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Genomes and GenesSpecies | David AxelsonSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Phenomenology of children and adolescents with bipolar spectrum disordersDavid Axelson
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA
Arch Gen Psychiatry 63:1139-48. 2006..Children and adolescents who present with manic symptoms frequently do not meet the full DSM-IV criteria for bipolar I disorder (BP-I)...
Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study (BIOS)Boris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Am J Psychiatry 167:321-30. 2010..The authors evaluated lifetime prevalence and specificity of DSM-IV psychiatric disorders and severity of depressive and manic symptoms at intake in preschool offspring of parents with bipolar I and II disorders...- Clinical course of children and adolescents with bipolar spectrum disordersBoris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Arch Gen Psychiatry 63:175-83. 2006..Despite the high morbidity associated with bipolar disorder (BP), few studies have prospectively studied the course of this illness in youth... - Dimensional psychopathology in offspring of parents with bipolar disorderRasim Somer Diler
Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
Bipolar Disord 13:670-8. 2011..To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL)... - Comparison of manic and depressive symptoms between children and adolescents with bipolar spectrum disordersBoris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Bipolar Disord 11:52-62. 2009..To compare the most severe lifetime (current or past) mood symptoms, duration of illness, and rates of lifetime comorbid disorders among youth with bipolar spectrum disorders [BP (bipolar-I, bipolar-II and bipolar-not otherwise specified)]... - Psychosocial functioning among bipolar youthTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
J Affect Disord 114:174-83. 2009..However, little is known about the association between psychosocial functioning and episodes of illness, demographic, and clinical variables in this population... - Psychosocial functioning in offspring of parents with bipolar disorderTolulope Bella
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Affect Disord 133:204-11. 2011..Offspring of parents with bipolar disorder are at increased risk for a range of psychopathology, including bipolar disorder. It is not clear if they also have impairments in their psychosocial functioning... - Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the Longitudinal Assessment of Manic Symptoms studyDavid Axelson
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
J Clin Psychiatry 73:1342-50. 2012..Evaluation of DMDD included 4 domains: clinical phenomenology, delimitation from other diagnoses, longitudinal stability, and association with parental psychiatric disorders... - The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorderRasim Somer Diler
Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
J Child Adolesc Psychopharmacol 19:23-30. 2009..The purpose of this study was to evaluate the usefulness of the CBCL and CBCL-PBD to identify BP in children <12 years old... - Family environment and suicidal ideation among bipolar youthTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Arch Suicide Res 13:378-88. 2009..Clinicians treating bipolar youth should consider family stress when conducting suicide risk assessment. Treatment goals may include enhancing family communication and addressing issues of loss... - Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorderSimerjit Kaur
Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
Am J Psychiatry 162:1637-43. 2005..64 cm3 [SD=0.21] versus 2.71 cm3 [SD=0.10]). CONCLUSIONS: The findings indicate smaller cingulate volumes in children and adolescents with bipolar disorder, suggesting that such abnormalities may be present early in the illness course... - What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses?Mary A Fristad
Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
Bipolar Disord 14:497-506. 2012.... - Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging studyMarsal Sanches
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
Psychiatry Res 138:43-9. 2005..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents... - Child comorbidity, maternal mood disorder, and perceptions of family functioning among bipolar youthChristianne Esposito-Smythers
Department of Psychiatry, Brown Medical School, Providence, RI 02912, USA
J Am Acad Child Adolesc Psychiatry 45:955-64. 2006..To examine the association between youth comorbid psychiatric disorders, maternal mood disorder, and perceptions of family cohesion and conflict among youth diagnosed with pediatric bipolar disorder (PBD)... - MRI study of thalamus volumes in juvenile patients with bipolar disorderE Serap Monkul
MOOD-CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Depress Anxiety 23:347-52. 2006..Any differences in thalamus size that may exist between patients with bipolar disorder and healthy controls must amount to small effect sizes... - Abnormal corpus callosum myelination in pediatric bipolar patientsSheila C Caetano
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
