S N Austad

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Why women live longer than men: sex differences in longevity
    Steven N Austad
    Deparment of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Gend Med 3:79-92. 2006
  2. pmc Methusaleh's Zoo: how nature provides us with clues for extending human health span
    S N Austad
    University of Texas Health Science Center San Antonio, Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, 15355 Lambda Drive, STCBM Rm 3 100, San Antonio, TX 78245, USA
    J Comp Pathol 142:S10-21. 2010
  3. doi request reprint Advances in vertebrate aging research 2007
    Steven Austad
    University of Texas Health Science Center, Barshop Center for Longevity and Aging Studies, San Antonio, TX 78245, USA
    Aging Cell 7:119-24. 2008
  4. ncbi request reprint Vertebrate aging research 2006
    Steven N Austad
    Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
    Aging Cell 6:135-8. 2007
  5. pmc Comparative biology of aging
    Steven N Austad
    Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, TX 78245 3207, USA
    J Gerontol A Biol Sci Med Sci 64:199-201. 2009
  6. ncbi request reprint Diverse aging rates in metazoans: targets for functional genomics
    Steven N Austad
    University of Texas Health Science Center, Barshop Institute for Longevity and Aging Studies, SCTBM Bldg Room 3 100, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Mech Ageing Dev 126:43-9. 2005
  7. ncbi request reprint Rebuttal to Bredesen: 'The non-existent aging program: how does it work?'
    Steven N Austad
    University of Texas Health Science Center, Barshop Center for Longevity and Aging Studies, San Antonio, TX 78245, USA
    Aging Cell 3:253-4. 2004
  8. ncbi request reprint Is aging programed?
    Steven N Austad
    Department of Cellular and Structural Biology, University of Texas Health Science Center, STCBM Bldg, Room 3 100, Barshop Center for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Aging Cell 3:249-51. 2004
  9. doi request reprint Recent advances in vertebrate aging research 2009
    Steven Austad
    University of Texas Health Science Center, Barshop Institute for Longevity and Aging Studies, San Antonio, USA
    Aging Cell 9:297-303. 2010
  10. doi request reprint Animal models of reproductive aging: what can they tell us?
    Steven N Austad
    University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
    Ann N Y Acad Sci 1204:123-6. 2010

