CRAIG STEPHEN ATWOOD

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply
    Craig S Atwood
    School of Medicine, University of Wisconsin and William S Middleton Memorial Veterans Administration, GRECC 11G, 2500 Overlook Terrace, Madison, WI 53705, USA
    Brain Res Brain Res Rev 43:164-78. 2003
  2. ncbi request reprint Metabolic clues regarding the enhanced performance of elite endurance athletes from orchiectomy-induced hormonal changes
    Craig S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
    Med Hypotheses 68:735-49. 2007
  3. pmc Hypothalamic-pituitary-gonadal axis homeostasis predicts longevity
    James A Yonker
    Department of Sociology, University of Wisconsin Madison, Madison, WI, USA
    Age (Dordr) 35:129-38. 2013
  4. pmc A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele
    Ryan J Haasl
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    BMC Med Genet 9:37. 2008
  5. pmc Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans
    Sivan Vadakkadath Meethal
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
    BMC Evol Biol 6:103. 2006
  6. doi request reprint A multi-hit endocrine model of intrinsic adult-onset asthma
    Craig S Atwood
    Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Ageing Res Rev 7:114-25. 2008
  7. ncbi request reprint Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta
    Craig S Atwood
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 43:560-8. 2004
  8. ncbi request reprint Leuprolide acetate: a drug of diverse clinical applications
    Andrea C Wilson
    University of Wisconsin Madison, Department of Medicine, and Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Expert Opin Investig Drugs 16:1851-63. 2007
  9. ncbi request reprint Alzheimer's disease: the impact of age-related changes in reproductive hormones
    C S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
    Cell Mol Life Sci 62:255-6. 2005
  10. ncbi request reprint Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence
    Craig S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, 53705, USA
    J Neuropathol Exp Neurol 64:93-103. 2005

