Karen O Badellino

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    Karen O Badellino
    Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e22. 2006
  2. ncbi Endothelial lipase is increased in vivo by inflammation in humans
    Karen O Badellino
    School of Nursing, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 117:678-85. 2008
  3. ncbi A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis
    Robert J Brown
    Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
    J Lipid Res 50:1910-6. 2009
  4. ncbi Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol
    Sumeet A Khetarpal
    Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002393. 2011
  5. ncbi Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation
    Nathalie Griffon
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:23322-30. 2009
  6. ncbi Vitamin D and the bariatric surgical patient: a review
    Charlene W Compher
    University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA 19104 6096, USA
    Obes Surg 18:220-4. 2008
  7. ncbi Role of N-linked glycosylation in the secretion and activity of endothelial lipase
    Gwen C Miller
    Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Lipid Res 45:2080-7. 2004
  8. ncbi The role of endothelial lipase in high-density lipoprotein metabolism
    Karen O Badellino
    School of Nursing, University of Pennsylvania, Philadelphia 19104, USA
    Curr Opin Cardiol 19:392-5. 2004
  9. ncbi Obesity and inflammation: lessons from bariatric surgery
    Charlene Compher
    University of Pennsylvania School of Nursing, Philadelphia, PA 19104 6096, USA
    JPEN J Parenter Enteral Nutr 32:645-7. 2008
  10. ncbi Allosteric modification of factor XIa functional activity upon binding to polyanions
    Dipali Sinha
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 43:7593-600. 2004

Research Grants

  1. Human endothelial lipase in cardiovascular disease
    KAREN BADELLINO; Fiscal Year: 2006

Collaborators

Detail Information

Publications13

  1. ncbi Endothelial lipase concentrations are increased in metabolic syndrome and associated with coronary atherosclerosis
    Karen O Badellino
    Institute for Translational Medicine and Therapeutics, School of Nursing, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    PLoS Med 3:e22. 2006
    ..We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans...
  2. ncbi Endothelial lipase is increased in vivo by inflammation in humans
    Karen O Badellino
    School of Nursing, and Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Circulation 117:678-85. 2008
    ..Furthermore, we directly tested the hypothesis that plasma EL concentrations would increase with induction of an inflammatory state by low-dose endotoxin in humans...
  3. ncbi A naturally occurring variant of endothelial lipase associated with elevated HDL exhibits impaired synthesis
    Robert J Brown
    Department of Medicine and Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
    J Lipid Res 50:1910-6. 2009
    ..Thus, this N-terminal variant results in reduced secretion of EL protein, plausibly leading to increased HDL-C levels...
  4. ncbi Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol
    Sumeet A Khetarpal
    Institute for Translational Medicine and Therapeutics, Institute for Diabetes, Obesity, and Metabolism, and Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS Genet 7:e1002393. 2011
    ..Taken together, the findings show that both rare and common noncoding regulatory variants are important contributors to the allelic spectrum in complex trait loci...
  5. ncbi Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation
    Nathalie Griffon
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 284:23322-30. 2009
    ..These data confirm the hypothesis that EL is active as a homodimer in head-to-tail conformation...
  6. ncbi Vitamin D and the bariatric surgical patient: a review
    Charlene W Compher
    University of Pennsylvania School of Nursing, 418 Curie Boulevard, Philadelphia, PA 19104 6096, USA
    Obes Surg 18:220-4. 2008
    ..The purpose of this review was to describe current knowledge about vitamin D and severe obesity, and the impact of obesity surgery on vitamin D status...
  7. ncbi Role of N-linked glycosylation in the secretion and activity of endothelial lipase
    Gwen C Miller
    Department of Medicine and Center for Experimental Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    J Lipid Res 45:2080-7. 2004
    ..The Asn-373 mutant demonstrated a 3-fold decrease in bridging compared with wild-type EL, whereas Asn-116 and Asn-471 were similar to wild-type EL...
  8. ncbi The role of endothelial lipase in high-density lipoprotein metabolism
    Karen O Badellino
    School of Nursing, University of Pennsylvania, Philadelphia 19104, USA
    Curr Opin Cardiol 19:392-5. 2004
    ..Endothelial lipase could be an important new target for novel therapies to raise high-density lipoprotein levels...
  9. ncbi Obesity and inflammation: lessons from bariatric surgery
    Charlene Compher
    University of Pennsylvania School of Nursing, Philadelphia, PA 19104 6096, USA
    JPEN J Parenter Enteral Nutr 32:645-7. 2008
    ..Obesity is associated with a series of comorbid conditions that are characterized by an inflammatory state. The purpose of this review is to update knowledge about obesity, adipose tissue, and inflammation...
  10. ncbi Allosteric modification of factor XIa functional activity upon binding to polyanions
    Dipali Sinha
    The Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA
    Biochemistry 43:7593-600. 2004
    ..These results provide compelling evidence that factor XIa binding to the polyanions, dextran sulfate and heparin, results in inhibition of the enzyme by an allosteric mechanism...
  11. ncbi Endothelial lipase is associated with inflammation in humans
    Marie Eve Paradis
    Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
    J Lipid Res 47:2808-13. 2006
    ..0005). In conclusion, our data reveal a strong association between proinflammatory cytokines and plasma EL concentrations among healthy people with low or high VAT levels...
  12. ncbi Visceral adiposity and endothelial lipase
    Marie Eve Paradis
    Nutraceuticals and Functional Foods Institute, 2440 Boulevard Hochelaga, Laval University, Quebec, Canada
    J Clin Endocrinol Metab 91:3538-43. 2006
    ..However, the extent to which EL contributes to modulate the deteriorated high-density lipoprotein profile observed in obesity in humans is less clear...
  13. ncbi Effect of fenofibrate on plasma lipoprotein composition and kinetics in patients with complete hepatic lipase deficiency
    Isabelle L Ruel
    Institute on Nutraceuticals and Functional Foods, Laval University, , Canada
    Arterioscler Thromb Vasc Biol 25:2600-7. 2005
    ..CONCLUSIONS: Fenofibrate therapy exerts a pronounced antiatherogenic effect on triglyceride-rich lipoproteins even in the complete absence of HL...

Research Grants1

  1. Human endothelial lipase in cardiovascular disease
    KAREN BADELLINO; Fiscal Year: 2006
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