Research Topics
Species | Melissa AustinSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Publications
Research guidelines in the era of large-scale collaborations: an analysis of Genome-wide Association Study ConsortiaMelissa A Austin
Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
Am J Epidemiol 175:962-9. 2012..Wider access to consortia guidelines is needed to establish appropriate research standards with broad applicability to emerging forms of large-scale collaboration...
Familial hypercholesterolemia and coronary heart disease: a HuGE association reviewMelissa A Austin
Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
Am J Epidemiol 160:421-9. 2004..Preliminary research indicates that the FH phenotype is influenced by other genetic and environmental factors; however, it is not clear if these are synergistic interactions or simply additive effects...- Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence reviewMelissa A Austin
Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
Am J Epidemiol 160:407-20. 2004..For screening to be successful, public health and general practitioners need to be aware of the signs and diagnosis of FH and the benefits of early treatment... - Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese AmericansM A Austin
Department of Epidemiology, School of Public Health and Community Medicine, Box 357236, University of Washington, Seattle, WA 98195 7236, USA
Ann Hum Genet 68:179-88. 2004..07). These results demonstrate the presence of both genetic and environmental effects on CRP levels among Asian Americans, and additional studies are needed to determine if the APOE gene contributes to these genetic influences... - Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americansMelissa A Austin
Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, 98195 7236, USA
Diabetes 53:1166-9. 2004..25, P = 0.026). This analysis shows that independent, multivariate factors of the metabolic syndrome are heritable, demonstrating genetic influences on the underlying pathophysiological mechanisms of the syndrome... - Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese AmericansMelissa A Austin
Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Ave, Box 357236, Seattle, WA 98195 7236, USA
Biochim Biophys Acta 1688:1-9. 2004..Therefore, the haplotype containing the -1131C and -3G variants, and possibly specifically the -3A>G SNP in APOA5, may be a major genetic determinant of LDL particle size and TG levels among ethnic Asians... - Genome-wide scan for quantitative trait loci influencing LDL size and plasma triglyceride in familial hypertriglyceridemiaMelissa A Austin
Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
J Lipid Res 44:2161-8. 2003..These peaks were retained with adjustment for LDL size and/or HDL cholesterol. These findings, if confirmed, suggest that LDL particle size and plasma TG levels could be caused by two different genetic loci in FHTG... - Genebanks: a comparison of eight proposed international genetic databasesMelissa A Austin
Institute for Public Health Genetics, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195 7236, USA
Community Genet 6:37-45. 2003.... - Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twinsM A Austin
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
Am J Hum Genet 62:406-19. 1998..These findings add to the growing evidence for genetic influences on the atherogenic lipoprotein phenotype and its role in genetic susceptibility to atherosclerosis... - Cardiovascular disease mortality in familial forms of hypertriglyceridemia: A 20-year prospective studyM A Austin
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195 7236, USA
Circulation 101:2777-82. 2000..The purposes of this study were to estimate 20-year total and CVD mortality risk among relatives in these families and to evaluate plasma triglyceride as a predictor of death... - The interface of genetics and public health: research and educational challengesM A Austin
Public Health Genetics Program, University of Washington, Seattle 98195 7236, USA
Annu Rev Public Health 21:81-99. 2000..These educational efforts must be ongoing so that the potential of genetic technology and information can be appropriately used to benefit the health of all... - Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotypeM A Austin
Department of Epidemiology, Box 357236, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 7236, USA
Curr Atheroscler Rep 2:200-7. 2000..Taken together, these data provide new insights into the importance of triglyceride and LDL particle size for understanding genetic susceptibility to cardiovascular disease and its prevention... - Plasma triglyceride as a risk factor for cardiovascular diseaseM A Austin
Department of Epidemiology, University of Washington, Seattle 98195, USA
Can J Cardiol 14:14B-17B. 1998..To determine whether cardiovascular disease can be predicted from plasma triglyceride levels independent of high density lipoprotein (HDL) cholesterol levels... - Ethical issues in human genome epidemiology: a case study based on the Japanese American Family Study in Seattle, WashingtonMelissa A Austin
Institute for Public Health Genetics, Seattle, WA 98195 7236, USA
Am J Epidemiol 155:585-92. 2002..Overall, the promise of genomics for improving public health must be pursued based on the fundamental ethical principles of respect for persons, beneficence, and justice... - Linkage analysis of candidate genes and the small, dense low-density lipoprotein phenotypeM A Austin
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
Atherosclerosis 142:79-87. 1999..These findings demonstrate the complexity of genetically mapping risk factor phenotypes, and emphasize the necessity of identifying new genetic loci, other than known candidate genes, involved in susceptibility to atherosclerosis... - Trp64Arg polymorphism of the beta3-adrenergic receptor gene, pre-pregnancy obesity and risk of pre-eclampsiaCuilin Zhang