Research Grants

  1. Antiapoptotic Activity of Alzheimer Abeta
    Craig Atwood; Fiscal Year: 2003

Collaborators

Detail Information

Publications50

  1. ncbi request reprint Cerebrovascular requirement for sealant, anti-coagulant and remodeling molecules that allow for the maintenance of vascular integrity and blood supply
    Craig S Atwood
    School of Medicine, University of Wisconsin and William S Middleton Memorial Veterans Administration, GRECC 11G, 2500 Overlook Terrace, Madison, WI 53705, USA
    Brain Res Brain Res Rev 43:164-78. 2003
    ..e. immunological responses to Abeta vaccination do not discriminate between physiologically purposive deposits of Abeta (vascular deposits) and pathological deposits of Abeta (senile plaques)...
  2. ncbi request reprint Metabolic clues regarding the enhanced performance of elite endurance athletes from orchiectomy-induced hormonal changes
    Craig S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
    Med Hypotheses 68:735-49. 2007
    ..These insights provide the foundation for future studies on the endocrinology of exercise metabolism, and suggest that Lance Armstrong's athletic advantage was not due to drug use...
  3. pmc Hypothalamic-pituitary-gonadal axis homeostasis predicts longevity
    James A Yonker
    Department of Sociology, University of Wisconsin Madison, Madison, WI, USA
    Age (Dordr) 35:129-38. 2013
    ..These results support the maintenance of the hypothalamic-pituitary-gonadal axis in homeostasis in prolonging human longevity, which provides a coherent framework for understanding the relationship between reproduction and longevity...
  4. pmc A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E epsilon4 allele
    Ryan J Haasl
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    BMC Med Genet 9:37. 2008
    ....
  5. pmc Identification of a gonadotropin-releasing hormone receptor orthologue in Caenorhabditis elegans
    Sivan Vadakkadath Meethal
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
    BMC Evol Biol 6:103. 2006
    ..This study examined whether GPCRs orthologous to human gonadotropin-releasing hormone receptor (GnRHR) exist in C. elegans...
  6. doi request reprint A multi-hit endocrine model of intrinsic adult-onset asthma
    Craig S Atwood
    Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Ageing Res Rev 7:114-25. 2008
    ..Future therapeutic strategies might therefore target the serotonergic, leptinergic and hypothalamic pathways in regulating cellular cAMP production and bronchoconstriction for the treatment of adult-onset asthma...
  7. ncbi request reprint Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta
    Craig S Atwood
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Biochemistry 43:560-8. 2004
    ..Given the elevated concentration of Cu in senile plaques, our results suggest that Cu interactions with Abeta could be responsible for causing the covalent cross-linking of Abeta in these structures...
  8. ncbi request reprint Leuprolide acetate: a drug of diverse clinical applications
    Andrea C Wilson
    University of Wisconsin Madison, Department of Medicine, and Geriatric Research, Education and Clinical Center, William S Middleton Memorial Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Expert Opin Investig Drugs 16:1851-63. 2007
    ..These observations also suggest that the potential uses of GnRH analogs in the modulation of GnRH signaling and treatment of disease has yet to be fully realized...
  9. ncbi request reprint Alzheimer's disease: the impact of age-related changes in reproductive hormones
    C S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
    Cell Mol Life Sci 62:255-6. 2005
  10. ncbi request reprint Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence
    Craig S Atwood
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, 53705, USA
    J Neuropathol Exp Neurol 64:93-103. 2005
    ..Ideally, supplementation with HPG hormones should mimic closely the serum concentrations of all HPG hormones in reproductive men and cycling women to prevent dyotic signaling and attempted neuron division...
  11. pmc The pregnancy hormones human chorionic gonadotropin and progesterone induce human embryonic stem cell proliferation and differentiation into neuroectodermal rosettes
    Miguel J Gallego
    Geriatric Research, Education and Clinical Center, Veterans Administration Hospital and Department of Medicine, University of Wisconsin Madison School of Medicine and Public Health, 2500 Highland Avenue, Madison, WI 53705, USA
    Stem Cell Res Ther 1:28. 2010
    ....
  12. doi request reprint The reproductive-cell cycle theory of aging: an update
    Craig S Atwood
    Geriatric Research, Education and Clinical Center, Veterans Administration Hospital and Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
    Exp Gerontol 46:100-7. 2011
    ..In essence, the Reproductive-Cell Cycle Theory can explain aging in all sexually reproductive life forms...
  13. ncbi request reprint Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Curr Drug Targets CNS Neurol Disord 3:281-5. 2004
    ..Therefore, the effects of agents that abolish LH, such as leuprolide acetate, which are currently being evaluated in Phase II clinical trials for the treatment of AD, are eagerly anticipated...
  14. pmc A preliminary study of the safety, feasibility and cognitive efficacy of soy isoflavone supplements in older men and women
    Carey E Gleason
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Madison, WI 53705, USA
    Age Ageing 38:86-93. 2009
    ..Unfortunately, few studies enrolled adults over the age of 70, and none included older men...
  15. ncbi request reprint The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease
    Catherine A Rottkamp
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Peptides 23:1333-41. 2002
    ..Below, we present a brief synopsis of the trial for you, the jury, to decide the verdict. Amyloid-beta: guilty or not-guilty?..
  16. ncbi request reprint Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease
    Cynthia M Carlsson
    Department of Medicine, Section of Geriatrics and Gerontology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    J Alzheimers Dis 13:187-97. 2008
