Stephen F Badylak

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Decellularized Allogeneic and Xenogeneic Tissue as a Bioscaffold for Regenerative Medicine: Factors that Influence the Host Response
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA, 15219 3130, USA
    Ann Biomed Eng 42:1517-27. 2014
  2. doi request reprint Biologic scaffold remodeling in a dog model of complex musculoskeletal injury
    Neill J Turner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Surg Res 176:490-502. 2012
  3. pmc Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation
    Vineet Agrawal
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15213, USA
    Tissue Eng Part A 18:1454-63. 2012
  4. ncbi request reprint The extracellular matrix as a biologic scaffold material
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 28:3587-93. 2007
  5. doi request reprint Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Annu Rev Biomed Eng 13:27-53. 2011
  6. pmc Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 17:1643-50. 2011
  7. ncbi request reprint Regenerative medicine and developmental biology: the role of the extracellular matrix
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, PA, USA
    Anat Rec B New Anat 287:36-41. 2005
  8. ncbi request reprint The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Transplant 15:S29-40. 2006
  9. ncbi request reprint Macrophage phenotype as a determinant of biologic scaffold remodeling
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Tissue Eng Part A 14:1835-42. 2008
  10. doi request reprint Extracellular matrix as a biological scaffold material: Structure and function
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Acta Biomater 5:1-13. 2009

Research Grants

  1. Mechanobiology and Regenerative Medicine
    Michael S Sacks; Fiscal Year: 2010
  2. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2000
  3. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2007
  4. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2003
  5. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2002
  6. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2006
  7. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2001
  8. Mechanobiology and Regenerative Medicine
    Stephen Badylak; Fiscal Year: 2009
  9. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen Badylak; Fiscal Year: 2009
  10. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2009

Collaborators

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Decellularized Allogeneic and Xenogeneic Tissue as a Bioscaffold for Regenerative Medicine: Factors that Influence the Host Response
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA, 15219 3130, USA
    Ann Biomed Eng 42:1517-27. 2014
    ....
  2. doi request reprint Biologic scaffold remodeling in a dog model of complex musculoskeletal injury
    Neill J Turner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Surg Res 176:490-502. 2012
    ..The aim of this study was to determine the ability of a xenogeneic ECM scaffold to restore functional skeletal muscle in a canine model of a complex quadriceps injury involving bone, tendon, and muscle...
  3. pmc Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation
    Vineet Agrawal
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Pittsburgh, PA 15213, USA
    Tissue Eng Part A 18:1454-63. 2012
    ....
  4. ncbi request reprint The extracellular matrix as a biologic scaffold material
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 28:3587-93. 2007
    ....
  5. doi request reprint Whole-organ tissue engineering: decellularization and recellularization of three-dimensional matrix scaffolds
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Annu Rev Biomed Eng 13:27-53. 2011
    ..Critical challenges and future directions are also discussed...
  6. pmc Esophageal preservation in five male patients after endoscopic inner-layer circumferential resection in the setting of superficial cancer: a regenerative medicine approach with a biologic scaffold
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 17:1643-50. 2011
    ..This experience provides evidence that a regenerative medicine approach may, for the first time, enable aggressive endoscopic resection of early stage neoplasia without the need for esophagectomy and its associated complications...
  7. ncbi request reprint Regenerative medicine and developmental biology: the role of the extracellular matrix
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, PA, USA
    Anat Rec B New Anat 287:36-41. 2005
    ..This article reviews composition of mammalian ECM, its poorly understood role in developmental biology, and the clinical applications that have resulted from the use of this naturally occurring scaffold...
  8. ncbi request reprint The use of extracellular matrix as an inductive scaffold for the partial replacement of functional myocardium
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Cell Transplant 15:S29-40. 2006
    ..We conclude that UBM facilitates a constructive remodeling of myocardial tissue when used as replacement scaffold for excisional defects...
  9. ncbi request reprint Macrophage phenotype as a determinant of biologic scaffold remodeling
    Stephen F Badylak
    Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Tissue Eng Part A 14:1835-42. 2008
    ..Routine histologic examination alone is inadequate to determine the phenotype of mononuclear cells that participate in the host response to the scaffold...
  10. doi request reprint Extracellular matrix as a biological scaffold material: Structure and function
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Acta Biomater 5:1-13. 2009
    ....
  11. pmc Immune response to biologic scaffold materials
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, United States
    Semin Immunol 20:109-16. 2008
    ..This manuscript provides an overview of studies that have evaluated the immune response to biologic scaffold materials and variables that affect this response...
  12. ncbi request reprint Esophageal reconstruction with ECM and muscle tissue in a dog model
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Surg Res 128:87-97. 2005
    ..We conclude that ECM bioscaffolds plus autologous muscle tissue, but not ECM scaffolds or muscle tissue alone, can facilitate the in situ reconstitution of structurally and functionally acceptable esophageal tissue...
