Research Topics
| S N AustadSummaryAffiliation: University of Texas Health Science Center Country: USA Publications
Research Grants
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Detail Information
Publications
Why women live longer than men: sex differences in longevitySteven N Austad
Deparment of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
Gend Med 3:79-92. 2006..With the advent of more rapid genome sequencing, molecular tools will become available for more species, thus further detailing the causes for the differences in longevity between the sexes...- Cats, "rats," and bats: the comparative biology of aging in the 21st centurySteven N Austad
Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, University of Texas Health Science Center San Antonio, 15355 Lambda Drive, STCBM 3 100 07, San Antonio, TX 78245, USA
Integr Comp Biol 50:783-92. 2010.... - Vertebrate aging research 2006Steven N Austad
Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Aging Cell 6:135-8. 2007.... - Advances in vertebrate aging research 2007Steven Austad
University of Texas Health Science Center, Barshop Center for Longevity and Aging Studies, San Antonio, TX 78245, USA
Aging Cell 7:119-24. 2008..A similar program for the disinterested evaluation of reported longevity mutations in mice would be a service to the community of vertebrate aging researchers... - Comparative biology of agingSteven N Austad
Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, TX 78245 3207, USA
J Gerontol A Biol Sci Med Sci 64:199-201. 2009..Cell repositories and tissue banks from key species, as well as genomic and analytic tools optimized for comparative studies, would make valuable contributions to a new comparative approach to basic aging research... - Methusaleh's Zoo: how nature provides us with clues for extending human health spanS N Austad
University of Texas Health Science Center San Antonio, Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, 15355 Lambda Drive, STCBM Rm 3 100, San Antonio, TX 78245, USA
J Comp Pathol 142:S10-21. 2010..The continuing acceleration of progress in genome sequencing and development of more and more cross-species investigatory techniques will facilitate even more contributions of these species in the near future... - Recent advances in vertebrate aging research 2009Steven Austad
University of Texas Health Science Center, Barshop Institute for Longevity and Aging Studies, San Antonio, USA
Aging Cell 9:297-303. 2010..Genetic inhibition of a TOR target made female, but not male, mice live longer. This year saw the mTOR network firmly established as a major modulator of mammalian lifespan... - Animal models of reproductive aging: what can they tell us?Steven N Austad
University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
Ann N Y Acad Sci 1204:123-6. 2010..As with most other biological phenomena, understanding the nature of genetic and environmental interactions is central to understanding of reproductive aging... - The development of small primate models for aging researchSteven N Austad
Barshop Institute for Longevity and Aging Studies, STCBM 3 100 07, 15355 Lambda Drive, San Antonio, TX 78245, USA
ILAR J 52:78-88. 2011..We discuss one other New World monkey group, Cebus spp., that might also be an effective NHP model of aging as these species are longer-lived for their body size than any primate except humans... - Candidate bird species for use in aging researchSteven N Austad
Barshop Institute for Longevity and Aging Studies, STCBM 3 100 07, 15355 Lambda Drive, San Antonio, TX 78245, USA
ILAR J 52:89-96. 2011..In addition, two wild species--the European starling and the house sparrow--may also make excellent models for aging research... - Is aging programed?Steven N Austad
Department of Cellular and Structural Biology, University of Texas Health Science Center, STCBM Bldg, Room 3 100, Barshop Center for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245, USA
Aging Cell 3:249-51. 2004.... - Diverse aging rates in metazoans: targets for functional genomicsSteven N Austad
University of Texas Health Science Center, Barshop Institute for Longevity and Aging Studies, SCTBM Bldg Room 3 100, 15355 Lambda Drive, San Antonio, TX 78245, USA
Mech Ageing Dev 126:43-9. 2005..The development of functional genetics over the next several decades promises to lead us toward an answer... - Rebuttal to Bredesen: 'The non-existent aging program: how does it work?'Steven N Austad
University of Texas Health Science Center, Barshop Center for Longevity and Aging Studies, San Antonio, TX 78245, USA
Aging Cell 3:253-4. 2004 - Tail tendon break time: a biomarker of aging?Lauren B Sloane
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, STCBM Room 3 325, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
J Gerontol A Biol Sci Med Sci 66:287-94. 2011..We conclude that for the range of genetic variation found among these mouse genotypes, TTBT cannot be considered a robust biomarker of longevity... - A new field record for bat longevityAndrej J Podlutsky
University of Texas Health Science Center, Barshop Institute for Longevity and Aging Study, STCBM Building, Suite 3.325, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA
J Gerontol A Biol Sci Med Sci 60:1366-8. 2005..The exceptional longevity of bats generally, and this species in particular, should make bats of special interest for researchers studying mechanisms of slow aging... - The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasisAdam B Salmon
Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr, San Antonio, TX 78245 3207, USA
FASEB J 23:2317-26. 2009..Together, these data suggest that long lifespan in some bat species might be regulated by very efficient maintenance of protein homeostasis... - Ageing studies on bats: a reviewAnja K Brunet-Rossinni
Department of Biological Sciences, University of Idaho, P O Box 443051, Moscow, ID 83844 3051, USA
Biogerontology 5:211-22. 2004..As long-lived and physiologically interesting organisms, bats may prove to be an informative model system for ageing research... - On Herrera and Jagadeeswaran's "Annual fish as a genetic model for aging"Steven N Austad
Department of Biological Sciences, University of Idaho, Moscow 83844, USA
J Gerontol A Biol Sci Med Sci 59:99-100. 2004 - Are mice calorically restricted in nature?Steven N Austad
University of Idaho, Department of Biological Sciences, Moscow, ID 83844 3051, USA
Aging Cell 2:201-7. 2003..We conclude that CR experiments do in fact restrict energy consumption beyond that typically experienced by mice in nature. Therefore, the retarded aging observed with CR is not due to eliminating the detrimental effects of overeating... - Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeothermsAdrian J Lambert
Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
Aging Cell 6:607-18. 2007..These findings indicate that enhanced longevity may be causally associated with low free radical production by mitochondria across species over two classes of vertebrate homeotherms... - Longevity genes: from primitive organisms to humansRobert N Butler
International Longevity Center-USA, New York, NY 10028, USA
J Gerontol A Biol Sci Med Sci 58:581-4. 2003 - Does caloric restriction extend life in wild mice?James M Harper
Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
Aging Cell 5:441-9. 2006.... - The aging factor in health and disease: the promise of basic research on agingRobert N Butler
International Longevity Center-USA, Alliance for Health and the Future, and Department of Geriatrics, Mount Sinai Medical Center, New York, NY 10028, USA
Aging Clin Exp Res 16:104-11; discussion 111-2. 2004 - Introduction to animal modelsSteven N Austad
Exp Gerontol 38:1327-8. 2003 - Oxidative stress in vascular senescence: lessons from successfully aging speciesZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
Front Biosci 13:5056-70. 2008.... - Cellular replicative capacity correlates primarily with species body mass not longevityAntonello Lorenzini
The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
Mech Ageing Dev 126:1130-3. 2005..In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span... - PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life spanKevin Flurkey
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
J Gerontol A Biol Sci Med Sci 62:1187-98. 2007..Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging... - Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevityAnna Csiszar
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Aging Cell 6:783-97. 2007..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging... - Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived miceJames M Harper
University of Michigan, 190 Zina Pitcher Pl, Room 3005, BSRB Box 2200, Ann Arbor, MI 48109 2200, USA
J Gerontol A Biol Sci Med Sci 61:1019-29. 2006..Overall, these finding suggest that wild-derived mice harbor alleles that increase longevity, perhaps through effects on growth, maturation, and early-life hormone levels... - Longer life spans and delayed maturation in wild-derived miceRichard A Miller
Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
Exp Biol Med (Maywood) 227:500-8. 2002..Genes present in the Id and Ma stocks may be valuable tools for the analysis of the physiology and biochemistry of aging in mice...
Research Grants
- Mechanisms of Exceptional Longevity in the World's Longest-Lived AnimalSteven N Austad; Fiscal Year: 2010..Because aging is the ultimate cause of many late life maladies, the research has the potential to not only enhance health but delay and mitigate numerous late life diseases. ..
- Mechanisms of Exceptional Longevity in the World's Longest-Lived AnimalSteven Austad; Fiscal Year: 2009..Because aging is the ultimate cause of many late life maladies, the research has the potential to not only enhance health but delay and mitigate numerous late life diseases. ..
- Comparative Mechanisms of Exceptionally Slow AgingSteven Austad; Fiscal Year: 2007..g. low ROS production per level of electron flux) might generally affect aging rate. ..
- San Antonio Comparative Biology of Aging CenterSteven Austad; Fiscal Year: 2007..abstract_text> ..
- TRAINING GRANT ON THE BIOLOGY OF AGINGSteven Austad; Fiscal Year: 2007..University of Texas at San Antonio and St. Mary's University. A strong effort will be made to do just this. Support of this program has all the potential of training a much needed group of scientists; the gerontologists of the future. ..
- Hydra: New Models for Aging ResearchSteven N Austad; Fiscal Year: 2010..Because aging is the ultimate cause of many late life maladies, the research has the potential to not only enhance health but delay and mitigate numerous late life diseases. ..