THOMAS BADGER

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. pmc Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis
    Rijin Xiao
    Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, AR 72202, USA
    Mol Cancer 4:1. 2005
  2. ncbi request reprint Developmental effects and health aspects of soy protein isolate, casein, and whey in male and female rats
    T M Badger
    Arkansas Children s Nutrition Center and Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72202, USA
    Int J Toxicol 20:165-74. 2001
  3. ncbi request reprint Soy protein isolate and protection against cancer
    Thomas M Badger
    Arkansas Children s Nutrition Center and Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Am Coll Nutr 24:146S-149S. 2005
  4. doi request reprint The health implications of soy infant formula
    Thomas M Badger
    Arkansas Children s Nutrition Center and the Departments of Pediatrics, University of Arkansas for Medical Science, Little Rock, AR, USA
    Am J Clin Nutr 89:1668S-1672S. 2009
  5. doi request reprint Soy protein isolate reduces hepatosteatosis in yellow Avy/a mice without altering coat color phenotype
    T M Badger
    Arkansas Children s Nutrition Center, Physiology and Biophysics, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 233:1242-54. 2008
  6. ncbi request reprint Effects of chronic ethanol on hepatic and renal CYP2C11 in the male rat: interactions with the Janus-kinase 2-signal transducer and activators of transcription proteins 5b pathway
    T M Badger
    Arkansas Children s Nutrition Center and Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Endocrinology 144:3969-76. 2003
  7. ncbi request reprint Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells
    J C Rowlands
    Arkansas Children Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Xenobiotica 33:389-97. 2003
  8. ncbi request reprint Alcohol metabolism: role in toxicity and carcinogenesis
    Thomas M Badger
    Arkansas Children s Nutrition Center and Departments of Physiology and Biophysics, Pediatrics at the University of Arkansas for Medical Sciences, Little Rock, Arkansas 72211, USA
    Alcohol Clin Exp Res 27:336-47. 2003
  9. ncbi request reprint The effects of pregnancy on ethanol clearance
    Thomas M Badger
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Life Sci 77:2111-26. 2005
  10. ncbi request reprint The health consequences of early soy consumption
    Thomas M Badger
    Arkansas Children s Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 132:559S-565S. 2002

Research Grants

Detail Information

Publications83

  1. pmc Dietary exposure to soy or whey proteins alters colonic global gene expression profiles during rat colon tumorigenesis
    Rijin Xiao
    Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, AR 72202, USA
    Mol Cancer 4:1. 2005
    ..To obtain insights into these effects, global gene expression profiles of colons from rats with lifetime ingestion of casein (CAS, control diet), soy protein isolate (SPI), and whey protein hydrolysate (WPH) diets were determined...
  2. ncbi request reprint Developmental effects and health aspects of soy protein isolate, casein, and whey in male and female rats
    T M Badger
    Arkansas Children s Nutrition Center and Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72202, USA
    Int J Toxicol 20:165-74. 2001
    ..The long-term health consequence implications of early diet exposure to SPI and WPH, such as reduced breast cancer incidence, are likely to be very positive...
  3. ncbi request reprint Soy protein isolate and protection against cancer
    Thomas M Badger
    Arkansas Children s Nutrition Center and Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Am Coll Nutr 24:146S-149S. 2005
    ..The purpose of this presentation was to evaluate the potential of soy protein to prevent occurrence of prostate, breast and colon cancer...
  4. doi request reprint The health implications of soy infant formula
    Thomas M Badger
    Arkansas Children s Nutrition Center and the Departments of Pediatrics, University of Arkansas for Medical Science, Little Rock, AR, USA
    Am J Clin Nutr 89:1668S-1672S. 2009
    ..Thus, to date, our results suggest that SF supports normal growth and may have advantages in promoting bone development...
  5. doi request reprint Soy protein isolate reduces hepatosteatosis in yellow Avy/a mice without altering coat color phenotype
    T M Badger
    Arkansas Children s Nutrition Center, Physiology and Biophysics, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 233:1242-54. 2008
    ....
  6. ncbi request reprint Effects of chronic ethanol on hepatic and renal CYP2C11 in the male rat: interactions with the Janus-kinase 2-signal transducer and activators of transcription proteins 5b pathway
    T M Badger
    Arkansas Children s Nutrition Center and Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Endocrinology 144:3969-76. 2003
    ..The mechanisms underlying ethanol-induced suppression of STAT5b is yet to be determined, as is the question of whether this is secondary to hormonal effects or a direct ethanol effect...
