David Axelson

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Phenomenology of children and adolescents with bipolar spectrum disorders
    David Axelson
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Gen Psychiatry 63:1139-48. 2006
  2. pmc Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study (BIOS)
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:321-30. 2010
  3. pmc Clinical course of children and adolescents with bipolar spectrum disorders
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Arch Gen Psychiatry 63:175-83. 2006
  4. pmc Dimensional psychopathology in offspring of parents with bipolar disorder
    Rasim Somer Diler
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Bipolar Disord 13:670-8. 2011
  5. pmc Psychosocial functioning in offspring of parents with bipolar disorder
    Tolulope Bella
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Affect Disord 133:204-11. 2011
  6. pmc Psychosocial functioning among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
    J Affect Disord 114:174-83. 2009
  7. pmc Comparison of manic and depressive symptoms between children and adolescents with bipolar spectrum disorders
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Bipolar Disord 11:52-62. 2009
  8. pmc Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the Longitudinal Assessment of Manic Symptoms study
    David Axelson
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 73:1342-50. 2012
  9. pmc Family environment and suicidal ideation among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Suicide Res 13:378-88. 2009
  10. ncbi request reprint Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder
    Simerjit Kaur
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Psychiatry 162:1637-43. 2005

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Phenomenology of children and adolescents with bipolar spectrum disorders
    David Axelson
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA
    Arch Gen Psychiatry 63:1139-48. 2006
    ..Children and adolescents who present with manic symptoms frequently do not meet the full DSM-IV criteria for bipolar I disorder (BP-I)...
  2. pmc Psychiatric disorders in preschool offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring Study (BIOS)
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Am J Psychiatry 167:321-30. 2010
    ..The authors evaluated lifetime prevalence and specificity of DSM-IV psychiatric disorders and severity of depressive and manic symptoms at intake in preschool offspring of parents with bipolar I and II disorders...
  3. pmc Clinical course of children and adolescents with bipolar spectrum disorders
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Arch Gen Psychiatry 63:175-83. 2006
    ..Despite the high morbidity associated with bipolar disorder (BP), few studies have prospectively studied the course of this illness in youth...
  4. pmc Dimensional psychopathology in offspring of parents with bipolar disorder
    Rasim Somer Diler
    Department of Psychiatry, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Bipolar Disord 13:670-8. 2011
    ..To compare the dimensional psychopathology in offspring of parents with bipolar disorder (BP) with offspring of community control parents as assessed by the Child Behavior Checklist (CBCL)...
  5. pmc Psychosocial functioning in offspring of parents with bipolar disorder
    Tolulope Bella
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Affect Disord 133:204-11. 2011
    ..Offspring of parents with bipolar disorder are at increased risk for a range of psychopathology, including bipolar disorder. It is not clear if they also have impairments in their psychosocial functioning...
  6. pmc Psychosocial functioning among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States
    J Affect Disord 114:174-83. 2009
    ..However, little is known about the association between psychosocial functioning and episodes of illness, demographic, and clinical variables in this population...
  7. pmc Comparison of manic and depressive symptoms between children and adolescents with bipolar spectrum disorders
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Bipolar Disord 11:52-62. 2009
    ..To compare the most severe lifetime (current or past) mood symptoms, duration of illness, and rates of lifetime comorbid disorders among youth with bipolar spectrum disorders [BP (bipolar-I, bipolar-II and bipolar-not otherwise specified)]...
  8. pmc Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the Longitudinal Assessment of Manic Symptoms study
    David Axelson
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 73:1342-50. 2012
    ..Evaluation of DMDD included 4 domains: clinical phenomenology, delimitation from other diagnoses, longitudinal stability, and association with parental psychiatric disorders...
  9. pmc Family environment and suicidal ideation among bipolar youth
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Arch Suicide Res 13:378-88. 2009
    ..Clinicians treating bipolar youth should consider family stress when conducting suicide risk assessment. Treatment goals may include enhancing family communication and addressing issues of loss...
  10. ncbi request reprint Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder
    Simerjit Kaur
    Department of Psychiatry, Division of Mood and Anxiety Disorders, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, TX 78229, USA
    Am J Psychiatry 162:1637-43. 2005
    ..This anatomical magnetic resonance imaging study examined the cingulate cortex in children and adolescents with bipolar disorder and matched healthy comparison subjects...
