Peter Bacchetti

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Estimating complex multi-state misclassification rates for biopsy-measured liver fibrosis in patients with hepatitis C
    Peter Bacchetti
    University of California, San Francisco, USA
    Int J Biostat 5:Article 5. 2009
  2. ncbi request reprint Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS
    P Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143 0840, USA
    Lifetime Data Anal 1:35-47. 1995
  3. pmc Estimating past hepatitis C infection risk from reported risk factor histories: implications for imputing age of infection and modeling fibrosis progression
    Peter Bacchetti
    Box 0560, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    BMC Infect Dis 7:145. 2007
  4. ncbi request reprint Age and variant Creutzfeldt-Jakob disease
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0560, USA
    Emerg Infect Dis 9:1611-2. 2003
  5. pmc Breaking free of sample size dogma to perform innovative translational research
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    Sci Transl Med 3:87ps24. 2011
  6. pmc Simple, defensible sample sizes based on cost efficiency
    Peter Bacchetti
    Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0560, USA
    Biometrics 64:577-85; discussion 586-94. 2008
  7. pmc Current sample size conventions: flaws, harms, and alternatives
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    BMC Med 8:17. 2010
  8. ncbi request reprint Uncertainty due to model choice in variant Creutzfeldt-Jakob disease projections
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0560, USA
    Stat Med 24:83-93. 2005
  9. ncbi request reprint Ethics and sample size
    Peter Bacchetti
    Division of Biostatistics, Department of Epidemiology and Biostatistics, School of Medicine, Box 0560, University of California, San Francisco, CA 94143, USA
    Am J Epidemiol 161:105-10. 2005
  10. pmc Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects
    Rebecca Scherzer
    Northern California Institute for Research and Education, San Francisco, CA, USA
    Am J Clin Nutr 87:1809-17. 2008

Research Grants

Collaborators

Detail Information

Publications103 found, 100 shown here

  1. pmc Estimating complex multi-state misclassification rates for biopsy-measured liver fibrosis in patients with hepatitis C
    Peter Bacchetti
    University of California, San Francisco, USA
    Int J Biostat 5:Article 5. 2009
    ....
  2. ncbi request reprint Survival trees with time-dependent covariates: application to estimating changes in the incubation period of AIDS
    P Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143 0840, USA
    Lifetime Data Anal 1:35-47. 1995
    ..Contrary to expectation, we find that rates of progression to AIDS appear to be faster after August 1989 than before...
  3. pmc Estimating past hepatitis C infection risk from reported risk factor histories: implications for imputing age of infection and modeling fibrosis progression
    Peter Bacchetti
    Box 0560, Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    BMC Infect Dis 7:145. 2007
    ..We sought to examine the accuracy of such imputation and implications for modeling factors that influence progression rates...
  4. ncbi request reprint Age and variant Creutzfeldt-Jakob disease
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0560, USA
    Emerg Infect Dis 9:1611-2. 2003
    ..This analysis shows that an influence of age on risk for death after infection better explains age patterns, suggesting that biologic factors peaking in the third decade of life may hasten disease...
  5. pmc Breaking free of sample size dogma to perform innovative translational research
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    Sci Transl Med 3:87ps24. 2011
    ..Renouncing false dogma about sample size would remove a serious barrier to innovation and translation...
  6. pmc Simple, defensible sample sizes based on cost efficiency
    Peter Bacchetti
    Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, California 94143 0560, USA
    Biometrics 64:577-85; discussion 586-94. 2008
    ..These methods are easy to implement, based on reliable inputs, and well justified, so they should be regarded as acceptable alternatives to current conventional approaches...
  7. pmc Current sample size conventions: flaws, harms, and alternatives
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143, USA
    BMC Med 8:17. 2010
    ..The belief remains widespread that medical research studies must have statistical power of at least 80% in order to be scientifically sound, and peer reviewers often question whether power is high enough...
  8. ncbi request reprint Uncertainty due to model choice in variant Creutzfeldt-Jakob disease projections
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0560, USA
    Stat Med 24:83-93. 2005
    ..The scientific publication process may have inherent disincentives for thorough assessment of uncertainty...
  9. ncbi request reprint Ethics and sample size
    Peter Bacchetti
    Division of Biostatistics, Department of Epidemiology and Biostatistics, School of Medicine, Box 0560, University of California, San Francisco, CA 94143, USA
    Am J Epidemiol 161:105-10. 2005
    ..Lower power does not make a study unethical. The analysis addresses only ethical acceptability, not optimality; large studies may be desirable for other than ethical reasons...
  10. pmc Simple anthropometric measures correlate with metabolic risk indicators as strongly as magnetic resonance imaging-measured adipose tissue depots in both HIV-infected and control subjects
    Rebecca Scherzer
    Northern California Institute for Research and Education, San Francisco, CA, USA
    Am J Clin Nutr 87:1809-17. 2008
    ..Studies in persons without HIV infection have compared percentage body fat (%BF) and waist circumference as markers of risk for the complications of excess adiposity, but only limited study has been conducted in HIV-infected subjects...