  7. ncbi request reprint Glucose inhibition of the induction of CYP2E1 mRNA expression by ethanol in FGC-4 cells
    J C Rowlands
    Arkansas Children Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Xenobiotica 33:389-97. 2003
    ....
  8. ncbi request reprint Alcohol metabolism: role in toxicity and carcinogenesis
    Thomas M Badger
    Arkansas Children s Nutrition Center and Departments of Physiology and Biophysics, Pediatrics at the University of Arkansas for Medical Sciences, Little Rock, Arkansas 72211, USA
    Alcohol Clin Exp Res 27:336-47. 2003
    ....
  9. ncbi request reprint The effects of pregnancy on ethanol clearance
    Thomas M Badger
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Life Sci 77:2111-26. 2005
    ..The greater ethanol clearance results in lower tissue ethanol concentrations achieved during pregnancy for a given dose, and this may have clinical significance as a mechanism to protect the growing fetus from ethanol toxicity...
  10. ncbi request reprint The health consequences of early soy consumption
    Thomas M Badger
    Arkansas Children s Nutrition Center, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 132:559S-565S. 2002
    ..Further research is needed to confirm the results of the few studies that have been conducted and new studies are needed to investigate the more subtle effects that could occur during development or that could surface later in life...
  11. ncbi request reprint Fetal programming of colon cancer in adult rats: correlations with altered neonatal growth trajectory, circulating IGF-I and IGF binding proteins, and testosterone
    Rijin Xiao
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock 72205, USA
    J Endocrinol 195:79-87. 2007
    ..Results indicate an effect of dietary protein type during pregnancy on colon tumor multiplicity and colon tissue gene expression, and serum IGF-I and testosterone in progeny rats as later adults...
  12. ncbi request reprint A new model for nonalcoholic steatohepatitis in the rat utilizing total enteral nutrition to overfeed a high-polyunsaturated fat diet
    January N Baumgardner
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Physiol Gastrointest Liver Physiol 294:G27-38. 2008
    ..These data suggest that intragastric infusion of a high-polyunsaturated fat diet at a caloric level of 17% excess total calories results in pathology similar to clinical NASH...
  13. ncbi request reprint Post-transcriptional regulation of sterol regulatory element-binding protein-1 by ethanol induces class I alcohol dehydrogenase in rat liver
    Ling He
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA
    J Biol Chem 279:28113-21. 2004
    ..We conclude that SREBP-1 is a negative regulator of the ADH gene and may work in concert with the CCAAT/enhancer-binding proteins to mediate ethanol induction of ADH in vivo...
  14. ncbi request reprint Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition
    January N Baumgardner
    Department of Pharmacology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Am J Physiol Gastrointest Liver Physiol 293:G355-64. 2007
    ..However, enhanced ethanol-induced cellular proliferation, perhaps as a result of enhanced PPAR-alpha signaling, may contribute to an increased risk of hepatocellular carcinoma in undernourished alcoholics...
  15. ncbi request reprint Chronic ethanol intake impairs insulin signaling in rats by disrupting Akt association with the cell membrane. Role of TRB3 in inhibition of Akt/protein kinase B activation
    Ling He
    Arkansas Children s Nutrition Center and the Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Biol Chem 281:11126-34. 2006
    ..Ethanol inhibition of insulin signaling reduces nuclear SREBP accumulation and results in disinhibition of Class 1 ADH transcription...
  16. ncbi request reprint Physiologic and genomic analyses of nutrition-ethanol interactions during gestation: Implications for fetal ethanol toxicity
    Kartik Shankar
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Exp Biol Med (Maywood) 231:1379-97. 2006
    ..Our data suggest that undernutrition potentiates the fetal toxicity of EtOH in part by disrupting maternal GH-IGF-1, signaling thereby decreasing maternal uterine capacity and placental growth...
  17. pmc Chronic ethanol exposure inhibits distraction osteogenesis in a mouse model: role of the TNF signaling axis
    Elizabeth C Wahl
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Toxicol Appl Pharmacol 220:302-10. 2007
    ..We conclude that chronic ethanol-associated inhibition of direct bone formation is mediated to a significant extent by the TNF signaling axis in a mouse model...
