Mohamad Azhar

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
  2. pmc Transforming growth factor Beta2 is required for valve remodeling during heart development
    Mohamad Azhar
    BIO5 Institute, University of Arizona, Tucson, Arizona Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 240:2127-41. 2011
  3. pmc Myocardial deletion of Smad4 using a novel α skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract
    Mohamad Azhar
    BIO5 Institute, and Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    Int J Biol Sci 6:546-55. 2010
  4. pmc Generation of mice with a conditional allele for transforming growth factor beta 1 gene
    Mohamad Azhar
    BIO5 Institute, University of Arizona, Tucson, Arizona, USA
    Genesis 47:423-31. 2009
  5. pmc Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development
    Mohamad Azhar
    BIO5 Institute, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 238:431-42. 2009
  6. pmc Generation of mice with a conditional allele for the transforming growth factor beta3 gene
    Thomas Doetschman
    BIO5 Institute, Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724 5217, USA
    Genesis 50:59-66. 2012
  7. pmc Adaptation of a planar microbiaxial optomechanical device for the tubular biaxial microstructural and macroscopic characterization of small vascular tissues
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    J Biomech Eng 133:075001. 2011
  8. doi request reprint The effects of angiotensin II on the coupled microstructural and biomechanical response of C57BL/6 mouse aorta
    Darren Haskett
    Graduate Interdisciplinary Program of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721 0119, USA
    J Biomech 45:772-9. 2012
  9. pmc Cardiac-specific inducible and conditional gene targeting in mice
    Thomas Doetschman
    BIO5 Institute and Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA
    Circ Res 110:1498-512. 2012
  10. pmc Transforming growth factor beta signaling in adult cardiovascular diseases and repair
    Thomas Doetschman
    BIO5 Institute, University of Arizona, Tucson, AZ 85724, USA
    Cell Tissue Res 347:203-23. 2012

Collaborators

  • Urs Utzinger
  • Jonathan P Vande Geest
  • Joseph T Keyes
  • Henk L Granzier
  • Jefferson J Doyle
  • C X Deng
  • Todd D Camenisch
  • Ming Zhou
  • Marian L Miller
  • I S McLennan
  • Thomas Doetschman
  • Darren Haskett
  • Mark A Estabrook
  • Connie Gard
  • Sergio Kaiser
  • Doug Larson
  • Corbie Ball
  • Jacqueline Friel
  • Harry C Dietz
  • Marie Fouts
  • Ronald L Heimark
  • Christina Grisham
  • Hongqi Li
  • Alejandra C Encinas
  • Joey V Barnett
  • L P Sanford
  • Erin Speicher
  • Raymond B Runyan
  • Thomas D Reed
  • Simon J Conway
  • HwuDauRw Chen
  • Teodora Georgieva
  • Shawn Levy
  • Stephen H Settle
  • Kevin Haigis
  • Sue Kong
  • Robert J Coffey
  • Michael Kleimeyer
  • Fausto Gonzales
  • Anika C Bissahoyo
  • Greg C Bloom
  • John Kleimeyer
  • Braden Boone
  • Huan Xu
  • Vivek Ramaswamy
  • Anil G Jegga
  • David W Threadgill
  • Bruce J Aronow
  • Richard B Halberg
  • Reade B Roberts
  • Timothy Reichling
  • Xiaodi Chen
  • William F Dove
  • Jeffrey L Franklin
  • Bhuvaneswari Sakthivel
  • Gregory P Boivin
  • Steven Eschrich
  • Walter J Jessen
  • Johannes Freudenberg
  • Young Kyu Park
  • Ming Yu
  • Jonathan M Graff
  • Joanna Groden
  • Jeremy E Aronow
  • Scott L Carter
  • Timothy J Yeatman

