Research Topics
| David A AxelsonSummaryAffiliation: University of Pittsburgh Country: USA Publications
Research Grants
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Detail Information
Publications
Examining the proposed disruptive mood dysregulation disorder diagnosis in children in the Longitudinal Assessment of Manic Symptoms studyDavid Axelson
Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
J Clin Psychiatry 73:1342-50. 2012..Evaluation of DMDD included 4 domains: clinical phenomenology, delimitation from other diagnoses, longitudinal stability, and association with parental psychiatric disorders...- Course of subthreshold bipolar disorder in youth: diagnostic progression from bipolar disorder not otherwise specifiedDavid A Axelson
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 50:1001-16.e3. 2011.... - Daily emotional dynamics in depressed youth: a cell phone ecological momentary assessment studyJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Exp Child Psychol 110:241-57. 2011.... - Expressed emotion in mothers of currently depressed, remitted, high-risk, and low-risk youth: links to child depression status and longitudinal courseJennifer S Silk
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Child Adolesc Psychol 38:36-47. 2009..Higher initial critical expressed emotion was associated with a greater likelihood of having a future onset of a depressive episode in high-risk and depressed participants. Diagnostic groups did not differ in Emotional Overinvolvement... - Negative life events in children and adolescents with bipolar disorderSoledad Romero
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania, USA
J Clin Psychiatry 70:1452-60. 2009.... - Significance of cigarette smoking among youths with bipolar disorderBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Addict 17:364-71. 2008..Daily heavy smokers had greater prevalence of SUD and suicide attempts, and worse depression versus daily light smokers. Smoking among youths with BP is independently associated with suicide attempts and SUD... - Factors associated with the persistence and onset of new anxiety disorders in youth with bipolar spectrum disordersRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 73:87-94. 2012..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder, but, to our knowledge, no studies examined the course of anxiety disorders in youth and adults with bipolar disorder... - Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controlsDiana J Whalen
Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
J Pediatr Psychol 33:358-67. 2008..We examined caffeine use and its relation to sleep and affect in youth's natural environments... - Pupillary reactivity to emotional information in child and adolescent depression: links to clinical and ecological measuresJennifer S Silk
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Am J Psychiatry 164:1873-80. 2007.... 
Acute antidepressant response and plasma levels of bupropion and metabolites in a pediatric-aged sample: an exploratory studyW Burleson Daviss
Western Psychiatric Institute and Clinic, Pittsburgh, PA, and the University of Pittsburgh, Pittsburgh, PA 15213, USA
Ther Drug Monit 28:190-8. 2006..009). These preliminary findings suggest that plasma levels of bupropion and metabolites, particularly hydroxybupropion, may predict acute antidepressant response in depressed youths taking bupropion SR...- Comorbid anxiety in children and adolescents with bipolar spectrum disorders: prevalence and clinical correlatesRegina Sala
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 71:1344-50. 2010..Anxiety disorders are among the most common comorbid conditions in youth with bipolar disorder. We aimed to examine the prevalence and correlates of comorbid anxiety disorders among youth with bipolar disorder... - Predictors of prospectively examined suicide attempts among youth with bipolar disorderTina R Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Arch Gen Psychiatry 69:1113-22. 2012..Individuals with early onset of bipolar disorder are at high risk for suicide. Yet, no study to date has examined factors associated with prospective risk for suicide attempts among youth with bipolar disorder... - Altered striatal activation predicting real-world positive affect in adolescent major depressive disorderErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Loeffler 319, Pittsburgh, PA 15213, USA
Am J Psychiatry 166:64-73. 2009..The authors tested differences in reward-related brain function in healthy and depressed adolescents, and the authors examined direct links between reward-related brain function and positive mood that occurred in real-world contexts... - Clinical differences between suicidal and nonsuicidal depressed children and adolescentsRémy P Barbe
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Clin Psychiatry 66:492-8. 2005..To examine the clinical symptoms and comorbid psychiatric disorders of depressed children and adolescents with and without clinically significant suicidal ideation... - Real-world affect and social context as predictors of treatment response in child and adolescent depression and anxiety: an ecological momentary assessment studyErika E Forbes
University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 22:37-47. 2012..Individual differences in the social and affective dynamics of daily life could help to elucidate the characteristics of youth who respond to treatment... - Preliminary findings regarding overweight and obesity in pediatric bipolar disorderBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Clin Psychiatry 69:1953-9. 2008..Overweight/obesity is highly prevalent among adults with bipolar disorder and has been associated with illness severity. Little is known regarding overweight/obesity among youth with bipolar disorder... - Differential patterns of abnormal activity and connectivity in the amygdala-prefrontal circuitry in bipolar-I and bipolar-NOS youthCecile D Ladouceur
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 50:1275-89.e2. 2011..We sought to examine patterns of activity and connectivity in youth with BP-NOS relative to youth with bipolar disorder type I (BP-I) and healthy controls (HC)... - "I won, but I'm not getting my hopes up": depression moderates the relationship of outcomes and reward anticipationThomas M Olino
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Psychiatry Res 194:393-5. 2011..This finding has implications for understanding the developmental pathophysiology of MDD and suggests specific contexts where altered motivational system functioning may play a role in maintaining depression... - Schedule for affective disorders and schizophrenia for school-age children (K-SADS-PL) for the assessment of preschool children--a preliminary psychometric studyBoris Birmaher
University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Psychiatr Res 43:680-6. 2009.... - Objective sleep in pediatric anxiety disorders and major depressive disorderErika E Forbes