  13. ncbi request reprint Xenogeneic extracellular matrix as a scaffold for tissue reconstruction
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Transpl Immunol 12:367-77. 2004
    ..The biologic response to these xenogeneic bioscaffolds, including the immune response, is discussed herein...
  14. pmc A hydrogel derived from decellularized dermal extracellular matrix
    Matthew T Wolf
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 33:7028-38. 2012
    ..These results show that ECM hydrogel properties can be varied and partially controlled by the scaffold tissue source, and that these properties can markedly affect cell behavior...
  15. pmc An elastomeric patch electrospun from a blended solution of dermal extracellular matrix and biodegradable polyurethane for rat abdominal wall repair
    Yi Hong
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part C Methods 18:122-32. 2012
    ..The processing of dECM and PEUU from a mixed solution thus provided a scaffold with evidence of better bioactivity and with mechanical properties not achievable with digested dECM alone...
  16. pmc An isolated cryptic peptide influences osteogenesis and bone remodeling in an adult mammalian model of digit amputation
    Vineet Agrawal
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Tissue Eng Part A 17:3033-44. 2011
    ....
  17. pmc Comparison of three methods for the derivation of a biologic scaffold composed of adipose tissue extracellular matrix
    Bryan N Brown
    Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng Part C Methods 17:411-21. 2011
    ....
  18. ncbi request reprint The host response to endotoxin-contaminated dermal matrix
    Kerry A Daly
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 18:1293-303. 2012
    ..These results suggest that current endotoxin standards may fall well below levels that induce an adverse acute proinflammatory response and associated long-term deleterious effects upon tissue remodeling outcomes...
  19. pmc Epimorphic regeneration approach to tissue replacement in adult mammals
    Vineet Agrawal
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Proc Natl Acad Sci U S A 107:3351-5. 2010
    ..The present findings demonstrate the recruitment of endogenous stem cells to a site of injury, and/or their generation/proliferation therein, in response to ECM degradation products...
  20. pmc Hydrogels derived from central nervous system extracellular matrix
    Christopher J Medberry
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 34:1033-40. 2013
    ..All hydrogels promoted three-dimensional uni- or bi-polar neurite outgrowth following 7 days in culture. These results suggest that CNS-ECM hydrogels may provide supportive scaffolding to promote in vivo axonal repair...
  21. pmc The effect of source animal age upon the in vivo remodeling characteristics of an extracellular matrix scaffold
    Brian M Sicari
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 33:5524-33. 2012
    ..Furthermore, the constructive remodeling response was associated with a dominant M2 macrophage response...
  22. doi request reprint Xenogeneic extracellular matrix as an inductive scaffold for regeneration of a functioning musculotendinous junction
    Neill J Turner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng Part A 16:3309-17. 2010
    ....
  23. pmc Biologic scaffolds composed of central nervous system extracellular matrix
    Peter M Crapo
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 33:3539-47. 2012
    ..These results suggest that CNS ECM may provide tissue-specific advantages in CNS regenerative medicine applications and that ECM scaffolds in general may aid functional recovery after CNS injury...
  24. ncbi request reprint Biologic scaffold composed of skeletal muscle extracellular matrix
    Matthew T Wolf
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 33:2916-25. 2012
    ..These results suggest that superior tissue remodeling outcomes are not universally dependent upon homologous tissue derived ECM scaffold materials...
  25. ncbi request reprint Constructive remodeling of biologic scaffolds is dependent on early exposure to physiologic bladder filling in a canine partial cystectomy model
    Alan V Boruch
    Department of Surgery, University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania 15219, USA
    J Surg Res 161:217-25. 2010
    ..These findings show that early exposure of site-appropriate mechanical loading (i.e., bladder filling) mediates a constructive remodeling response after ECM repair in a canine partial cystectomy model...
  26. pmc Preparation and characterization of a biologic scaffold from esophageal mucosa
    Timothy J Keane
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 34:6729-37. 2013
    ..Perivascular stem cells remained viable when seeded upon the esophageal ECM scaffold in-vitro, and the in-vivo host response showed a pattern of constructive remodeling when implanted in soft tissue...
  27. pmc Esophagus and regenerative medicine
    Ricardo Londono
    McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA
    World J Gastroenterol 18:6894-9. 2012
    ..These studies provide evidence that a regenerative medicine approach may enable aggressive resection of neoplastic tissue without the need for radical esophagectomy and its associated complications...
  28. pmc Recruitment of progenitor cells by an extracellular matrix cryptic peptide in a mouse model of digit amputation
    Vineet Agrawal
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Tissue Eng Part A 17:2435-43. 2011
    ....
