W W Au

Summary

Affiliation: University of Texas Medical Branch
Country: USA

Publications

  1. ncbi request reprint Life style factors and acquired susceptibility to environmental disease
    W W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 204:17-22. 2001
  2. ncbi request reprint Assessing DNA damage and health risk using biomarkers
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Mutat Res 509:153-63. 2002
  3. ncbi request reprint Usefulness of biomarkers in population studies: from exposure to susceptibility and to prediction of cancer
    William W Au
    Department of Preventive Medicine and Community Health, 2 102 Ewing Hall, 700 Harborside Drive, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 210:239-46. 2007
  4. ncbi request reprint International conferences on environmental mutagens in human populations-opportunities, accomplishments and challenges
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 2 102 Ewing Hall, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Mutat Res 544:93-8. 2003
  5. ncbi request reprint Environmental risk factors for prevention and molecular intervention of cervical cancer
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 210:671-8. 2007
  6. pmc Inhibition of growth of cervical cancer cells using a dominant negative estrogen receptor gene
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Gynecol Oncol 104:276-80. 2007
  7. ncbi request reprint Heritable susceptibility factors for the development of cancer
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    J Radiat Res 47:B13-7. 2006
  8. pmc Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
    Environ Health Perspect 111:1843-50. 2003
  9. doi request reprint Challenge assay: A functional biomarker for exposure-induced DNA repair deficiency and for risk of cancer
    William W Au
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 213:32-9. 2010
  10. ncbi request reprint Mutagen sensitivity assays in population studies
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Mutat Res 544:273-7. 2003