  18. ncbi request reprint Chronic ethanol consumption inhibits postlactational anabolic bone rebuilding in female rats
    Kartik Shankar
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Bone Miner Res 23:338-49. 2008
    ..EtOH-induced skeletal deficits were prevented by treatment with either NAC or sTNFR1. These data suggest that postlactational anabolic rebuilding is influenced by EtOH consumption and may affect the long-term risk of osteopenia...
  19. doi request reprint Estrogenic status modulates the effect of soy on hepatic responses to 7,12-dimethylbenz(a)anthracene (DMBA)
    Rohit Singhal
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Toxicol Appl Pharmacol 234:89-97. 2009
    ..Our data suggest that although E2 status does not effect soy-mediated AhR degradation, it modulates the effects of soy on many genes, including CYP1A1...
  20. ncbi request reprint Rats fed soy protein isolate (SPI) have impaired hepatic CYP1A1 induction by polycyclic aromatic hydrocarbons as a result of interference with aryl hydrocarbon receptor signaling
    Rohit Singhal
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Toxicol Appl Pharmacol 227:275-83. 2008
    ..These data suggest that feeding SPI-containing diets antagonizes AhR signaling by a novel mechanism which differs from those established for known AhR antagonists...
  21. ncbi request reprint Estradiol protects against ethanol-induced bone loss by inhibiting up-regulation of receptor activator of nuclear factor-kappaB ligand in osteoblasts
    Jin Ran Chen
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Pharmacol Exp Ther 319:1182-90. 2006
    ..Therefore, E(2) prevents EtOH-induced bone loss by opposing the induction of RANKL mRNA in osteoblasts and ethanol-induced osteoclastogenesis, through opposing effects on sustained ERK signaling...
  22. pmc N-acetylcysteine attenuates progression of liver pathology in a rat model of nonalcoholic steatohepatitis
    January N Baumgardner
    Departments of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 138:1872-9. 2008
    ..Using NAC in a TEN model of NASH, we have demonstrated that NAC prevents many aspects of NASH progression by decreasing development of oxidative stress and subsequent increases in TNFalpha but does not block development of steatosis...
  23. ncbi request reprint Altered mammary gland differentiation and progesterone receptor expression in rats fed soy and whey proteins
    J Craig Rowlands
    Arkansas Children s Nutrition Center and Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Toxicol Sci 70:40-5. 2002
    ..The SPI- and WPH-dependent changes in mammary differentiation may contribute to the reduced sensitivity to DMBA-induced mammary cancer in rats fed these proteins...
  24. pmc Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF
    Elizabeth C Wahl
    Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    J Bone Miner Res 25:114-23. 2010
    ..It has been hypothesized recently that TNF antagonists may represent novel anabolic agents, and we believe that the data presented here represent a successful test of this hypothesis...
  25. doi request reprint Ultrasonographic patterns of reproductive organs in infants fed soy formula: comparisons to infants fed breast milk and milk formula
    Janet M Gilchrist
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Pediatr 156:215-20. 2010
    ..To determine if differences exist in hormone-sensitive organ size between infants who were fed soy formula (SF), milk formula (MF), or breast milk (BF)...
  26. ncbi request reprint Tumor-protective and tumor-promoting actions of dietary whey proteins in an N-methyl-N-nitrosourea model of rat mammary carcinogenesis
    Renea R Eason
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, AR 72202, USA
    Nutr Cancer 55:171-7. 2006
    ....
  27. doi request reprint Hepatic gene expression following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17{beta}-estradiol treatment
    Rohit Singhal
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Endocrinol 202:141-52. 2009
    ..The different hepatic gene signatures produced by SPI feeding compared with E(2) and the lack of increase in uterine wet weight in rats fed with SPI suggest that SPI is not estrogenic in these tissues...
  28. ncbi request reprint Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/
    Jin Ran Chen
    Arkansas Children s Nutrition Center, Slot 512 20B, 1120 Marshall St, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 324:50-9. 2008
    ..These data suggest that the molecular mechanisms whereby E(2) prevents EtOH-induced bone loss involve interference with ROS generation and cytoplasmic kinase activation...