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
J Matern Fetal Neonatal Med 17:19-28. 2005..We investigated the relation of the beta3-AR gene to pre-pregnancy obesity and risk of pre-eclampsia. The present study is a case-control study of 87 Caucasian pre-eclampsia cases and 214 controls... - Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese AmericansCarolyn M Hutter
Department of Epidemiology, Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195, USA
Atherosclerosis 185:78-86. 2006..In conclusion, this community-based family study of Japanese Americans demonstrates that LIPG variants are associated with HDL related risk factors, and may play a role in susceptibility to cardiovascular disease in this population... - Familial hypercholesterolemia, peripheral arterial disease, and stroke: a HuGE minireviewCarolyn M Hutter
Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
Am J Epidemiol 160:430-5. 2004.... - Hepatic lipase gene polymorphism, pre-pregnancy overweight status and risk of preeclampsia among Peruvian womenDaniel A Enquobahrie
Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA
Gynecol Endocrinol 21:211-7. 2005..In this study, we found that LIPC -514TT genotype and overweight status, when occurring together, were associated with a 3-fold increase in risk of preeclampsia among Peruvian women... - Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot studyMegan Dann Fesinmeyer
Institute for Public Health Genetics, University of Washington, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, Seattle, WA 98195, USA
Pancreas 38:631-7. 2009..This pilot study tested for the association between Pro12Ala and pancreatic cancer risk in a high-risk sample of smokers... - Measuring dietary acculturation in Japanese Americans with the use of confirmatory factor analysis of food-frequency dataBrandon L Pierce
Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
Am J Clin Nutr 86:496-503. 2007..Epidemiologic evidence suggests that dietary changes associated with acculturation to a Western diet may increase the risk of type 2 diabetes in Japanese Americans... - Small, dense LDL and elevated apolipoprotein B are the common characteristics for the three major lipid phenotypes of familial combined hyperlipidemiaAmir F Ayyobi
Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Wash, USA
Arterioscler Thromb Vasc Biol 23:1289-94. 2003..CONCLUSIONS: Although triglyceride and cholesterol levels are variable by lipoprotein phenotype, sdLDL and elevated plasma apolipoprotein B levels are consistent characteristics of FCHL shared by the 3 different lipoprotein phenotypes... - Improvement of BMI, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose toleranceDavid Liao
Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98195, USA
Diabetes Care 25:1504-10. 2002..To determine whether diet and endurance exercise improved adiposity-related measurements in Japanese Americans with impaired glucose tolerance (IGT)... - Monitoring ethical, legal, and social issues in developing population genetic databasesMelissa A Austin
Institute for Public Health Genetics, University of Washington, Seattle 98195-7236, USA
Genet Med 5:451-7. 2003..By comparing ethical, legal and social issues as they arise in genebanks, researchers can better evaluate how to best use these projects to improve public health while protecting participating populations... - The impact of patents on the development of genome-based clinical diagnostics: an analysis of case studiesBrandon L Pierce
Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
Genet Med 11:202-9. 2009.... - High "population attributable fraction" for coronary heart disease mortality among relatives in monogenic familial hypercholesterolemiaMelissa A Austin
Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195-7236, USA
Genet Med 4:275-8. 2002.... - Polymorphisms in the androgen receptor and the prostate-specific antigen genes and prostate cancer riskClaudia A Salinas
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Prostate 65:58-65. 2005..Polymorphic CAG and GGC microsatellites in the androgen receptor (AR) can alter transactivation of androgen-responsive genes in in vitro studies. Potentially, this may influence PCa risk... - Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancerBrandon L Pierce
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Prostate 67:410-5. 2007.... - C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and olderBrandon L Pierce
Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
Cancer Causes Control 20:1193-203. 2009..21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation... - Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma-pancreatic carcinoma syndromeStephen J Rulyak
Division of Gastroenterology, University of Washington, Seattle, Washington 98195, USA
Cancer 98:798-804. 2003..Other malignancies may be a part of the phenotype in these families, although this hypothesis requires additional study... - Ethical issues in identifying and recruiting participants for familial genetic researchLaura M Beskow
Department of Health Policy and Administration, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC 27599 7411, USA
Am J Med Genet A 130:424-31. 2004..They suggest a framework for considering alternative recruitment strategies and their implications, as well as highlight areas in need of further empirical research...
Research Grants
- GENETICS OF THE METABOLIC SYNDROME IN JAPANESE AMERICANSMelissa Austin; Fiscal Year: 2002....
- GENETIC EPIDEMIOLOGY OF HYPERTRIGLYCERIDEMIAMelissa Austin; Fiscal Year: 1999....
- GENETIC EPIDEMIOLOGY OF HYPERTRIGLYCERIDEMIAMelissa Austin; Fiscal Year: 1993....
- Pilot Study of Pancreas Cancer & Diabetes Genes in CARETMelissa Austin; Fiscal Year: 2006..The results may facilitate translational studies of early detection and prevention of pancreatic cancer, especially among patients diagnosed with diabetes. ..