  29. pmc Surface characterization of extracellular matrix scaffolds
    Bryan N Brown
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 31:428-37. 2010
    ..Furthermore, the results show that the surface characteristics of an ECM scaffold are changed through chemical cross-linking...
  30. ncbi request reprint Macrophage phenotype as a predictor of constructive remodeling following the implantation of biologically derived surgical mesh materials
    Bryan N Brown
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Suite 300, 450 Technology Drive, Pittsburgh, PA 15219, USA
    Acta Biomater 8:978-87. 2012
    ..05). A more thorough understanding of these issues will logically influence the design of next generation biomaterials and the development of regenerative medicine strategies for the formation of functional host tissues...
  31. doi request reprint Hydrated versus lyophilized forms of porcine extracellular matrix derived from the urinary bladder
    Donald O Freytes
    McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA
    J Biomed Mater Res A 87:862-72. 2008
    ..We conclude that lyophilization affects the overall in vitro cell growth of NIH 3T3 cells and the ultrastructural morphology of UBM devices, but does not result in significant changes in structural properties...
  32. pmc The effects of processing methods upon mechanical and biologic properties of porcine dermal extracellular matrix scaffolds
    Janet E Reing
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 31:8626-33. 2010
    ....
  33. ncbi request reprint Tissue-engineered myocardial patch derived from extracellular matrix provides regional mechanical function
    Paul V Kochupura
    Department of Surgery, Stony Brook University, Stony Brook, New York, USA
    Circulation 112:I144-9. 2005
    ..Surgical restoration of myocardium frequently uses Dacron as a myocardial patch. We hypothesized that an ECM-derived myocardial patch would provide a mechanical benefit not seen with Dacron...
  34. pmc Inductive, scaffold-based, regenerative medicine approach to reconstruction of the temporomandibular joint disk
    Bryan N Brown
    Department of Bioengineering and McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Oral Maxillofac Surg 70:2656-68. 2012
    ..A device composed of extracellular matrix (ECM) was investigated as an inductive template in vivo for reconstruction of the temporomandibular joint (TMJ) disk after discectomy...
  35. doi request reprint Resistance to infection of five different materials in a rat body wall model
    Christopher J Medberry
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Surg Res 173:38-44. 2012
    ..We evaluated the infection resistance of five different materials in a rat model of body wall repair, two of which, urinary bladder matrix (UBM-ECM) and Revive, were not previously evaluated in a controlled model of infection...
  36. doi request reprint Consequences of ineffective decellularization of biologic scaffolds on the host response
    Timothy J Keane
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 33:1771-81. 2012
    ..M2 macrophages within the various scaffolds. A clear association between macrophage phenotype and remodeling outcome exists and effective decellularization remains an important component in the processing of ECM-based scaffolds...
  37. pmc Right ventricular outflow tract repair with a cardiac biologic scaffold
    John M Wainwright
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA, USA
    Cells Tissues Organs 195:159-70. 2012
    ....
  38. doi request reprint Effect of the alphaGal epitope on the response to small intestinal submucosa extracellular matrix in a nonhuman primate model
    Kerry A Daly
    Department of Surgery, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng Part A 15:3877-88. 2009
    ..The findings of the present study show that the presence of the Gal epitope within a porcine-derived ECM scaffold material elicits a serum antibody response, but no adverse effect upon tissue remodeling...
  39. pmc A fusion protein of hepatocyte growth factor enhances reconstruction of myocardium in a cardiac patch derived from porcine urinary bladder matrix
    Takeyoshi Ota
    Division of Cardiac Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Thorac Cardiovasc Surg 136:1309-17. 2008
    ..Collagen-binding domain acted as an intermediary to promote hepatocyte growth factor binding and enhance hepatocyte growth factor stability within urinary bladder matrix...
  40. pmc The effect of source animal age upon extracellular matrix scaffold properties
    Stephen Tottey
    McGowan Institute for Regenerative Medicine, Department of Bioengineering, University of Pittsburgh, Bridgeside Point Building II, 450 Technology Dr Suite 300, Pittsburgh, PA 15219, USA
    Biomaterials 32:128-36. 2011
    ..In summary, distinct differences exist in the mechanical, structural, and biologic properties of SIS-ECM harvested from different aged animals...
  41. ncbi request reprint Gene expression by fibroblasts seeded on small intestinal submucosa and subjected to cyclic stretching
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng 13:1313-23. 2007
    ....
  42. ncbi request reprint Degradation and remodeling of small intestinal submucosa in canine Achilles tendon repair
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    J Bone Joint Surg Am 89:621-30. 2007
    ....
