Melissa Austin

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Research guidelines in the era of large-scale collaborations: an analysis of Genome-wide Association Study Consortia
    Melissa A Austin
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Am J Epidemiol 175:962-9. 2012
  2. ncbi request reprint Familial hypercholesterolemia and coronary heart disease: a HuGE association review
    Melissa A Austin
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:421-9. 2004
  3. ncbi request reprint Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review
    Melissa A Austin
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:407-20. 2004
  4. ncbi request reprint Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, Box 357236, University of Washington, Seattle, WA 98195 7236, USA
    Ann Hum Genet 68:179-88. 2004
  5. ncbi request reprint Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans
    Melissa A Austin
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, 98195 7236, USA
    Diabetes 53:1166-9. 2004
  6. ncbi request reprint Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans
    Melissa A Austin
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Ave, Box 357236, Seattle, WA 98195 7236, USA
    Biochim Biophys Acta 1688:1-9. 2004
  7. ncbi request reprint Genome-wide scan for quantitative trait loci influencing LDL size and plasma triglyceride in familial hypertriglyceridemia
    Melissa A Austin
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 44:2161-8. 2003
  8. ncbi request reprint Genebanks: a comparison of eight proposed international genetic databases
    Melissa A Austin
    Institute for Public Health Genetics, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195 7236, USA
    Community Genet 6:37-45. 2003
  9. pmc Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 62:406-19. 1998
  10. ncbi request reprint Cardiovascular disease mortality in familial forms of hypertriglyceridemia: A 20-year prospective study
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195 7236, USA
    Circulation 101:2777-82. 2000

