Hani Awad

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Recent advances in gene delivery for structural bone allografts
    Hani A Awad
    Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
    Tissue Eng 13:1973-85. 2007
  2. pmc Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis
    Erik R Sampson
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Sci Transl Med 3:101ra93. 2011
  3. pmc Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice
    Qiuqian Wu
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 58:3132-44. 2008
  4. pmc Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1
    Lan Zhao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Stem Cells 29:1601-10. 2011
  5. pmc Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    Amish A Naik
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 24:251-64. 2009
  6. ncbi request reprint Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Tissue Eng 13:435-45. 2007
  7. pmc Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice
    Ying Yan
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Sci 122:3566-78. 2009
  8. pmc Establishment of an index with increased sensitivity for assessing murine arthritis
    Erik R Sampson
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 29:1145-51. 2011
  9. ncbi request reprint Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering
    Xinping Zhang
    Department of Orthopaedics, University of Rochester Medical Center, New York, USA
    J Bone Miner Res 20:2124-37. 2005
  10. pmc A perspective: engineering periosteum for structural bone graft healing
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Orthop Relat Res 466:1777-87. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Recent advances in gene delivery for structural bone allografts
    Hani A Awad
    Department of Biomedical Engineering, The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14620, USA
    Tissue Eng 13:1973-85. 2007
    ..Therefore, innovations in gene delivery offer promising therapeutic approaches for tissue engineering of structural bone substitutes that can potentially have clinical applications in challenging indications...
  2. pmc Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis
    Erik R Sampson
    Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, NY 14642, USA
    Sci Transl Med 3:101ra93. 2011
    ..These preclinical findings provide proof of concept that Forteo may be useful for decelerating cartilage degeneration and inducing matrix regeneration in patients with osteoarthritis...
  3. pmc Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice
    Qiuqian Wu
    Department of Orthopaedics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 58:3132-44. 2008
    ..To determine whether Smurf2, an E3 ubiquitin ligase known to inhibit transforming growth factor beta (TGFbeta) signaling, is expressed in human osteoarthritic (OA) cartilage and can initiate OA in mice...
  4. pmc Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1
    Lan Zhao
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Stem Cells 29:1601-10. 2011
    ....
  5. pmc Reduced COX-2 expression in aged mice is associated with impaired fracture healing
    Amish A Naik
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA
    J Bone Miner Res 24:251-64. 2009
    ..The findings suggest that COX-2/EP4 agonists may compensate for deficient molecular signals that result in the reduced fracture healing associated with aging...
  6. ncbi request reprint Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering
    Chao Xie
    Center for Musculoskeletal Research, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Tissue Eng 13:435-45. 2007
    ..Taken together, we propose a novel strategy to combine structural bone allograft with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering...
  7. pmc Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice
    Ying Yan
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Sci 122:3566-78. 2009
    ..Taken together, our findings demonstrate that Axin2 is a key negative regulator in bone remodeling in adult mice and regulates osteoblast differentiation through the beta-catenin-BMP2/4-Osx signaling pathway in osteoblasts...
  8. pmc Establishment of an index with increased sensitivity for assessing murine arthritis
    Erik R Sampson
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 29:1145-51. 2011
    ..Enhanced sensitivity can be achieved by performing the Arthritis Index calculation, a novel method for quantitatively assessing mouse knee arthritis...
  9. ncbi request reprint Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering
    Xinping Zhang
    Department of Orthopaedics, University of Rochester Medical Center, New York, USA
    J Bone Miner Res 20:2124-37. 2005
    ....
  10. pmc A perspective: engineering periosteum for structural bone graft healing
    Xinping Zhang
    The Center for Musculoskeletal Research, University of Rochester Medical Center, School of Medicine and Dentistry, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Clin Orthop Relat Res 466:1777-87. 2008
    ....
  11. pmc Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity
    Dan Li
    The Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 665, Rochester, New York 14642, USA
    J Orthop Res 26:96-105. 2008
    ..05). Collectively, these studies demonstrate the first quantitative model of implant-associated OM that defines the kinetics of microbial growth, osteolysis, and humoral immunity following infection...
  12. ncbi request reprint Functional tissue engineering for tendon repair: A multidisciplinary strategy using mesenchymal stem cells, bioscaffolds, and mechanical stimulation
    David L Butler
