Research Topics
Species | CRAIG STEPHEN ATWOODSummaryAffiliation: University of Wisconsin Country: USA Publications
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Publications
A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 alleleRyan J Haasl
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
BMC Med Genet 9:37. 2008....
Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegansSivan Vadakkadath Meethal
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
BMC Evol Biol 6:103. 2006..This study examined whether GPCRs orthologous to human gonadotropin-releasing hormone receptor (GnRHR) exist in C. elegans...
Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supplyCraig S Atwood
School of Medicine, University of Wisconsin and William S Middleton Memorial Veterans Administration, GRECC 11G, 2500 Overlook Terrace, Madison, WI 53705, USA
Brain Res Brain Res Rev 43:164-78. 2003..e. immunological responses to Abeta vaccination do not discriminate between physiologically purposive deposits of Abeta (vascular deposits) and pathological deposits of Abeta (senile plaques)...- Metabolic clues regarding the enhanced performance of elite endurance athletes from orchiectomy-induced hormonal changesCraig S Atwood
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
Med Hypotheses 68:735-49. 2007..These insights provide the foundation for future studies on the endocrinology of exercise metabolism, and suggest that Lance Armstrong's athletic advantage was not due to drug use... - Alzheimer's disease: the impact of age-related changes in reproductive hormonesC S Atwood
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
Cell Mol Life Sci 62:255-6. 2005 
The reproductive-cell cycle theory of aging: an updateCraig S Atwood
Geriatric Research, Education and Clinical Center, Veterans Administration Hospital and Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
Exp Gerontol 46:100-7. 2011..In essence, the Reproductive-Cell Cycle Theory can explain aging in all sexually reproductive life forms...- Leuprolide acetate: a drug of diverse clinical applicationsAndrea C Wilson
University of Wisconsin Madison, Department of Medicine, and Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Expert Opin Investig Drugs 16:1851-63. 2007..These observations also suggest that the potential uses of GnRH analogs in the modulation of GnRH signaling and treatment of disease has yet to be fully realized... - A multi-hit endocrine model of intrinsic adult-onset asthmaCraig S Atwood
Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
Ageing Res Rev 7:114-25. 2008..Future therapeutic strategies might therefore target the serotonergic, leptinergic and hypothalamic pathways in regulating cellular cAMP production and bronchoconstriction for the treatment of adult-onset asthma... - Copper mediates dityrosine cross-linking of Alzheimer's amyloid-betaCraig S Atwood
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Biochemistry 43:560-8. 2004..Given the elevated concentration of Cu in senile plaques, our results suggest that Cu interactions with Abeta could be responsible for causing the covalent cross-linking of Abeta in these structures... - The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettesMiguel J Gallego
Geriatric Research, Education and Clinical Center, Veterans Administration Hospital and Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, 2500 Highland Avenue, Madison, WI 53705, USA
Stem Cell Res Ther 1:28. 2010.... - Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescenceCraig S Atwood
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, 53705, USA
J Neuropathol Exp Neurol 64:93-103. 2005..Ideally, supplementation with HPG hormones should mimic closely the serum concentrations of all HPG hormones in reproductive men and cycling women to prevent dyotic signaling and attempted neuron division... - Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic miceGemma Casadesus
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Biochim Biophys Acta 1762:447-52. 2006..Since both cognitive loss and amyloid-beta deposition are features of Alzheimer disease, leuprolide acetate treatment may prove to be a useful therapeutic strategy for this disease... - A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and womenCarey E Gleason
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
Age Ageing 38:86-93. 2009..Unfortunately, few studies enrolled adults over the age of 70, and none included older men... - Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's diseaseCynthia M Carlsson
Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
J Alzheimers Dis 13:187-97. 2008..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD... - Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's diseaseGemma Casadesus
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Curr Drug Targets CNS Neurol Disord 3:281-5. 2004..Therefore, the effects of agents that abolish LH, such as leuprolide acetate, which are currently being evaluated in Phase II clinical trials for the treatment of AD, are eagerly anticipated... - The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer diseaseCatherine A Rottkamp