  11. pmc The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorder
    Rasim Somer Diler
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    J Child Adolesc Psychopharmacol 19:23-30. 2009
    ..The purpose of this study was to evaluate the usefulness of the CBCL and CBCL-PBD to identify BP in children <12 years old...
  12. pmc Abnormal corpus callosum myelination in pediatric bipolar patients
    Sheila C Caetano
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA
    J Affect Disord 108:297-301. 2008
    ..Here we compared the callosal signal intensity of children and adolescents with bipolar disorder to that of matched healthy subjects, to investigate the hypothesis that callosal myelination is abnormal in pediatric bipolar patients...
  13. pmc What differentiates children visiting outpatient mental health services with bipolar spectrum disorder from children with other psychiatric diagnoses?
    Mary A Fristad
    Division of Child and Adolescent Psychiatry, Department of Psychiatry, Ohio State University, Columbus, OH 43210, USA
    Bipolar Disord 14:497-506. 2012
    ....
  14. ncbi request reprint Child comorbidity, maternal mood disorder, and perceptions of family functioning among bipolar youth
    Christianne Esposito-Smythers
    Department of Psychiatry, Brown Medical School, Providence, RI 02912, USA
    J Am Acad Child Adolesc Psychiatry 45:955-64. 2006
    ..To examine the association between youth comorbid psychiatric disorders, maternal mood disorder, and perceptions of family cohesion and conflict among youth diagnosed with pediatric bipolar disorder (PBD)...
  15. ncbi request reprint Subgenual prefrontal cortex of child and adolescent bipolar patients: a morphometric magnetic resonance imaging study
    Marsal Sanches
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, 7703 Curl Drive, San Antonio, TX 87229, USA
    Psychiatry Res 138:43-9. 2005
    ..55 +/- 73.67 mm(3), respectively. There were no statistically significant differences between groups regarding right or left SGPFC volumes. We found no evidence of volumetric abnormalities in the SGPFC of bipolar children and adolescents...
  16. ncbi request reprint MRI study of thalamus volumes in juvenile patients with bipolar disorder
    E Serap Monkul
    MOOD CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Depress Anxiety 23:347-52. 2006
    ..Any differences in thalamus size that may exist between patients with bipolar disorder and healthy controls must amount to small effect sizes...
  17. pmc Phenomenology, longitudinal course, and outcome of children and adolescents with bipolar spectrum disorders
    Regina Sala
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Child Adolesc Psychiatr Clin N Am 18:273-89, vii. 2009
    ..Thus, early diagnosis and treatment of pediatric bipolar is of utmost importance...
  18. pmc History of suicide attempts in pediatric bipolar disorder: factors associated with increased risk
    Tina R Goldstein
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Bipolar Disord 7:525-35. 2005
    ..Despite evidence indicating high morbidity associated with pediatric bipolar disorder (BP), little is known about the prevalence and clinical correlates of suicidal behavior among this population...
  19. pmc Aggression, hostility, and irritability in children at risk for bipolar disorder
    Tiffany R Farchione
    Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 9:496-503. 2007
    ..To assess aggression, irritability and hostility in children at risk for bipolar disorder (BP)...
  20. pmc Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) study
    Robert L Findling
    Department of Psychiatry, Division of Child and Adolescent Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 71:1664-72. 2010
    ..This article describes the initial demographic information, diagnostic and symptom prevalence, and medication exposure for the LAMS cohort that will be followed longitudinally...
  21. pmc MRI study of the cerebellum in young bipolar patients
    E Serap Monkul
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:613-9. 2008
    ..Our results are preliminary, but consistent with the findings from studies in adult bipolar patients suggesting the involvement of structural changes in cerebellar vermis in the pathophysiology of bipolar disorder...
  22. pmc Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring study
    Boris Birmaher
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213 2593, USA
    Arch Gen Psychiatry 66:287-96. 2009
    ..Whether offspring of parents with bipolar disorder (BP) are at specifically high risk to develop BP and other psychiatric disorders has not been adequately studied...