  29. doi request reprint A longitudinal study of differences in electroencephalographic activity among breastfed, milk formula-fed, and soy formula-fed infants during the first year of life
    Hongkui Jing
    Arkansas Children s Nutrition Center, Slot 512 20B, 15 Children s Way, Little Rock, Arkansas 72202, United States
    Early Hum Dev 86:119-25. 2010
    ..The extent to which adequate nutrition from infant diets differentially influence developmental outcomes in healthy infants has not been determined...
  30. ncbi request reprint Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage
    Susan R Shelnutt
    Arkansas Children s Nutrition Center and the Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock 72202, USA
    Am J Clin Nutr 76:588-94. 2002
    ..Isoflavone conjugates may serve as sources of aglycones at specific target tissues and may have bioactivity. Yet, very little is known about the plasma pharmacokinetics of isoflavone conjugates after soy ingestion...
  31. ncbi request reprint Skeletal toxicity associated with chronic ethanol exposure in a rat model using total enteral nutrition
    Elizabeth C Brown
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, 1120 Marshall Street, Little Rock, AR 72202, USA
    J Pharmacol Exp Ther 301:1132-8. 2002
    ..Also, the DO studies demonstrate, for the first time, that chronic ethanol inhibits rapid bone formation during limb lengthening...
  32. ncbi request reprint Uterine phenotype of young adult rats exposed to dietary soy or genistein during development
    Renea R Eason
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr Biochem 16:625-32. 2005
    ..Given its limited influence on uterine phenotype of young adult females, GEN, when taken as part of soy foods or as supplement, should be favorably considered for other potential health benefits...
  33. ncbi request reprint Effects of light and dark beer on hepatic cytochrome P-450 expression in male rats receiving alcoholic beverages as part of total enteral nutrition
    Mats Hidestrand
    Arkansas Children s Nutrition Center and University of Arkansas for Medical Sciences, Department of Pharmacology and Toxicology, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 29:888-95. 2005
    ....
  34. ncbi request reprint Interleukin-1 and tumor necrosis factor antagonists attenuate ethanol-induced inhibition of bone formation in a rat model of distraction osteogenesis
    Daniel S Perrien
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Pharmacol Exp Ther 303:904-8. 2002
    ....
  35. ncbi request reprint Ethanol induction of class I alcohol dehydrogenase expression in the rat occurs through alterations in CCAAT/enhancer binding proteins beta and gamma
    Ling He
    Arkansas Children s Nutrition Center, Little Rock 72202, USA
    J Biol Chem 277:43572-7. 2002
    ..05). These data provide the first evidence for the mechanism by which ethanol regulates rat hepatic Class I ADH gene expression in vivo. This mechanism involves the C/EBP site and the enhancer binding proteins beta and gamma...
  36. ncbi request reprint In vitro actions on human cancer cells and the liquid chromatography-mass spectrometry/mass spectrometry fingerprint of phytochemicals in rice protein isolate
    Shanggong Yu
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 54:4482-92. 2006
    ..The major components bound to RPI were lysoglycerophospholipids, fatty acids, and fatty acid 3-[2-(2,3-dihydroxy-propoxycarbonyl)-2-hydroxy-ethoxy]-2-hydroxy-propyl esters...
  37. ncbi request reprint Chronic ethanol exposure is associated with a local increase in TNF-alpha and decreased proliferation in the rat distraction gap
    Daniel S Perrien
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Cytokine 23:179-89. 2003
    ..These results support the hypothesis that attenuation of bone formation by ethanol may be mediated, in part, by local increases in TNF-alpha during osteogenesis...
  38. ncbi request reprint Characterization of isoflavones and their conjugates in female rat urine using LC/MS/MS
    Nianbai Fang
    Arkansas Children s Nutrition Center, 1120 South Marshall Street, Little Rock, AR 72202, USA
    J Agric Food Chem 50:2700-7. 2002
    ..The application of LC/MS/MS to analyze isoflavone metabolites is simple and sensitive, and appears to be an excellent method for determining the bioavailability and metabolism of food phytochemistry...
  39. ncbi request reprint In utero exposure to maternal diets containing soy protein isolate, but not genistein alone, protects young adult rat offspring from NMU-induced mammary tumorigenesis
    Ying Su
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA
    Carcinogenesis 28:1046-51. 2007
    ..Preventative strategies against mammary and other types of cancer might be uncovered by refinement of the developmental window for dietary factor exposure...