  11. pmc Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women
    Monica Gandhi
    Department of Medicine, University of California San Francisco, 405 Irving Street, 2nd Floor, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 50:482-91. 2009
    ....
  12. pmc Association of HIV infection, demographic and cardiovascular risk factors with all-cause mortality in the recent HAART era
    Leslie Cockerham
    Department of Medicine, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 53:102-6. 2010
    ..To determine the relationship of HIV infection, demographic, and cardiovascular disease (CVD) risk factors with mortality in the recent highly active antiretroviral therapy era...
  13. pmc Comparison of dual-energy X-ray absorptiometry and magnetic resonance imaging-measured adipose tissue depots in HIV-infected and control subjects
    Rebecca Scherzer
    University of California, San Francisco, CA 94121, USA
    Am J Clin Nutr 88:1088-96. 2008
    ....
  14. doi request reprint Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infection
    Rebecca Scherzer
    University of California, San Francisco, USA
    AIDS 25:1405-14. 2011
    ..Unintentional loss of weight and muscle due to aging and disease has been associated with increased mortality. Wasting and weight loss occur in HIV infection even in the modern era of effective antiretroviral therapy...
  15. pmc Lower liver-related death in African-American women with human immunodeficiency virus/hepatitis C virus coinfection, compared to Caucasian and Hispanic women
    Monika Sarkar
    Department of Medicine, University of California, San Francisco, CA, USA
    Hepatology 56:1699-705. 2012
    ..19-0.88; P = 0.022) and Hispanic coinfected women (HR, 0.38; 95% CI: 0.19-0.76; P = 0.006). All-cause mortality was similar between racial/ethnic groups (HRs for all comparisons: 0.82-1.03; log-rank test: P = 0.8)...
  16. pmc Association between hepatitis C virus coinfection and regional adipose tissue volume in HIV-infected men and women
    Phyllis C Tien
    Department of Medicine, University of California San Francisco and Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 45:60-5. 2007
    ..Coinfection with hepatitis C virus (HCV) is reported to be associated with a higher prevalence of lipodystrophy than HIV infection alone. We examine the association between HCV and adipose tissue volume in HIV-infected men and women...
  17. pmc Atazanavir concentration in hair is the strongest predictor of outcomes on antiretroviral therapy
    Monica Gandhi
    Departments of Medicine, University of California, San Francisco, 94122, USA
    Clin Infect Dis 52:1267-75. 2011
    ..Hair concentrations of antiretrovirals can integrate adherence and pharmacokinetics into a single assay...
  18. pmc Regional adipose tissue and elevations in serum aminotransferases in HIV-infected individuals
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 48:169-76. 2008
    ..Obesity is associated with hepatic steatosis, and ALT is a marker of steatosis in the general population...
  19. pmc Association of antiretroviral therapy with fibrinogen levels in HIV-infection
    Erin Madden
    Northern California Institute for Research and Education, San Francisco, USA
    AIDS 22:707-15. 2008
    ..HIV infection is associated with an increased risk of coronary artery disease, but the contribution of inflammation versus antiretroviral drugs is not well understood. Fibrinogen is an inflammatory factor associated with atherosclerosis...
  20. pmc Regional adipose tissue measured by MRI over 5 years in HIV-infected and control participants indicates persistence of HIV-associated lipoatrophy
    Carl Grunfeld
    Office of the Principal Investigator, The FRAM Study, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 94121, USA
    AIDS 24:1717-26. 2010
    ..controls. Therefore, we determined change in regional adipose tissue from baseline examination to 5 years later among participants in the study of Fat Redistribution and Metabolic Change in HIV Infection...
  21. pmc Protease inhibitor levels in hair strongly predict virologic response to treatment
    Monica Gandhi
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    AIDS 23:471-8. 2009
    ..The currently available methods to assess ARV exposure are limited. Levels of ARVs in hair reflect plasma concentrations over weeks to months, and may provide a novel method for predicting therapeutic responses...
  22. pmc A single-nucleotide polymorphism in CYP2B6 leads to >3-fold increases in efavirenz concentrations in plasma and hair among HIV-infected women
    Monica Gandhi
    Department of Medicine, University of California, San Francisco, CA, USA
    J Infect Dis 206:1453-61. 2012
    ..We analyzed numerous genetic and nongenetic factors impacting short-term and long-term exposure in a large heterogeneous population of human immunodeficiency virus (HIV)-infected women...
  23. pmc Inflammation and mortality in HIV-infected adults: analysis of the FRAM study cohort
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94121, USA
    J Acquir Immune Defic Syndr 55:316-22. 2010
    ..To determine the association of inflammatory markers, fibrinogen, and C-reactive protein (CRP), with 5-year mortality risk...
  24. pmc Cystatin C, albuminuria, and 5-year all-cause mortality in HIV-infected persons
    ANDY CHOI
    University of California, San Francisco, CA, USA
    Am J Kidney Dis 56:872-82. 2010
    ..However, the clinical importance of increased cystatin C level and albuminuria in the HIV-infected population has not been studied...