  23. ncbi request reprint Developmental abnormalities in striatum in young bipolar patients: a preliminary study
    Marsal Sanches
    Division of Mood and Anxiety Disorders, Department of Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Bipolar Disord 7:153-8. 2005
    ..To investigate whether these abnormalities are present early in illness course, we compared the volume of striatal structures in young bipolar patients and healthy controls...
  24. ncbi request reprint Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder
    Barbara K Chen
    Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Biol Psychiatry 56:399-405. 2004
    ....
  25. pmc Reward-related brain function as a predictor of treatment response in adolescents with major depressive disorder
    Erika E Forbes
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Cogn Affect Behav Neurosci 10:107-18. 2010
    ..Final levels of severity and anxiety symptoms were associated with pretreatment striatal reactivity, and rate of anxiety symptom reduction was associated with greater striatal reactivity and lower medial PFC reactivity...
  26. ncbi request reprint MRI study of corpus callosum in children and adolescents with bipolar disorder
    A Sibel Yasar
    MOOD CNS Program Mood Disorders Clinical Neurosciences Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, TX 78229 3900, USA
    Psychiatry Res 146:83-5. 2006
    ..No significant differences in CC length or area were observed, suggesting that reported CC abnormalities appear late in the course of bipolar disorder...
  27. pmc Phenomenology of bipolar disorder not otherwise specified in youth: a comparison of clinical characteristics across the spectrum of manic symptoms
    Danella Hafeman
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA
    Bipolar Disord 15:240-52. 2013
    ....
  28. pmc Anatomical measurements of the orbitofrontal cortex in child and adolescent patients with bipolar disorder
    Pablo Najt
    MOOD CNS Program, Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Neurosci Lett 413:183-6. 2007
    ..Male patients exhibit smaller gray matter volumes, while female patients exhibit larger volumes in some OFC sub-regions. Gender differences in OFC abnormalities may be involved in illness pathophysiology among young bipolar patients...
  29. ncbi request reprint Fluoxetine for the treatment of childhood anxiety disorders: open-label, long-term extension to a controlled trial
    Duncan B Clark
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 44:1263-70. 2005
    ..To assess the efficacy of fluoxetine for the long-term treatment of children and adolescents with anxiety disorders, including generalized anxiety disorder, separation anxiety disorder, and/or social phobia...
  30. pmc Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) study
    Boris Birmaher
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:795-804. 2009
    ..The authors sought to assess the longitudinal course of youths with bipolar spectrum disorders over a 4-year period...
  31. ncbi request reprint Is bipolar disorder specifically associated with panic disorder in youths?
    Boris Birmaher
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Clin Psychiatry 63:414-9. 2002
    ..To replicate previous findings of high rates of bipolar disorder (BPD) in patients with panic disorder (PD) and determine if youths with both PD and BPD have more severe illness...
  32. pmc Replicable differences in preferred circadian phase between bipolar disorder patients and control individuals
    Joel Wood
    Departments of Psychiatry and Human Genetics, University of Pittsburgh School of Medicine and Graduate School of Public Health, Western Psychiatric Institute and Clinic, Pittsburgh, PA, United States
    Psychiatry Res 166:201-9. 2009
    ..Individuals with elevated depressive mood scores are more likely to be evening types. Our results suggest a replicable relationship between circadian phase and morbid mood states...
  33. ncbi request reprint Citalopram treatment of pediatric recurrent abdominal pain and comorbid internalizing disorders: an exploratory study
    John V Campo
    Department of Pyschiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 43:1234-42. 2004
    ..To assess the potential efficacy, tolerability, and safety of citalopram in the treatment of functional pediatric recurrent abdominal pain and comorbid internalizing disorders...
  34. pmc Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:701-10. 2009
    ..The results are plausible, based on prior studies of circadian abnormalities. As replications have not been attempted uniformly, we evaluated representative, common polymorphisms in all three disorders...
  35. pmc Differentiating major depressive disorder in youths with attention deficit hyperactivity disorder
    Rasim Somer Diler
    Division of Child Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    J Affect Disord 102:125-30. 2007
    ..Our objective was to examine which depressive symptoms best discriminate MDD among youths with ADHD...
  36. ncbi request reprint A preliminary study of the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children mania rating scale for children and adolescents
    David Axelson
    Division of Child Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Child Adolesc Psychopharmacol 13:463-70. 2003
    ..To construct a mania rating scale designed for children and adolescents...