  43. doi request reprint Bone marrow-derived cells participate in the long-term remodeling in a mouse model of esophageal reconstruction
    Alejandro Nieponice
    Departments of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Surg Res 182:e1-7. 2013
    ..However, the mechanisms responsible for this change in the default response to esophageal injury are not fully understood...
  44. doi request reprint Prevention of seroma formation with TissuGlu® surgical adhesive in a canine abdominoplasty model: long term clinical and histologic studies
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15261, United States
    J Plast Reconstr Aesthet Surg 66:414-22. 2013
    ..This current study evaluates efficacy of the adhesive (TissuGlu®, Cohera Medical, Inc.) in the same model at longer time points, and examines the histological tissue response to extended exposure to the adhesive...
  45. pmc A murine model of volumetric muscle loss and a regenerative medicine approach for tissue replacement
    Brian M Sicari
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Tissue Eng Part A 18:1941-8. 2012
    ..The present study provides a reproducible animal model with which to study VML and shows the therapeutic potential of a bioscaffold-based regenerative medicine approach to VML...
  46. pmc Functional skeletal muscle formation with a biologic scaffold
    Jolene E Valentin
    Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 450 Technology Drive, Suite 300, Pittsburgh, PA 15219 3130, USA
    Biomaterials 31:7475-84. 2010
    ..The findings of this study show that non-crosslinked xenogeneic SIS scaffolds and autologous tissue are associated with the restoration of functional skeletal muscle with histomorphologic characteristics that resemble native muscle...
  47. pmc Macrophage participation in the degradation and remodeling of extracellular matrix scaffolds
    Jolene E Valentin
    Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219 3130, USA
    Tissue Eng Part A 15:1687-94. 2009
    ..Results showed that peripheral blood monocytes are required for the early and rapid degradation of both SIS scaffolds and autologous body wall, and that CDI crosslinked SIS is resistant to macrophage-mediated degradation...
  48. pmc Macrophage phenotype and remodeling outcomes in response to biologic scaffolds with and without a cellular component
    Bryan N Brown
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Biomaterials 30:1482-91. 2009
    ....
  49. doi request reprint Adrenal extracellular matrix scaffolds support adrenocortical cell proliferation and function in vitro
    Robert A Allen
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 16:3363-74. 2010
    ..We conclude that adrenal ECM supports endocrine function and proliferation of adrenocortical cells in vitro. Adrenal ECM scaffolds may form the basis for biocompatible tissue-engineered adrenal replacements...
  50. ncbi request reprint Fiber kinematics of small intestinal submucosa under biaxial and uniaxial stretch
    Thomas W Gilbert
    Department of Bioengineering, McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Biomech Eng 128:890-8. 2006
    ..Nonaffine structural models will be necessary to fully predict the fiber kinematics under large uniaxial strains in SIS...
  51. pmc Evidence of innervation following extracellular matrix scaffold-mediated remodelling of muscular tissues
    Vineet Agrawal
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Tissue Eng Regen Med 3:590-600. 2009
    ..The findings of this study suggest that the reconstruction of tissues in which innervation is an important functional component is possible with the use of biological scaffolds composed of extracellular matrix...
  52. doi request reprint Quantitative multispectral imaging of Herovici's polychrome for the assessment of collagen content and tissue remodelling
    Neill J Turner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, PA, USA
    J Tissue Eng Regen Med 7:139-48. 2013
    ....
  53. ncbi request reprint Extracellular matrix bioscaffolds for orthopaedic applications. A comparative histologic study
    Jolene E Valentin
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    J Bone Joint Surg Am 88:2673-86. 2006
    ..The purpose of the present study was to evaluate the host-tissue morphologic response to five commercially available extracellular matrix-derived biologic scaffolds used for orthopaedic soft-tissue repair in a rodent model...
  54. doi request reprint Histopathologic host response to polypropylene-based surgical mesh materials in a rat abdominal wall defect model
    Alexander Huber
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Biomed Mater Res B Appl Biomater 100:709-17. 2012
    ..The devices elicited a similar inflammatory response and the presence of a mild foreign body response in spite of the different composition and morphology of these composite mesh materials...
  55. ncbi request reprint A histomorphologic study of the normal healing response following digit amputation in C57bl/6 and MRL/MpJ mice
    Neill J Turner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pennsylvania 15219, USA
    Arch Histol Cytol 73:103-11. 2010
    ..Both mouse strains show a similar healing response by day 14...
  56. ncbi request reprint Reinforcement of esophageal anastomoses with an extracellular matrix scaffold in a canine model
    Alejandro Nieponice
    Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Ann Thorac Surg 82:2050-8. 2006
    ..The aim of the present study was to determine if healing of end-to-end anastomoses of the esophagus could be improved by reinforcement with an ECM scaffold...