  40. ncbi request reprint Agouti signaling protein stimulates cell division in "viable yellow" (A(vy)/a) mouse liver
    George L Wolff
    Arkansas Children s Nutrition Center, Little Rock, AR72202, USA
    Exp Biol Med (Maywood) 232:1326-9. 2007
    ..We found that ASIP levels were approximately 100-fold higher in yellow than in pseudoagouti or black mice and that the proportion of PCNA-positive hepatocytes was greater (P < 0.001) in yellow than in pseudoagouti or black mice...
  41. doi request reprint Lipid fatty acid profile analyses in liver and serum in rats with nonalcoholic steatohepatitis using improved gas chromatography-mass spectrometry methodology
    Xianli Wu
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 15 Children s Way, Little Rock, Arkansas 72202, United States
    J Agric Food Chem 59:747-54. 2011
    ..Alteration of FA composition in liver after overfeeding of high polyunsaturated fat diets may contribute to the progression of pathological changes from steatosis to inflammation, necrosis, and fibrosis observed in NASH...
  42. doi request reprint Enhanced expression and glucocorticoid-inducibility of hepatic cytochrome P450 3A involve recruitment of the pregnane-X-receptor to promoter elements in rats fed soy protein isolate
    Martin J J Ronis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 141:10-6. 2011
    ....
  43. ncbi request reprint Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression
    Shanmugam Nagarajan
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 138:332-7. 2008
    ....
  44. pmc Effects of long-term ethanol administration in a rat total enteral nutrition model of alcoholic liver disease
    Martin J J Ronis
    epartment of Pharmacology and Toxicology, 2University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    Am J Physiol Gastrointest Liver Physiol 300:G109-19. 2011
    ....
  45. doi request reprint Carbohydrate-responsive gene expression in the adipose tissue of rats
    Kartik Shankar
    U S Department of Agriculture Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 151:153-64. 2010
    ..These results suggest that C/F and interactions with excessive caloric intake per se may regulate body composition and play important roles in the development of obesity and metabolic syndrome...
  46. pmc The role of ethanol metabolism in development of alcoholic steatohepatitis in the rat
    Martin J Ronis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, 72205, USA
    Alcohol 44:157-69. 2010
    ..Ethanol metabolism by CYP2E1 may be linked in part to triglyceride accumulation, to induction of TNF-alpha, and to chemokine production. Ethanol metabolism by ADH may be linked in part to oxidative and ER stress and necrotic injury...
  47. doi request reprint Early infant diet and the omega 3 fatty acid DHA: effects on resting cardiovascular activity and behavioral development during the first half-year of life
    R T Pivik
    Arkansas Children s Nutrition Center, Little Rock, Arkansas 72202, USA
    Dev Neuropsychol 34:139-58. 2009
    ..In general, the results do not indicate differences in any of the study variables attributable to soy formula per se...
  48. pmc Maternal overweight programs insulin and adiponectin signaling in the offspring
    Kartik Shankar
    Arkansas Children s Nutrition Center, 15 Children s Way, Slot 512 20B, Little Rock, Arkansas 72202, USA
    Endocrinology 151:2577-89. 2010
    ..Our results strongly suggest that gestational exposure to maternal obesity programs multiple aspects of energy-balance regulation in the offspring...
  49. pmc Ethanol impairs estrogen receptor signaling resulting in accelerated activation of senescence pathways, whereas estradiol attenuates the effects of ethanol in osteoblasts
    Jin Ran Chen
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Bone Miner Res 24:221-30. 2009
    ..We conclude that inhibitory cross-talk between EtOH and E2 in osteoblasts on ERs, p53/p21, and cell senescence provides a pathophysiologic mechanism underlying bone loss and the protective effects of estrogens in alcohol-exposed females...
  50. doi request reprint Dietary-induced serum phenolic acids promote bone growth via p38 MAPK/β-catenin canonical Wnt signaling
    Jin Ran Chen
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Bone Miner Res 25:2399-411. 2010
    ....
  51. doi request reprint Dietary blueberries attenuate atherosclerosis in apolipoprotein E-deficient mice by upregulating antioxidant enzyme expression
    Xianli Wu
    USDA Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 140:1628-32. 2010
    ..The potential mechanisms may involve reduction in oxidative stress by both inhibition of lipid peroxidation and enhancement of antioxidant defense...