  37. ncbi request reprint Subjective sleep complaints in pediatric depression: a controlled study and comparison with EEG measures of sleep and waking
    Michele A Bertocci
    University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Am Acad Child Adolesc Psychiatry 44:1158-66. 2005
    ..This article examines subjective sleep reports of children with MDD and healthy controls focusing on comparing subjective and objective sleep measures...
  38. ncbi request reprint Course and outcome of bipolar spectrum disorder in children and adolescents: a review of the existing literature
    Boris Birmaher
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Dev Psychopathol 18:1023-35. 2006
    ..Thus, early recognition and treatment of BP in children and adolescents is of utmost importance...
  39. ncbi request reprint Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study
    Hua Hsua Chen
    Division of Mood and Anxiety Disorders, Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Neurosci Lett 363:65-8. 2004
    ..Decreased white matter connections may be the core of abnormalities in STG, which is an important region for speech, language and communication, and could possibly underlie neurocognitive deficits present in bipolar patients...
  40. pmc Childhood-onset bipolar disorder: Evidence for increased familial loading of psychiatric illness
    Richard Rende
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    J Am Acad Child Adolesc Psychiatry 46:197-204. 2007
    ..To determine whether childhood-onset bipolar disorder (BP) is associated with an increased psychiatric family history compared with adolescent-onset BP...
  41. ncbi request reprint Clinical characteristics of depressive symptoms in children and adolescents with major depressive disorder
    Ozgur Yorbik
    Gulhane Military Medical Faculty, The Department of Child and Adolescent Psychiatry, Ankara, Turkey
    J Clin Psychiatry 65:1654-9; quiz 1760-1. 2004
    ..Very few studies have compared the symptoms of major depressive disorder (MDD) and rates of comorbid psychiatric disorders between depressed children and adolescents. The aim of this study was to reproduce and extend these findings...
  42. ncbi request reprint Reduced NAA levels in the dorsolateral prefrontal cortex of young bipolar patients
    Roberto B Sassi
    Division of Mood and Anxiety Disorders, Associate Professor of Psychiatry and Radiology, Krus Endowed Chair in Psychiatry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Psychiatry 162:2109-15. 2005
    ..In order to examine whether such abnormalities would also be found in younger patients, a 1H spectroscopy study was conducted that focused on the dorsolateral prefrontal cortex of children and adolescents with bipolar disorder...
  43. pmc Pediatric bipolar disease: current and future perspectives for study of its long-term course and treatment
    Michael Strober
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    Bipolar Disord 8:311-21. 2006
    ..Findings from recent long-term, prospective longitudinal studies of the course, outcome and naturalistic treatment of adults with bipolar illness are highlighted as background for long-term developmental study of pediatric bipolar illness...
  44. ncbi request reprint Psychotic symptoms in pediatric bipolar disorder and family history of psychiatric illness
    Richard Rende
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    J Affect Disord 96:127-31. 2006
    ..Few studies have examined the specificity and non-specificity in patterns of familial loading for presentation of psychotic symptoms in pediatric bipolar disorder (BP)...
  45. ncbi request reprint Normal pituitary volumes in children and adolescents with bipolar disorder: a magnetic resonance imaging study
    Hua Hsuan Chen
    Department of Radiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, USA
    Depress Anxiety 20:182-6. 2004
    ..This suggests that anatomical abnormalities in this structure may develop later in illness course as a result of continued HPA dysfunction...
  46. pmc Factors associated with mental health service utilization among bipolar youth
    Christie J Rizzo
    Department of Psychiatry and Human Behavior, Brown Medical School, CAAS, Box G BH, Providence, RI 02912, USA
    Bipolar Disord 9:839-50. 2007
    ..Demographic variables, youth bipolar characteristics, youth comorbid conditions, and parental psychopathology were examined as predictors of treatment utilization across different levels of care...
  47. pmc Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder
    Carrie E Bearden
    Department of Psychiatry and Biobehavioral Sciences, UCLA, 300 Building Medical Plaza, Suite 2265, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 47:515-25. 2008
    ..Using the same three-dimensional mapping methods, we sought to investigate whether a similar pattern exists in adolescents with bipolar disorder...