E H Baehrecke

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi who encodes a KH RNA binding protein that functions in muscle development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Development 124:1323-32. 1997
  2. ncbi Growth control: p53, the guardian angel of compensatory proliferation
    Eric H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Curr Biol 16:R840-2. 2006
  3. pmc Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila
    Deborah L Berry
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    Cell 131:1137-48. 2007
  4. pmc Visualization and analysis of microarray and gene ontology data with treemaps
    Eric H Baehrecke
    University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    BMC Bioinformatics 5:84. 2004
  5. ncbi How death shapes life during development
    Eric H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Nat Rev Mol Cell Biol 3:779-87. 2002
  6. ncbi Autophagy: dual roles in life and death?
    Eric H Baehrecke
    Eric H Baehrecke is at the Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Nat Rev Mol Cell Biol 6:505-10. 2005
  7. ncbi Steroid regulation of programmed cell death during Drosophila development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland, MD 20742, USA
    Cell Death Differ 7:1057-62. 2000
  8. ncbi miRNAs: micro managers of programmed cell death
    Eric H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park 20742, USA
    Curr Biol 13:R473-5. 2003
  9. ncbi Steroid regulation of autophagic programmed cell death during development
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Development 128:1443-55. 2001
  10. ncbi E93 directs steroid-triggered programmed cell death in Drosophila
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Mol Cell 6:433-43. 2000

Research Grants

  1. Genetic regulation of autophagic cell death
    ERIC BAEHRECKE; Fiscal Year: 2007

Collaborators

  • J Chen
  • Ben Shneiderman
  • Miklos Sass
  • Thomas Neufeld
  • Israel Muro
  • Soon Ji Yoo
  • Nicholas A DiProspero
  • Guido Kroemer
  • Bruce Hay
  • Sharad Kumar
  • Li Yu
  • Ming Guo
  • Deborah L Berry
  • Cheng Yu Lee
  • Udai Bhan Pandey
  • C Y Lee
  • Gabor Juhasz
  • Sudeshna Dutta
  • D N Martin
  • J Paul Taylor
  • Yakup Batlevi
  • Tina M Fortier
  • Jayanta Debnath
  • Craig T Woodard
  • Damali N Martin
  • Dimitrios Cakouros
  • Ying Yan
  • Jonathan M Backer
  • Jahda H Hill
  • Marc Hild
  • Charlotte C Hubbert
  • Melanie A Knight
  • S Kantartzis
  • Ranjani Padmanabhan
  • Tso Pang Yao
  • Natalia B Nedelsky
  • Brett A McCray
  • Gillian P Ritson
  • P Rudnick
  • C Lee
  • B Balgley
  • Oren Schuldiner
  • J Cranford
  • D L DeVoe
  • Zhiping Nie
  • Dan Garza
  • Stephanie L Schwartz
  • S Dutta
  • Runa Chatterjee
  • Susan Klinedinst
  • Tanya M Teslovich
  • Dietrich A Stephan
  • Emily A Clough
  • Paula Yellon
  • Bridget A K Cooksey
  • Damali Martin
  • Tasman Daish
  • Claudio R Simon
  • C S Thummel
  • P Reid
  • G Lam
  • D P Wendel