  25. pmc Intermuscular adipose tissue and metabolic associations in HIV infection
    Rebecca Scherzer
    University of California, San Francisco, California, USA
    Obesity (Silver Spring) 19:283-91. 2011
    ..Stavudine exposure is associated with both decreased IMAT and SAT, suggesting that IMAT shares cellular origins with SAT...
  26. doi request reprint Low rates of antiretroviral therapy among HIV-infected patients with chronic kidney disease
    Andy I Choi
    Department of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
    Clin Infect Dis 45:1633-9. 2007
    ....
  27. pmc HIV viremia and changes in kidney function
    Chris T Longenecker
    University of California, San Francisco, California 94121, USA
    AIDS 23:1089-96. 2009
    ..To evaluate the effect of HIV infection on longitudinal changes in kidney function and to identify independent predictors of kidney function changes in HIV-infected individuals...
  28. ncbi request reprint Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study
    Donald I Abrams
    Community Consortium, Positive Health Program, University of California, San Francisco, CA 94143, USA
    AIDS Res Hum Retroviruses 23:77-85. 2007
    ....
  29. pmc Racial/ethnic differences in spontaneous HCV clearance in HIV infected and uninfected women
    Monika Sarkar
    Department of Medicine, Division of Gastroenterology and Hepatology, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0358, USA
    Dig Dis Sci 58:1341-8. 2013
    ..Few studies report racial/ethnic differences in acute HCV in HIV infected, or Hispanic women. We examined racial/ethnic differences in spontaneous HCV clearance in a population of HCV mono- and co-infected women...
  30. pmc Fibrosis progression in African Americans and Caucasian Americans with chronic hepatitis C
    Norah A Terrault
    Department of Medicine, University of California San Francisco, San Francisco, California 94143 0538, USA
    Clin Gastroenterol Hepatol 6:1403-11. 2008
    ..Prior studies suggest the rate of liver fibrosis progression is slower in African Americans (AAs) than Caucasian Americans (CAs) with chronic HCV infection...
  31. ncbi request reprint Herpes simplex virus infection in women in the WIHS: epidemiology and effect of antiretroviral therapy on clinical manifestations
    Niloufar Ameli
    Department of Medicine, Division of Infectious Diseases, University of California San Francisco School of Medicine, San Francisco, CA 94143, USA
    AIDS 20:1051-8. 2006
    ..To determine the prevalence of infection with herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) among women with and at high risk for HIV infection, and to evaluate the effect of HAART on the recurrence of genital lesions...
  32. pmc Association of HIV infection and HIV/HCV coinfection with C-reactive protein levels: the fat redistribution and metabolic change in HIV infection (FRAM) study
    Jason Reingold
    University of California, San Francisco, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 48:142-8. 2008
    ..We evaluated C-reactive protein (CRP) in HIV-infected and HIV/HCV-coinfected individuals in the era of effective antiretroviral (ARV) therapy...
  33. pmc Association of upper trunk and visceral adipose tissue volume with insulin resistance in control and HIV-infected subjects in the FRAM study
    Carl Grunfeld
    Department of Medicine, University of California, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 46:283-90. 2007
    ..Thus, VAT and upper trunk SAT are independently associated with insulin resistance in controls and in HIV-infected persons...
  34. pmc Non-Markov multistate modeling using time-varying covariates, with application to progression of liver fibrosis due to hepatitis C following liver transplant
    Peter Bacchetti
    University of California, San Francisco, CA, USA
    Int J Biostat 6:Article 7. 2010
    ....
  35. pmc Insulin resistance and cognition among HIV-infected and HIV-uninfected adult women: the Women's Interagency HIV Study
    Victor Valcour
    Memory and Aging Center, Department of Neurology and Division of Geriatric Medicine, Department of Medicine, University of California at San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
    AIDS Res Hum Retroviruses 28:447-53. 2012
    ..HIV status did not appear to substantially impact the relationship of HOMA with SCN. There was a small but statistically significant association of HOMA and reduced neuropsychological performance on the SCN test in this cohort of women...
  36. ncbi request reprint Racial differences in end-stage renal disease rates in HIV infection versus diabetes
    Andy I Choi
    Department of Medicine, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Am Soc Nephrol 18:2968-74. 2007
    ..HIV and diabetes carry a similar risk of ESRD among black patients, highlighting the importance of developing strategies to prevent and treat renal disease among HIV-infected black individuals...
  37. pmc White/black racial differences in risk of end-stage renal disease and death
    Andy I Choi
    Department of Medicine, San Francisco Veterans Affairs VA Medical Center and University of California, San Francisco, CA 94121, USA
    Am J Med 122:672-8. 2009
    ..Understanding the natural history of racial differences in kidney disease may help guide efforts to reduce disparities...
  38. ncbi request reprint Enrichment of activated monocytes in cerebrospinal fluid during antiretroviral therapy
    Jutta K Neuenburg
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94158, USA
    AIDS 19:1351-9. 2005
    ..Although clinical brain disease is uncommon during combination antiretroviral therapy (ART), autopsy series indicate that HIV-infected brain tissue can contain high numbers of monocytes/macrophages despite ART...