Detail Information

Publications13

  1. pmc Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
    Sergio Kaiser
    Biomedical Informatics, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Genome Biol 8:R131. 2007
    ..5-18.5...
  2. pmc Transforming growth factor Beta2 is required for valve remodeling during heart development
    Mohamad Azhar
    BIO5 Institute, University of Arizona, Tucson, Arizona Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 240:2127-41. 2011
    ..Collectively, the data indicate that TGFβ2 promotes valve remodeling and differentiation by inducing matrix organization and suppressing cushion mesenchyme differentiation into cartilage cell lineage during heart development...
  3. pmc Myocardial deletion of Smad4 using a novel α skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract
    Mohamad Azhar
    BIO5 Institute, and Department of Cell Biology and Anatomy, University of Arizona, Tucson, AZ 85724, USA
    Int J Biol Sci 6:546-55. 2010
    ..In conclusion, MuCre mice effectively delete genes in both heart and skeletal muscles, thus enabling the discovery that myocardial Smad4 deletion causes misalignment of the outflow tract and DORV...
  4. pmc Generation of mice with a conditional allele for transforming growth factor beta 1 gene
    Mohamad Azhar
    BIO5 Institute, University of Arizona, Tucson, Arizona, USA
    Genesis 47:423-31. 2009
    ..The results indicate that T-cell-produced TGFbeta1 is required for normal in vivo regulation of peripheral T-cell activation, maintenance of T-cell homeostasis, and suppression of autoimmunity...
  5. pmc Ligand-specific function of transforming growth factor beta in epithelial-mesenchymal transition in heart development
    Mohamad Azhar
    BIO5 Institute, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 238:431-42. 2009
    ..5 with elevated levels of well-validated indicators of EMT. Collectively, these data indicate that TGFbeta2, and not TGFbeta1 or TGFbeta3, mediates cardiac cushion EMT by promoting both the initiation and cessation of EMT...
  6. pmc Generation of mice with a conditional allele for the transforming growth factor beta3 gene
    Thomas Doetschman
    BIO5 Institute, Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724 5217, USA
    Genesis 50:59-66. 2012
    ..This Tgfb3cko allele will now enable studies of TGFβ3 function in different cell or tissue types in embryonic development and during adulthood...
  7. pmc Adaptation of a planar microbiaxial optomechanical device for the tubular biaxial microstructural and macroscopic characterization of small vascular tissues
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    J Biomech Eng 133:075001. 2011
    ..Several other hard-to-test tubular specimens such as cerebral aneurysm arteries and atherosclerotic coronary arteries can also be tested using the described modular device...
  8. doi request reprint The effects of angiotensin II on the coupled microstructural and biomechanical response of C57BL/6 mouse aorta
    Darren Haskett
    Graduate Interdisciplinary Program of Biomedical Engineering, The University of Arizona, Tucson, AZ 85721 0119, USA
    J Biomech 45:772-9. 2012
    ..We chose here to investigate the effect of angiotensin II (AngII) in C57BL/6 mice as a first step towards understanding how such changes occur in the established ApoE(-/-) AngII infused mouse model of AAA...
  9. pmc Cardiac-specific inducible and conditional gene targeting in mice
    Thomas Doetschman
    BIO5 Institute and Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ, USA
    Circ Res 110:1498-512. 2012
    ..They have also led to the development of clinically relevant models of human cardiac diseases. Here, we review the technologies and their limitations in general and the cardiovascular research community in particular...
  10. pmc Transforming growth factor beta signaling in adult cardiovascular diseases and repair
    Thomas Doetschman
    BIO5 Institute, University of Arizona, Tucson, AZ 85724, USA
    Cell Tissue Res 347:203-23. 2012
    ....
  11. pmc Gene targeted ablation of high molecular weight fibroblast growth factor-2
    Mohamad Azhar
    BIO5 Institute, and Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, USA
    Dev Dyn 238:351-7. 2009
    ..These mice along with the FGF2- and FGF2 LMW-deficient mice that we have generated previously will be very useful for elucidating the differential functions of FGF2 isoforms in pathophysiology of cardiovascular diseases...
  12. doi request reprint Altered tissue behavior of a non-aneurysmal descending thoracic aorta in the mouse model of Marfan syndrome
    Darren Haskett
    Graduate Interdisciplinary Program of Biomedical Engineering, University of Arizona, Tucson, Ariz, USA
    Cell Tissue Res 347:267-77. 2012
    ..The ability to reveal the presence of altered biomechanics and microstructure coupled with subtle changes in TGFβ signaling provides a novel surrogate measure of tissue susceptibility to aneurysm before disease onset...
  13. doi request reprint Design and demonstration of a microbiaxial optomechanical device for multiscale characterization of soft biological tissues with two-photon microscopy
    Joseph T Keyes
    Graduate Interdisciplinary Program in Biomedical Engineering, The University of Arizona, Tucson, AZ 85721, USA
    Microsc Microanal 17:167-75. 2011
    ..We also demonstrate that nonhomogeneities in fiber strain exist over biaxial regions of assumed homogeneity...