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Peptides 23:1333-41. 2002..Below, we present a brief synopsis of the trial for you, the jury, to decide the verdict. Amyloid-beta: guilty or not-guilty?.. - fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's diseaseMehul A Trivedi
Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
Neuropsychologia 46:1667-78. 2008..These results suggest that FH and aging are exerting independent effects in both tasks while APOE affected the relationship with age in the hippocampus in one of the two tasks given... - Neuroprotective properties of Bcl-w in Alzheimer diseaseXiongwei Zhu
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
J Neurochem 89:1233-40. 2004..Taken together, these series of results suggest that Bcl-w may play an important protective role in neurons in the diseased brain and that this aspect could be therapeutically harnessed to afford neuroprotection... - Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidenceJian Dong
Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
Biochemistry 42:2768-73. 2003..The results also reveal a direct chemical basis for oxidative damage caused by amyloid-beta protein in AD... - The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic targetKate M Webber
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106. USA
Curr Pharm Des 12:691-7. 2006..Therapeutic interventions targeted at gonadotropins, if they are indeed the driving mitogenic force, could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted... - The gonadotropin connection in Alzheimer's diseaseSivan Vadakkadath Meethal
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison, Veterans Administration Hospital, Madison, 53705, USA
Endocrine 26:317-26. 2005..Clinical trials are underway for the treatment of AD using GnRH analogs and should provide further insights into the gonadotropin connection in AD... - Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expressionAndrea C Wilson
Department of Pathology and Laboratory Medicine, Veterans Administration Hospital, University of Wisconsin, 2500 Overlook Terrace, Madison, Wisconsin 53705, USA
J Endocrinol 191:651-63. 2006..Post-reproductive surges in GnRH I secretion may explain the accumulation of LH in pyramidal neurons of the aged human and rat... - Menopause, estrogen, and gonadotropins in Alzheimer's diseaseGemma Casadesus
Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
Adv Clin Chem 45:139-53. 2008..Moreover, targeting gonadotropins appears to have beneficial actions as a therapeutic regimen... - Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's diseaseSandra L Siedlak
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Free Radic Res 43:156-64. 2009.... - Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studiesRobert P Friedland
Department of Neurology, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Biol Chem 283:22550-6. 2008..Immune responses generated from dietary exposure to proteins homologous to Abeta may induce antibodies that could influence the normal physiological processing of the protein and the development or progression of AD... - The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implicationsGeorge Perry
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
CNS Drugs 16:339-52. 2002..In this article, we examine not only the possible mechanism of disease but also how pharmaceuticals may intervene, from direct and indirect antioxidant therapy to strategies involving gene therapy... - Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?Mark A Smith
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Neurochem Int 40:527-31. 2002..However, this rationale may be misguided since new evidence from our laboratories and others suggest that the lesions not only occur as a by-product of the fundamental disease process but also that they may be protective... - Amyloid-beta: a vascular sealant that protects against hemorrhage?Craig S Atwood
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 USA
J Neurosci Res 70:356. 2002 - Amyloid-beta: a (life) preserver for the brainMark E Obrenovich
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Neurobiol Aging 23:1097-9. 2002 - Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer diseaseGeorge Perry
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
Biometals 16:77-81. 2003.... - Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expressionTianbing Liu
Department of Medicine, University of Wisconsin-Madison, Geriatrics, Research, Education and Clinical Center, Wm. S. Middleton Memorial Veterans Hospital, 53705, USA
J Neurochem 88:554-63. 2004..Our results predict that only cells containing appreciable levels of tau are susceptible to Abeta-induced toxicity and may explain why Abeta is more toxic to neurons compared with other cell types... - Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-betaCraig S Atwood
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Brain Res Brain Res Rev 43:1-16. 2003..ccirf;), leading to enhanced, rather than reduced, neuronal oxidative stress... - The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's diseaseGemma Casadesus
Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Drugs R D 7:187-93. 2006.... - Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?George Perry
Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
Free Radic Biol Med 33:1475-9. 2002..Although much data remain to be collected, the broad spectrum of changes found in AD are only seen, albeit to a lesser extent, in normal aging with other neurodegenerative diseases showing distinct spectrums of change... - Pennington scientific symposium on mechanisms and retardation of agingCraig S Atwood
Section of Geriatrics and Gerontology, University of Wisconsin Medical School, Madison, WI, USA
Exp Gerontol 38:1217-26. 2003 - Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cellsPrashob Porayette
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Affairs Hospital, Madison, Wisconsin 53705, USA
J Biol Chem 284:23806-17. 2009..Together these data suggest that differential processing of AbetaPP is normally required for embryonic neurogenesis... - Reproductive hormones regulate the selective permeability of the blood-brain barrierAndrea C Wilson
Department of Medicine, University of Wisconsin Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705 USA
Biochim Biophys Acta 1782:401-7. 2008..Furthermore, these findings implicate Cx43 in mediating changes in BBB permeability, and serum gonadotropins in the cerebropathophysiology of age-related neurodegenerative diseases such as stroke and Alzheimer's disease... - Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteinsCraig S Atwood
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
Peptides 23:1343-50. 2002.... - Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesisKate M Webber
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd, Cleveland, OH 44106, USA
Ann N Y Acad Sci 1052:201-9. 2005..On this basis, we suggest that the results of the WHI Memory Study are not only predictable but also avoidable by therapeutically targeting the gonadotropins instead of the sex steroids... - Iron: a pathological mediator of Alzheimer disease?Glenda M Bishop
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Dev Neurosci 24:184-7. 2002..Continued examination of the complex interactions that occur between iron and amyloid-beta may assist in the elucidation of the mechanisms that underlie the neurodegeneration that leads to dementia in AD... - Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotectionKate M Webber
Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
Acta Neurobiol Exp (Wars) 64:113-8. 2004..Based on this, we suggest that therapeutic interventions targeted at gonadotropins could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted... - Gonadotropins: a cohesive gender-based etiology of Alzheimer diseaseKate M Webber
Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
Mol Cell Endocrinol 260:271-5. 2007..In this review, we examine how the gonadotropins may play a central and determining role in modulating the susceptibility to, and progression of, Alzheimer disease... - Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brainJohn K Wung
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Curr Alzheimer Res 4:67-72. 2007.... - Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expressionTianbing Liu
Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
J Neurochem 100:1329-39. 2007.... - Identification of a regulatory loop for the synthesis of neurosteroids: a steroidogenic acute regulatory protein-dependent mechanism involving hypothalamic-pituitary-gonadal axis receptorsSivan Vadakkadath Meethal
Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
J Neurochem 110:1014-27. 2009..Further delineation of these feedback loops that regulate NSS production will aid in developing therapies to maintain brain sex steroid levels and cognition... - Activin receptor signaling regulates prostatic epithelial cell adhesion and viabilityDerek P Simon
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Veterans Administration Hospital, Madison, WI 53705, USA
Neoplasia 11:365-76. 2009..That ActRII signaling governs both cell viability and cell adhesion has important implications for developing therapeutic strategies to regulate cancer growth and metastasis... - Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesisKate M Webber
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
Alzheimer Dis Assoc Disord 19:95-9. 2005..Based on this, we suggest that therapeutic interventions targeted at gonadotropins may both prevent disease in those patients currently asymptomatic or may halt, and even reverse, disease in those currently afflicted... - Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxiaGlenda M Bishop
Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
Redox Rep 12:257-66. 2007..Together, these results indicate that there is a tighter regulation of iron metabolism in the brain than the liver, which limits the redistribution of Fe3+ following hypoxia... - Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic gonadotropinPrashob Porayette
Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
Biochem Biophys Res Commun 364:522-7. 2007....
Research Grants
- Antiapoptotic Activity of Alzheimer AbetaCraig Atwood; Fiscal Year: 2003..We also will test whether oxidative stress induces neurons to re-enter the cell cycle as a mechanism leading to cell death. ..