  39. pmc Preclinical atherosclerosis due to HIV infection: carotid intima-medial thickness measurements from the FRAM study
    Carl Grunfeld
    Medical Service, Department of Veterans Affairs Medical Center, University of California, San Francisco, California 94121, USA
    AIDS 23:1841-9. 2009
    ..However, it is controversial whether HIV infection contributes to accelerated atherosclerosis independent of traditional CVD risk factors...
  40. ncbi request reprint Predictors of publication: characteristics of submitted manuscripts associated with acceptance at major biomedical journals
    Kirby P Lee
    University of California, San Francisco, CA, USA
    Med J Aust 184:621-6. 2006
    ..To identify characteristics of submitted manuscripts that are associated with acceptance for publication by major biomedical journals...
  41. doi request reprint Common clinical conditions - age, low BMI, ritonavir use, mild renal impairment - affect tenofovir pharmacokinetics in a large cohort of HIV-infected women
    Sanjiv M Baxi
    aDepartment of Medicine bDepartment of Clinical Pharmacy cDepartment of Epidemiology and Biostatistics, University of California San Francisco UCSF, San Francisco, California dDepartment of Medicine, SUNY Downstate Medical Center, Brooklyn, New York eDepartment of Bioengineering and Therapeutic Sciences, University of California San Francisco UCSF, San Francisco, California fDepartment of Medicine, Albert Einstein University, Bronx, New York gDepartment of Medicine, Stroger Hospital and Rush University, Chicago, Illinois hDepartment of Medicine, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland iDepartment of Medicine, Georgetown University Medical Center, Washington DC jSection of General Internal Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA
    AIDS 28:59-66. 2014
    ..Tenofovir is used commonly in HIV treatment and prevention settings, but factors that correlate with tenofovir exposure in real-world settings are unknown...
  42. pmc Risk factors and outcomes in transfusion-associated circulatory overload
    Edward L Murphy
    Department of Laboratory Medicine, University of California, San Francisco, CA 94118, USA
    Am J Med 126:357.e29-38. 2013
    ..Transfusion-associated circulatory overload is characterized by new respiratory distress and hydrostatic pulmonary edema within 6 hours after blood transfusion, but its risk factors and outcomes are poorly characterized...
  43. ncbi request reprint Serum sodium predicts mortality in patients listed for liver transplantation
    Scott W Biggins
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Hepatology 41:32-9. 2005
    ..Addition of serum sodium to MELD increases the ability to predict 3- and 6-month mortality in patients with cirrhosis...
  44. ncbi request reprint Management of hepatitis C-infected liver transplant recipients at large North American centres: changes in recent years
    Mandana Khalili
    Department of Medicine, University of California, San Francisco, CA 94110, USA
    Clin Transplant 20:1-9. 2006
    ..We conclude that there is considerable variability in the management of HCV among transplant programs and over time...
  45. ncbi request reprint Geography matters: relationships among urban residential segregation, dialysis facilities, and patient outcomes
    Rudolph A Rodriguez
    San Francisco General Hospital, University of California, San Francisco, Veterans Affairs Medical Center, San Francisco, California 94110, USA
    Ann Intern Med 146:493-501. 2007
    ..However, the impact of residential segregation by race-a prominent feature of many U.S. cities--on outcomes of patients receiving dialysis and on facility performance has not been evaluated...
  46. pmc Regional adipose tissue and lipid and lipoprotein levels in HIV-infected women
    Judith Currier
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    J Acquir Immune Defic Syndr 48:35-43. 2008
    ..HIV infection and antiretroviral therapy are associated with dyslipidemia, but the association between regional body fat and lipid levels is not well described...
  47. pmc Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children
    Robert H Lustig
    Division of Pediatric Endocrinology, Department of Pediatrics, University of California, San Francisco, USA
    J Pediatr 148:23-9. 2006
    ....
  48. ncbi request reprint Physician predictors of mammographic accuracy
    Rebecca Smith-Bindman
    Department of Radiology, University of California, San Francisco, 1600 Divisadero St, San Francisco, CA 94115, USA
    J Natl Cancer Inst 97:358-67. 2005
    ..The association between physician experience and the accuracy of screening mammography in community practice is not well studied. We identified characteristics of U.S. physicians associated with the accuracy of screening mammography...
  49. doi request reprint HIV/hepatitis C virus coinfection ameliorates the atherogenic lipoprotein abnormalities of HIV infection
    Amber L Wheeler
    aDepartment of Medicine, University of California San Francisco bDivision of Endocrinology and Metabolism, Department of Veterans Affairs Medical Center San Francisco, San Francisco cDepartment of Medicine, University of California, San Diego School of Medicine, San Diego, California dDepartment of Epidemiology, University of Washington, Seattle, Washington eDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco fDivision of Research, Kaiser Permanente, Oakland, California, USA
    AIDS 28:49-58. 2014
    ..The extent to which HIV infection and HIV/hepatitis C virus (HCV) coinfection are associated with abnormalities of lipoprotein subclasses is unknown...
