Research Topics
| B B AvantsSummaryAffiliation: University of Pennsylvania Country: USA Publications
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Detail Information
Publications
The shape operator for differential analysis of imagesBrian Avants
University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Inf Process Med Imaging 18:101-13. 2003..A novel variant of Demons registration, extensible for use with differentiable similarity metrics, is also applied for deformable curvature-driven registration of medical images...- Lagrangian frame diffeomorphic image registration: Morphometric comparison of human and chimpanzee cortexBrian B Avants
Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Med Image Anal 10:397-412. 2006..The population statistics show a significant doubling of the relative prefrontal lobe size in humans, as compared to chimpanzees... - Spatiotemporal normalization for longitudinal analysis of gray matter atrophy in frontotemporal dementiaBrian Avants
Dept of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Med Image Comput Comput Assist Interv 10:303-10. 2007..This paper shows the statistical power of symmetric diffeomorphic normalization for performing deformation-based studies of longitudinal atrophy... 
The optimal template effect in hippocampus studies of diseased populationsBrian B Avants
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 49:2457-66. 2010..Furthermore, explicit geometric optimization of the shape component of the unbiased template positively impacts the study of diseased hippocampi...- Effects of heavy in utero cocaine exposure on adolescent caudate morphologyBrian B Avants
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Pediatr Neurol 37:275-9. 2007..The right (P < 0.025) and left (P < 0.035) caudate, studied independently, show the same significant trend. Permutation testing and the false discovery rate were used to assess significance... - Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brainB B Avants
Department of Radiology, University of Pennsylvania, 3600 Market Street, Philadelphia, PA 19104, United States
Med Image Anal 12:26-41. 2008..This study indicates that SyN, with cross-correlation, is a reliable method for normalizing and making anatomical measurements in volumetric MRI of patients and at-risk elderly individuals... - Dementia induces correlated reductions in white matter integrity and cortical thickness: a multivariate neuroimaging study with sparse canonical correlation analysisBrian B Avants
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Neuroimage 50:1004-16. 2010..We conclude that SCCA is a potentially valuable approach in image analysis that can be applied productively to distinguishing between neurodegenerative conditions... - Multivariate normalization with symmetric diffeomorphisms for multivariate studiesB B Avants
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Med Image Comput Comput Assist Interv 10:359-66. 2007..In this initial study, we develop the theory for Multivariate Symmetric Normalization (MVSyN), establish its feasibility and discuss preliminary results on a multivariate statistical study of 22q deletion syndrome... - A reproducible evaluation of ANTs similarity metric performance in brain image registrationBrian B Avants
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 54:2033-44. 2011..This is the first study to use a consistent transformation framework to provide a reproducible evaluation of the isolated effect of the similarity metric on optimal template construction and brain labeling... - Sparse unbiased analysis of anatomical variance in longitudinal imagingBrian Avants
Dept of Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389 USA
Med Image Comput Comput Assist Interv 13:324-31. 2010.... - The correlation of cognitive decline with frontotemporal dementia induced annualized gray matter loss using diffeomorphic morphometryBrian Avants
University of Pennsylvania School of Medicine, Philadelphia, 19104 6389, USA
Alzheimer Dis Assoc Disord 19:S25-8. 2005..This study gives insight into the relationship between FTD-related progressive cortical atrophy and loss in cognitive function... - Geodesic estimation for large deformation anatomical shape averaging and interpolationBrian Avants
University of Pennsylvania, Philadelphia, PA 19104, USA
Neuroimage 23:S139-50. 2004..The procedures generate improved average representations of highly variable anatomy from distinct populations... - Speech errors in progressive non-fluent aphasiaSharon Ash
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Brain Lang 113:13-20. 2010..We conclude that the speech errors produced by PNFA patients are mainly errors at the phonemic level of language processing and are not caused by a motor planning impairment... - The role of ventral medial prefrontal cortex in social decisions: converging evidence from fMRI and frontotemporal lobar degenerationMurray Grossman
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Neuropsychologia 48:3505-12. 2010..These converging results support the role of vmPFC in social decision-making where potentially negative consequences must be considered... - Characterization of sexual dimorphism in the human corpus callosumAbraham Dubb