J Affect Disord 108:297-301. 2008..Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients... - History of suicide attempts in pediatric bipolar disorder: factors associated with increased riskTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Bipolar Disord 7:525-35. 2005..Despite evidence indicating high morbidity associated with pediatric bipolar disorder (BP), little is known about the prevalence and clinical correlates of suicidal behavior among this population... - Phenomenology, longitudinal course, and outcome of children and adolescents with bipolar spectrum disordersRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
Child Adolesc Psychiatr Clin N Am 18:273-89, vii. 2009..Thus, early diagnosis and treatment of pediatric bipolar is of utmost importance... - MRI study of the cerebellum in young bipolar patientsE Serap Monkul
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:613-9. 2008..Our results are preliminary, but consistent with the findings from studies in adult bipolar patients suggesting the involvement of structural changes in cerebellar vermis in the pathophysiology of bipolar disorder... - Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) studyRobert L Findling
Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
J Clin Psychiatry 71:1664-72. 2010..This article describes the initial demographic information, diagnostic and symptom prevalence, and medication exposure for the LAMS cohort that will be followed longitudinally... - Aggression, hostility, and irritability in children at risk for bipolar disorderTiffany R Farchione
Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 9:496-503. 2007..To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP)... - Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring studyBoris Birmaher
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
Arch Gen Psychiatry 66:287-96. 2009..Whether offspring of parents with bipolar disorder (BP) are at specifically high risk to develop BP and other psychiatric disorders has not been adequately studied... - Developmental abnormalities in striatum in young bipolar patients: a preliminary studyMarsal Sanches
Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Bipolar Disord 7:153-8. 2005..66, p = 0.02) and left putamen (r = -0.71, p = 0.01) in bipolar patients, not present in healthy controls. CONCLUSIONS: Abnormalities in striatal development may be involved in the pathophysiology of bipolar disorder... - Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorderBarbara K Chen
Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA
Biol Psychiatry 56:399-405. 2004..48, p = .03). CONCLUSIONS: The direct correlation between left amygdala volumes and age in bipolar patients, not present in healthy control subjects, may reflect abnormal developmental mechanisms in bipolar disorder... - Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorderErika E Forbes
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Cogn Affect Behav Neurosci 10:107-18. 2010..Final levels of severity and anxiety symptoms were associated with pretreatment striatal reactivity, and rate of anxiety symptom reduction was associated with greater striatal reactivity and lower medial PFC reactivity... - MRI study of corpus callosum in children and adolescents with bipolar disorderA Sibel Yasar
MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA
Psychiatry Res 146:83-5. 2006..No significant differences in CC length or area were observed, suggesting that reported CC abnormalities appear late in the course of bipolar disorder... - Anatomical measurements of the orbitofrontal cortex in child and adolescent patients with bipolar disorderPablo Najt
MOOD CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Neurosci Lett 413:183-6. 2007..Male patients exhibit smaller gray matter volumes, while female patients exhibit larger volumes in some OFC sub-regions. Gender differences in OFC abnormalities may be involved in illness pathophysiology among young bipolar patients... - Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) studyBoris Birmaher
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:795-804. 2009..The authors sought to assess the longitudinal course of youths with bipolar spectrum disorders over a 4-year period... - Fluoxetine for the treatment of childhood anxiety disorders: open-label, long-term extension to a controlled trialDuncan B Clark
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:1263-70. 2005..To assess the efficacy of fluoxetine for the long-term treatment of children and adolescents with anxiety disorders, including generalized anxiety disorder, separation anxiety disorder, and/or social phobia... - Is bipolar disorder specifically associated with panic disorder in youths?Boris Birmaher
Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
J Clin Psychiatry 63:414-9. 2002..To replicate previous findings of high rates of bipolar disorder (BPD) in patients with panic disorder (PD) and determine if youths with both PD and BPD have more severe illness... - Replicable differences in preferred circadian phase between bipolar disorder patients and control individualsJoel Wood
Departments of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, Pittsburgh, PA, United States