  50. pmc Influence of cannabis use on severity of hepatitis C disease
    Julie H Ishida
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Clin Gastroenterol Hepatol 6:69-75. 2008
    ..Complications of HCV infection are primarily related to the development of advanced fibrosis and whether cannabis use is a risk factor for more severe fibrosis is controversial...
  51. pmc Progression of biopsy-measured liver fibrosis in untreated patients with hepatitis C infection: non-Markov multistate model analysis
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e20104. 2011
    ..Fibrosis stages from liver biopsies reflect liver damage from hepatitis C infection, but analysis is challenging due to their ordered but non-numeric nature, infrequent measurement, misclassification, and unknown infection times...
  52. ncbi request reprint Effect of emergency department crowding on pneumonia admission care components
    Christopher Fee
    Department of Emergency Medicine, University of California, San Francisco Medical Center, 94143, USA
    Am J Manag Care 17:269-78. 2011
    ..To determine pneumonia admission care components that are most affected by emergency department (ED) crowding...
  53. pmc HIV RNA level in early infection is predicted by viral load in the transmission source
    Frederick M Hecht
    HIV AIDS Division, Department of Medicine, San Francisco General Hospital, University of California, CA 94110, USA
    AIDS 24:941-5. 2010
    ..We sought to determine the relationship between HIV-1 RNA levels in the source partner and recently infected recipient partners within transmission pairs...
  54. pmc Cystatin C level as a marker of kidney function in human immunodeficiency virus infection: the FRAM study
    Michelle C Odden
    Department of Medicine, San FranciscoVeterans Affairs Medical Center 4150 Clement Street, San Francisco, CA 94121, USA
    Arch Intern Med 167:2213-9. 2007
    ..Cystatin C measurement may be more sensitive than creatinine for detecting impaired kidney function in persons with HIV...
  55. ncbi request reprint Trends in human immunodeficiency virus seroincidence among street-recruited injection drug users in San Francisco, 1987-1998
    Alex H Kral
    Urban Health Study, Department of Family and Community Medicine, University of California, San Francisco, San Francisco, CA 94110, USA
    Am J Epidemiol 157:915-22. 2003
    ..21, 0.87). Sensitive/less sensitive enzyme immunoassay testing is an effective tool for assessing HIV incidence. HIV incidence among street-recruited IDUs in San Francisco appears to have remained stable and moderate since the late 1980s...
  56. pmc Association between syphilis, antibodies to herpes simplex virus type 2, and recreational drug use and hepatitis B virus infection in the Women's Interagency HIV Study
    Phyllis C Tien
    Department of Medicine, University of California, San Francisco, CA, USA
    Clin Infect Dis 39:1363-70. 2004
    ..Liver disease is a leading cause of death in human immunodeficiency virus (HIV)-infected women; however, risk factors for hepatitis b virus (hbv) infection in this population have not been well studied...
  57. ncbi request reprint Quantifying smoking cessation outcomes: from The Women's Initiative for Nonsmoking Study (X): methodological implications
    Roberta K Oka
    Department of Community Health Systems, University of California, San Francisco, CA 94143 0608, USA
    Nurs Res 55:292-7. 2006
    ..Classification of smoking status has a major impact on the conclusions drawn from smoking cessation intervention research, yet few studies have addressed this critical issue...
  58. ncbi request reprint Prediction of survival after liver retransplantation for late graft failure based on preoperative prognostic scores
    Francis Y Yao
    Department of Medicine University of California, San Francisco, San Francisco, CA, USA
    Hepatology 39:230-8. 2004
    ..In conclusion, our results suggest that severity of graft failure based on CTP and MELD scores may be associated with worse outcome after re-OLT and provide a cautionary note for the "sickest first" policy of organ allocation...
  59. pmc Impact of insulin resistance on HCV treatment response and impact of HCV treatment on insulin sensitivity using direct measurements of insulin action
    Danielle Brandman
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    Diabetes Care 35:1090-4. 2012
    ....
  60. pmc Clinical predictors of early second event in patients with clinically isolated syndrome
    Ellen M Mowry
    Department of Neurology, Multiple Sclerosis Center, University of California, San Francisco, San Francisco, CA 94117, USA
    J Neurol 256:1061-6. 2009
    ..Since early relapse is predictive of worse long-term outcome, identifying and treating such patients after the IDE may be of benefit to them...
  61. doi request reprint Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis
    Ellen M Mowry
    MS Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94117, USA
    Ann Neurol 67:618-24. 2010
    ..We sought to determine if vitamin D status, a risk factor for multiple sclerosis, is associated with the rate of subsequent clinical relapses in pediatric-onset multiple sclerosis...
  62. ncbi request reprint Decreased survival among sedentary patients undergoing dialysis: results from the dialysis morbidity and mortality study wave 2
    ANN M O'HARE
    Departments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, CA, USA
    Am J Kidney Dis 41:447-54. 2003
    ..However, the association between inactivity and mortality has not been studied in a large cohort of dialysis patients despite the high prevalence of sedentary behavior in this group...