Department of Bioengineering, Psychiatry, and Radiology, University of Pennsylvania, Philadelphia, PA 19104 6389, USA
Neuroimage 20:512-9. 2003..Our results demonstrate significant morphologic differences in the corpus callosum between genders and a possible sex difference in the neuro-developmental cycle... - A learning-based wrapper method to correct systematic errors in automatic image segmentation: consistently improved performance in hippocampus, cortex and brain segmentationHongzhi Wang
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
Neuroimage 55:968-85. 2011..908 for normal controls and 0.893 for patients with mild cognitive impairment. Average Dice overlaps of 0.964, 0.905 and 0.951 are obtained for brain extraction, white matter segmentation and gray matter segmentation, respectively... - Integrated graph cuts for brain MRI segmentationZhuang Song
Penn Image Computing and Science Lab, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv 9:831-8. 2006..In the experiments of real neonatal brain MRIs, the results of the proposed method have good overlap with the manual segmentations by human experts... - Hierarchical organization of scripts: converging evidence from FMRI and frontotemporal degenerationChristine Farag
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Cereb Cortex 20:2453-63. 2010..Our findings suggest that frontal cortex contributes to clustering events during script comprehension, underlining the role of frontal cortex in the hierarchical organization of a script... - Standing on the shoulders of giants: improving medical image segmentation via bias correctionHongzhi Wang
Department of Radiology, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv 13:105-12. 2010..We apply this methodology on three segmentation problems/methods and show significant improvements for all of them... - Neuroanatomy of apathy and disinhibition in frontotemporal lobar degenerationLauren Massimo
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Dement Geriatr Cogn Disord 27:96-104. 2009..To investigate the neural basis for the behavioral symptoms of frontotemporal lobar degeneration (FTLD) that cause the greatest caregiver distress... - Structural consequences of diffuse traumatic brain injury: a large deformation tensor-based morphometry studyJunghoon Kim
Moss Rehabilitation Research Institute, Albert Einstein Healthcare Network, Philadelphia, PA 19141, USA
Neuroimage 39:1014-26. 2008.... - Reversal of the concreteness effect in semantic dementiaMichael F Bonner
Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
Cogn Neuropsychol 26:568-79. 2009..These observations raise the possibility that degraded visual feature knowledge contributes in part to the impaired comprehension of concrete words in SD... 
Multivariate analysis of structural and diffusion imaging in traumatic brain injuryBrian Avants
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Acad Radiol 15:1360-75. 2008..We use this technique to study MV effects of traumatic brain injury (TBI)...- Towards a dynamic model of pulmonary parenchymal deformation: evaluation of methods for temporal reparameterization of lung dataTessa A Sundaram
University of Pennsylvania, Philadelphia PA 19104, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8:328-35. 2005..Our ultimate goal is to be able to characterize normal parenchymal biomechanics over a population of healthy individuals, and to use this statistical model to evaluate lung deformation under various pathological states... - Multivariate examination of brain abnormality using both structural and functional MRIYong Fan
Department of Radiology, University of Pennsylvania, PA 19104, USA
Neuroimage 36:1189-99. 2007..Therefore, the proposed approach provided not only a multivariate classification method for detecting brain abnormalities, but also an alternative way for group analysis of multimodality images... 
Canine and human visual cortex intact and responsive despite early retinal blindness from RPE65 mutationGeoffrey K Aguirre
Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
PLoS Med 4:e230. 2007..We therefore studied the cortex of RPE65-mutant dogs before and after retinal gene therapy. Then, we inquired whether there is visual pathway integrity and responsivity in adult humans with LCA due to RPE65 mutations (RPE65-LCA)...- High-dimensional spatial normalization of diffusion tensor images improves the detection of white matter differences: an example study using amyotrophic lateral sclerosisHui Zhang
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 26:1585-97. 2007..We also found that high-dimensional approaches, by leveraging full tensor features instead of tensor-derived indices, can further improve the alignment of WM tracts... - Altered resting cerebral blood flow in adolescents with in utero cocaine exposure revealed by perfusion functional MRIHengyi Rao
Department of Radiology and Neurology, Center for Functional Neuroimaging, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Pediatrics 120:e1245-54. 2007....