Research Grants

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Why women live longer than men: sex differences in longevity
    Steven N Austad
    Deparment of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78245, USA
    Gend Med 3:79-92. 2006
    ..With the advent of more rapid genome sequencing, molecular tools will become available for more species, thus further detailing the causes for the differences in longevity between the sexes...
  2. pmc Methusaleh's Zoo: how nature provides us with clues for extending human health span
    S N Austad
    University of Texas Health Science Center San Antonio, Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, 15355 Lambda Drive, STCBM Rm 3 100, San Antonio, TX 78245, USA
    J Comp Pathol 142:S10-21. 2010
    ..The continuing acceleration of progress in genome sequencing and development of more and more cross-species investigatory techniques will facilitate even more contributions of these species in the near future...
  3. doi request reprint Advances in vertebrate aging research 2007
    Steven Austad
    University of Texas Health Science Center, Barshop Center for Longevity and Aging Studies, San Antonio, TX 78245, USA
    Aging Cell 7:119-24. 2008
    ..A similar program for the disinterested evaluation of reported longevity mutations in mice would be a service to the community of vertebrate aging researchers...
  4. ncbi request reprint Vertebrate aging research 2006
    Steven N Austad
    Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
    Aging Cell 6:135-8. 2007
    ....
  5. pmc Comparative biology of aging
    Steven N Austad
    Department of Cellular and Structural Biology, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, San Antonio, TX 78245 3207, USA
    J Gerontol A Biol Sci Med Sci 64:199-201. 2009
    ..Cell repositories and tissue banks from key species, as well as genomic and analytic tools optimized for comparative studies, would make valuable contributions to a new comparative approach to basic aging research...
  6. ncbi request reprint Diverse aging rates in metazoans: targets for functional genomics
    Steven N Austad
    University of Texas Health Science Center, Barshop Institute for Longevity and Aging Studies, SCTBM Bldg Room 3 100, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Mech Ageing Dev 126:43-9. 2005
    ..The development of functional genetics over the next several decades promises to lead us toward an answer...
  7. ncbi request reprint Rebuttal to Bredesen: 'The non-existent aging program: how does it work?'
    Steven N Austad
    University of Texas Health Science Center, Barshop Center for Longevity and Aging Studies, San Antonio, TX 78245, USA
    Aging Cell 3:253-4. 2004
  8. ncbi request reprint Is aging programed?
    Steven N Austad
    Department of Cellular and Structural Biology, University of Texas Health Science Center, STCBM Bldg, Room 3 100, Barshop Center for Longevity and Aging Studies, 15355 Lambda Drive, San Antonio, TX 78245, USA
    Aging Cell 3:249-51. 2004
    ....
  9. doi request reprint Recent advances in vertebrate aging research 2009
    Steven Austad
    University of Texas Health Science Center, Barshop Institute for Longevity and Aging Studies, San Antonio, USA
    Aging Cell 9:297-303. 2010
    ..Genetic inhibition of a TOR target made female, but not male, mice live longer. This year saw the mTOR network firmly established as a major modulator of mammalian lifespan...
  10. doi request reprint Animal models of reproductive aging: what can they tell us?
    Steven N Austad
    University of Texas Health Science Center San Antonio, San Antonio, Texas, USA
    Ann N Y Acad Sci 1204:123-6. 2010
    ..As with most other biological phenomena, understanding the nature of genetic and environmental interactions is central to understanding of reproductive aging...
  11. ncbi request reprint The development of small primate models for aging research
    Steven N Austad
    Barshop Institute for Longevity and Aging Studies, STCBM 3 100 07, 15355 Lambda Drive, San Antonio, TX 78245, USA
    ILAR J 52:78-88. 2011
    ..We discuss one other New World monkey group, Cebus spp., that might also be an effective NHP model of aging as these species are longer-lived for their body size than any primate except humans...
  12. ncbi request reprint Candidate bird species for use in aging research
    Steven N Austad
    Barshop Institute for Longevity and Aging Studies, STCBM 3 100 07, 15355 Lambda Drive, San Antonio, TX 78245, USA
    ILAR J 52:89-96. 2011
    ..In addition, two wild species--the European starling and the house sparrow--may also make excellent models for aging research...
  13. pmc Cats, "rats," and bats: the comparative biology of aging in the 21st century
    Steven N Austad
    Barshop Institute for Longevity and Aging Studies, Department of Cellular and Structural Biology, University of Texas Health Science Center San Antonio, 15355 Lambda Drive, STCBM 3 100 07, San Antonio, TX 78245, USA
    Integr Comp Biol 50:783-92. 2010
    ....
  14. pmc Tail tendon break time: a biomarker of aging?
    Lauren B Sloane
    Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center San Antonio, STCBM Room 3 325, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    J Gerontol A Biol Sci Med Sci 66:287-94. 2011
    ..We conclude that for the range of genetic variation found among these mouse genotypes, TTBT cannot be considered a robust biomarker of longevity...
  15. ncbi request reprint A new field record for bat longevity
    Andrej J Podlutsky
    University of Texas Health Science Center, Barshop Institute for Longevity and Aging Study, STCBM Building, Suite 3 325, 15355 Lambda Drive, San Antonio, TX 78245 3207, USA
    J Gerontol A Biol Sci Med Sci 60:1366-8. 2005
    ..The exceptional longevity of bats generally, and this species in particular, should make bats of special interest for researchers studying mechanisms of slow aging...
  16. pmc The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis
    Adam B Salmon
    Sam and Ann Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Dr, San Antonio, TX 78245 3207, USA
    FASEB J 23:2317-26. 2009
    ..Together, these data suggest that long lifespan in some bat species might be regulated by very efficient maintenance of protein homeostasis...
  17. pmc Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice
    J Halloran
    Barshop Institute, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245, United States
    Neuroscience 223:102-13. 2012
    ....
  18. ncbi request reprint Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms
    Adrian J Lambert
    Medical Research Council, Dunn Human Nutrition Unit, Hills Road, Cambridge CB2 2XY, UK
    Aging Cell 6:607-18. 2007
    ..These findings indicate that enhanced longevity may be causally associated with low free radical production by mitochondria across species over two classes of vertebrate homeotherms...
  19. ncbi request reprint Ageing studies on bats: a review
    Anja K Brunet-Rossinni
    Department of Biological Sciences, University of Idaho, P O Box 443051, Moscow, ID 83844 3051, USA
    Biogerontology 5:211-22. 2004
    ..As long-lived and physiologically interesting organisms, bats may prove to be an informative model system for ageing research...
  20. ncbi request reprint Longevity genes: from primitive organisms to humans
    Robert N Butler
    International Longevity Center USA, New York, NY 10028, USA
    J Gerontol A Biol Sci Med Sci 58:581-4. 2003
  21. ncbi request reprint A proposal to sequence genomes of unique interest for research on aging
    João Pedro de Magalhães
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    J Gerontol A Biol Sci Med Sci 62:583-4. 2007
  22. ncbi request reprint Are mice calorically restricted in nature?
    Steven N Austad
    University of Idaho, Department of Biological Sciences, Moscow, ID 83844 3051, USA
    Aging Cell 2:201-7. 2003
    ..We conclude that CR experiments do in fact restrict energy consumption beyond that typically experienced by mice in nature. Therefore, the retarded aging observed with CR is not due to eliminating the detrimental effects of overeating...
  23. pmc Does caloric restriction extend life in wild mice?
    James M Harper
    Department of Biological Sciences, University of Idaho, Moscow, ID 83844, USA
    Aging Cell 5:441-9. 2006
    ....
  24. ncbi request reprint On Herrera and Jagadeeswaran's "Annual fish as a genetic model for aging"
    Steven N Austad
    Department of Biological Sciences, University of Idaho, Moscow 83844, USA
    J Gerontol A Biol Sci Med Sci 59:99-100. 2004
  25. ncbi request reprint The aging factor in health and disease: the promise of basic research on aging
    Robert N Butler
    International Longevity Center USA, Alliance for Health and the Future, and Department of Geriatrics, Mount Sinai Medical Center, New York, NY 10028, USA
    Aging Clin Exp Res 16:104-11; discussion 111-2. 2004
  26. ncbi request reprint Introduction to animal models
    Steven N Austad
    Exp Gerontol 38:1327-8. 2003
  27. ncbi request reprint Vascular superoxide and hydrogen peroxide production and oxidative stress resistance in two closely related rodent species with disparate longevity
    Anna Csiszar
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Aging Cell 6:783-97. 2007
    ..Thus, increased lifespan potential in P. leucopus is associated with a decreased cellular ROS generation and increased oxidative stress resistance, which accords with the prediction of the oxidative stress hypothesis of aging...
  28. ncbi request reprint Cellular replicative capacity correlates primarily with species body mass not longevity
    Antonello Lorenzini
    The Lankenau Institute for Medical Research, 100 Lancaster Avenue, Wynnewood, PA 19096, USA
    Mech Ageing Dev 126:1130-3. 2005
    ..In this report we establish that body mass is the primary correlative of proliferative potential rather than species life-span...
  29. pmc Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice
    James M Harper
    University of Michigan, 190 Zina Pitcher Pl, Room 3005, BSRB Box 2200, Ann Arbor, MI 48109 2200, USA
    J Gerontol A Biol Sci Med Sci 61:1019-29. 2006
    ..Overall, these finding suggest that wild-derived mice harbor alleles that increase longevity, perhaps through effects on growth, maturation, and early-life hormone levels...
  30. ncbi request reprint Oxidative stress in vascular senescence: lessons from successfully aging species
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, New York 10595, USA
    Front Biosci 13:5056-70. 2008
    ....
  31. ncbi request reprint PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span
    Kevin Flurkey
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    J Gerontol A Biol Sci Med Sci 62:1187-98. 2007
    ..Possibly, out-crossing Pohn mice unmasked cryptic alleles that promote extended female reproduction. This work establishes the PohnB6F1 hybrid as a new model for delayed reproductive aging...
  32. ncbi request reprint Longer life spans and delayed maturation in wild-derived mice
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Exp Biol Med (Maywood) 227:500-8. 2002
    ..Genes present in the Id and Ma stocks may be valuable tools for the analysis of the physiology and biochemistry of aging in mice...

