Research Topics
| W W AuSummaryAffiliation: University of Texas Medical Branch Country: USA Publications
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Detail Information
Publications
Life style factors and acquired susceptibility to environmental diseaseW W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
Int J Hyg Environ Health 204:17-22. 2001..The acquired susceptibility is expected to interact with environmental factors and with genetic susceptibility to increase risk for environmental disease...- Assessing DNA damage and health risk using biomarkersWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
Mutat Res 509:153-63. 2002..These information gaps can be viewed as research opportunities to provide more precise data for assessment of toxicological effects and health risk... - Usefulness of biomarkers in population studies: from exposure to susceptibility and to prediction of cancerWilliam W Au
Department of Preventive Medicine and Community Health, 2 102 Ewing Hall, 700 Harborside Drive, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Int J Hyg Environ Health 210:239-46. 2007..The assessment can be used to drive the implementation of disease prevention and intervention activities. Such an approach is consistent with the current priority in translating basic science knowledge into health applications... - International conferences on environmental mutagens in human populations-opportunities, accomplishments and challengesWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 2 102 Ewing Hall, 700 Harborside Drive, Galveston, TX 77555 1110, USA
Mutat Res 544:93-8. 2003..These conferences have led to significant enhancement of regional scientific expertise from the acquisition of scientific knowledge and from the generation of sustainable collaborative programs... - Environmental risk factors for prevention and molecular intervention of cervical cancerWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Int J Hyg Environ Health 210:671-8. 2007..g., the core apoptotic machinery, that can cause self-destruction of the CC cells, thus providing potentially effective molecular therapy. These topics are discussed in this review... 
Inhibition of growth of cervical cancer cells using a dominant negative estrogen receptor geneWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Gynecol Oncol 104:276-80. 2007..Estrogen stimulates human papilloma virus oncogene expression, promotes cervical cancer (CC) cell proliferation and prevents apoptosis. Therefore, blockage of estrogen function may have therapeutic application to CC...- Heritable susceptibility factors for the development of cancerWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
J Radiat Res 47:B13-7. 2006..These questions include the understanding of combinations of different polymorphic genes for susceptibility and of specific disease susceptibility for different ethnic populations... 
Functional characterization of polymorphisms in DNA repair genes using cytogenetic challenge assaysWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
Environ Health Perspect 111:1843-50. 2003..In addition, the variant genotypes interact significantly, with limited overlap of the two different repair pathways...
Challenge assay: A functional biomarker for exposure-induced DNA repair deficiency and for risk of cancerWilliam W Au
Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Int J Hyg Environ Health 213:32-9. 2010..Therefore, the challenge assay is a useful functional biomarker for population studies. Details of the challenge assay and its application will be presented in this review...- Mutagen sensitivity assays in population studiesWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, Galveston, TX 77555 1110, USA
Mutat Res 544:273-7. 2003..When studies are conducted under appropriate conditions, expression of mutagen sensitivity is suggestive of increased risk for environmental disease such as cancer... - Acquired and genetic susceptibility to cervical cancerWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, 700 Harborside Drive, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
Mutat Res 544:361-4. 2003..Our study indicates that different acquired and genetic susceptibility factors can make significant contributions to the development of environmental disease such as cervical cancer... - Life style, environmental and genetic susceptibility to cervical cancerWilliam W Au
Department of Preventive Medicine and Community Health, 700 Harborside Drive, 2 102 Ewing Hall, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Toxicology 198:117-20. 2004..The information is useful for the development of effective but different disease prevention programs for different countries in the control of CC... - Biomarker research in occupational healthWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas, Medical Branch, Galveston, Texas 77555 1110, USA
J Occup Environ Med 47:145-53. 2005..A variety of biomarkers have been used to study worker populations, and these studies have achieved different levels of success in the improvement of occupational health... - Use of biomarkers to characterize functions of polymorphic DNA repair genotypesWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
Int J Hyg Environ Health 207:301-13. 2004..XPD 312Asn and XPD 751Gln are deficient in the repair of UV-light- but not X-ray-induced chromosome aberrations, therefore they are defective in nucleotide excision repair... - Vth International Conference on Environmental Mutagens in Human Populations: introductionWilliam W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Mutat Res 659:2-3. 2008..Like the previous conferences in this series, collaborative and sustainable projects were developed among the participants. Publications in this monograph represent outstanding reviews and experimental data from invited speakers... - Superfund research program--accomplishments and future opportunitiesWilliam W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Ewing Hall 700 Harborside Drive, Galveston, TX 77555 1110, USA