Research Grants

Detail Information

Publications31

  1. pmc Research guidelines in the era of large-scale collaborations: an analysis of Genome-wide Association Study Consortia
    Melissa A Austin
    Department of Epidemiology, School of Public Health, University of Washington, Seattle, USA
    Am J Epidemiol 175:962-9. 2012
    ..Wider access to consortia guidelines is needed to establish appropriate research standards with broad applicability to emerging forms of large-scale collaboration...
  2. ncbi request reprint Familial hypercholesterolemia and coronary heart disease: a HuGE association review
    Melissa A Austin
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:421-9. 2004
    ..Preliminary research indicates that the FH phenotype is influenced by other genetic and environmental factors; however, it is not clear if these are synergistic interactions or simply additive effects...
  3. ncbi request reprint Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review
    Melissa A Austin
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:407-20. 2004
    ..For screening to be successful, public health and general practitioners need to be aware of the signs and diagnosis of FH and the benefits of early treatment...
  4. ncbi request reprint Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, Box 357236, University of Washington, Seattle, WA 98195 7236, USA
    Ann Hum Genet 68:179-88. 2004
    ..07). These results demonstrate the presence of both genetic and environmental effects on CRP levels among Asian Americans, and additional studies are needed to determine if the APOE gene contributes to these genetic influences...
  5. ncbi request reprint Heritability of multivariate factors of the metabolic syndrome in nondiabetic Japanese americans
    Melissa A Austin
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, 98195 7236, USA
    Diabetes 53:1166-9. 2004
    ..25, P = 0.026). This analysis shows that independent, multivariate factors of the metabolic syndrome are heritable, demonstrating genetic influences on the underlying pathophysiological mechanisms of the syndrome...
  6. ncbi request reprint Association of apolipoprotein A5 variants with LDL particle size and triglyceride in Japanese Americans
    Melissa A Austin
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Ave, Box 357236, Seattle, WA 98195 7236, USA
    Biochim Biophys Acta 1688:1-9. 2004
    ..Therefore, the haplotype containing the -1131C and -3G variants, and possibly specifically the -3A>G SNP in APOA5, may be a major genetic determinant of LDL particle size and TG levels among ethnic Asians...
  7. ncbi request reprint Genome-wide scan for quantitative trait loci influencing LDL size and plasma triglyceride in familial hypertriglyceridemia
    Melissa A Austin
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    J Lipid Res 44:2161-8. 2003
    ..These peaks were retained with adjustment for LDL size and/or HDL cholesterol. These findings, if confirmed, suggest that LDL particle size and plasma TG levels could be caused by two different genetic loci in FHTG...
  8. ncbi request reprint Genebanks: a comparison of eight proposed international genetic databases
    Melissa A Austin
    Institute for Public Health Genetics, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195 7236, USA
    Community Genet 6:37-45. 2003
    ....
  9. pmc Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Hum Genet 62:406-19. 1998
    ..These findings add to the growing evidence for genetic influences on the atherogenic lipoprotein phenotype and its role in genetic susceptibility to atherosclerosis...
  10. ncbi request reprint Cardiovascular disease mortality in familial forms of hypertriglyceridemia: A 20-year prospective study
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195 7236, USA
    Circulation 101:2777-82. 2000
    ..The purposes of this study were to estimate 20-year total and CVD mortality risk among relatives in these families and to evaluate plasma triglyceride as a predictor of death...
  11. ncbi request reprint The interface of genetics and public health: research and educational challenges
    M A Austin
    Public Health Genetics Program, University of Washington, Seattle 98195 7236, USA
    Annu Rev Public Health 21:81-99. 2000
    ..These educational efforts must be ongoing so that the potential of genetic technology and information can be appropriately used to benefit the health of all...
  12. ncbi request reprint Triglyceride, small, dense low-density lipoprotein, and the atherogenic lipoprotein phenotype
    M A Austin
    Department of Epidemiology, Box 357236, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 7236, USA
    Curr Atheroscler Rep 2:200-7. 2000
    ..Taken together, these data provide new insights into the importance of triglyceride and LDL particle size for understanding genetic susceptibility to cardiovascular disease and its prevention...
  13. ncbi request reprint Plasma triglyceride as a risk factor for cardiovascular disease
    M A Austin
    Department of Epidemiology, University of Washington, Seattle 98195, USA
    Can J Cardiol 14:14B-17B. 1998
    ..To determine whether cardiovascular disease can be predicted from plasma triglyceride levels independent of high density lipoprotein (HDL) cholesterol levels...
  14. ncbi request reprint Ethical issues in human genome epidemiology: a case study based on the Japanese American Family Study in Seattle, Washington
    Melissa A Austin
    Institute for Public Health Genetics, Seattle, WA 98195 7236, USA
    Am J Epidemiol 155:585-92. 2002
    ..Overall, the promise of genomics for improving public health must be pursued based on the fundamental ethical principles of respect for persons, beneficence, and justice...
  15. ncbi request reprint Linkage analysis of candidate genes and the small, dense low-density lipoprotein phenotype
    M A Austin
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle 98195, USA
    Atherosclerosis 142:79-87. 1999
    ..These findings demonstrate the complexity of genetically mapping risk factor phenotypes, and emphasize the necessity of identifying new genetic loci, other than known candidate genes, involved in susceptibility to atherosclerosis...
  16. ncbi request reprint Trp64Arg polymorphism of the beta3-adrenergic receptor gene, pre-pregnancy obesity and risk of pre-eclampsia
    Cuilin Zhang
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA
    J Matern Fetal Neonatal Med 17:19-28. 2005
    ..We investigated the relation of the beta3-AR gene to pre-pregnancy obesity and risk of pre-eclampsia. The present study is a case-control study of 87 Caucasian pre-eclampsia cases and 214 controls...