  63. doi request reprint Comparison of surrogate and direct measurement of insulin resistance in chronic hepatitis C virus infection: impact of obesity and ethnicity
    Khoa D Lam
    Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Hepatology 52:38-46. 2010
    ..Repeat HOMA-IR measurements had higher within-person variation in the obese (standard deviation = 0.77 higher than normal-weight, 95% confidence interval = 0.25-1.30, P = 0.005)...
  64. pmc Insulin sensitivity and variability in hepatitis C virus infection using direct measurement
    Nizar A Mukhtar
    Department of Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA
    Dig Dis Sci 58:1141-8. 2013
    ..We aimed to describe the distribution and risk factors associated with IR and its change over time in HCV using direct measurement...
  65. ncbi request reprint HIV-producing T cells in cerebrospinal fluid
    Jutta K Neuenburg
    Gladstone Institute of Virology and Immunology, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 37:1237-44. 2004
    ..In HIV-1 infection, CSF white cell counts seem to contain a large number of uninfected cells. White cell counts and viral load in CSF may result from systemic inflammation and immune activation...
  66. pmc Differential persistence of transmitted HIV-1 drug resistance mutation classes
    Vivek Jain
    HIV AIDS Division, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA 94143, USA
    J Infect Dis 203:1174-81. 2011
    ..The impact of class-specific mutations on this rate of mutation replacement is uncertain...
  67. ncbi request reprint Eligibility criteria for HIV clinical trials and generalizability of results: the gap between published reports and study protocols
    Monica Gandhi
    Department of Medicine, University of California, San Francisco 94122, USA
    AIDS 19:1885-96. 2005
    ....
  68. pmc The impact of Medicaid managed care on hospitalizations for ambulatory care sensitive conditions
    Andrew B Bindman
    Primary Care Research Center, University of California, San Francisco, San Francisco, CA 94143 1364, USA
    Health Serv Res 40:19-38. 2005
    ..We also explored whether there was a differential effect of Medicaid managed care by patient's race or ethnicity on the hospitalization rates for ambulatory care sensitive conditions...
  69. pmc Growth hormone enhances thymic function in HIV-1-infected adults
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Clin Invest 118:1085-98. 2008
    ..Further, these randomized, prospective data have shown that thymic involution can be pharmacologically reversed in humans, suggesting that immune-based therapies could be used to enhance thymopoiesis in immunodeficient individuals...
  70. ncbi request reprint Impact of renal insufficiency on short-term morbidity and mortality after lower extremity revascularization: data from the Department of Veterans Affairs' National Surgical Quality Improvement Program
    ANN M O'HARE
    Department of Medicine, San Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    J Am Soc Nephrol 14:1287-95. 2003
    ..Further studies are needed to explore reasons for the higher rate of limb-threatening infection in patients with renal insufficiency undergoing revascularization...
  71. ncbi request reprint Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial
    Donald I Abrams
    University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
    Ann Intern Med 139:258-66. 2003
    ..Cannabinoid use could potentially alter HIV RNA levels by two mechanisms: immune modulation or cannabinoid-protease inhibitor interactions (because both share cytochrome P-450 metabolic pathways)...
  72. ncbi request reprint Low ankle-brachial index associated with rise in creatinine level over time: results from the atherosclerosis risk in communities study
    ANN M O'HARE
    Department of Medicine, University of California, San Francisco, USA
    Arch Intern Med 165:1481-5. 2005
    ..A low ankle-brachial index (ABI) predicts risk of cardiovascular death, myocardial infarction, peripheral arterial disease events, and stroke. However, it is unknown whether a low ABI also predicts a decline in renal function...
  73. ncbi request reprint Prognostic significance of postoperative in-hospital complications in elderly patients. I. Long-term survival
    Kawalpreet Manku
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA
    Anesth Analg 96:583-9, table of contents. 2003
    ..9, P = 0.023). An effort to improve perioperative care delivery to elderly surgical patients must include measures to minimize in-hospital postoperative complications, particularly those involving the pulmonary and renal systems...
  74. pmc Citalopram provides little or no benefit in nondepressed patients with irritable bowel syndrome
    Uri Ladabaum
    Division of Gastroenterology, University of California, San Francisco, California Department of Medicine, University of California, San Francisco, California, USA
    Clin Gastroenterol Hepatol 8:42-48.e1. 2010
    ..We assessed the benefit of citalopram and explored the relationships between symptoms, quality of life (QOL), and rectal sensitivity to barostat distension in non-depressed IBS patients...
  75. doi request reprint Are the uninsured responsible for the increase in emergency department visits in the United States?
    Ellen J Weber
    Division of Emergency Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA 94143 0208, USA
    Ann Emerg Med 52:108-15. 2008
    ..The rise in emergency department (ED) use in the United States is frequently attributed to increased visits by the uninsured. We determine whether insurance status is associated with the increase in ED visits...