Collaborators

Detail Information

Publications49

  1. ncbi request reprint Life style factors and acquired susceptibility to environmental disease
    W W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 204:17-22. 2001
    ..The acquired susceptibility is expected to interact with environmental factors and with genetic susceptibility to increase risk for environmental disease...
  2. ncbi request reprint Assessing DNA damage and health risk using biomarkers
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Mutat Res 509:153-63. 2002
    ..These information gaps can be viewed as research opportunities to provide more precise data for assessment of toxicological effects and health risk...
  3. ncbi request reprint Usefulness of biomarkers in population studies: from exposure to susceptibility and to prediction of cancer
    William W Au
    Department of Preventive Medicine and Community Health, 2 102 Ewing Hall, 700 Harborside Drive, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 210:239-46. 2007
    ..The assessment can be used to drive the implementation of disease prevention and intervention activities. Such an approach is consistent with the current priority in translating basic science knowledge into health applications...
  4. ncbi request reprint International conferences on environmental mutagens in human populations-opportunities, accomplishments and challenges
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 2 102 Ewing Hall, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Mutat Res 544:93-8. 2003
    ..These conferences have led to significant enhancement of regional scientific expertise from the acquisition of scientific knowledge and from the generation of sustainable collaborative programs...
  5. ncbi request reprint Environmental risk factors for prevention and molecular intervention of cervical cancer
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 210:671-8. 2007
    ..g., the core apoptotic machinery, that can cause self-destruction of the CC cells, thus providing potentially effective molecular therapy. These topics are discussed in this review...
  6. pmc Inhibition of growth of cervical cancer cells using a dominant negative estrogen receptor gene
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Gynecol Oncol 104:276-80. 2007
    ..Estrogen stimulates human papilloma virus oncogene expression, promotes cervical cancer (CC) cell proliferation and prevents apoptosis. Therefore, blockage of estrogen function may have therapeutic application to CC...
  7. ncbi request reprint Heritable susceptibility factors for the development of cancer
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    J Radiat Res 47:B13-7. 2006
    ..These questions include the understanding of combinations of different polymorphic genes for susceptibility and of specific disease susceptibility for different ethnic populations...
  8. pmc Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assays
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
    Environ Health Perspect 111:1843-50. 2003
    ..In addition, the variant genotypes interact significantly, with limited overlap of the two different repair pathways...
  9. doi request reprint Challenge assay: A functional biomarker for exposure-induced DNA repair deficiency and for risk of cancer
    William W Au
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 213:32-9. 2010
    ..Therefore, the challenge assay is a useful functional biomarker for population studies. Details of the challenge assay and its application will be presented in this review...
  10. ncbi request reprint Mutagen sensitivity assays in population studies
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Mutat Res 544:273-7. 2003
    ..When studies are conducted under appropriate conditions, expression of mutagen sensitivity is suggestive of increased risk for environmental disease such as cancer...
  11. ncbi request reprint Acquired and genetic susceptibility to cervical cancer
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
    Mutat Res 544:361-4. 2003
    ..Our study indicates that different acquired and genetic susceptibility factors can make significant contributions to the development of environmental disease such as cervical cancer...
  12. ncbi request reprint Life style, environmental and genetic susceptibility to cervical cancer
    William W Au
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, 2 102 Ewing Hall, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Toxicology 198:117-20. 2004
    ..The information is useful for the development of effective but different disease prevention programs for different countries in the control of CC...
  13. ncbi request reprint Biomarker research in occupational health
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas, Medical Branch, Galveston, Texas 77555 1110, USA
    J Occup Environ Med 47:145-53. 2005
    ..A variety of biomarkers have been used to study worker populations, and these studies have achieved different levels of success in the improvement of occupational health...
  14. ncbi request reprint Use of biomarkers to characterize functions of polymorphic DNA repair genotypes
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Int J Hyg Environ Health 207:301-13. 2004
    ..XPD 312Asn and XPD 751Gln are deficient in the repair of UV-light- but not X-ray-induced chromosome aberrations, therefore they are defective in nucleotide excision repair...
  15. doi request reprint Vth International Conference on Environmental Mutagens in Human Populations: introduction
    William W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Mutat Res 659:2-3. 2008
    ..Like the previous conferences in this series, collaborative and sustainable projects were developed among the participants. Publications in this monograph represent outstanding reviews and experimental data from invited speakers...
  16. ncbi request reprint Superfund research program--accomplishments and future opportunities
    William W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Ewing Hall 700 Harborside Drive, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 205:165-8. 2002
