YOGESH CHANDRA AWASTHI

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. pmc RLIP76, a non-ABC transporter, and drug resistance in epilepsy
    Sanjay Awasthi
    Department of Chemistry and Biochemistry, University of Texas at Arlington, USA
    BMC Neurosci 6:61. 2005
  2. ncbi request reprint The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance
    Yogesh C Awasthi
    Department of Biochemistry and Molecular Biology, 551 Basic Science Bldg, University of Texas Medical Branch at Galveston, Galveston, TX 77555 0647, USA
    Curr Drug Metab 8:315-23. 2007
  3. ncbi request reprint Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases
    Yogesh C Awasthi
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Free Radic Biol Med 37:607-19. 2004
  4. ncbi request reprint Energy dependent transport of xenobiotics and its relevance to multidrug resistance
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Curr Cancer Drug Targets 3:89-107. 2003
  5. ncbi request reprint Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling
    Yusong Yang
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77550, USA
    Acta Biochim Pol 50:319-36. 2003
  6. ncbi request reprint Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases
    Yogesh C Awasthi
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA
    Methods Enzymol 401:379-407. 2005
  7. ncbi request reprint RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch at Galveston, Galveston, TX, USA
    Int J Cancer 112:934-42. 2004
  8. ncbi request reprint Role of 4-hydroxynonenal in stress-mediated apoptosis signaling
    Yogesh C Awasthi
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 551 Basic Science Building, Galveston, TX 77555 0647, USA
    Mol Aspects Med 24:219-30. 2003
  9. ncbi request reprint Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    Invest Ophthalmol Vis Sci 44:3438-49. 2003
  10. ncbi request reprint Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Acta Biochim Pol 49:693-701. 2002