  57. doi request reprint Transoral endoscopic inner layer esophagectomy: management of high-grade dysplasia and superficial cancer with organ preservation
    Bart P L Witteman
    Division of Thoracic and Foregut Surgery, Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, PA, USA
    J Gastrointest Surg 13:2104-12. 2009
    ..The objective of this study was to determine technical feasibility of transoral resection of the esophageal lining...
  58. doi request reprint An extracellular matrix scaffold for esophageal stricture prevention after circumferential EMR
    Alejandro Nieponice
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Gastrointest Endosc 69:289-96. 2009
    ..One of the limitations of this technique is that extensive mucosal resection and endoscopic submucosal dissection may be required to obtain complete removal of the neoplasm, which may result in significant stricture formation...
  59. ncbi request reprint Biologic scaffolds for musculotendinous tissue repair
    Neill J Turner
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Eur Cell Mater 25:130-43. 2013
    ..Some of the recent advances in the use of biologic scaffolds to target key stages of the musculotendinous repair process and promote the restoration of functional tissue are described herein...
  60. doi request reprint Hydrated xenogeneic decellularized tracheal matrix as a scaffold for tracheal reconstruction
    Nathaniel T Remlinger
    McGowan Institute for Regenerative Medicine, Bioengineering, University of Pittsburgh, PA 15219, USA
    Biomaterials 31:3520-6. 2010
    ..However, for long-term success, it appears that pre-implantation to allow vascularization or preseeding of the graft with chondrocytes will be necessary...
  61. doi request reprint Oxygen diffusivity of biologic and synthetic scaffold materials for tissue engineering
    Jolene E Valentin
    McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania 15219, USA
    J Biomed Mater Res A 91:1010-7. 2009
    ..Dacron showed oxygen diffusivity values seven times greater than the ECM biomaterials. The current study showed that each material has unique oxygen diffusivity values, and these values may be dependent on the scaffold's ultrastructure...
  62. pmc Collagen fiber alignment and biaxial mechanical behavior of porcine urinary bladder derived extracellular matrix
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 29:4775-82. 2008
    ..There are distinct differences in the mechanical behavior of different layers of ECM from the porcine urinary bladder, and the processing methods can substantially alter the mechanical behavior observed...
  63. ncbi request reprint Analytically derived material properties of multilaminated extracellular matrix devices using the ball-burst test
    Donald O Freytes
    Department of Surgery, University of Pittsburgh School of Medicine, McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA
    Biomaterials 26:5518-31. 2005
    ..The proposed approximations were used to compute biaxial failure properties for a variety of multilaminate ECM devices with varying number of layers, disinfection and sterilization, and organ origin...
  64. ncbi request reprint Liver-derived extracellular matrix as a biologic scaffold for acute vocal fold repair in a canine model
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Laryngoscope 119:1856-63. 2009
    ..The objective of the study was to evaluate a naturally derived liver extracellular matrix (L-ECM) scaffold for repair of an acute injury to the vocal fold lamina propria in a canine model...
  65. pmc Mechanical properties and in vivo behavior of a biodegradable synthetic polymer microfiber-extracellular matrix hydrogel biohybrid scaffold
    Yi Hong
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Biomaterials 32:3387-94. 2011
    ..The described elastic biohybrid material imparts features of ECM gel bioactivity with PEUU strength and handling to provide a promising composite biomaterial for soft tissue repair and replacement...
  66. ncbi request reprint Production and characterization of ECM powder: implications for tissue engineering applications
    Thomas W Gilbert
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Biomaterials 26:1431-5. 2005
    ..We conclude that the production of a comminuted form of ECM is possible and that the uniformity of particle size and shape are dependent upon the manufacturing methodology...
  67. ncbi request reprint Host protection against deliberate bacterial contamination of an extracellular matrix bioscaffold versus Dacron mesh in a dog model of orthopedic soft tissue repair
    Stephen F Badylak
    McGowan Institute for Regenerative Medicine and Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biomed Mater Res B Appl Biomater 67:648-54. 2003
    ..03). The ECM implant material was more resistant than the synthetic implant material to persistent infection following deliberate bacterial contamination and the ECM scaffold supported constructive tissue remodeling...
  68. ncbi request reprint A quantitative method for evaluating the degradation of biologic scaffold materials
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Biomaterials 28:147-50. 2007
    ..This model represents the first described quantitative method to determine the rate of degradation for an ECM scaffold and to track the fate of the degradation products...
  69. pmc Antibacterial activity within degradation products of biological scaffolds composed of extracellular matrix
    Ellen P Brennan
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng 12:2949-55. 2006
    ....