  52. doi request reprint Rice protein isolate improves lipid and glucose homeostasis in rats fed high fat/high cholesterol diets
    Martin J Ronis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 15 Children s Way, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 235:1102-13. 2010
    ....
  53. doi request reprint Infant formula promotes bone growth in neonatal piglets by enhancing osteoblastogenesis through bone morphogenic protein signaling
    Jin Ran Chen
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 139:1839-47. 2009
    ..SF piglets had the highest bone volume over tissue volume. This suggests that SF-fed piglets may have the best quality bone. The anabolic effects of SF on bone appear to be mediated through enhanced BMP signaling...
  54. pmc Chronic ethanol consumption leads to disruption of vitamin D3 homeostasis associated with induction of renal 1,25 dihydroxyvitamin D3-24-hydroxylase (CYP24A1)
    Kartik Shankar
    Departments of Pharmacology and Toxicology, University of Arkansas for Medical Sciences and Arkansas Children s Nutrition Center, 1120 Marshall Street, Little Rock, AR 72202, USA
    Endocrinology 149:1748-56. 2008
    ....
  55. ncbi request reprint Soy protein isolate induces CYP3A1 and CYP3A2 in prepubertal rats
    Martin J Ronis
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 231:60-9. 2006
    ..Effects on CYP3A1 expression appear to be primarily due to phytochemical components of SPI other than isoflavones. In contrast, consumption of soy protein and daidzein appear to be associated with the induction of CYP3A2...
  56. pmc Effects of N-acetylcysteine on ethanol-induced hepatotoxicity in rats fed via total enteral nutrition
    Martin J J Ronis
    Arkansas Children s Nutrition Center University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Free Radic Biol Med 39:619-30. 2005
    ..These data suggest that ethanol-induced oxidative stress can contribute to inflammation and liver injury even in the absence of Kupffer cell activation by endotoxemia...
  57. ncbi request reprint Diets containing soy protein isolate increase hepatic CYP3A expression and inducibility in weanling male rats exposed during early development
    Martin J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 134:3270-6. 2004
    ....
  58. ncbi request reprint Tp53-associated growth arrest and DNA damage repair gene expression is attenuated in mammary epithelial cells of rats fed whey proteins
    Bhuvanesh Dave
    Arkansas Children s Nutrition Center and Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Nutr 136:1156-60. 2006
    ..Results indicate that mammary glands of rats fed a WPH diet are more protected from endogenous DNA damage than are those of CAS-fed rats, and identify MCP-1 as a potential serum biomarker for the positive effects of healthy diets...
  59. ncbi request reprint Sulfation of the isoflavones genistein and daidzein in human and rat liver and gastrointestinal tract
    Martin J Ronis
    Department of Pharmacology, University of Arkansas for Medical Sciences, Arkansas, USA
    J Med Food 9:348-55. 2006
    ..However, human intestinal daidzein sulfation appears to be catalyzed by a separate enzyme...
  60. doi request reprint No difference indicated in electroencephalographic power spectral analysis in 3- and 6-month-old infants fed soy- or milk-based formula
    Hongkui Jing
    Arkansas Children s Nutrition Center ACNC, Little Rock, Arkansas 72202, USA
    Matern Child Nutr 4:136-45. 2008
    ..In addition, EEG spectral development appears more advanced in female than in male infants at 6 months...
  61. ncbi request reprint A novel mouse model for the study of the inhibitory effects of chronic ethanol exposure on direct bone formation
    Elizabeth C Wahl
    Laboratory for Limb Regeneration Research, Arkansas Children s Hospital Research Institute, Little Rock, AR, USA
    Alcohol 39:159-67. 2006
    ..002). We conclude that this model can be used to study the mechanisms underlying inhibition of bone formation by chronic ethanol exposure and to test preclinical interventions...
  62. ncbi request reprint Lack of sexual dimorphism in alcohol-induced liver damage (ALD) in rats treated chronically with ethanol-containing low carbohydrate diets: The role of ethanol metabolism and endotoxin
    Martin J J Ronis
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Life Sci 75:469-83. 2004
    ..These data do not support previous observations that female rats have a greater susceptibility to ethanol-induced hepatotoxicity than males...