  76. ncbi request reprint Variation in care for nonmelanoma skin cancer in a private practice and a veterans affairs clinic
    Mary Margaret Chren
    Dermatology Service, Research Enhancement Award Program of the Health Services Research and Development Service, Department of Veterans Affairs, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Med Care 42:1019-26. 2004
    ..Clinical variables that may affect treatment choices can be identified, but little is known about how clinicians choose among therapies...
  77. ncbi request reprint Women's Initiative for Nonsmoking-VII: evaluation of health service utilization and costs among women smokers with cardiovascular disease
    Erika Sivarajan Froelicher
    Department of Physiological, Nursing, School of Nursing, University of California San Francisco, 94143 0610, USA
    J Cardiopulm Rehabil 24:218-28. 2004
    ....
  78. ncbi request reprint High rates of sustained smoking cessation in women hospitalized with cardiovascular disease: the Women's Initiative for Nonsmoking (WINS)
    Erika S Sivarajan Froelicher
    University of California at San Francisco, Department of Physiological Nursing, School of Nursing, San Francisco, CA 94143 0610, USA
    Circulation 109:587-93. 2004
    ..Although men hospitalized with cardiovascular disease (CVD) show high smoking-cessation rates, similar data for women are lacking. We tested the efficacy of smoking-cessation intervention in women hospitalized for CVD...
  79. ncbi request reprint Liver transplantation for hepatocellular carcinoma: comparison of the proposed UCSF criteria with the Milan criteria and the Pittsburgh modified TNM criteria
    Francis Y Yao
    Division of Gastroenterology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0538, USA
    Liver Transpl 8:765-74. 2002
    ..UCSF criteria confer a different advantage over Pittsburgh criteria, which require information on microvascular invasion that is difficult to ascertain preoperatively without the attendant risk of biopsy...
  80. ncbi request reprint Prenatal screening for Down syndrome in England and Wales and population-based birth outcomes
    Rebecca Smith-Bindman
    Department of Radiology, University of California, San Francisco 94115, USA
    Am J Obstet Gynecol 189:980-5. 2003
    ..The purpose of this study was to relate pregnancy outcomes to the dominant method used for prenatal Down syndrome screening...
  81. ncbi request reprint HIV-related neuropathology, 1985 to 1999: rising prevalence of HIV encephalopathy in the era of highly active antiretroviral therapy
    Jutta K Neuenburg
    Department of Neurology, University of California, San Francisco, USA
    J Acquir Immune Defic Syndr 31:171-7. 2002
    ..Although combination therapies decrease overall mortality and prevalence of CNS opportunistic infections, these therapies may be less active in preventing direct HIV-1 effects on the brain...
  82. ncbi request reprint Pupil examination: validity and clinical utility of an automated pupillometer
    Michele Meeker
    Department of Neurological Surgery at UCSF San Francisco General Hospital, USA
    J Neurosci Nurs 37:34-40. 2005
    ..For these reasons, such a device may be a beneficial addition in the clinical assessment of neurologically impaired patients...
  83. ncbi request reprint Racial and etiopathologic dichotomies in insulin hypersecretion and resistance in obese children
    Chaluntorn Preeyasombat
    Department of Pediatrics, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0434, USA
    J Pediatr 146:474-81. 2005
    ..To assess insulin dynamics to oral glucose tolerance testing in obese children, denoting individual contributions of insulin hypersecretion versus resistance to racial and etiopathogenetic specificity...
  84. ncbi request reprint Evaluation of the portable infrared pupillometer
    Rose Du
    Department of Neurological Surgery, University of California, San Francisco, California 94110, USA
    Neurosurgery 57:198-203; discussion 198-203. 2005
  85. pmc Peer review of statistics in medical research: the other problem
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco, CA 94143 0560, USA
    BMJ 324:1271-3. 2002
  86. ncbi request reprint The impact of highly active antiretroviral therapy on non-AIDS-defining cancers among adults with AIDS
    Nancy A Hessol
    Department of Medicine, University of California, San Francisco, CA 94122, USA
    Am J Epidemiol 165:1143-53. 2007
    ..4). The impact of HAART on non-AIDS-defining cancer incidence rates and survival is not uniform, and the mechanism(s) responsible for these differences should be investigated further...
  87. pmc Factors associated with findings of published trials of drug-drug comparisons: why some statins appear more efficacious than others
    Lisa Bero
    Clinical Pharmacy and Health Policy, University of California, San Francisco, California, United States of America
    PLoS Med 4:e184. 2007
    ....
  88. ncbi request reprint Effect of managed care on preventable hospitalization rates in California
    Lisa Backus
    Department of Medicine, Primary Care Research Center, San Francisco General Hospital, 1001 Potrero Avenue Ward 95, San Francisco, CA 94110, USA
    Med Care 40:315-24. 2002
    ..Hospitalization rates for ambulatory care-sensitive (ACS) conditions have emerged as a potential indicator of health care access and quality. The effect of managed care on reducing these potentially preventable hospitalizations is unknown...
  89. ncbi request reprint US evaluation of fetal growth: prediction of neonatal outcomes
    Rebecca Smith-Bindman
    Department of Radiology, University of California, San Francisco, CA 94115, USA
    Radiology 223:153-61. 2002
    ..To determine whether fetal growth measured at serial ultrasonographic (US) examinations can predict neonatal morbidity, independent of whether gestational age is known...
