial vaginosis in HIV-1-seronegative African womenR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Sex Transm Dis 35:617-23. 2008..Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1... - HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune responseAnne Piantadosi
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
AIDS 23:579-87. 2009..To evaluate relationships between HIV-1 evolution, including immune evasion, and markers of disease progression during chronic infection... - A prospective study of risk factors for herpes simplex virus type 2 acquisition among high-risk HIV-1 seronegative women in KenyaV Chohan
Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
Sex Transm Infect 85:489-92. 2009..The objective of this analysis was to determine the incidence and risk factors for HSV-2 acquisition among HIV-1-seronegative female sex workers in Kenya... - Increased risk of genital ulcer disease in women during the first month after initiating antiretroviral therapySusan M Graham
Departments of Medicine, Epidemiology and Global Health, University of Washington, Seattle, WA 98104 2499, USA
J Acquir Immune Defic Syndr 52:600-3. 2009..To better define this risk, we monitored 134 women at ART initiation and monthly thereafter... - Daily acyclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trialJairam R Lingappa
Department of Global Health, Seattle, WA, USA
Lancet 375:824-33. 2010..Daily suppression of this herpes virus reduces plasma HIV-1 concentrations, but whether it delays HIV-1 disease progression is unknown. We investigated the effect of acyclovir on HIV-1 progression... - Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in womenLudo Lavreys
Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, Washington 98104 2499, USA
J Infect Dis 189:303-11. 2004..These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection... - Frequent detection of human adenovirus from the lower gastrointestinal tract in men who have sex with menMarcel E Curlin
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
PLoS ONE 5:e11321. 2010.... - Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan womenLudo Lavreys
University of Washington, Seattle, WA, 98104, USA
Clin Infect Dis 35:77-81. 2002..4 log(10) copies/mL... - HIV-1 acquisition and disease progression are associated with decreased high-risk sexual behaviour among Kenyan female sex workersR Scott McClelland
Departments of Medicine, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
AIDS 20:1969-73. 2006..Changes in sexual risk behaviour may occur following HIV-1 infection... - Hormonal contraception and risk of HIV-1 acquisition: results of a 10-year prospective studyLudo Lavreys
Departments of Epidemiology and Medicine, University of Washington, Seattle, WA, USA
AIDS 18:695-7. 2004 - Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trialR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 37:1657-63. 2004..The potential benefit of micronutrient supplementation in HIV-1-seropositive women should be considered in relation to the potential for increased infectivity... - Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected womenPaul K Drain
Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
BMC Infect Dis 6:85. 2006..Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response... - Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisitionR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Infect Dis 195:698-702. 2007..52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women... - A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelinesR Scott McClelland
Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 41:611-5. 2006..Guidelines for initiating antiretrovirals are based on markers of advanced disease and are not directly linked to markers of HIV-1 transmission such as viral shedding... - Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African womenLudo Lavreys
Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, WA 98104 2499, USA
Clin Infect Dis 42:1333-9. 2006..We used data from a prospective cohort study of female sex workers in Mombasa, Kenya, who were followed up monthly from before the date of HIV-1 infection... - Vaginal washing and increased risk of HIV-1 acquisition among African women: a 10-year prospective studyR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
AIDS 20:269-73. 2006..No prospective study has examined the risk of HIV-1 acquisition associated with vaginal washing, although intravaginal practices have been identified as potentially important contributors to HIV-1 susceptibility... - A decrease in albumin in early HIV type 1 infection predicts subsequent disease progressionSusan M Graham
Department of Medicine, University of Washington, Seattle, Washington 98104, USA
AIDS Res Hum Retroviruses 23:1197-200. 2007..0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression... - Contribution of HIV-1 infection to acquisition of sexually transmitted disease: a 10-year prospective studyR Scott McClelland
Department of Medicine, University of Washington, Seattle, Washington 98104, USA
J Infect Dis 191:333-8. 2005..Sexually transmitted diseases (STDs) enhance human immunodeficiency virus (HIV)-1 susceptibility, but few studies have examined the reciprocal effect of HIV-1 on STD acquisition... - Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trialR Scott McClelland
Department of Medicine, University of Washington, Seattle, USA
J Infect Dis 197:1361-8. 2008..Vaginal infections are common and have been associated with increased risk for acquisition of human immunodeficiency virus type 1 (HIV-1)... - Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasisR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Infect Dis 199:1883-90. 2009..Our objective was to determine the relationship between vaginal bacterial flora and VVC... - Correlates of human herpesvirus 8 seropositivity among heterosexual men in KenyaJared M Baeten
Department of Epidemiology, University of Washington, Seattle 98104-2499, USA
AIDS 16:2073-8. 2002..Prospective studies of HHV-8 acquisition in heterosexual African populations are needed to demonstrate whether safer sexual practices can reduce transmission... - Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progressionManish Sagar
Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
J Virol 77:12921-6. 2003..01) 4 to 24 months after infection compared to women who were infected with a single viral genotype. These studies suggest that early HIV-1 genetic diversity is linked to faster disease progression... - Re: distinguishing the temporal association between women's intravaginal practices and risk of human immunodeficiency virus infection: a prospective study of South African womenR Scott McClelland
Am J Epidemiol 165:474-5; author reply 475-6. 2007