Azhar M, Wang P, Frugier T, Koishi K, Deng C, Noakes P, et al. Myocardial deletion of Smad4 using a novel ? skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. Int J Biol Sci. 2010;6:546-55 pubmed
..In conclusion, MuCre mice effectively delete genes in both heart and skeletal muscles, thus enabling the discovery that myocardial Smad4 deletion causes misalignment of the outflow tract and DORV. ..
Azhar M, Runyan R, Gard C, Sanford L, Miller M, Andringa A, et al. Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development. Dev Dyn. 2009;238:431-42 pubmed publisher
..5 with elevated levels of well-validated indicators of EMT. Collectively, these data indicate that TGFbeta2, and not TGFbeta1 or TGFbeta3, mediates cardiac cushion EMT by promoting both the initiation and cessation of EMT. ..
Azhar M, Brown K, Gard C, Chen H, Rajan S, Elliott D, et al. Transforming growth factor Beta2 is required for valve remodeling during heart development. Dev Dyn. 2011;240:2127-41 pubmed publisher
..Collectively, the data indicate that TGF?2 promotes valve remodeling and differentiation by inducing matrix organization and suppressing cushion mesenchyme differentiation into cartilage cell lineage during heart development. ..