Collaborators

Detail Information

Publications26

  1. pmc RLIP76, a non-ABC transporter, and drug resistance in epilepsy
    Sanjay Awasthi
    Department of Chemistry and Biochemistry, University of Texas at Arlington, USA
    BMC Neurosci 6:61. 2005
    ..Because of a significant overlap in substrates between P-glycoprotein and RLIP76, present studies were carried out to determine the potential role of RLIP76 in AED transport in the brain...
  2. ncbi request reprint The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance
    Yogesh C Awasthi
    Department of Biochemistry and Molecular Biology, 551 Basic Science Bldg, University of Texas Medical Branch at Galveston, Galveston, TX 77555 0647, USA
    Curr Drug Metab 8:315-23. 2007
    ..Studies summarized in this review strongly suggest that RLIP76 is a logical target for clinical intervention of not only multi-drug resistance but also for diseases resulting from oxidative stress...
  3. ncbi request reprint Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases
    Yogesh C Awasthi
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Free Radic Biol Med 37:607-19. 2004
    ....
  4. ncbi request reprint Energy dependent transport of xenobiotics and its relevance to multidrug resistance
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Curr Cancer Drug Targets 3:89-107. 2003
    ..In the present article, we review the comparative functional, structural, and molecular characteristics of some transporters and discuss their role in xenobiotic transport and multidrug resistance...
  5. ncbi request reprint Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling
    Yusong Yang
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77550, USA
    Acta Biochim Pol 50:319-36. 2003
    ..These studies and previous reports discussed in this article strongly suggest a key role of 4-HNE in stress mediated signaling...
  6. ncbi request reprint Regulation of 4-hydroxynonenal mediated signaling by glutathione S-transferases
    Yogesh C Awasthi
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, USA
    Methods Enzymol 401:379-407. 2005
    ..Available evidence strongly suggests that besides their well-established pharmacological role of detoxifying xenobiotics, GSTs also play an important physiological role in the regulation of cellular signaling processes...
  7. ncbi request reprint RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch at Galveston, Galveston, TX, USA
    Int J Cancer 112:934-42. 2004
    ..These results suggest that RLIP76 is the major LTC(4) transporter in cancer cells and that its transport activity is regulated by PKC-alpha-mediated phosphorylation...
  8. ncbi request reprint Role of 4-hydroxynonenal in stress-mediated apoptosis signaling
    Yogesh C Awasthi
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, 551 Basic Science Building, Galveston, TX 77555 0647, USA
    Mol Aspects Med 24:219-30. 2003
    ..Furthermore, a decrease in intracellular concentration of 4-HNE achieved by transfecting cells with mGSTA4-4 or hGSTA4-4 results in a faster growth rate. These studies strongly suggest a role of 4-HNE in stress mediated signaling...
  9. ncbi request reprint Mechanisms and physiological significance of the transport of the glutathione conjugate of 4-hydroxynonenal in human lens epithelial cells
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas, USA
    Invest Ophthalmol Vis Sci 44:3438-49. 2003
    ..To study the mechanism and physiological significance of the transport of the glutathione (GSH) conjugate of 4-hydroxynonenal (4-HNE) from lens epithelial cells...
  10. ncbi request reprint Functional reconstitution of Ral-binding GTPase activating protein, RLIP76, in proteoliposomes catalyzing ATP-dependent transport of glutathione conjugate of 4-hydroxynonenal
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Acta Biochim Pol 49:693-701. 2002
    ....
  11. ncbi request reprint Mitogenic responses of vascular smooth muscle cells to lipid peroxidation-derived aldehyde 4-hydroxy-trans-2-nonenal (HNE): role of aldose reductase-catalyzed reduction of the HNE-glutathione conjugates in regulating cell growth
    Kota V Ramana
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
    J Biol Chem 281:17652-60. 2006
    ..These results raise the possibility that the glutathione conjugates of lipid peroxidation products are novel mediators of cell signaling and growth...
  12. pmc Glutathione level regulates HNE-induced genotoxicity in human erythroleukemia cells
    Umesh C S Yadav
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Toxicol Appl Pharmacol 227:257-64. 2008
    ..These results suggest that the genotoxicity of HNE is highly dependent on cellular GSH/GST/AR levels and favorable modulation of the aldehyde detoxification system may help in controlling the oxidative stress-induced complications...
  13. ncbi request reprint Cells preconditioned with mild, transient UVA irradiation acquire resistance to oxidative stress and UVA-induced apoptosis: role of 4-hydroxynonenal in UVA-mediated signaling for apoptosis
    Yusong Yang
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555
    J Biol Chem 278:41380-8. 2003
    ..These studies strongly suggest a role of 4-HNE in UVA-mediated apoptosis...
  14. ncbi request reprint Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555 0647, USA
    Eur J Biochem 271:1690-701. 2004
    ..These studies suggest that alterations in 4-HNE homeostasis can profoundly affect cell-cycle signaling events...
  15. ncbi request reprint The course of CCl4 induced hepatotoxicity is altered in mGSTA4-4 null (-/-) mice
    Seema Dwivedi
    Department of Pathology, University of Texas Medical Branch, 301 University Blvd, Galveston, 77555 0609, USA
    Toxicology 218:58-66. 2006
    ....
  16. ncbi request reprint Depletion of 4-hydroxynonenal in hGSTA4-transfected HLE B-3 cells results in profound changes in gene expression
    Brad Patrick
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77555, USA
    Biochem Biophys Res Commun 334:425-32. 2005
    ..These results demonstrate that HNE serves as a crucial signaling molecule and, by modulating the expression of genes, can influence cellular functions...
  17. ncbi request reprint Antioxidant role of glutathione S-transferases: protection against oxidant toxicity and regulation of stress-mediated apoptosis
    Rajendra Sharma
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX 77550, USA
    Antioxid Redox Signal 6:289-300. 2004
    ....
  18. pmc 4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas
    Rajendra Sharma
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555, USA unt edu
    Biochemistry 47:143-56. 2008
    ..Cytoplasmic translocation of Daxx also results in up-regulation of HSF1-associated stress-responsive genes...
  19. pmc Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-kappaB translocation
    Yongzhen Yang
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Toxicol Appl Pharmacol 230:187-96. 2008
    ..These studies suggest that GSTA4-4 may play an important defensive role against atherogenesis through detoxification of 4-HNE and upregulation of iNOS...
  20. ncbi request reprint Role of 4-hydroxynonenal and its metabolites in signaling
    Seema Dwivedi
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Redox Rep 12:4-10. 2007
    ..Against a backdrop of various reported effects of HNE, in vitro and in vivo, we have critically evaluated the above mentioned hypotheses suggesting a key role of HNE in signaling...
  21. ncbi request reprint Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal
    Jie Li
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 0647, USA
    Biochemistry 45:12253-64. 2006
    ..We also demonstrate that during 4-HNE-induced apoptosis of HLE B-3 cells, Daxx is induced and it binds to Fas. Together, these results show an important role of 4-HNE in regulation of the expression and functions of Fas...
  22. ncbi request reprint Glutathione S-transferases as antioxidant enzymes: small cell lung cancer (H69) cells transfected with hGSTA1 resist doxorubicin-induced apoptosis
    Abha Sharma
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA
    Arch Biochem Biophys 452:165-73. 2006
    ..These results are consistent with the idea that the alpha-class GSTs provide protection against oxidative stress by attenuating lipid peroxidation and these enzymes can modulate signaling for apoptosis...
  23. ncbi request reprint Protection of HLE B-3 cells against hydrogen peroxide- and naphthalene-induced lipid peroxidation and apoptosis by transfection with hGSTA1 and hGSTA2
    Yusong Yang
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, Texas 77555 1067, USA
    Invest Ophthalmol Vis Sci 43:434-45. 2002
    ..To investigate the physiological role of two major alpha-class glutathione S-transferases (GSTs), hGSTA1-1 and hGSTA2-2 in protection against oxidative stress and lipid peroxidation (LPO) in human lens epithelial (HLE B-3) cells...
  24. ncbi request reprint Glutathione-S-transferase A4-4 modulates oxidative stress in endothelium: possible role in human atherosclerosis
    Yongzhen Yang
    Department of Pathology, University of Texas Medical Branch, Galveston, TX 77555, USA
    Atherosclerosis 173:211-21. 2004
    ..Our results indicate that endothelial cell mGSTA4-4 can play a key role in protecting blood vessels against oxidative stress and, thus, is likely to be a critical defense mechanism against oxidants that act as atherogens...
  25. ncbi request reprint Role of alpha class glutathione S-transferases as antioxidant enzymes in rodent tissues
    Yusong Yang
    Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston 77555, USA
    Toxicol Appl Pharmacol 182:105-15. 2002
    ..276, 19220-19230, 2001) and demonstrate that alpha class GSTs are of physiological importance, not only in the conjugative detoxification of electrophiles, but are also an essential component of cellular antioxidant defense mechanisms...
  26. pmc Adenovirus-mediated overexpression of glutathione-s-transferase mitigates transplant arteriosclerosis in rabbit carotid allografts
    Ya Xu
    Department of Pathology, University of Texas Medical Branch, Galveston, TX, USA
    Transplantation 89:409-16. 2010
    ..However, the contribution of human GST A4-4 (hGSTA4-4) to vascular cell injury and consequent transplant arteriosclerosis is unknown...