Research Topics
| Francesca T AweekaSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The metabolic effects of lopinavir/ritonavir in HIV-negative menGrace A Lee
Metabolism Section 111F, San Francisco Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
AIDS 18:641-9. 2004..Therefore, we tested the effects of the PI combination lopinavir and ritonavir on glucose and lipid metabolism in HIV-negative subjects...
The impact of sex and contraceptive therapy on the plasma and intracellular pharmacokinetics of zidovudineFrancesca T Aweeka
Drug Research Unit, University of California, San Francisco, California 94143 0622, USA
AIDS 20:1833-41. 2006..This study evaluated the impact of female sex and contraceptive therapy on zidovudine plasma and intracellular pharmacokinetics and the impact of contraceptive therapy on HIV viral load...- Clinical pharmacology of artemisinin-based combination therapiesPolina I German
Drug Research Unit, University of California, San Francisco, California 94143 0622, USA
Clin Pharmacokinet 47:91-102. 2008..Alterations in antimalarial drug plasma concentrations may lead to either suboptimal efficacy or drug toxicity and may compromise treatment... - Pharmacokinetic evaluation of the effects of ribavirin on zidovudine triphosphate formation: ACTG 5092s Study TeamF T Aweeka
Drug Research Unit, University of California, San Francisco, CA 94143 0622, USA
HIV Med 8:288-94. 2007..We sought to investigate the potential antagonism between RBV and ZDV by evaluating the impact of RBV on the formation of intracellular ZDV triphosphate (TP) in HIV-infected patients receiving ZDV who were treated for HCV infection... - Lopinavir protein binding in HIV-1-infected pregnant womenF T Aweeka
Drug Research Unit, University of California, San Francisco, CA 94143 0622, USA
HIV Med 11:232-8. 2010..We report lopinavir (LPV) PB during third trimester (antepartum, AP) compared to > or =1.7 weeks postpartum (PP) to determine if FU changes compensate for reduced total concentrations reported previously... - Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trialDonald I Abrams
University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
Ann Intern Med 139:258-66. 2003..CONCLUSIONS: Smoked and oral cannabinoids did not seem to be unsafe in people with HIV infection with respect to HIV RNA levels, CD4+ and CD8+ cell counts, or protease inhibitor levels over a 21-day treatment... 
The protease inhibitor combination lopinavir/ritonavir does not decrease insulin secretion in healthy, HIV-seronegative volunteersVivian Y Pao
Department of Medicine, University of California, CA, USA
AIDS 24:265-70. 2010..We studied the effects of the protease inhibitor combination lopinavir and ritonavir on insulin secretion, insulin sensitivity, and lipid metabolism in HIV-negative persons...- Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteersLiusheng Huang
Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, CA Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 61:310-6. 2012..A study in healthy volunteers was completed to address the concern that EFV impacts AL pharmacokinetics (PKs)... - Boosting dose ritonavir does not alter peripheral insulin sensitivity in healthy HIV-seronegative volunteersSteven A Taylor
Department of Medicine, University of California, San Francisco, CA, USA
J Acquir Immune Defic Syndr 55:361-4. 2010..Boosting dose ritonavir (100-200 mg) is the most commonly prescribed PI, yet its effects on glucose metabolism have not been described in the absence of another PI... - Development and validation of a high-performance liquid chromatography/tandem mass spectrometry method for the determination of artemether and its active metabolite dihydroartemisinin in human plasmaLiusheng Huang
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94110, USA
J Pharm Biomed Anal 50:959-65. 2009..The calibration range was 2-200 ng/mL. The recovery was 73-81% for artemether and 90-99% for dihydroartemisinin. The validated method was applied to analysis of clinical samples with results in good agreement with an existing method... - Determination of lumefantrine in small-volume human plasma by LC-MS/MS: using a deuterated lumefantrine to overcome matrix effect and ionization saturationLiusheng Huang
Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94110, USA
Bioanalysis 4:157-66. 2012..To support pediatric study, a method to determine lumefantrine (LF) with small sample volume is needed. Matrix effect (ME) is a daunting issue in LF quantification in human plasma with LC-MS/MS... - Simultaneous determination of five HIV protease inhibitors nelfinavir, indinavir, ritonavir, saquinavir and amprenavir in human plasma by LC/MS/MSJingduan Chi
Department of Clinical Pharmacy, Drug Research Unit, School of Pharmacy, University of California, San Francisco, CA 94143, USA
J Pharm Biomed Anal 30:675-84. 2002..Mean inter- and intra-assay coefficients of variation (CVs) over the ranges of the standard curves were less than 10%. The overall recovery of NFV, IDV, RTV, SQV and APV were 88.4, 91.4, 92.2, 88.9 and 87.6%, respectively... - Pharmacokinetics of nelfinavir and indinavir in HIV-1-infected pregnant womenBradley W Kosel
Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, 94143, USA
AIDS 17:1195-9. 2003..This may warrant dosage adjustment during pregnancy. This induction is offset by concomitant use of ritonavir. Nelfinavir results were variable and, therefore, the impact of pregnancy on nelfinavir disposition was not fully determined... - Population pharmacokinetics of enfuvirtide in pediatric patients with human immunodeficiency virus: searching for exposure-response relationshipsDolors Soy
Department of Biopharmaceutical Sciences, School of Pharmacy, University of California-San Francisco, San Francisco, Calif, USA
Clin Pharmacol Ther 74:569-80. 2003..CONCLUSIONS: Regarding pharmacokinetics and pharmacodynamics, no statistically significant correlation between exposure measures and viral clearance was observed... - Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteersPolina German
Department of Clinical Pharmacy, Drug Research, University of California, School of Medicine, San Francisco, CA 94143 0622, USA