Int J Hyg Environ Health 205:165-8. 2002..The continuation of research will contribute significantly towards achieving the Healthy People 2010 goals that have been set for the United States... - Factors contributing to discrepancies in population monitoring studiesW W Au
Department of Preventive Medicine and Community Health, Division of Environmental Toxicology, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Mutat Res 400:467-78. 1998..The inclusion of susceptibility factors in population monitoring may revolutionize the approach for health risk assessment and for environmental regulations... - Population monitoring: experience with residents exposed to uranium mining/milling wasteW W Au
Department of Preventive Medicine and Community Health, Division of Environmental Toxicology, The University of Texas Medical Branch, 2 102 Ewing Hall, Galveston, TX 77555 1110, USA
Mutat Res 405:237-45. 1998.... - Cytogenetic effects from exposure to mixed pesticides and the influence from genetic susceptibilityW W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
Environ Health Perspect 107:501-5. 1999..Our genotype data suggest that the well-recognized "healthy worker effect" may be influenced by unrecognized occupational selection pressure against genetically susceptible individuals... - Inheritance of polymorphic metabolizing genes on environmental disease and quality of lifeW W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Mutat Res 428:131-40. 1999..It is obvious that through the understanding of susceptibility, more precise disease prevention strategies can be implemented which will not only reduce the disease burden but also improve the quality of life... - Usefulness of genetic susceptibility and biomarkers for evaluation of environmental health riskW W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
Environ Mol Mutagen 37:215-25. 2001..Environ. Mol. Mutagen. 37:215-225, 2001. © 2001 Wiley-Liss, Inc... - Use of biomarkers to elucidate genetic susceptibility to cancerWilliam W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555, USA
Environ Mol Mutagen 45:222-8. 2005..These data will be useful for a better understanding of the complexity of disease causation and development, developing new models for human disease, and identifying pathways for prevention of cancer... - Biomarkers in population studies: environmental mutagenesis and risk for cancerWilliam W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Rev Environ Health 24:117-27. 2009..The usefulness and application of these biomarkers and technologies will be presented... - Biomarker monitoring for health risk based on sensitivity to environmental mutagensW W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, USA
Rev Environ Health 16:41-64. 2001..Such sensitivity can be either genetically determined or acquired from the exposure to environmental mutagens... - Monitoring populations for DNA repair deficiency and for cancer susceptibilityW W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555 1110, USA
Environ Health Perspect 104:579-84. 1996..Our experience in using genetic polymorphism and host-reactivation assays will be discussed... - Role of polymorphic CYP2E1 and CYP2D6 genes in NNK-induced chromosome aberrations in cultured human lymphocytesS Z Abdel-Rahman
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston 77555 1110, USA
Pharmacogenetics 10:239-49. 2000.... - Cytogenetic assays for monitoring populations exposed to environmental mutagensW W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555-1110, USA
Occup Med 16:345-57. 2001..The latter may involve previous or concurrent exposure to environmental mutagens, e.g., cigarette smoking habits... - Cytogenetic challenge assays for assessment of DNA repair capacitiesWilliam W Au
Department of Preventative Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
Methods Mol Biol 314:25-42. 2006..The protocol for the assay is straightforward and the data have practical applications... - Genotoxic effects of a sub-acute low-level inhalation exposure to a mixture of carcinogenic chemicalsW W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77550
Mutat Res 203:103-15. 1988..The present study indicates that the CTP is sufficiently sensitive to identify toxicological effects after exposure to ambient levels of a gas mixture... - Association of the NAT1*10 genotype with increased chromosome aberrations and higher lung cancer risk in cigarette smokersS Z Abdel-Rahman
Department of Preventive Medicine and Community Health, Galveston, TX 77555, USA
Mutat Res 398:43-54. 1998.... - Chromosome damage and DNA repair response in lymphocytes of women who had children with neural tube defectsW W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston 77555, USA
Mutat Res 361:17-21. 1996..However, exposure to non-mutagenic environmental teratogens cannot be ruled out... - Polymorphisms for chemical metabolizing genes and risk for cervical neoplasiaCarlos H Sierra-Torres
Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555, USA
Environ Mol Mutagen 41:69-76. 2003..Further studies using larger populations will be needed to confirm our observations and to validate data for disease prevention... - The CYP2D6 extensive metabolizer genotype is associated with increased risk for bladder cancerS Z Abdel-Rahman
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Cancer Lett 119:115-22. 1997..These data suggest that the predisposing CYP2D6 gene may not only increase the risk for bladder cancer among Egyptians, but may also influence the clinicopathological tumor outcome... - Polymorphic metabolizing genes and susceptibility to atherosclerosis among cigarette smokersSalama A Salama