    ..The continuation of research will contribute significantly towards achieving the Healthy People 2010 goals that have been set for the United States...
  17. ncbi request reprint Factors contributing to discrepancies in population monitoring studies
    W W Au
    Department of Preventive Medicine and Community Health, Division of Environmental Toxicology, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Mutat Res 400:467-78. 1998
    ..The inclusion of susceptibility factors in population monitoring may revolutionize the approach for health risk assessment and for environmental regulations...
  18. ncbi request reprint Population monitoring: experience with residents exposed to uranium mining/milling waste
    W W Au
    Department of Preventive Medicine and Community Health, Division of Environmental Toxicology, The University of Texas Medical Branch, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
    Mutat Res 405:237-45. 1998
    ....
  19. pmc Cytogenetic effects from exposure to mixed pesticides and the influence from genetic susceptibility
    W W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Environ Health Perspect 107:501-5. 1999
    ..Our genotype data suggest that the well-recognized "healthy worker effect" may be influenced by unrecognized occupational selection pressure against genetically susceptible individuals...
  20. ncbi request reprint Inheritance of polymorphic metabolizing genes on environmental disease and quality of life
    W W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Mutat Res 428:131-40. 1999
    ..It is obvious that through the understanding of susceptibility, more precise disease prevention strategies can be implemented which will not only reduce the disease burden but also improve the quality of life...
  21. ncbi request reprint Usefulness of genetic susceptibility and biomarkers for evaluation of environmental health risk
    W W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Environ Mol Mutagen 37:215-25. 2001
    ..Environ. Mol. Mutagen. 37:215-225, 2001. &copy 2001 Wiley-Liss, Inc...
  22. ncbi request reprint Use of biomarkers to elucidate genetic susceptibility to cancer
    William W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Environ Mol Mutagen 45:222-8. 2005
    ..These data will be useful for a better understanding of the complexity of disease causation and development, developing new models for human disease, and identifying pathways for prevention of cancer...
  23. ncbi request reprint Biomarkers in population studies: environmental mutagenesis and risk for cancer
    William W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Rev Environ Health 24:117-27. 2009
    ..The usefulness and application of these biomarkers and technologies will be presented...
  24. ncbi request reprint Biomarker monitoring for health risk based on sensitivity to environmental mutagens
    W W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, USA
    Rev Environ Health 16:41-64. 2001
    ..Such sensitivity can be either genetically determined or acquired from the exposure to environmental mutagens...
  25. pmc Monitoring populations for DNA repair deficiency and for cancer susceptibility
    W W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555 1110, USA
    Environ Health Perspect 104:579-84. 1996
    ..Our experience in using genetic polymorphism and host-reactivation assays will be discussed...
  26. ncbi request reprint Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytes
    S Z Abdel-Rahman
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston 77555 1110, USA
    Pharmacogenetics 10:239-49. 2000
    ....
  27. ncbi request reprint Cytogenetic assays for monitoring populations exposed to environmental mutagens
    W W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555-1110, USA
    Occup Med 16:345-57. 2001
    ..The latter may involve previous or concurrent exposure to environmental mutagens, e.g., cigarette smoking habits...
  28. ncbi request reprint Cytogenetic challenge assays for assessment of DNA repair capacities
    William W Au
    Department of Preventative Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
    Methods Mol Biol 314:25-42. 2006
    ..The protocol for the assay is straightforward and the data have practical applications...
  29. ncbi request reprint Genotoxic effects of a sub-acute low-level inhalation exposure to a mixture of carcinogenic chemicals
    W W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77550
    Mutat Res 203:103-15. 1988
    ..The present study indicates that the CTP is sufficiently sensitive to identify toxicological effects after exposure to ambient levels of a gas mixture...
  30. ncbi request reprint Association of the NAT1*10 genotype with increased chromosome aberrations and higher lung cancer risk in cigarette smokers
    S Z Abdel-Rahman
    Department of Preventive Medicine and Community Health, Galveston, TX 77555, USA
    Mutat Res 398:43-54. 1998
    ....
  31. ncbi request reprint Chromosome damage and DNA repair response in lymphocytes of women who had children with neural tube defects
    W W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555, USA
    Mutat Res 361:17-21. 1996
    ..However, exposure to non-mutagenic environmental teratogens cannot be ruled out...
  32. ncbi request reprint Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia
    Carlos H Sierra-Torres
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555, USA
    Environ Mol Mutagen 41:69-76. 2003
    ..Further studies using larger populations will be needed to confirm our observations and to validate data for disease prevention...
  33. ncbi request reprint The CYP2D6 extensive metabolizer genotype is associated with increased risk for bladder cancer
    S Z Abdel-Rahman
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Cancer Lett 119:115-22. 1997
    ..These data suggest that the predisposing CYP2D6 gene may not only increase the risk for bladder cancer among Egyptians, but may also influence the clinicopathological tumor outcome...
  34. ncbi request reprint Polymorphic metabolizing genes and susceptibility to atherosclerosis among cigarette smokers