J Acquir Immune Defic Syndr 51:424-9. 2009.... - Nelfinavir pharmacokinetics in stable human immunodeficiency virus-positive children: Pediatric AIDS Clinical Trials Group Protocol 377Leslie Carstensen Floren
Drug Research Unit, Department of Clinical Pharmacy, University of California, San Francisco, California, USA
Pediatrics 112:e220-7. 2003..NFV dosed at 55 mg/kg BID in children who are <30 kg provides comparable exposure to that measured in children who are >25 kg and receiving NFV 30 mg/kg TID... - Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African womenBetty J Dong
University of California, San Francisco, 94143 0622, USA
AIDS 26:833-41. 2012..To estimate nevirapine (NVP) pharmacokinetics and examine its association with rash and/or hepatotoxicity in women starting antiretroviral treatment in the AIDS Clinical Trials Group A5208/OCTANE study in Africa... - An LC-MS-MS method for the determination of nevirapine, a non-nucleoside reverse transcriptase inhibitor, in human plasmaJingduan Chi
Drug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94143, USA
J Pharm Biomed Anal 31:953-9. 2003..Mean inter- and intra-assay coefficients of variation (CVs) over the ranges of the two standard curves were less than 10%. The overall recovery of NVP was 92.4%... - The effects of cannabinoids on the pharmacokinetics of indinavir and nelfinavirBradley W Kosel
Department of Clinical Pharmacy, University of California-San Francisco, San Francisco, CA 94110, USA
AIDS 16:543-50. 2002..The use of marijuana or dronabinol is unlikely to impact antiretroviral efficacy... - Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for determination of isoniazid in human plasmaLiusheng Huang
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94110, USA
J Chromatogr B Analyt Technol Biomed Life Sci 877:285-90. 2009..The recovery was over 90% and matrix effect was negligible. The method is simple and fast, which is advantageous in respect to instability of isoniazid in human plasma and loss on reconstitution due to its low molecular weight... - A Modified Method for Determination of Lumefantrine in Human Plasma by HPLC-UV and Combination of Protein Precipitation and Solid-Phase Extraction: Application to a Pharmacokinetic StudyLiusheng Huang
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94110, USA
Anal Chem Insights 5:15-23. 2010..This method was successfully applied to a pharmacokinetic interaction study between a first-line antimalarial combination (artemether-lumefantrine) and antiretroviral therapy... - Effect of renal disease and hemodialysis on foscarnet pharmacokinetics and dosing recommendationsF T Aweeka
Department of Clinical Pharmacy, University of California, San Francisco 94143 0622, USA
J Acquir Immune Defic Syndr Hum Retrovirol 20:350-7. 1999..To develop specific dosage guidelines, information on the disposition of this compound in patients with varying degrees of renal function and those requiring dialysis is essential... - Indinavir acutely inhibits insulin-stimulated glucose disposal in humans: a randomized, placebo-controlled studyMustafa A Noor
Department of Medicine, University of California, Berkeley, California, USA
AIDS 16:F1-8. 2002..Our data are compatible with the hypothesis that an acute effect of indinavir on glucose disposal in humans is mediated by a direct blockade of GLUT-4 transporters... - Nevirapine Inhibits the Anti-HIV Activity of CD8+ CellsLianxing Liu
Division of Hematology Oncology, Department of Medicine, and the Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA and the Department of Clinical Pharmacy, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA
J Acquir Immune Defic Syndr 63:184-8. 2013..These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8 cells and thus could influence the effectiveness of antiretroviral therapy... - Determination of nelfinavir free drug concentrations in plasma by equilibrium dialysis and liquid chromatography/tandem mass spectrometry: important factors for method optimizationClaudia Herforth
Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA 94143-0622, USA
Eur J Pharm Sci 15:185-95. 2002..0 ng/ml, permitting analysis of samples with total concentrations of nelfinavir in plasma that are > or = 400 ng/ml. This developed method proves reproducible and sensitive and its application to patient plasma samples is also reported... - Characterization of nelfinavir binding to plasma proteins and the lack of drug displacement interactionsT Motoya
Department of Clinical Pharmacy, University of California at San Francisco, San Francisco, CA 94143-0622, USA
HIV Med 7:122-8. 2006..The free fraction of nelfinavir was not affected by drugs that bind extensively to AAG or albumin when these drugs were added to whole plasma in combination, suggesting a compensatory effect of alternate binding proteins... - A direct determination of thymidine triphosphate concentrations without dephosphorylation in peripheral blood mononuclear cells by LC/MS/MSJ Chi
Department of Clinical Pharmacy, Drug Research Unit, School of Pharmacy, University of California, San Francisco, CA 94143-0622, USA
J Pharm Biomed Anal 26:829-36. 2001..The calibration curve was linear over the range 0.8-800 ng/ml. Mean inter- and intra-assay coefficients of variation (CVs) over the range of the standard curve were less than 10%. The overall recovery of TTP was 103.5%... - An LC-MS-MS method for the determination of indinavir, an HIV-1 protease inhibitor, in human plasmaA L Jayewardene
Department of Clinical Pharmacy, Drug Research Unit, School of Pharmacy, University of California, San Francisco, CA 94143-0622, USA
J Pharm Biomed Anal 25:309-17. 2001..The robust nature of this assay has been further verified during routine use over several months involving multiple analysts... - Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenzPolina German
Clin Infect Dis 44:889-91. 2007 - Safety, tolerability, and pharmacokinetic effects of thalidomide in patients infected with human immunodeficiency virus: AIDS Clinical Trials Group 267David A Wohl
Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599, USA
J Infect Dis 185:1359-63. 2002..Previous suggestions of autoinduction of drug metabolism were not confirmed by this study. At the doses studied, thalidomide was tolerated well and had linear pharmacokinetics...