Detail Information

Publications32

  1. ncbi who encodes a KH RNA binding protein that functions in muscle development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Development 124:1323-32. 1997
    ..These results indicate that who plays an essential role in steroid regulation of muscle development...
  2. ncbi Growth control: p53, the guardian angel of compensatory proliferation
    Eric H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Curr Biol 16:R840-2. 2006
    ..Recent work has revealed a new role for Drosophila p53 in the compensatory proliferation of cells that are needed to repair damaged tissues, a role that requires the non-apoptotic function of the caspase protease Dronc...
  3. pmc Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila
    Deborah L Berry
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    Cell 131:1137-48. 2007
    ....
  4. pmc Visualization and analysis of microarray and gene ontology data with treemaps
    Eric H Baehrecke
    University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    BMC Bioinformatics 5:84. 2004
    ..The use of Gene Ontology enables researchers to summarize results of quantitative analyses in this framework, but the limitations of typical browser presentation restrict data access...
  5. ncbi How death shapes life during development
    Eric H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Nat Rev Mol Cell Biol 3:779-87. 2002
    ..Recent studies indicate that cells can die by many different mechanisms, and these differences have implications for proper animal development and disorders such as cancer and autoimmunity...
  6. ncbi Autophagy: dual roles in life and death?
    Eric H Baehrecke
    Eric H Baehrecke is at the Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Nat Rev Mol Cell Biol 6:505-10. 2005
    ..Here I discuss the possible roles for autophagy in dying cells and how understanding the relationship between autophagy, cell survival and cell death is important for health and development...
  7. ncbi Steroid regulation of programmed cell death during Drosophila development
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland, MD 20742, USA
    Cell Death Differ 7:1057-62. 2000
    ..This article reviews the current knowledge of steroid signaling and the regulation of programmed cell death during development of Drosophila...
  8. ncbi miRNAs: micro managers of programmed cell death
    Eric H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park 20742, USA
    Curr Biol 13:R473-5. 2003
    ..Genomes encode numerous small RNAs, but the function of these molecules has been elusive. Recent studies show that two distinct microRNAs regulate programmed cell death, and provide new mechanisms for the regulation of animal development...
  9. ncbi Steroid regulation of autophagic programmed cell death during development
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park, Maryland 20742, USA
    Development 128:1443-55. 2001
    ..In contrast, E93 expression is sufficient to induce the removal of cells by phagocytes in the absence of the H99 genes. These studies indicate that apoptosis and autophagy utilize some common regulatory mechanisms...
  10. ncbi E93 directs steroid-triggered programmed cell death in Drosophila
    C Y Lee
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Mol Cell 6:433-43. 2000
    ..Furthermore, expression of E93 is sufficient to induce programmed cell death. We propose that the steroid induction of E93 determines a programmed cell death response during development...
  11. ncbi Ecdysone signaling cascade and regulation of Drosophila metamorphosis
    E H Baehrecke
    Center for Agricultural Biotechnology, University of Maryland Biotechnology Institute, College Park 20742, USA
    Arch Insect Biochem Physiol 33:231-44. 1996
    ..The regulation and function of these genes is discussed in the context of the cell- and tissue-specific changes required for the reorganization of a larva to form an adult fly...
  12. ncbi Steroid regulation of midgut cell death during Drosophila development
    Cheng Yu Lee
    Center for Biosystems Research, University of Maryland Biotechnology Institute, University of Maryland, College Park, Maryland 20742, USA
    Dev Biol 250:101-11. 2002
    ..These studies indicate that ecdysone triggers a two-step hierarchy composed of steroid-induced regulatory genes and apoptosis genes that, in turn, regulate the autophagic death of midgut cells during development...
  13. ncbi Caspases function in autophagic programmed cell death in Drosophila
    Damali N Martin
    Center for Biosystems Research, University of Maryland Biotechnology Institute, and Department of Cell Biology, University of Maryland, College Park, Maryland 20742, USA
    Development 131:275-84. 2004
    ..These studies suggest that aspects of the cytoskeleton may be required for changes in dying salivary glands. Furthermore, caspases are not only used during apoptosis, but also function in the regulation of autophagic cell death...
  14. ncbi Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development
    D N Martin
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742 4450, USA
    Cell Death Differ 14:916-23. 2007
    ..Wts regulates cell-cycle arrest and apoptosis, and significantly, mutations in wts prevent destruction of salivary glands...
  15. ncbi Autophagic programmed cell death in Drosophila
    E H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    Cell Death Differ 10:940-5. 2003
    ..This article reviews the current knowledge of the regulation of autophagic programmed cell death during development of Drosophila...
  16. pmc Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila
    Sudeshna Dutta
    Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
    Curr Biol 18:1466-75. 2008
    ..Although the Warts (Wts) tumor suppressor is a critical regulator of tissue growth in animals, it is not clear how this signaling pathway controls cell growth...
  17. ncbi Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila
    Cheng Yu Lee
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, 20742, USA
    Dev Biol 252:138-48. 2002
