Jeffrey L Bada

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Miller revealed new ways to study the origins of life
    Jeffrey L Bada
    Nature 416:475. 2002
  2. ncbi request reprint A search for endogenous amino acids in martian meteorite ALH84001
    J L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0212, USA
    Science 279:362-5. 1998
  3. doi request reprint The Miller volcanic spark discharge experiment
    Adam P Johnson
    Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47401, USA
    Science 322:404. 2008
  4. pmc Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment
    Eric T Parker
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093, USA
    Orig Life Evol Biosph 41:201-12. 2011
  5. doi request reprint New insights into prebiotic chemistry from Stanley Miller's spark discharge experiments
    Jeffrey L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0212, USA
    Chem Soc Rev 42:2186-96. 2013
  6. ncbi request reprint Origin of life. Some like it hot, but not the first biomolecules
    Jeffrey L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 02093, USA
    Science 296:1982-3. 2002
  7. ncbi request reprint Perceptions of science. Prebiotic soup--revisiting the Miller experiment
    Jeffrey L Bada
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
    Science 300:745-6. 2003
  8. ncbi request reprint Amino acid racemization on Mars: implications for the preservation of biomolecules from an extinct martian biota
    J L Bada
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093 0212, USA
    Icarus 114:139-43. 1995
  9. pmc Preservation of key biomolecules in the fossil record: current knowledge and future challenges
    J L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093 0212, USA
    Philos Trans R Soc Lond B Biol Sci 354:77-86; discussion 86-7. 1999
  10. pmc Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment
    Eric T Parker
    Geosciences Research Division, Scripps Institution of Oceanography, University of California at San Diego, 8615 Kennel Way, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:5526-31. 2011

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Miller revealed new ways to study the origins of life
    Jeffrey L Bada
    Nature 416:475. 2002
  2. ncbi request reprint A search for endogenous amino acids in martian meteorite ALH84001
    J L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0212, USA
    Science 279:362-5. 1998
    ....
  3. doi request reprint The Miller volcanic spark discharge experiment
    Adam P Johnson
    Interdisciplinary Biochemistry Program, Indiana University, Bloomington, IN 47401, USA
    Science 322:404. 2008
    ..Prebiotic compounds synthesized in these environments could have locally accumulated, where they could have undergone further processing...
  4. pmc Prebiotic synthesis of methionine and other sulfur-containing organic compounds on the primitive Earth: a contemporary reassessment based on an unpublished 1958 Stanley Miller experiment
    Eric T Parker
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093, USA
    Orig Life Evol Biosph 41:201-12. 2011
    ....
  5. doi request reprint New insights into prebiotic chemistry from Stanley Miller's spark discharge experiments
    Jeffrey L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 92093 0212, USA
    Chem Soc Rev 42:2186-96. 2013
    ..Some of the alternatives to the Miller-based prebiotic synthesis and the "primordial soup" paradigm are evaluated in the context of their relevance under plausible planetary conditions...
  6. ncbi request reprint Origin of life. Some like it hot, but not the first biomolecules
    Jeffrey L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA 02093, USA
    Science 296:1982-3. 2002
  7. ncbi request reprint Perceptions of science. Prebiotic soup--revisiting the Miller experiment
    Jeffrey L Bada
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093, USA
    Science 300:745-6. 2003
    ..Also see the archival list of the Essays on Science and Society. PERCEPTIONS IN SCIENCE: Prebiotic Soup--Revisiting the Miller Experiment Jeffrey L. Bada and Antonio Lazcano..
  8. ncbi request reprint Amino acid racemization on Mars: implications for the preservation of biomolecules from an extinct martian biota
    J L Bada
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093 0212, USA
    Icarus 114:139-43. 1995
    ..The best preservation of both amino acid homochirality and nucleic acid genetic information associated with extinct martian life would be in the polar regions...
  9. pmc Preservation of key biomolecules in the fossil record: current knowledge and future challenges
    J L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093 0212, USA
    Philos Trans R Soc Lond B Biol Sci 354:77-86; discussion 86-7. 1999
    ....
  10. pmc Primordial synthesis of amines and amino acids in a 1958 Miller H2S-rich spark discharge experiment
    Eric T Parker
    Geosciences Research Division, Scripps Institution of Oceanography, University of California at San Diego, 8615 Kennel Way, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:5526-31. 2011
    ....
  11. doi request reprint Enhanced synthesis of alkyl amino acids in Miller's 1958 H2S experiment
    Eric T Parker
    Scripps Institution of Oceanography, University of California at San Diego, 8615 Kennel Way, La Jolla, CA 92093 0212, USA
    Orig Life Evol Biosph 41:569-74. 2011
    ....
  12. ncbi request reprint Evolutionary anomalies among the aminoacyl-tRNA synthetases
    R F Doolittle
    Center for Molecular Genetics, University of California, San Diego, La Jolla, California 92093 0634, USA
    Curr Opin Genet Dev 8:630-6. 1998
    ..The question arises - is this mainly the result of promiscuous exchange, or is the confusion really a reflection of the differential loss of past duplications? Phylogenetic analysis may yet provide the answer...
  13. ncbi request reprint Relative amino acid concentrations as a signature for parent body processes of carbonaceous chondrites
    Oliver Botta
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA, USA
    Orig Life Evol Biosph 32:143-63. 2002
    ..In contrast to CMs, the data from the CI carbonaceous chondrites indicate that the Strecker synthesis was not active on their parent bodies...