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555 1110, USA
Environ Mol Mutagen 40:153-60. 2002..31 +/- 0.35). Since the analysis of genetic susceptibility factors is still in its infancy, our study may stimulate additional investigations to understand the roles of genetic susceptibility and cigarette smoking in AR... - Effect of epoxide hydrolase polymorphisms on chromosome aberrations and risk for lung cancerNohelia Cajas-Salazar
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
Cancer Genet Cytogenet 145:97-102. 2003..In conclusion, the CA data provides evidence to support that susceptibility mEH alleles are significantly involved with the development of lung cancer from cigarette smoking... - Combined effect of MPO, GSTM1 and GSTT1 polymorphisms on chromosome aberrations and lung cancer riskNohelia Cajas-Salazar
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Int J Hyg Environ Health 206:473-83. 2003..Therefore, our study strengthens the combined use of genotype and biomarkers for genetic susceptibility to environmental cancer... - Susceptibility and biomarker knowledge for improvement of environmental healthSalama A Salama
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555-1110, USA
Int J Hyg Environ Health 206:401-12. 2003..Success in disease prevention is dependent upon multidisciplinary collaborations at the local and international levels... - Susceptibility of children to environmental toxic substancesWilliam W Au
Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas 77555-1110, USA
Int J Hyg Environ Health 205:501-3. 2002..More emphasis should therefore be focused on addressing the information gap for improving the health of our children... - Towards the world-wide ban of indoor cigarette smoking in public placesLuis R Rivero
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX 77555-1110, USA
Int J Hyg Environ Health 209:1-14. 2006..A global ban on indoor smoking in public places is an important first step in an international effort to prevent morbidity and mortality caused by tobacco smoking and ETS... - Aquaculture: Environmental, toxicological, and health issuesDavid W Cole
Department of Preventive Medicine and Community Health, 700 Harborside Drive, University of Texas Medical Branch, Galveston, TX 77555 1110, USA
Int J Hyg Environ Health 212:369-77. 2009..Specifically, concerns and recommendations for improving the aquaculture industry, and for protection of the environment and the consumers will be concisely presented... - Perspectives on the use of scientific knowledge for public health practiceWilliam W Au
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA
Int J Hyg Environ Health 208:135-9. 2005..This manuscript provides a summary of the approaches to address certain crucial environmental health concerns towards the goal of increasing quality and years of healthy life... - Health concerns regarding consumption of irradiated foodBradford C Ashley
Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, Texas 77555-1110, USA
Int J Hyg Environ Health 207:493-504. 2004..Different countries should further evaluate their local and global risks and benefits prior to developing and recommending national and international food irradiation policies... - Biomarkers in molecular epidemiology studies for health risk predictionStefano Bonassi
Department of Environmental Epidemiology, National Cancer Research Institute, Genoa, Italy
Mutat Res 511:73-86. 2002..By building reliable biomarker databases, a promising future is the integration of information from the genome programs to expand the scientific frontiers on etiology, health risk prediction and prevention of environmental disease... - HLA-DQB1 and cervical cancer in Venezuelan womenDat D Dao
Houston Advanced Research Center HARC, The Woodlands, TX 77381, USA
Gynecol Oncol 96:349-54. 2005..The role of the HLA system in presenting peptides to antigen-specific T-cells may be critical for genetic susceptibility and genetic resistance to cervical carcinoma... - Polymorphisms in DNA repair genes, chromosome aberrations, and lung cancerCarsten Harms
Center of Environmental Research and Technology, Laboratory of Bioanalytic, UFT, University of Bremen, Bremen, Germany
Environ Mol Mutagen 44:74-82. 2004..The observation that patients had significantly increased CA frequencies compared with controls, irrespective of genotype, suggests that patients have additional factors that contribute to the development of lung cancer... - Ionizing radiation-induced bioeffects in space and strategies to reduce cellular injury and carcinogenesisJeffrey A Jones
NASA Johnson Space Center, Medical Operations, Houston, TX 77058, USA
Aviat Space Environ Med 78:A67-78. 2007..Potential mutagenic effects from space radiation exposure result from direct DNA damage or indirectly from the production of reactive oxygen species (ROS)... - Abrogation of estrogen receptor signaling augments cytotoxicity of anticancer drugs on CaSki cervical cancer cellsMoon Y Heo
College of Pharmacy, Kangwon National University, Chuncheon, Korea
Anticancer Res 28:2181-7. 2008..We investigated the mechanisms for enhanced cell killing when DN was combined with cisplatin (CP) and paclitaxel (TX)... - The p53 codon 72 polymorphism and risk of oral cancer in Southern ThailandSuparp Kietthubthew
Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand
Asian Pac J Cancer Prev 4:209-14. 2003..13, 95%CI 0.04-1.10). This is the first report on p53 polymorphism and oral cancer in Thailand... - Polymorphism in DNA repair genes and oral squamous cell carcinoma in ThailandSuparp Kietthubthew
Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand
Int J Hyg Environ Health 209:21-9. 2006..In addition, these SNPs influence the repair of DNA damage that is caused by environmental risk factors for oral cancer...