  70. doi request reprint Degradation products of extracellular matrix affect cell migration and proliferation
    Janet E Reing
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng Part A 15:605-14. 2009
    ..These findings support the concept that degradation products of ECM bioscaffolds are important modulators of the recruitment and proliferation of appropriate cell types during the process of ECM scaffold remodeling...
  71. pmc Maintenance of human hepatocyte function in vitro by liver-derived extracellular matrix gels
    Tiffany L Sellaro
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Tissue Eng Part A 16:1075-82. 2010
    ..We conclude that like Matrigel, PLECM represents a favorable substrate for in vitro culture of human hepatocytes...
  72. ncbi request reprint Maintenance of hepatic sinusoidal endothelial cell phenotype in vitro using organ-specific extracellular matrix scaffolds
    Tiffany L Sellaro
    Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng 13:2301-10. 2007
    ..The replacement of complex tissues and 3-dimensional organs may require specialized scaffolds to support multiple, functional cell phenotypes...
  73. ncbi request reprint Electromechanical characterization of a tissue-engineered myocardial patch derived from extracellular matrix
    Takeyoshi Ota
    Division of Cardiac Surgery, Heart, Lung and Esophageal Surgery Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Thorac Cardiovasc Surg 133:979-85. 2007
    ..In the present study, we evaluated the remodeled scaffold for evidence of electrical activation...
  74. pmc Repair of the tympanic membrane with urinary bladder matrix
    Aron Parekh
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Laryngoscope 119:1206-13. 2009
    ..To test urinary bladder matrix (UBM) as a potential treatment for tympanic membrane (TM) healing and regeneration...
  75. pmc A whole-organ regenerative medicine approach for liver replacement
    Alejandro Soto-Gutierrez
    Transplantation Section, Department of Surgery, Children s Hospital of Pittsburgh, Center for Innovative Regenerative Therapies, University of Pittsburgh, Pennsylvania, USA
    Tissue Eng Part C Methods 17:677-86. 2011
    ..The present study investigates a new, minimally disruptive method for whole-organ liver decellularization and three different cell reseeding strategies to engineer functional liver tissue...
  76. ncbi request reprint Morphologic assessment of extracellular matrix scaffolds for patch tracheoplasty in a canine model
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Ann Thorac Surg 86:967-74; discussion 967-74. 2008
    ..ECM scaffolds facilitate site-specific tissue remodeling when used to reconstruct a variety of soft-tissue structures...
  77. ncbi request reprint Repair of the thoracic wall with an extracellular matrix scaffold in a canine model
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Surg Res 147:61-7. 2008
    ..This study shows that a naturally occurring ECM scaffold promotes site-specific constructive remodeling in a large thoracic wall defect...
  78. ncbi request reprint Uniaxial and biaxial properties of terminally sterilized porcine urinary bladder matrix scaffolds
    Donald O Freytes
    McGowan Institute for Regenerative Medicine, Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Biomed Mater Res B Appl Biomater 84:408-14. 2008
    ..The present study showed that the choice of terminal sterilization method affects the structural properties of scaffolds composed of extracellular matrix...
  79. ncbi request reprint Effect of storage upon material properties of lyophilized porcine extracellular matrix derived from the urinary bladder
    Donald O Freytes
    McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania 15219, USA
    J Biomed Mater Res B Appl Biomater 78:327-33. 2006
    ..05). These results indicate that structural changes in the UBM device may slowly occur as a function of prolonged storage and storage temperature...
  80. pmc Preparation of cardiac extracellular matrix from an intact porcine heart
    John M Wainwright
    Department of Surgery, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Tissue Eng Part C Methods 16:525-32. 2010
    ..The intact decellularized porcine heart provides a tissue engineering template that may be beneficial for future preclinical studies and eventual clinical applications...
  81. pmc Extracellular matrix degradation products and low-oxygen conditions enhance the regenerative potential of perivascular stem cells
    Stephen Tottey
    Department of Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng Part A 17:37-44. 2011
    ....
  82. ncbi request reprint The use of porcine small intestinal submucosa to enhance the healing of the medial collateral ligament--a functional tissue engineering study in rabbits
    Volker Musahl
    Musculoskeletal Research Center, Department of Orthopedic Surgery, University of Pittsburgh, E1641 Biomedical Science Tower, 210 Lothrop Street, P O Box 71199, Pittsburgh, PA 15213, USA
    J Orthop Res 22:214-20. 2004
    ..The objective of this study was to evaluate whether SIS can be used to enhance the healing process of a medial collateral ligament (MCL) with a gap injury in a rabbit model...
  83. pmc Hybrid nanofibrous scaffolds from electrospinning of a synthetic biodegradable elastomer and urinary bladder matrix
    John J Stankus
    Department of Chemical Engineering, University of Pittsburgh, 1249 Benedum Hall, Pittsburgh, PA 15261, USA
    J Biomater Sci Polym Ed 19:635-52. 2008
    ..Electrospun UBM/PEUU combined the attractive bioactivity and mechanical features of its individual components to result in scaffolds with considerable potential for soft tissue engineering applications...