    ..Together, these observations indicate that betaFTZ-F1 regulates the timing of hormone-induced cell responses, while E93 functions to specify programmed cell death...
  18. ncbi Caspase activation finds fertile ground
    Eric H Baehrecke
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    Dev Cell 4:608-9. 2003
    ..Recent work demonstrates that cytochrome c and caspases function in Drosophila sperm cell differentiation and indicates that caspase activity can be regulated in a subcellular manner in cells that live...
  19. ncbi Autophagy and caspases: a new cell death program
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Cell Cycle 3:1124-6. 2004
    ..The factors that enable autophagy to regulate distinct cell survival and death responses are not clear, and future work is needed to determine the mechanism(s) that regulate autophagic cell death...
  20. ncbi Integration of capillary isoelectric focusing with capillary reversed-phase liquid chromatography for two-dimensional proteomics separation
    Jinzhi Chen
    Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA
    Electrophoresis 23:3143-8. 2002
    ..The results of our preliminary studies display significant differences in the separation profiles of peptide samples obtained from salivary glands of animals staged at the 6 and 12 h following puparium formation...
  21. ncbi Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila
    Cheng Yu Lee
    Center for Biosystems Research, University of Maryland Biotechnology Institute and Department of Medicine, University of Maryland, College Park, MD 20742, USA
    Curr Biol 13:350-7. 2003
    ..This study also identifies numerous novel genes as candidate cell death regulators and suggests new links between apoptosis and autophagic cell death...
  22. ncbi How functions in leg development during Drosophila metamorphosis
    Tina M Fortier
    Department of Biological Sciences, Mount Holyoke College, South Hadley, Massachusetts 01075, USA
    Dev Dyn 235:2248-59. 2006
    ..Consequently, how mutants exhibit short, crooked legs. Our findings suggest that how functions in interactions between imaginal epithelium, peripodial epithelium, and larval epidermal cells during imaginal disc eversion...
  23. ncbi The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process
    Israel Muro
    Division of Biology, MC 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Development 133:3305-15. 2006
    ..Finally, we demonstrate that Ice participates in, but is not absolutely required for, the non-apoptotic process of spermatid differentiation...
  24. pmc Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex
    Dimitrios Cakouros
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, Adelaide, SA 5000, Australia
    J Cell Biol 157:985-95. 2002
    ..Finally, we show that the dronc promoter has BR-C interaction sites, and that it can be transactivated by a specific isoform of BR-C. These results indicate that BR-C plays a key role in ecdysone-mediated caspase regulation...
  25. pmc Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila
    Thomas P Neufeld
    University of Minnesota, Department of Genetics, Cell Biology and Development, Minneapolis, Minnesota 55455, USA
    Autophagy 4:557-62. 2008
    ..We discuss genetic screening approaches that are being used to identify novel regulators and effectors of autophagy, and speculate about areas of research in this system likely to bear fruit in future studies...
  26. pmc Autophagy functions in programmed cell death
    Deborah L Berry
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Autophagy 4:359-60. 2008
    ..Our results provide the first in vivo evidence that autophagy and the Atg genes are required for autophagic cell death and confirm that autophagic cell death is a physiological death program that occurs during development...
  27. pmc The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila
    Gabor Juhasz
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    J Cell Biol 181:655-66. 2008
    ..Our results suggest that Vps34 is regulated by TOR-dependent nutrient signals directly at sites of autophagosome formation...
  28. ncbi Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 304:1500-2. 2004
    ..Clinical therapies involving caspase inhibitors may arrest apoptosis but also have the unanticipated effect of promoting autophagic cell death...
  29. ncbi HDAC6 at the intersection of autophagy, the ubiquitin-proteasome system and neurodegeneration
    Udai Bhan Pandey
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Autophagy 3:643-5. 2007
    ..Our findings indicate that HDAC6 facilitates degradation of potentially noxious protein substrates, contributing vitally to the neuroprotective role of autophagy...
  30. ncbi HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
    Udai Bhan Pandey
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Nature 447:859-63. 2007
    ..Morover, these findings suggest that it may be possible to intervene in neurodegeneration by augmenting HDAC6 to enhance autophagy...
  31. pmc Autophagic programmed cell death by selective catalase degradation
    Li Yu
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
    Proc Natl Acad Sci U S A 103:4952-7. 2006
    ..These findings unveil a molecular mechanism for the role of autophagy in cell death and provide insight into the complex relationship between ROS and nonapoptotic programmed cell death...
  32. ncbi Does autophagy contribute to cell death?
    Jayanta Debnath
    Department of Pathology, University of California San Francisco, San Francisco, California, USA
    Autophagy 1:66-74. 2005
    ..Here, we review the emerging evidence in favor of and against autophagic cell death, discuss the possible roles that autophagic degradation might play in dying cells, and identify salient issues for future investigation...

Research Grants1

  1. Genetic regulation of autophagic cell death
    ERIC BAEHRECKE; Fiscal Year: 2007
    ..The recent association of autophagic cell death with neurodegenerative disorders and cancer indicates the importance of investigating this understudied form of programmed cell death. ..