I S Ayene

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts
    I S Ayene
    University of Pennsylvania School of Medicine, Department of Radiation Oncology, Philadelphia 19104 6072, USA
    Int J Radiat Biol 76:343-54. 2000
  2. ncbi Oxidation of cellular thiols by hydroxyethyldisulphide inhibits DNA double-strand-break rejoining in G6PD deficient mammalian cells
    I S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Int J Radiat Biol 76:1523-31. 2000
  3. ncbi Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress
    Iraimoudi S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:9929-35. 2002
  4. ncbi Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation
    Iraimoudi S Ayene
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 195 John Morgan Building, Philadelphia, PA 19104 6072, USA
    Mol Cancer Ther 4:529-36. 2005
  5. ncbi Radiation response of cells during altered protein thiol redox
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 159:484-94. 2003
  6. ncbi Role of vicinal protein thiols in radiation and cytotoxic responses
    John E Biaglow
    Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 165:307-17. 2006
  7. ncbi DNA strand breakage by bivalent metal ions and ionizing radiation
    Iraimoudi S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Int J Radiat Biol 83:195-210. 2007
  8. ncbi Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication
    Iraimoudi S Ayene
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    J Cell Biochem 103:123-35. 2008
  9. ncbi Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia
    Stephen W Tuttle
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    J Biol Chem 282:36790-6. 2007

Detail Information

Publications9

  1. ncbi DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts
    I S Ayene
    University of Pennsylvania School of Medicine, Department of Radiation Oncology, Philadelphia 19104 6072, USA
    Int J Radiat Biol 76:343-54. 2000
    ..This study uses a radiation chemistry approach to determine if DNA is an important target for radiation-induced apoptosis of myc (MR4) and myc plus ras (3.7) transfected rat embryo fibroblast cell lines...
  2. ncbi Oxidation of cellular thiols by hydroxyethyldisulphide inhibits DNA double-strand-break rejoining in G6PD deficient mammalian cells
    I S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Int J Radiat Biol 76:1523-31. 2000
    ..We investigated the effect of protein- and non protein-thiol oxidation on DNA double-strand-break (DSB) rejoining after irradiation and its relevance in the survival of CHO cells...
  3. ncbi Mutation in the glucose-6-phosphate dehydrogenase gene leads to inactivation of Ku DNA end binding during oxidative stress
    Iraimoudi S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 277:9929-35. 2002
    ..In view of the rapidly escalating number of roles ascribed to Ku, these results may have widespread ramifications...
  4. ncbi Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation
    Iraimoudi S Ayene
    Department of Radiation Oncology, School of Medicine, University of Pennsylvania, 195 John Morgan Building, Philadelphia, PA 19104 6072, USA
    Mol Cancer Ther 4:529-36. 2005
    ..Studies with HCT116 cells using the same Ku70 siRNA (CS #5) showed a direct correlation between expression of Ku70 and sensitization to radiation and etoposide treatments...
  5. ncbi Radiation response of cells during altered protein thiol redox
    John E Biaglow
    Department of Radiation Oncology and Biochemistry, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 159:484-94. 2003
    ..The results also show that protein thiol status is a critical factor in cell survival after irradiation...
  6. ncbi Role of vicinal protein thiols in radiation and cytotoxic responses
    John E Biaglow
    Department of Biochemistry, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Radiat Res 165:307-17. 2006
    ..We conclude that radiation sensitivity and cell survival are dependent on vicinal thiol and GSH. In the former and latter cases, the protein thiols are also important...
  7. ncbi DNA strand breakage by bivalent metal ions and ionizing radiation
    Iraimoudi S Ayene
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Int J Radiat Biol 83:195-210. 2007
    ..To investigate mechanisms of DNA breakage via the interaction of bivalent metal ion, thiol reducing agent and ionizing radiation, in *OH scavenging abilities comparable to those in cells...
  8. ncbi Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: mechanism and implication
    Iraimoudi S Ayene
    Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    J Cell Biochem 103:123-35. 2008
    ..The specific role of G6PD in the control of such global protein glutathionylation and Ku function was further demonstrated by reintroducing the G6PD gene into E89 (A1A) cells, which showed a normal phenotype...
  9. ncbi Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia
    Stephen W Tuttle
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6072, USA
    J Biol Chem 282:36790-6. 2007
    ..Therefore, we conclude that the oxygen dependence of the prolyl hydroxylase reaction is sufficient to mediate HIF-1alpha stability under moderate as well as severe hypoxia...