  84. pmc Quantification of DNA in biologic scaffold materials
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, USA
    J Surg Res 152:135-9. 2009
    ..Results showed that the majority of DNA is removed from ECM devices but that small amounts remained in most tested materials...
  85. pmc Chemoattraction of progenitor cells by remodeling extracellular matrix scaffolds
    Allison J Beattie
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Tissue Eng Part A 15:1119-25. 2009
    ..The magnitude and temporal pattern of the chemotactic response differed between the two mouse strains...
  86. doi request reprint Lysine-derived urethane surgical adhesive prevents seroma formation in a canine abdominoplasty model
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine and the Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, and Cohera Medical, Inc, Pittsburgh, PA, USA
    Plast Reconstr Surg 122:95-102. 2008
    ..Several approaches have been investigated to prevent seroma formation by draining fluid or attempting to eliminate dead space, but these approaches have limited effectiveness...
  87. doi request reprint FGF-2 enhances vascularization for adipose tissue engineering
    Kacey G Marra
    Division of Plastic Surgery, Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Plast Reconstr Surg 121:1153-64. 2008
    ..The authors hypothesized that particulate small intestinal submucosa could be useful as injectable cell delivery vehicles for preadipocytes, and that the release of fibroblast growth factor (FGF)-2 would enhance vascularization...
  88. doi request reprint Preparation and rheological characterization of a gel form of the porcine urinary bladder matrix
    Donald O Freytes
    University of Pittsburgh, Department of Bioengineering, Pittsburgh, PA 15219, USA
    Biomaterials 29:1630-7. 2008
    ..The present study showed that an intact form of UBM can be successfully solubilized without purification steps and induced to repolymerize into a gel form of the UBM biologic scaffold material...
  89. ncbi request reprint The basement membrane component of biologic scaffolds derived from extracellular matrix
    Bryan Brown
    Department of Mechanical Engineering, University of Pittsburgh, Pennsylvania 15219, USA
    Tissue Eng 12:519-26. 2006
    ....
  90. pmc Chemoattractant activity of degradation products of fetal and adult skin extracellular matrix for keratinocyte progenitor cells
    Ellen P Brennan
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15219, USA
    J Tissue Eng Regen Med 2:491-8. 2008
    ....
  91. pmc The emerging relationship between regenerative medicine and physical therapeutics
    Fabrisia Ambrosio
    Cellular Rehabilitation Laboratory, W1453 Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Phys Ther 90:1807-14. 2010
    ..The purposes of this article are to provide a current perspective on biological approaches to the management of musculoskeletal disorders and to highlight the needed integration of physical therapeutics with regenerative medicine...
  92. ncbi request reprint Decellularization of tissues and organs
    Thomas W Gilbert
    McGowan Institute for Regenerative Medicine, University of Pittsburgh, 100 Technology Drive, Suite 200, Pittsburgh, PA 15219, USA
    Biomaterials 27:3675-83. 2006
    ..Herein, the most commonly used decellularization methods are described, and consideration give to the effects of these methods upon the biologic scaffold material...
  93. ncbi request reprint Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization
    Jason P Hodde
    Department of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47906, USA
    Tissue Eng 8:225-34. 2002
    ....
  94. ncbi request reprint The extracellular matrix as a scaffold for tissue reconstruction
    Stephen F Badylak
    Department of Biomedical Engineering, Purdue University, Room 204, 1296 Potter Building, West Lafayette, IN 47907 1296, USA
    Semin Cell Dev Biol 13:377-83. 2002
    ..The ECM-induced remodeling response is a distinctly different phenomenon from that of scar tissue formation...
  95. ncbi request reprint Extracellular matrix scaffolds are repopulated by bone marrow-derived cells in a mouse model of achilles tendon reconstruction
    Thore Zantop
    Department of Trauma, Hand and Reconstructive Surgery, Wilhelms University, Muenster, Germany
    J Orthop Res 24:1299-309. 2006
    ..The involvement of these cells in the remodeling process may explain in part the process of site specific constructive remodeling as opposed to scar tissue formation when the ECM is used as a biologic scaffold for tendon reconstruction...
  96. ncbi request reprint Extracellular matrix scaffold for cardiac repair
    Keith A Robinson
    American Cardiovascular Research Institute, Norcross, GA, USA
    Circulation 112:I135-43. 2005
    ..Heart failure remains a significant problem. Tissue-engineered cardiac patches offer potential to treat severe heart failure. We studied an extracellular matrix scaffold for repairing the infarcted left ventricle...
