Research Topics
Genomes and Genes | Hani AwadSummaryAffiliation: University of Rochester Country: USA Publications
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Publications
Recent advances in gene delivery for structural bone allograftsHani A Awad
Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
Tissue Eng 13:1973-85. 2007..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications...
Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritisErik R Sampson
Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
Sci Transl Med 3:101ra93. 2011..These preclinical findings provide proof of concept that Forteo may be useful for decelerating cartilage degeneration and inducing matrix regeneration in patients with osteoarthritis...- Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic miceQiuqian Wu
Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York 14642, USA
Arthritis Rheum 58:3132-44. 2008..To determine whether Smurf2, an E3 ubiquitin ligase known to inhibit transforming growth factor beta (TGFbeta) signaling, is expressed in human osteoarthritic (OA) cartilage and can initiate OA in mice... 
Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1Lan Zhao
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
Stem Cells 29:1601-10. 2011....- Reduced COX-2 expression in aged mice is associated with impaired fracture healingAmish A Naik
The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
J Bone Miner Res 24:251-64. 2009..The findings suggest that COX-2/EP4 agonists may compensate for deficient molecular signals that result in the reduced fracture healing associated with aging... - Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineeringChao Xie
Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
Tissue Eng 13:435-45. 2007..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering... - Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult miceYing Yan
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
J Cell Sci 122:3566-78. 2009..Taken together, our findings demonstrate that Axin2 is a key negative regulator in bone remodeling in adult mice and regulates osteoblast differentiation through the beta-catenin-BMP2/4-Osx signaling pathway in osteoblasts... - Establishment of an index with increased sensitivity for assessing murine arthritisErik R Sampson
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
J Orthop Res 29:1145-51. 2011..Enhanced sensitivity can be achieved by performing the Arthritis Index calculation, a novel method for quantitatively assessing mouse knee arthritis... - Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineeringXinping Zhang
Department of Orthopaedics, University of Rochester Medical Center, New York, USA
J Bone Miner Res 20:2124-37. 2005.... - A perspective: engineering periosteum for structural bone graft healingXinping Zhang
The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
Clin Orthop Relat Res 466:1777-87. 2008.... - Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunityDan Li
The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
J Orthop Res 26:96-105. 2008..05). Collectively, these studies demonstrate the first quantitative model of implant-associated OM that defines the kinetics of microbial growth, osteolysis, and humoral immunity following infection... - Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulationDavid L Butler
Department of Biomedical Engineering, 840 Engineering Research Center, Colleges of Engineering and Medicine, University of Cincinnati, 2901 Woodside Drive, Cincinnati, Ohio 45221 0048, USA
J Orthop Res 26:1-9. 2008..Our contributions in the area of tendon functional tissue engineering have the potential to create functional load-bearing repairs that will revolutionize surgical reconstruction after tendon and ligament injury... - muCT-based measurement of cortical bone graft-to-host unionDavid G Reynolds
Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA
J Bone Miner Res 24:899-907. 2009..The union ratio has important clinical implications as a novel biometric for noninvasive assessment of functional strength and failure risk... - Biological effects of rAAV-caAlk2 coating on structural allograft healingMette Koefoed
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Mol Ther 12:212-8. 2005..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation... - Inhibition of beta-catenin signaling causes defects in postnatal cartilage developmentMo Chen
Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
J Cell Sci 121:1455-65. 2008..Altogether the findings confirm a crucial role for Wnt/beta-catenin in postnatal growth... - Screw orientation and plate type (variable- vs. fixed-angle) effect strength of fixation for in vitro biomechanical testing of the Synthes CSLPChristian P DiPaola
University of Rochester Medical Center, Rochester, NY 14642, USA
Spine J 8:717-22. 2008..Despite these teachings, there is a paucity of supporting biomechanical evidence. The purpose of our study is to test the influence of screw orientation and plate design on the maximum screw pullout force... - Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene deliveryPatrick Basile
Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, New York 14642, USA
Mol Ther 16:466-73. 2008..Collectively, our data demonstrate the feasibility and efficacy of therapeutic tendon allograft processing as a novel paradigm in tissue engineering in order to address difficult clinical problems such as tendon adhesions... - Micro-computed tomography prediction of biomechanical strength in murine structural bone graftsDavid G Reynolds
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14620, USA
J Biomech 40:3178-86. 2007..The statistical correlations approach used in this mouse study could be useful in guiding future development of non-invasive predictors of the biomechanical properties of allografts using clinical CT... - The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatingsCemal Yazici
The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
Biomaterials 29:3882-7. 2008..Thus, surface demineralization of human cortical bone allograft increases its absorbance for uniform rAAV coating, without affecting vector transduction efficiency... - Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstructionSys Hasslund
The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
J Orthop Res 26:824-33. 2008..This mouse model can be useful in elucidating the molecular mechanisms in tendon repair and can aid in preliminary screening of molecular treatments of flexor tendon adhesions... - Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomographySteven T Proulx
Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
Arthritis Rheum 56:4024-37. 2007.... - Clonal analysis of the differentiation potential of human adipose-derived adult stem cellsFarshid Guilak
Orthopaedic Research Laboratories, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Cell Physiol 206:229-37. 2006..However, it is important to exercise caution in interpreting these results until they are validated using functional in vivo assays... - Adipose-derived adult stem cells for cartilage tissue engineeringFarshid Guilak
Departments of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
Biorheology 41:389-99. 2004..Overall, ADAS cells show significant promise for the development of functional tissue replacements for various tissues of the musculoskeletal system... - Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditionsHolly A Leddy
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Biomed Mater Res B Appl Biomater 70:397-406. 2004..The increase in diffusivity in the acellular constructs is probably due to scaffold degradation and swelling... - Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffoldsHani A Awad
Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA
Biomaterials 25:3211-22. 2004....
Research Grants
- Allografts and Gene Therapy in Flexor Tendon Tissue EngineeringHani Awad; Fiscal Year: 2009..The studies will demonstrate the efficacy of using allografts (tissues from deceased donors) and gene therapy in eradicating adhesions and restoring the joint's range of motion. ..
- Allografts and Gene Therapy in Flexor Tendon Tissue EngineeringHani A Awad; Fiscal Year: 2010..The studies will demonstrate the efficacy of using allografts (tissues from deceased donors) and gene therapy in eradicating adhesions and restoring the joint's range of motion. ..