    Salama A Salama
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Environ Mol Mutagen 40:153-60. 2002
    ..31 +/- 0.35). Since the analysis of genetic susceptibility factors is still in its infancy, our study may stimulate additional investigations to understand the roles of genetic susceptibility and cigarette smoking in AR...
  35. ncbi request reprint Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancer
    Nohelia Cajas-Salazar
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
    Cancer Genet Cytogenet 145:97-102. 2003
    ..In conclusion, the CA data provides evidence to support that susceptibility mEH alleles are significantly involved with the development of lung cancer from cigarette smoking...
  36. ncbi request reprint Combined effect of MPO, GSTM1 and GSTT1 polymorphisms on chromosome aberrations and lung cancer risk
    Nohelia Cajas-Salazar
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 206:473-83. 2003
    ..Therefore, our study strengthens the combined use of genotype and biomarkers for genetic susceptibility to environmental cancer...
  37. ncbi request reprint Susceptibility and biomarker knowledge for improvement of environmental health
    Salama A Salama
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Int J Hyg Environ Health 206:401-12. 2003
    ..Success in disease prevention is dependent upon multidisciplinary collaborations at the local and international levels...
  38. ncbi request reprint Susceptibility of children to environmental toxic substances
    William W Au
    Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Int J Hyg Environ Health 205:501-3. 2002
    ..More emphasis should therefore be focused on addressing the information gap for improving the health of our children...
  39. ncbi request reprint Towards the world-wide ban of indoor cigarette smoking in public places
    Luis R Rivero
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 209:1-14. 2006
    ..A global ban on indoor smoking in public places is an important first step in an international effort to prevent morbidity and mortality caused by tobacco smoking and ETS...
  40. doi request reprint Aquaculture: Environmental, toxicological, and health issues
    David W Cole
    Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
    Int J Hyg Environ Health 212:369-77. 2009
    ..Specifically, concerns and recommendations for improving the aquaculture industry, and for protection of the environment and the consumers will be concisely presented...
  41. ncbi request reprint Perspectives on the use of scientific knowledge for public health practice
    William W Au
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
    Int J Hyg Environ Health 208:135-9. 2005
    ..This manuscript provides a summary of the approaches to address certain crucial environmental health concerns towards the goal of increasing quality and years of healthy life...
  42. ncbi request reprint Health concerns regarding consumption of irradiated food
    Bradford C Ashley
    Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
    Int J Hyg Environ Health 207:493-504. 2004
    ..Different countries should further evaluate their local and global risks and benefits prior to developing and recommending national and international food irradiation policies...
  43. ncbi request reprint Biomarkers in molecular epidemiology studies for health risk prediction
    Stefano Bonassi
    Department of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy
    Mutat Res 511:73-86. 2002
    ..By building reliable biomarker databases, a promising future is the integration of information from the genome programs to expand the scientific frontiers on etiology, health risk prediction and prevention of environmental disease...
  44. ncbi request reprint HLA-DQB1 and cervical cancer in Venezuelan women
    Dat D Dao
    Houston Advanced Research Center HARC, The Woodlands, TX 77381, USA
    Gynecol Oncol 96:349-54. 2005
    ..The role of the HLA system in presenting peptides to antigen-specific T-cells may be critical for genetic susceptibility and genetic resistance to cervical carcinoma...
  45. ncbi request reprint Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancer
    Carsten Harms
    Center of Environmental Research and Technology, Laboratory of Bioanalytic, UFT, University of Bremen, Bremen, Germany
    Environ Mol Mutagen 44:74-82. 2004
    ..The observation that patients had significantly increased CA frequencies compared with controls, irrespective of genotype, suggests that patients have additional factors that contribute to the development of lung cancer...
  46. ncbi request reprint Ionizing radiation-induced bioeffects in space and strategies to reduce cellular injury and carcinogenesis
    Jeffrey A Jones
    NASA Johnson Space Center, Medical Operations, Houston, TX 77058, USA
    Aviat Space Environ Med 78:A67-78. 2007
    ..Potential mutagenic effects from space radiation exposure result from direct DNA damage or indirectly from the production of reactive oxygen species (ROS)...
  47. ncbi request reprint Abrogation of estrogen receptor signaling augments cytotoxicity of anticancer drugs on CaSki cervical cancer cells
    Moon Y Heo
    College of Pharmacy, Kangwon National University, Chuncheon, Korea
    Anticancer Res 28:2181-7. 2008
    ..We investigated the mechanisms for enhanced cell killing when DN was combined with cisplatin (CP) and paclitaxel (TX)...
  48. ncbi request reprint The p53 codon 72 polymorphism and risk of oral cancer in Southern Thailand
    Suparp Kietthubthew
    Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand
    Asian Pac J Cancer Prev 4:209-14. 2003
    ..13, 95%CI 0.04-1.10). This is the first report on p53 polymorphism and oral cancer in Thailand...
  49. ncbi request reprint Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand
    Suparp Kietthubthew
    Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand
    Int J Hyg Environ Health 209:21-9. 2006
    ..In addition, these SNPs influence the repair of DNA damage that is caused by environmental risk factors for oral cancer...