University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:148-55. 2008..To examine objective and subjective sleep problems in early-onset anxiety and depression... - Mother-child interactions in depressed children and children at high risk and low risk for future depressionLaura J Dietz
Department of Psychiatry at the University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:574-82. 2008..To compare mother-child interactions and parenting styles in families of children with major depressive disorder, youths at high risk for depression, and healthy controls... - Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patientsDavid J Kupfer
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Psychiatr Serv 60:888-97. 2009..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder... - Processing emotional facial expressions influences performance on a Go/NoGo task in pediatric anxiety and depressionCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Child Psychol Psychiatry 47:1107-15. 2006..This study investigated whether processing emotionally salient information such as emotional facial expressions influences the performance on a cognitive control task in pediatric anxiety and depression... - Substance use disorders among adolescents with bipolar spectrum disordersBenjamin I Goldstein
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Bipolar Disord 10:469-78. 2008..We set out to examine the prevalence and correlates of substance use disorders (SUD) in a large sample of adolescents with bipolar disorder (BP)... - Steady-state clinical pharmacokinetics of bupropion extended-release in youthsW Burleson Daviss
Western Psychiatric Institute and Clinic, University of Pittsburgh, USA
J Am Acad Child Adolesc Psychiatry 45:1503-9. 2006..To examine in children and adolescents the 24-hour, steady-state clinical pharmacokinetics of an extended-release (XL) formulation of bupropion (Wellbutrin XL)... - Reward-related decision-making in pediatric major depressive disorder: an fMRI studyErika E Forbes
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15218, USA
J Child Psychol Psychiatry 47:1031-40. 2006..Depression is postulated to involve decreased activity in reward-related affective systems... - Phenomenology of panic disorder in youthRasim Somer Diler
Division of Child Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
Depress Anxiety 20:39-43. 2004..Subjects with both panic and non-panic anxiety disorders were more likely to have comorbid major depression and conduct disorders than those with other non-anxiety disorders... - Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localizationCecile D Ladouceur
Department of Psychiatry, School of Medicine, Western Psychiatric Institute and Clinic, University of Pittsburgh, PA 15213, USA
J Child Psychol Psychiatry 47:1073-82. 2006.... - Altered error-related brain activity in youth with major depressionCecile D Ladouceur
Department of Psychiatry, University of Pittsburgh, School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
Dev Cogn Neurosci 2:351-62. 2012.... - Psychosocial functioning in youths at high risk to develop major depressive disorderBoris Birmaher
Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:839-46. 2004..To compare the psychosocial functioning of children and adolescents at high risk of major depressive disorder with youths with acute major depressive disorder and healthy controls... - Altered development of white matter in youth at high familial risk for bipolar disorder: a diffusion tensor imaging studyAmelia Versace
University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 49:1249-59, 1259.e1. 2010..Age-related changes in WM microstructure using diffusion tensor imaging with tract-based spatial statistics in healthy offspring having a parent with BD were compared with those in healthy controls... - Platelet serotonin reuptake inhibition and response to SSRIs in depressed adolescentsDavid A Axelson
Western Psychiatric Institute and Clinic, 3811 O'Hara St, Pittsburgh, PA 15213, USA
Am J Psychiatry 162:802-4. 2005..CONCLUSIONS: Platelet serotonin reuptake inhibition may be an appropriate surrogate biological marker for the pharmacodynamic activity of SSRIs in depressed adolescents... - Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians StudyAndrea Fagiolini
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Bipolar Disord 11:382-90. 2009..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder... - Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder?Cecile D Ladouceur
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 47:532-9. 2008..The goal of this study was to examine whole-brain regional GM volume in healthy bipolar offspring (HBO) relative to age-matched controls to identify possible structural abnormalities that may be associated with risk for BD... - First episode of depression in children at low and high familial risk for depressionDouglas E Williamson
Department of Child and Adolescent Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:291-7. 2004..To examine the development of first-onset major depressive disorder (MDD) in children at high and low familial risk for depression in a prospective study... - Risk for suicidal ideation among the offspring of bipolar parents: results from the Bipolar Offspring Study (BIOS)Tina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara St, Pittsburgh, PA 15213, USA
Arch Suicide Res 15:207-22. 2011..Offspring of parents with bipolar disorder are at elevated risk for suicidal ideation as compared with offspring of controls. Suicide risk assessment in this population should attend to specific risk factors identified... - Peri-sleep-onset cortisol levels in children and adolescents with affective disordersErika E Forbes
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Biol Psychiatry 59:24-30. 2006..Evidence also indicates that pubertal development may influence the expression of HPA dysregulation. We hypothesized that adolescents with depression and youth with anxiety disorders exhibit elevated peri-sleep-onset cortisol... - Steady-state pharmacokinetics of bupropion SR in juvenile patientsW Burleson Daviss
Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 44:349-57. 2005..To examine the steady-state pharmacokinetic properties of bupropion sustained release (SR) and their potential developmental differences in youths... - Superior temporal gyrus volumes in pediatric generalized anxiety disorderMichael D De Bellis
University of Pittsburgh Medical Center, Developmental Traumatology Program (Developmental Family Health Clinic and Neuroimaging Laboratory, Western Psychiatric Institute and Clinic, Rm 392, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
Biol Psychiatry 51:553-62. 2002..CONCLUSIONS: These data agree with previous work implicating posterior right-hemispheric regions in anxiety disorders and may suggest developmental alterations in pediatric GAD... 