Psychiatry Res 166:201-9. 2009..Individuals with elevated depressive mood scores are more likely to be evening types. Our results suggest a replicable relationship between circadian phase and morbid mood states... - Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophreniaHader A Mansour
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:701-10. 2009..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders... - Differentiating major depressive disorder in youths with attention deficit hyperactivity disorderRasim Somer Diler
Division of Child Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
J Affect Disord 102:125-30. 2007..Our objective was to examine which depressive symptoms best discriminate MDD among youths with ADHD... - Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory studyJohn V Campo
Department of Pyschiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:1234-42. 2004..To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders... - A preliminary study of the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children mania rating scale for children and adolescentsDavid Axelson
Division of Child Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 13:463-70. 2003..To construct a mania rating scale designed for children and adolescents... - Course and outcome of bipolar spectrum disorder in children and adolescents: a review of the existing literatureBoris Birmaher
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
Dev Psychopathol 18:1023-35. 2006..Thus, early recognition and treatment of BP in children and adolescents is of utmost importance... - Subjective sleep complaints in pediatric depression: a controlled study and comparison with EEG measures of sleep and wakingMichele A Bertocci
University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:1158-66. 2005..These findings raise provocative questions regarding the nature of sleep complaints associated with early-onset depression... - Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging studyHua Hsua Chen
Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
Neurosci Lett 363:65-8. 2004..Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients... - Childhood-onset bipolar disorder: Evidence for increased familial loading of psychiatric illnessRichard Rende
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
J Am Acad Child Adolesc Psychiatry 46:197-204. 2007..To determine whether childhood-onset bipolar disorder (BP) is associated with an increased psychiatric family history compared with adolescent-onset BP... - Pediatric bipolar disease: current and future perspectives for study of its long-term course and treatmentMichael Strober
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
Bipolar Disord 8:311-21. 2006..Findings from recent long-term, prospective longitudinal studies of the course, outcome and naturalistic treatment of adults with bipolar illness are highlighted as background for long-term developmental study of pediatric bipolar illness... - Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorderOzgur Yorbik
Gulhane Military Medical Faculty, The Department of Child and Adolescent Psychiatry, Ankara, Turkey
J Clin Psychiatry 65:1654-9; quiz 1760-1. 2004..Very few studies have compared the symptoms of major depressive disorder (MDD) and rates of comorbid psychiatric disorders between depressed children and adolescents. The aim of this study was to reproduce and extend these findings... - Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illnessRichard Rende
Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
J Affect Disord 96:127-31. 2006..Few studies have examined the specificity and non-specificity in patterns of familial loading for presentation of psychotic symptoms in pediatric bipolar disorder (BP)... - Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patientsRoberto B Sassi
Division of Mood and Anxiety Disorders, Associate Professor of Psychiatry and Radiology, Krus Endowed Chair in Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA
Am J Psychiatry 162:2109-15. 2005..These neuronal abnormalities in the dorsolateral prefrontal cortex of bipolar disorder youth are unlikely to represent long-term degenerative processes, at least in the subgroup of patients where the illness had relatively early onset... - Normal pituitary volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging studyHua Hsuan Chen
Department of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
Depress Anxiety 20:182-6. 2004..This suggests that anatomical abnormalities in this structure may develop later in illness course as a result of continued HPA dysfunction... - Factors associated with mental health service utilization among bipolar youthChristie J Rizzo
Department of Psychiatry and Human Behavior, Brown Medical School, CAAS, Box G BH, Providence, RI 02912, USA
Bipolar Disord 9:839-50. 2007..Demographic variables, youth bipolar characteristics, youth comorbid conditions, and parental psychopathology were examined as predictors of treatment utilization across different levels of care... - Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorderCarrie E Bearden
Department of Psychiatry and Biobehavioral Sciences, UCLA, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 47:515-25. 2008..Using the same three-dimensional mapping methods, we sought to investigate whether a similar pattern exists in adolescents with bipolar disorder...