  97. ncbi request reprint Use of a particulate extracellular matrix bioscaffold for treatment of acquired urinary incontinence in dogs
    Jeffrey D Wood
    Northside Veterinary Hospital, 1091 W Moore Rd, Hillsdale, MI 49242, USA
    J Am Vet Med Assoc 226:1095-7. 2005
    ..To evaluate use of a particulate bioscaffold consisting of the extracellular matrix (ECM) of the urinary bladder from pigs for treatment of acquired urinary incontinence in dogs resistant to medical treatment...
  98. ncbi request reprint The application of tissue engineering procedures to repair the larynx
    Robert L Ringel
    Purdue University, West Lafayette, IN, USA
    J Speech Lang Hear Res 49:194-208. 2006
    ..A discussion of the mechanisms of ECM remodeling is presented along with the implications of such remodeling in the repair of laryngeal structures...
  99. ncbi request reprint Biaxial strength of multilaminated extracellular matrix scaffolds
    Donald O Freytes
    Department of Biomedical Engineering, Purdue University, West Lafayette, IN 47907 2022, USA
    Biomaterials 25:2353-61. 2004
    ..e. vascular, musculotendinous, etc) by varying the number of layers and modifying the disinfection/sterilization treatments used for manufacturing...
  100. ncbi request reprint A comparison of suture retention strengths for three biomaterials
    Joseph F Obermiller
    School of Mechanical Engineering, Purdue University, West Lafayette, IN, USA
    Med Sci Monit 10:PI1-5. 2004
    ....
  101. ncbi request reprint Natural anti-galactose alpha1,3 galactose antibodies delay, but do not prevent the acceptance of extracellular matrix xenografts
    Roberta H Raeder
    Center for Immunology and Microbial Disease, Albany Medical College, NY 12208, USA
    Transpl Immunol 10:15-24. 2002
    ..We conclude that, in contrast to xenotransplantation of whole organs, naturally-occurring anti-alpha gal antibodies do not influence the ability of xenogeneic extracellular matrices to serve as bioscaffolds for tissue remodeling...

Research Grants19

  1. Mechanobiology and Regenerative Medicine
    Michael S Sacks; Fiscal Year: 2010
    ..A timeline for completion of these studies, hypotheses to drive the specific aims, alternative approaches for completion of the work, and quantitative criteria for success are provided. ..
  2. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2000
    ..abstract_text> ..
  3. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2007
    ..We have identified clearly defined specific aims with quantifiable end points and an efficient three year timeline to conduct this work. ..
  4. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2003
    ..abstract_text> ..
  5. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2002
    ..abstract_text> ..
  6. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2006
    ..The work will be conducted by an experienced interdisciplinary team of scientists and a timeline is presented for completion of the work. ..
  7. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2001
    ..abstract_text> ..
  8. Mechanobiology and Regenerative Medicine
    Stephen Badylak; Fiscal Year: 2009
    ..A timeline for completion of these studies, hypotheses to drive the specific aims, alternative approaches for completion of the work, and quantitative criteria for success are provided. ..
  9. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen Badylak; Fiscal Year: 2009
    ..The objectives of the studies, the hypothesis upon which the experimental design is based, and a timeline for completion of the studies are presented. ..
  10. Cellular Remodeling of ECM Scaffolds
    Stephen Badylak; Fiscal Year: 2009
    ..We have identified clearly defined specific aims with quantifiable end points and an efficient three year timeline to conduct this work. ..
  11. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen Badylak; Fiscal Year: 2007
    ..The objectives of the studies, the hypothesis upon which the experimental design is based, and a timeline for completion of the studies are presented. ..
  12. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen Badylak; Fiscal Year: 2006
    ..The objectives of the studies, the hypothesis upon which the experimental design is based, and a timeline for completion of the studies are presented. ..
  13. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2005
    ..The work will be conducted by an experienced interdisciplinary team of scientists and a timeline is presented for completion of the work. ..
  14. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2004
    ..The work will be conducted by an experienced interdisciplinary team of scientists and a timeline is presented for completion of the work. ..
  15. Mechanisms of ECM Scaffold Remodeling
    Stephen Badylak; Fiscal Year: 2003
    ..The work will be conducted by an experienced interdisciplinary team of scientists and a timeline is presented for completion of the work. ..
  16. ORIGIN OF CELLS THAT REPOPULATE RESORBABLE ECM SCAFFOLDS
    Stephen Badylak; Fiscal Year: 2002
    ..abstract_text> ..
  17. Cell Recruitment Induced by ECM Scaffold Degradation
    Stephen F Badylak; Fiscal Year: 2010
    ..The objectives of the studies, the hypothesis upon which the experimental design is based, and a timeline for completion of the studies are presented. ..