  63. ncbi request reprint Dietary saturated fat reduces alcoholic hepatotoxicity in rats by altering fatty acid metabolism and membrane composition
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 134:904-12. 2004
    ..These findings may be important in the nutritional management and treatment of alcoholic liver disease...
  64. ncbi request reprint Diet regulates the development of gut-associated lymphoid tissue in neonatal piglets
    Ricki M Helm
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Neonatology 91:248-55. 2007
    ..Furthermore, studies on dietary effects on the development of the neonatal immune system, especially gut-associated lymphoid tissue (GALT), are lacking...
  65. ncbi request reprint Characterization of triterpene alcohol and sterol ferulates in rice bran using LC-MS/MS
    Nianbai Fang
    Arkansas Children s Nutrition Center, 1120 South Marshall Street, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 51:3260-7. 2003
    ..LC-MS/MS equipped with reverse-phase LC and ESI-MS should be well-suited for identification and quantification of the polar metabolites of phytosterols in biological fluids after consumption of rice bran oil or other oils...
  66. ncbi request reprint LC-MS/MS analysis of lysophospholipids associated with soy protein isolate
    Nianbai Fang
    Arkansas Children s Nutrition Center, 1120 South Marshall Street, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 51:6676-82. 2003
    ..These findings suggest that biological effects of PLs associated with SPI in infants clearly needs to be considered as part of an overall evaluation of potential health benefits...
  67. ncbi request reprint The soy isoflavone genistein promotes apoptosis in mammary epithelial cells by inducing the tumor suppressor PTEN
    Bhuvanesh Dave
    Arkansas Children s Nutrition Center, Little Rock, AR 72202, USA
    Carcinogenesis 26:1793-803. 2005
    ....
  68. ncbi request reprint Comprehensive phytochemical profile of soy protein isolate
    Nianbai Fang
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, 1120 South Marshall Street, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 52:4012-20. 2004
    ..13% total fat), followed by saponins (21.48%), and then isoflavones at 6.82%. Of the 56 lysophospholipids identified in SPI, 0.50% was lysophosphatidylcholines and 0.23% was lysophosphatidylethanolamines...
  69. pmc Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury
    Brante P Sampey
    Department of Pharmaceutical Sciences, University of Colorado Health Sciences Center, Denver, 80262, USA
    Alcohol Clin Exp Res 27:1015-22. 2003
    ..The purpose of this study was to characterize hepatocellular formation of aldehyde-protein adducts during early stages of alcohol-induced liver injury...
  70. ncbi request reprint Cytotoxic hydroxylated triterpene alcohol ferulates from rice bran
    Hong Feng Luo
    Arkansas Children s Nutrition Center, Department of Pharmaceutical Sciences, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Nat Prod 68:94-7. 2005
    ..Their structures were elucidated by means of chemical and spectroscopic analysis. Compounds 2-5 showed moderate cytotoxicity against MCF-7 cells...
  71. ncbi request reprint Alcoholic liver disease in rats fed ethanol as part of oral or intragastric low-carbohydrate liquid diets
    Martin J J Ronis
    Department of Pharmacology and Toxicology, UAMS, Arkansas Children s Nutrition Center, Little Rock Arkansas, 72205, USA
    Exp Biol Med (Maywood) 229:351-60. 2004
    ....
  72. ncbi request reprint Isoflavone conjugates are underestimated in tissues using enzymatic hydrolysis
    Liwei Gu
    Arkansas Children s Nutrition Center, Department of Physiology Biophysics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    J Agric Food Chem 53:6858-63. 2005
    ..2-0.25 nmol/g range, far below the concentrations required for most in vitro effects of genistein or daidzein...
  73. ncbi request reprint Inhibition of NMU-induced mammary tumorigenesis by dietary soy
    Rosalia C M Simmen
    Arkansas Children s Nutrition Center, Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Cancer Lett 224:45-52. 2005
    ..Thus, dietary soy protects against mammary tumorigenesis induced by a direct-acting carcinogen and alters signaling pathways involving PR and HER-2/neu...
