F J Ayala


Affiliation: University of California
Country: USA


  1. Elguero E, Délicat Loembet L, Rougeron V, Arnathau C, Roche B, Becquart P, et al. Malaria continues to select for sickle cell trait in Central Africa. Proc Natl Acad Sci U S A. 2015;112:7051-4 pubmed publisher
    ..Our results provide evidence that evolution is still present in humans, although this is sometimes questioned by scientific, political, or religious personalities. ..
  2. Zhou Q, Gu J, Lun Z, Ayala F, Li Z. Two distinct cytokinesis pathways drive trypanosome cell division initiation from opposite cell ends. Proc Natl Acad Sci U S A. 2016;113:3287-92 pubmed publisher
  3. Qin A, Lai D, Liu Q, Huang W, Wu Y, Chen X, et al. Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proc Natl Acad Sci U S A. 2017;114:1365-1370 pubmed publisher
    ..gondii infection. Taken together, our results suggest that hGBP1 plays a pivotal role in anti-T. gondii protection of hMSCs and may shed new light on clarifying the mechanism of host defense properties of hMSCs. ..
  4. Shen J, Lai D, Wilson R, Chen Y, WANG L, Yu Z, et al. Nitric oxide blocks the development of the human parasite Schistosoma japonicum. Proc Natl Acad Sci U S A. 2017;114:10214-10219 pubmed publisher
    ..japonicum but also offers insights into a better understanding of host-parasite interactions and drug development strategies against schistosomiasis. ..
  5. Karadjian G, Hassanin A, Saintpierre B, Gembu Tungaluna G, Ariey F, Ayala F, et al. Highly rearranged mitochondrial genome in Nycteria parasites (Haemosporidia) from bats. Proc Natl Acad Sci U S A. 2016;113:9834-9 pubmed publisher
    ..We report four complete mitochondrial genomes, including two rearranged mitochondrial genomes within Haemosporidia. Our results open outlooks into potentially undiscovered Haemosporidian diversity. ..
  6. Skalicky T, Dobáková E, Wheeler R, Tesarová M, Flegontov P, Jirsová D, et al. Extensive flagellar remodeling during the complex life cycle of Paratrypanosoma, an early-branching trypanosomatid. Proc Natl Acad Sci U S A. 2017;114:11757-11762 pubmed publisher
  7. Ayala F. Elixir of life: In vino veritas. Proc Natl Acad Sci U S A. 2011;108:3457-8 pubmed publisher
  8. Ayala F. Cloning humans? Biological, ethical, and social considerations. Proc Natl Acad Sci U S A. 2015;112:8879-86 pubmed publisher
    ..Genomes can be cloned; individuals cannot. In the future, therapeutic cloning will bring enhanced possibilities for organ transplantation, nerve cells and tissue healing, and other health benefits. ..
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    Ayala F, Balakirev E, Saez A. Genetic polymorphism at two linked loci, Sod and Est-6, in Drosophila melanogaster. Gene. 2002;300:19-29 pubmed
    ..Some linkage disequilibrium also exists between the two genes. ..

More Information


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    Ayala F. Neutralism and selectionism: the molecular clock. Gene. 2000;261:27-33 pubmed
    ..SOD evolves very fast in Drosophila species and also in mammals, but much more slowly in other animals and still slower when plants and fungi are compared to one another, or to animals. ..
  2. Ayala F, Coluzzi M. Chromosome speciation: humans, Drosophila, and mosquitoes. Proc Natl Acad Sci U S A. 2005;102 Suppl 1:6535-42 pubmed publisher