  17. ncbi request reprint Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans
    Carolyn M Hutter
    Department of Epidemiology, Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, 1959 N E Pacific Avenue, Box 357236, Seattle, WA 98195, USA
    Atherosclerosis 185:78-86. 2006
    ..In conclusion, this community-based family study of Japanese Americans demonstrates that LIPG variants are associated with HDL related risk factors, and may play a role in susceptibility to cardiovascular disease in this population...
  18. ncbi request reprint Familial hypercholesterolemia, peripheral arterial disease, and stroke: a HuGE minireview
    Carolyn M Hutter
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195, USA
    Am J Epidemiol 160:430-5. 2004
    ....
  19. ncbi request reprint Hepatic lipase gene polymorphism, pre-pregnancy overweight status and risk of preeclampsia among Peruvian women
    Daniel A Enquobahrie
    Center for Perinatal Studies, Swedish Medical Center, Seattle, WA, USA
    Gynecol Endocrinol 21:211-7. 2005
    ..In this study, we found that LIPC -514TT genotype and overweight status, when occurring together, were associated with a 3-fold increase in risk of preeclampsia among Peruvian women...
  20. pmc Association between the peroxisome proliferator-activated receptor gamma Pro12Ala variant and haplotype and pancreatic cancer in a high-risk cohort of smokers: a pilot study
    Megan Dann Fesinmeyer
    Institute for Public Health Genetics, University of Washington, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Department of Epidemiology, Seattle, WA 98195, USA
    Pancreas 38:631-7. 2009
    ..This pilot study tested for the association between Pro12Ala and pancreatic cancer risk in a high-risk sample of smokers...
  21. ncbi request reprint Measuring dietary acculturation in Japanese Americans with the use of confirmatory factor analysis of food-frequency data
    Brandon L Pierce
    Department of Epidemiology and Institute for Public Health Genetics, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195, USA
    Am J Clin Nutr 86:496-503. 2007
    ..Epidemiologic evidence suggests that dietary changes associated with acculturation to a Western diet may increase the risk of type 2 diabetes in Japanese Americans...
  22. ncbi request reprint Small, dense LDL and elevated apolipoprotein B are the common characteristics for the three major lipid phenotypes of familial combined hyperlipidemia
    Amir F Ayyobi
    Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, University of Washington, Seattle, Wash, USA
    Arterioscler Thromb Vasc Biol 23:1289-94. 2003
    ..This study sought to characterize consistent lipoprotein and lipid abnormalities across the 3 lipoprotein phenotypes in 62 patients with documented FCHL (IIa [n=14], IIb [n=19], and IV [n=29]) and 44 healthy individuals...
  23. ncbi request reprint Improvement of BMI, body composition, and body fat distribution with lifestyle modification in Japanese Americans with impaired glucose tolerance
    David Liao
    Department of Medicine, Division of Metabolism, Endocrinology, and Nutrition, University of Washington, Seattle, Washington 98195, USA
    Diabetes Care 25:1504-10. 2002
    ..To determine whether diet and endurance exercise improved adiposity-related measurements in Japanese Americans with impaired glucose tolerance (IGT)...
  24. ncbi request reprint Monitoring ethical, legal, and social issues in developing population genetic databases
    Melissa A Austin
    Institute for Public Health Genetics, University of Washington, Seattle 98195 7236, USA
    Genet Med 5:451-7. 2003
    ....
  25. pmc The impact of patents on the development of genome-based clinical diagnostics: an analysis of case studies
    Brandon L Pierce
    Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
    Genet Med 11:202-9. 2009
    ....
  26. ncbi request reprint High "population attributable fraction" for coronary heart disease mortality among relatives in monogenic familial hypercholesterolemia
    Melissa A Austin
    Institute for Public Health Genetics and Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98195 7236, USA
    Genet Med 4:275-8. 2002
    ....
  27. ncbi request reprint Polymorphisms in the androgen receptor and the prostate-specific antigen genes and prostate cancer risk
    Claudia A Salinas
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Prostate 65:58-65. 2005
    ..Polymorphic CAG and GGC microsatellites in the androgen receptor (AR) can alter transactivation of androgen-responsive genes in in vitro studies. Potentially, this may influence PCa risk...
  28. ncbi request reprint Genomic scan of 12 hereditary prostate cancer families having an occurrence of pancreas cancer
    Brandon L Pierce
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Prostate 67:410-5. 2007
    ....
  29. pmc C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older
    Brandon L Pierce
    Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
    Cancer Causes Control 20:1193-203. 2009
    ..21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation...
  30. ncbi request reprint Characterization of the neoplastic phenotype in the familial atypical multiple-mole melanoma-pancreatic carcinoma syndrome
    Stephen J Rulyak
    Division of Gastroenterology, University of Washington, Seattle, Washington 98195, USA
    Cancer 98:798-804. 2003
    ..It has been found that many of these families harbor mutations in the CDKN2A gene on chromosome 9p21. The phenotypic expression of CDKN2A mutations in these families has not been characterized fully...
  31. ncbi request reprint Ethical issues in identifying and recruiting participants for familial genetic research
    Laura M Beskow
    Department of Health Policy and Administration, University of North Carolina at Chapel Hill School of Public Health, Chapel Hill, NC 27599 7411, USA
    Am J Med Genet A 130:424-31. 2004
    ..They suggest a framework for considering alternative recruitment strategies and their implications, as well as highlight areas in need of further empirical research...

Research Grants18

  1. GENETICS OF THE METABOLIC SYNDROME IN JAPANESE AMERICANS
    Melissa Austin; Fiscal Year: 2002
    ....
  2. GENETIC EPIDEMIOLOGY OF HYPERTRIGLYCERIDEMIA
    Melissa Austin; Fiscal Year: 1999
    ....
  3. GENETIC EPIDEMIOLOGY OF HYPERTRIGLYCERIDEMIA
    Melissa Austin; Fiscal Year: 1993
    ....
  4. Pilot Study of Pancreas Cancer & Diabetes Genes in CARET
    Melissa Austin; Fiscal Year: 2006
    ..The results may facilitate translational studies of early detection and prevention of pancreatic cancer, especially among patients diagnosed with diabetes. ..