Research Grants13

  1. Mechanisms of Exceptional Longevity in the World's Longest-Lived Animal
    Steven N Austad; Fiscal Year: 2010
    ..Because aging is the ultimate cause of many late life maladies, the research has the potential to not only enhance health but delay and mitigate numerous late life diseases. ..
  2. Mechanisms of Exceptional Longevity in the World's Longest-Lived Animal
    Steven Austad; Fiscal Year: 2009
    ..Because aging is the ultimate cause of many late life maladies, the research has the potential to not only enhance health but delay and mitigate numerous late life diseases. ..
  3. Comparative Mechanisms of Exceptionally Slow Aging
    Steven Austad; Fiscal Year: 2007
    ..g. low ROS production per level of electron flux) might generally affect aging rate. ..
  4. San Antonio Comparative Biology of Aging Center
    Steven Austad; Fiscal Year: 2007
    ..abstract_text> ..
  5. TRAINING GRANT ON THE BIOLOGY OF AGING
    Steven Austad; Fiscal Year: 2007
    ..University of Texas at San Antonio and St. Mary's University. A strong effort will be made to do just this. Support of this program has all the potential of training a much needed group of scientists; the gerontologists of the future. ..
  6. Hydra: New Models for Aging Research
    Steven N Austad; Fiscal Year: 2010
    ..Because aging is the ultimate cause of many late life maladies, the research has the potential to not only enhance health but delay and mitigate numerous late life diseases. ..