    ..It is unclear if statins modify Abeta metabolism or improve cognition in asymptomatic middle-aged adults at increased risk for AD...
  17. ncbi request reprint Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice
    Gemma Casadesus
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Biochim Biophys Acta 1762:447-52. 2006
    ..Since both cognitive loss and amyloid-beta deposition are features of Alzheimer disease, leuprolide acetate treatment may prove to be a useful therapeutic strategy for this disease...
  18. pmc fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer's disease
    Mehul A Trivedi
    Geriatric Research Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Neuropsychologia 46:1667-78. 2008
    ..These results suggest that FH and aging are exerting independent effects in both tasks while APOE affected the relationship with age in the hippocampus in one of the two tasks given...
  19. ncbi request reprint The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 USA
    Curr Pharm Des 12:691-7. 2006
    ..Therapeutic interventions targeted at gonadotropins, if they are indeed the driving mitogenic force, could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted...
  20. ncbi request reprint The gonadotropin connection in Alzheimer's disease
    Sivan Vadakkadath Meethal
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin Madison, Veterans Administration Hospital, Madison, 53705, USA
    Endocrine 26:317-26. 2005
    ..Clinical trials are underway for the treatment of AD using GnRH analogs and should provide further insights into the gonadotropin connection in AD...
  21. ncbi request reprint Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression
    Andrea C Wilson
    Department of Pathology and Laboratory Medicine, Veterans Administration Hospital, University of Wisconsin, 2500 Overlook Terrace, Madison, Wisconsin 53705, USA
    J Endocrinol 191:651-63. 2006
    ..Post-reproductive surges in GnRH I secretion may explain the accumulation of LH in pyramidal neurons of the aged human and rat...
  22. ncbi request reprint Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence
    Jian Dong
    Department of Biochemistry, School of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA
    Biochemistry 42:2768-73. 2003
    ..The results also reveal a direct chemical basis for oxidative damage caused by amyloid-beta protein in AD...
  23. ncbi request reprint Neuroprotective properties of Bcl-w in Alzheimer disease
    Xiongwei Zhu
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    J Neurochem 89:1233-40. 2004
    ..Taken together, these series of results suggest that Bcl-w may play an important protective role in neurons in the diseased brain and that this aspect could be therapeutically harnessed to afford neuroprotection...
  24. ncbi request reprint Menopause, estrogen, and gonadotropins in Alzheimer's disease
    Gemma Casadesus
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Adv Clin Chem 45:139-53. 2008
    ..Moreover, targeting gonadotropins appears to have beneficial actions as a therapeutic regimen...
  25. pmc Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease
    Sandra L Siedlak
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Free Radic Res 43:156-64. 2009
    ....
  26. pmc Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies
    Robert P Friedland
    Department of Neurology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 283:22550-6. 2008
    ..Immune responses generated from dietary exposure to proteins homologous to Abeta may induce antibodies that could influence the normal physiological processing of the protein and the development or progression of AD...
  27. ncbi request reprint Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?
    Mark A Smith
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Neurochem Int 40:527-31. 2002
    ..However, this rationale may be misguided since new evidence from our laboratories and others suggest that the lesions not only occur as a by-product of the fundamental disease process but also that they may be protective...
  28. ncbi request reprint Amyloid-beta: a chameleon walking in two worlds: a review of the trophic and toxic properties of amyloid-beta
    Craig S Atwood
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Brain Res Brain Res Rev 43:1-16. 2003
    ..ccirf;), leading to enhanced, rather than reduced, neuronal oxidative stress...
  29. ncbi request reprint Amyloid-beta: a (life) preserver for the brain
    Mark E Obrenovich
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Neurobiol Aging 23:1097-9. 2002
  30. ncbi request reprint Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression
    Tianbing Liu
    Department of Medicine, University of Wisconsin Madison, Geriatrics, Research, Education and Clinical Center, Wm S Middleton Memorial Veterans Hospital, 53705, USA
    J Neurochem 88:554-63. 2004
    ..Our results predict that only cells containing appreciable levels of tau are susceptible to Abeta-induced toxicity and may explain why Abeta is more toxic to neurons compared with other cell types...
  31. ncbi request reprint Amyloid-beta: a vascular sealant that protects against hemorrhage?
    Craig S Atwood
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106 USA
    J Neurosci Res 70:356. 2002
  32. ncbi request reprint Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease
    George Perry
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Biometals 16:77-81. 2003
    ....
  33. ncbi request reprint The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications
    George Perry
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    CNS Drugs 16:339-52. 2002
    ..In this article, we examine not only the possible mechanism of disease but also how pharmaceuticals may intervene, from direct and indirect antioxidant therapy to strategies involving gene therapy...
  34. ncbi request reprint The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease
    Gemma Casadesus
    Department of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Drugs R D 7:187-93. 2006
    ....