    Department of Biomedical Engineering, 840 Engineering Research Center, Colleges of Engineering and Medicine, University of Cincinnati, 2901 Woodside Drive, Cincinnati, Ohio 45221 0048, USA
    J Orthop Res 26:1-9. 2008
    ..Our contributions in the area of tendon functional tissue engineering have the potential to create functional load-bearing repairs that will revolutionize surgical reconstruction after tendon and ligament injury...
  13. pmc muCT-based measurement of cortical bone graft-to-host union
    David G Reynolds
    Department of Biomedical Engineering, University of Rochester, Rochester, New York, USA
    J Bone Miner Res 24:899-907. 2009
    ..The union ratio has important clinical implications as a novel biometric for noninvasive assessment of functional strength and failure risk...
  14. ncbi request reprint Biological effects of rAAV-caAlk2 coating on structural allograft healing
    Mette Koefoed
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Mol Ther 12:212-8. 2005
    ..These results indicate that cell-free, rAAV-coated allografts have the potential to revitalize in vivo following transplantation...
  15. pmc Inhibition of beta-catenin signaling causes defects in postnatal cartilage development
    Mo Chen
    Department of Orthopaedics, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Cell Sci 121:1455-65. 2008
    ..Altogether the findings confirm a crucial role for Wnt/beta-catenin in postnatal growth...
  16. ncbi request reprint Screw orientation and plate type (variable- vs. fixed-angle) effect strength of fixation for in vitro biomechanical testing of the Synthes CSLP
    Christian P DiPaola
    University of Rochester Medical Center, Rochester, NY 14642, USA
    Spine J 8:717-22. 2008
    ..Despite these teachings, there is a paucity of supporting biomechanical evidence. The purpose of our study is to test the influence of screw orientation and plate design on the maximum screw pullout force...
  17. pmc Freeze-dried tendon allografts as tissue-engineering scaffolds for Gdf5 gene delivery
    Patrick Basile
    Center for Musculoskeletal Research, Department of Orthopaedics, University of Rochester, Rochester, New York 14642, USA
    Mol Ther 16:466-73. 2008
    ..Collectively, our data demonstrate the feasibility and efficacy of therapeutic tendon allograft processing as a novel paradigm in tissue engineering in order to address difficult clinical problems such as tendon adhesions...
  18. ncbi request reprint Micro-computed tomography prediction of biomechanical strength in murine structural bone grafts
    David G Reynolds
    Department of Biomedical Engineering, University of Rochester, Rochester, NY 14620, USA
    J Biomech 40:3178-86. 2007
    ..The statistical correlations approach used in this mouse study could be useful in guiding future development of non-invasive predictors of the biomechanical properties of allografts using clinical CT...
  19. pmc The effect of surface demineralization of cortical bone allograft on the properties of recombinant adeno-associated virus coatings
    Cemal Yazici
    The Center for Musculoskeletal Research, University of Rochester, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Biomaterials 29:3882-7. 2008
    ..Thus, surface demineralization of human cortical bone allograft increases its absorbance for uniform rAAV coating, without affecting vector transduction efficiency...
  20. pmc Adhesions in a murine flexor tendon graft model: autograft versus allograft reconstruction
    Sys Hasslund
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Orthop Res 26:824-33. 2008
    ..This mouse model can be useful in elucidating the molecular mechanisms in tendon repair and can aid in preliminary screening of molecular treatments of flexor tendon adhesions...
  21. pmc Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography
    Steven T Proulx
    Center for Musculoskeletal Research, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Arthritis Rheum 56:4024-37. 2007
    ....
  22. ncbi request reprint Clonal analysis of the differentiation potential of human adipose-derived adult stem cells
    Farshid Guilak
    Orthopaedic Research Laboratories, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Cell Physiol 206:229-37. 2006
    ..However, it is important to exercise caution in interpreting these results until they are validated using functional in vivo assays...
  23. ncbi request reprint Adipose-derived adult stem cells for cartilage tissue engineering
    Farshid Guilak
    Departments of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
    Biorheology 41:389-99. 2004
    ..Overall, ADAS cells show significant promise for the development of functional tissue replacements for various tissues of the musculoskeletal system...
  24. ncbi request reprint Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions
    Holly A Leddy
    Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biomed Mater Res B Appl Biomater 70:397-406. 2004
    ..The increase in diffusivity in the acellular constructs is probably due to scaffold degradation and swelling...
  25. ncbi request reprint Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds
    Hani A Awad
    Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Biomaterials 25:3211-22. 2004
    ....

Research Grants2

  1. Allografts and Gene Therapy in Flexor Tendon Tissue Engineering
    Hani Awad; Fiscal Year: 2009
    ..The studies will demonstrate the efficacy of using allografts (tissues from deceased donors) and gene therapy in eradicating adhesions and restoring the joint's range of motion. ..
  2. Allografts and Gene Therapy in Flexor Tendon Tissue Engineering
    Hani A Awad; Fiscal Year: 2010
    ..The studies will demonstrate the efficacy of using allografts (tissues from deceased donors) and gene therapy in eradicating adhesions and restoring the joint's range of motion. ..