Neural correlates of treatment in adolescents with bipolar depression during response inhibitionRasim Somer Diler
1 Department of Child Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania
J Child Adolesc Psychopharmacol 23:214-21. 2013....- Dialectical behavior therapy for adolescents with bipolar disorder: a 1-year open trialTina R Goldstein
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 46:820-30. 2007..To describe an adapted version of dialectical behavior therapy for adolescents with bipolar disorder... - Sertraline pharmacokinetics and dynamics in adolescentsDavid A Axelson
University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 41:1037-44. 2002..To determine the pharmacokinetics of sertraline in adolescents and assess its effect on a surrogate marker of serotonin transport... - Fluoxetine for the treatment of childhood anxiety disordersBoris Birmaher
Department of Child Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 42:415-23. 2003..To assess the efficacy and tolerability of fluoxetine for the acute treatment of children and adolescents with generalized anxiety disorder, separation anxiety disorder, and/or social phobia... - Clinical presentation and course of depression in youth: does onset in childhood differ from onset in adolescence?Boris Birmaher
University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
J Am Acad Child Adolesc Psychiatry 43:63-70. 2004..To simultaneously and prospectively compare the clinical presentation, course, and parental psychiatric history between children and adolescents with major depressive disorder... - Measuring mood and complex behavior in natural environments: use of ecological momentary assessment in pediatric affective disordersDavid A Axelson
Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
J Child Adolesc Psychopharmacol 13:253-66. 2003..Potential applications of the EMA methodology to the study of neurobehavioral systems and the pathophysiology of pediatric affective disorders are discussed... - Use of medical and behavioral health services by adolescents with bipolar disorderPamela B Peele
University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA
Psychiatr Serv 55:1392-6. 2004..This study compared use of medical and behavioral health care by adolescents with bipolar disorder and other adolescents and identified areas in need of more clinical attention... - Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trialDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Arch Gen Psychiatry 65:1053-61. 2008..Family interventions have been found to hasten episode recovery and delay recurrences among adults with bipolar disorder... - Criterion validity of the Mood and Feelings Questionnaire for depressive episodes in clinic and non-clinic subjectsW Burleson Daviss
Western Psychiatric Institute and Clinic and the University of Pittsburgh, USA
J Child Psychol Psychiatry 47:927-34. 2006..The current study re-examines the criterion validity of child- and parent-versions of the Mood and Feelings Questionnaire (MFQ-C, MFQ-P) in a heterogeneous sample of children and adolescents from clinic and non-clinic sources... - The contribution of pharmacoepidemiology to the antidepressant-suicidality debate in children and adolescentsJeffrey A Bridge
The Research Institute at Nationwide Children s Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH 43205, USA
Int Rev Psychiatry 20:209-14. 2008.... - Family-focused treatment for adolescents with bipolar disorderDavid J Miklowitz
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
J Affect Disord 82:S113-28. 2004..The adult version of FFT has been shown to be effective in forestalling relapses in two randomized clinical trials involving bipolar adults...
Research Grants
- PSYCHOPHARMACOLOGY OF PEDIATRIC BIPOLAR DISORDERDavid Axelson; Fiscal Year: 2004..abstract_text> ..
- Treatment of Early-Age ManiaDavid Axelson; Fiscal Year: 2007..The chief study statistician, Dr. Satish lyengar is subcontracted to the coordinating site at Washington U in St. Louis and Dr. Philip Lavori is a major consultant for statistical analyses. ..
- Family-Focused Treatment for Bipolar AdolescentsDavid Axelson; Fiscal Year: 2007..At the study's completion, we will have obtained a knowledge base to help develop a best practice model of treatment for BP adolescents that integrates family-focused problem-solving with psychopharmacology. ..
- Family-Focused Treatment for Bipolar AdolescentsDavid Axelson; Fiscal Year: 2009..At the study's completion, we will have obtained a knowledge base to help develop a best practice model of treatment for BP adolescents that integrates family-focused problem-solving with psychopharmacology. ..
- Family-Focused Treatment for Bipolar AdolescentsDavid A Axelson; Fiscal Year: 2010..At the study's completion, we will have obtained a knowledge base to help develop a best practice model of treatment for BP adolescents that integrates family-focused problem-solving with psychopharmacology. ..