  35. pmc Identification of a regulatory loop for the synthesis of neurosteroids: a steroidogenic acute regulatory protein-dependent mechanism involving hypothalamic-pituitary-gonadal axis receptors
    Sivan Vadakkadath Meethal
    Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin 53705, USA
    J Neurochem 110:1014-27. 2009
    ..Further delineation of these feedback loops that regulate NSS production will aid in developing therapies to maintain brain sex steroid levels and cognition...
  36. pmc Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells
    Prashob Porayette
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Affairs Hospital, Madison, Wisconsin 53705, USA
    J Biol Chem 284:23806-17. 2009
    ..Together these data suggest that differential processing of AbetaPP is normally required for embryonic neurogenesis...
  37. ncbi request reprint Iron: a pathological mediator of Alzheimer disease?
    Glenda M Bishop
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Dev Neurosci 24:184-7. 2002
    ..Continued examination of the complex interactions that occur between iron and amyloid-beta may assist in the elucidation of the mechanisms that underlie the neurodegeneration that leads to dementia in AD...
  38. ncbi request reprint Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins
    Craig S Atwood
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, OH 44106, USA
    Peptides 23:1343-50. 2002
    ....
  39. ncbi request reprint Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?
    George Perry
    Institute of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
    Free Radic Biol Med 33:1475-9. 2002
    ..Although much data remain to be collected, the broad spectrum of changes found in AD are only seen, albeit to a lesser extent, in normal aging with other neurodegenerative diseases showing distinct spectrums of change...
  40. doi request reprint Reproductive hormones regulate the selective permeability of the blood-brain barrier
    Andrea C Wilson
    Department of Medicine, University of Wisconsin Madison and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, 2500 Overlook Terrace, Madison, WI 53705 USA
    Biochim Biophys Acta 1782:401-7. 2008
    ..Furthermore, these findings implicate Cx43 in mediating changes in BBB permeability, and serum gonadotropins in the cerebropathophysiology of age-related neurodegenerative diseases such as stroke and Alzheimer's disease...
  41. ncbi request reprint Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Rd, Cleveland, OH 44106, USA
    Ann N Y Acad Sci 1052:201-9. 2005
    ..On this basis, we suggest that the results of the WHI Memory Study are not only predictable but also avoidable by therapeutically targeting the gonadotropins instead of the sex steroids...
  42. ncbi request reprint Luteinizing hormone receptor mediates neuronal pregnenolone production via up-regulation of steroidogenic acute regulatory protein expression
    Tianbing Liu
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Neurochem 100:1329-39. 2007
    ....
  43. ncbi request reprint Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain
    John K Wung
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Curr Alzheimer Res 4:67-72. 2007
    ....
  44. ncbi request reprint Gonadotropins: a cohesive gender-based etiology of Alzheimer disease
    Kate M Webber
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Mol Cell Endocrinol 260:271-5. 2007
    ..In this review, we examine how the gonadotropins may play a central and determining role in modulating the susceptibility to, and progression of, Alzheimer disease...
  45. ncbi request reprint Gonadotropins and Alzheimer's disease: the link between estrogen replacement therapy and neuroprotection
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, 2085 Adelbert Road, Cleveland, Ohio 44106, USA
    Acta Neurobiol Exp (Wars) 64:113-8. 2004
    ..Based on this, we suggest that therapeutic interventions targeted at gonadotropins could both prevent disease in those patients currently asymptomatic or halt, and even reverse, disease in those currently afflicted...
  46. ncbi request reprint Pennington scientific symposium on mechanisms and retardation of aging
    Craig S Atwood
    Section of Geriatrics and Gerontology, University of Wisconsin Medical School, Madison, WI, USA
    Exp Gerontol 38:1217-26. 2003
  47. ncbi request reprint Amyloid-beta precursor protein expression and modulation in human embryonic stem cells: a novel role for human chorionic gonadotropin
    Prashob Porayette
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin and Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, WI 53705, USA
    Biochem Biophys Res Commun 364:522-7. 2007
    ....
  48. ncbi request reprint Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia
    Glenda M Bishop
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, USA
    Redox Rep 12:257-66. 2007
    ..Together, these results indicate that there is a tighter regulation of iron metabolism in the brain than the liver, which limits the redistribution of Fe3+ following hypoxia...
  49. ncbi request reprint Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis
    Kate M Webber
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Alzheimer Dis Assoc Disord 19:95-9. 2005
    ..Based on this, we suggest that therapeutic interventions targeted at gonadotropins may both prevent disease in those patients currently asymptomatic or may halt, and even reverse, disease in those currently afflicted...
  50. pmc Activin receptor signaling regulates prostatic epithelial cell adhesion and viability
    Derek P Simon
    Section of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin, Veterans Administration Hospital, Madison, WI 53705, USA
    Neoplasia 11:365-76. 2009
    ..That ActRII signaling governs both cell viability and cell adhesion has important implications for developing therapeutic strategies to regulate cancer growth and metastasis...

Research Grants3

  1. Antiapoptotic Activity of Alzheimer Abeta
    Craig Atwood; Fiscal Year: 2003
    ..We also will test whether oxidative stress induces neurons to re-enter the cell cycle as a mechanism leading to cell death. ..