  74. ncbi request reprint Alcohol-induced disruption of endocrine signaling
    Martin J J Ronis
    Arkansas Children s Nutrition Center, Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202, USA
    Alcohol Clin Exp Res 31:1269-85. 2007
    ..Lang; (5) The role of reduced plasma estradiol and impaired estrogen signaling in alcohol-induced bone loss, by Martin J. Ronis; and (6) Short-term influence of alcohol on appetite-regulating hormones in man, by Jan Calissendorff...
  75. ncbi request reprint Maternal obesity at conception programs obesity in the offspring
    Kartik Shankar
    Arkansas Children s Nutrition Center, 1212 Marshall Street, Little Rock, AR 72202, USA
    Am J Physiol Regul Integr Comp Physiol 294:R528-38. 2008
    ..Our data suggest that maternal obesity at conception leads to fetal programming of offspring, which could result in obesity in later life...
  76. ncbi request reprint Effects of breast milk and milk formula diets on synthesized speech sound-induced event-related potentials in 3- and 6-month-old infants
    Hongkui Jing
    Arkansas Children s Nutrition Center, Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    Dev Neuropsychol 31:349-62. 2007
    ..These data suggest that the processing of the present speech stimuli is not affected by the investigated diets in the early infancy...
  77. ncbi request reprint The influence of infant diet on early developmental changes in processing human voice speech stimuli: ERP variations in breast and milk formula-fed infants at 3 and 6 months after birth
    R T Pivik
    Arkansas Children s Nutrition Center, Little Rock, AR, USA
    Dev Neuropsychol 31:279-335. 2007
    ..g., the P600 to the frequent syllable at 6 months. These variations appeared to be related to individual differences in development or paradigm-related features, i.e., ISI and frequency of syllable occurrence...
  78. ncbi request reprint Reduction in 7,12-dimethylbenz[a]anthracene-induced hepatic cytochrome-P450 1A1 expression following soy consumption in female rats is mediated by degradation of the aryl hydrocarbon receptor
    Rohit Singhal
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Nutr 137:19-24. 2007
    ..Our findings suggest that the cancer preventive effect of soy-based diets is mediated in part by reduction in AhR protein level posttranslationally, which reduces procarcinogen-induced CYP1A1 induction and metabolic activation...
  79. doi request reprint Cytokine and chemokine expression associated with steatohepatitis and hepatocyte proliferation in rats fed ethanol via total enteral nutrition
    Martin J J Ronis
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 1120 Marshall Street, Little Rock, AR 72202, USA
    Exp Biol Med (Maywood) 233:344-55. 2008
    ....
  80. ncbi request reprint Soy isoflavones attenuate human monocyte adhesion to endothelial cell-specific CD54 by inhibiting monocyte CD11a
    Shanmugam Nagarajan
    Department of Physiology and Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    J Nutr 136:2384-90. 2006
    ..Collectively, these data suggest that the athero-protective effect of soy diets may be mediated by blocking monocyte-endothelial cell interaction...
  81. ncbi request reprint Inhibition of growth and induction of apoptosis in human cancer cell lines by an ethyl acetate fraction from shiitake mushrooms
    Nianbai Fang
    Arkansas Children s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA
    J Altern Complement Med 12:125-32. 2006
    ..In this study, potential roles of an ethyl acetate fraction from shiitake mushrooms were investigated by in vitro bioassays...
  82. ncbi request reprint Effects of pregnancy and nutritional status on alcohol metabolism
    Kartik Shankar
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Alcohol Res Health 30:55-9. 2007
    ..Research using the TEN system has demonstrated that alcohol-induced fetal growth retardation is potentiated by undernutrition in part via impaired alcohol metabolism and clearance...
  83. ncbi request reprint Immunohistochemical study of osteopontin expression during distraction osteogenesis in the rat
    Daniel S Perrien
    Department of Pediatrics and Orthopaedics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, 1120 Marshall Street, Little Rock, AR 72202, USA
    J Histochem Cytochem 50:567-74. 2002
    ..Early expression may facilitate pre-osteoblastic proliferation and migration, while the latter downregulation may be necessary for hydroxyapatite crystal formation...

Research Grants10

  1. Alcohol: Direct and Indirect Effects in Drug Metabolism
    THOMAS BADGER; Fiscal Year: 2007
    ..abstract_text> ..
  2. ALCOHOL--DIRECT AND INDIRECT EFFECTS ON DRUG METABOLISM
    THOMAS BADGER; Fiscal Year: 2002
    ....