  14. doi request reprint Primordial ocean chemistry and its compatibility with the RNA world
    Jeremy Kua
    Department of Chemistry and Biochemistry, University of San Diego, 5998 Alcala Park, San Diego, CA 92110, USA
    Orig Life Evol Biosph 41:553-8. 2011
    ..The conditions we have chosen range from highly acidic or alkaline hydrothermal vents, to the milder conditions in a primordial ocean at a range of atmospheric CO(2) partial pressures...
  15. pmc Development and evaluation of a microdevice for amino acid biomarker detection and analysis on Mars
    Alison M Skelley
    Department of Chemistry, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 102:1041-6. 2005
    ..These results demonstrate the feasibility of using the MOA to perform sensitive in situ amino acid biomarker analysis on soil samples representative of a Mars-like environment...
  16. ncbi request reprint Direct isolation of purines and pyrimidines from nucleic acids using sublimation
    Daniel P Glavin
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093, USA
    Anal Chem 74:6408-12. 2002
    ..These results demonstrate the feasibility of using sublimation to isolate purines and pyrimidines from native E. coli DNA and RNA without any chemical treatment of the cells...
  17. ncbi request reprint Survival of amino acids in micrometeorites during atmospheric entry
    D P Glavin
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla, CA, USA
    Astrobiology 1:259-69. 2001
    ....
  18. pmc The first living systems: a bioenergetic perspective
    D W Deamer
    Department of Chemistry and Biochemistry, University of California, Santa Cruz 95064, USA
    Microbiol Mol Biol Rev 61:239-61. 1997
    ..Despite this progress, there is still no clear mechanism by which the free energy of light, ion gradients, or redox potential can be coupled to polymer bond formation in a protocellular structure...
  19. ncbi request reprint Radiation-dependent limit for the viability of bacterial spores in halite fluid inclusions and on Mars
    Gerhard Kminek
    Scripps Institution of Oceanography, University of California, San Diego, USA
    Radiat Res 159:722-9. 2003
    ....
  20. ncbi request reprint Determination of alpha-dialkylamino acids and their enantiomers in geological samples by high-performance liquid chromatography after derivatization with a chiral adduct of o-phthaldialdehyde
    M Zhao
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093, USA
    J Chromatogr A 690:55-63. 1995
    ..The estimated detection limit for alpha-dialkylamino acids is 1-2 pmol, comparable to that for protein amino acids...
  21. ncbi request reprint Entropy and charge in molecular evolution--the case of phosphate
    G Arrhenius
    Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093 0220, USA
    J Theor Biol 187:503-22. 1997
    ..As a manifestation of life arisen, phosphate already appears in an organic context in the oldest preserved sedimentary record...
  22. ncbi request reprint The origin of life--a review of facts and speculations
    L E Orgel
    Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Trends Biochem Sci 23:491-5. 1998
    ..It is not possible to decide which is correct. It is also unclear whether the RNA world was the first biological world or whether some simpler world preceded it...
  23. pmc Impact melting of frozen oceans on the early Earth: implications for the origin of life
    J L Bada
    Scripps Institution of Oceanography, University of California at San Diego, La Jolla 92093 0212, USA
    Proc Natl Acad Sci U S A 91:1248-50. 1994
    ..Thaw-freeze cycles associated with bolide impacts could have been important for the initiation of abiotic reactions that gave rise to the first living organisms...
  24. ncbi request reprint Nonenzymatic template-directed reactions on altritol oligomers, preorganized analogues of oligonucleotides
    I A Kozlov
    The Salk Institute for Biological Studies, San Diego, California 92186, USA
    Chemistry 6:151-5. 2000
    ..Activated ANA and HNA monomers do not oligomerize efficiently on DNA, RNA, HNA, or ANA templates...
  25. doi request reprint A reassessment of prebiotic organic synthesis in neutral planetary atmospheres
    H James Cleaves
    Geophysical Laboratory, Carnegie Institution of Washington, Washington, DC, 20015, USA
    Orig Life Evol Biosph 38:105-15. 2008
    ..The results reported here suggest that endogenous synthesis from neutral atmospheres may be more important than previously thought...
  26. ncbi request reprint The 1953 Stanley L. Miller experiment: fifty years of prebiotic organic chemistry
    Antonio Lazcano
    Facultad de Ciencias, UNAM, Mexico DF, Mexico
    Orig Life Evol Biosph 33:235-42. 2003
  27. ncbi request reprint Debating evidence for the origin of life on Earth
    Jeffrey L Bada
    Science 315:937-9; author reply 937-9. 2007
  28. ncbi request reprint Application of the Mars Organic Analyzer to nucleobase and amine biomarker detection
    Alison M Skelley
    Department of Chemistry, University of California at Berkeley, 94720, USA
    Astrobiology 6:824-37. 2006
    ..04% and 0.0003%, respectively. This study demonstrates that the MOA provides sensitive detection and analysis of low levels of a wide variety of amine-containing organic compounds from both biological and abiotic sources...
  29. pmc New method for estimating bacterial cell abundances in natural samples by use of sublimation
    Daniel P Glavin
    NASA Goddard Space Flight Center, Greenbelt, Maryland 20071, USA
    Appl Environ Microbiol 70:5923-8. 2004
    ..coli cell equivalents per gram. For most of these samples, the sublimation-based cell counts were in agreement with total bacterial counts obtained by traditional DAPI (4,6-diamidino-2-phenylindole) staining...