  90. pmc Increased circulating interleukin-7 levels in HIV-1-infected women
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, 94158, USA
    J Acquir Immune Defic Syndr 40:581-4. 2005
    ..0032) after controlling for CD4 count, age, and race. Given the important role of IL-7 in T-cell development and homeostasis, these findings suggest that higher IL-7 levels may contribute to higher CD4 counts in women...
  91. ncbi request reprint Does patient sex affect human immunodeficiency virus levels?
    Monica Gandhi
    Department of Medicine, Infectious Diseases Division, University of California, San Francisco, CA, 94143, USA
    Clin Infect Dis 35:313-22. 2002
    ..This finding is significant, because viral loads are frequently used to guide the initiation and modification of antiretroviral therapy...
  92. doi request reprint Trauma, transfusions, and use of recombinant factor VIIa: A multicenter case registry report of 380 patients from the Western Trauma Association
    M Margaret Knudson
    Department of Surgery, University of California, San Francisco, USA
    J Am Coll Surg 212:87-95. 2011
    ..We hypothesized that we could describe the setting in which rFVIIa would be most successful in arresting hemorrhage after injury...
  93. ncbi request reprint Adverse birth outcomes in relation to prenatal sonographic measurements of fetal size
    Rebecca Smith-Bindman
    Department of Radiology, University of California, San Francisco 94115, USA
    J Ultrasound Med 22:347-56; quiz 357-8. 2003
    ..To evaluate and quantify the prediction of multiple neonatal outcomes by sonographically estimated fetal weight across a broad range of gestational ages...
  94. ncbi request reprint Effect of emergency department crowding on time to antibiotics in patients admitted with community-acquired pneumonia
    Christopher Fee
    Division of Emergency Medicine, Department of Medicine, University of California, San Francisco Medical Center, San Francisco, CA 94143, USA
    Ann Emerg Med 50:501-9, 509.e1. 2007
    ..We hypothesize that emergency department (ED) volume and increased patient complexity are associated with lower quality of care, as measured by time to antibiotics for patients being admitted with community-acquired pneumonia...
  95. pmc Relationship of fat distribution with adipokines in human immunodeficiency virus infection
    Lisa A Kosmiski
    University of Colorado at Denver and Health Sciences Center, Denver, Colorado 80217, USA
    J Clin Endocrinol Metab 93:216-24. 2008
    ....
  96. pmc Clinic-based study of family history of vascular risk factors and migraine
    Grace Yoon
    Division of Medical Genetics, Department of Pediatrics, University of California, San Francisco, CA 94143 2922, USA
    J Headache Pain 6:412-6. 2005
    ..CM patients were more likely to have a negative FH of stroke compared to other headache types, suggesting that CM is likely a neuronal disease rather than a vascular one...
  97. ncbi request reprint Association of journal quality indicators with methodological quality of clinical research articles
    Kirby P Lee
    Institute for Health Policy Studies, School of Medicine, University of California, San Francisco, CA, USA
    JAMA 287:2805-8. 2002
    ..The ability to identify scientific journals that publish high-quality research would help clinicians, scientists, and health-policy analysts to select the most up-to-date medical literature to review...
  98. ncbi request reprint Generalized additive models with interval-censored data and time-varying covariates: application to human immunodeficiency virus infection in hemophiliacs
    Peter Bacchetti
    Department of Epidemiology and Biostatistics, University of California, San Francisco 94143 0560, USA
    Biometrics 58:443-7. 2002
    ....
  99. pmc Fat distribution in men with HIV infection
    Peter Bacchetti
    University of California, San Francisco Veterans Affairs Medical Center, Metabolism Section, 94121, USA
    J Acquir Immune Defic Syndr 40:121-31. 2005
    ..Which changes are specific to HIV were determined by comparison with control subjects and the associations among different adipose tissue depots were determined...
  100. ncbi request reprint Sample size calculations in clinical research
    Peter Bacchetti
    Anesthesiology 97:1028-9; author reply 1029-32. 2002
  101. ncbi request reprint Serum albumin is a powerful predictor of survival among HIV-1-infected women
    Joseph G Feldman
    State University of New York Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    J Acquir Immune Defic Syndr 33:66-73. 2003
    ..We now extend this to the use of serial measurements and single albumin values prior to initiation of highly active antiretroviral therapy...

Research Grants6

  1. Statistical Methods for Complex HIV Cohort Studies
    Peter Bacchetti; Fiscal Year: 2004
    ..Applications to relevant data sets will provide both realistic testing and new substantive insights. Software implementing the methods and technical papers will be available through the Internet at a project-related website. ..
  2. Statistical methods for modeling hepatitis C fibrosis progression
    Peter Bacchetti; Fiscal Year: 2007
    ..Because methods previously used to analyze the data that those studies provide have been prone to inaccuracy, this proposal will develop better methods and apply them to several studies. ..