ALAN ATTIE

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation
    Tomas Babak
    Rosetta Inpharmatics, LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    BMC Genomics 11:473. 2010
  2. doi request reprint Gene co-expression modules and type 2 diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Results Probl Cell Differ 52:47-56. 2010
  3. pmc Defending science education against intelligent design: a call to action
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706 1544, USA
    J Clin Invest 116:1134-8. 2006
  4. pmc Insig: a significant integrator of nutrient and hormonal signals
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Clin Invest 113:1112-4. 2004
  5. ncbi request reprint ABCA1: at the nexus of cholesterol, HDL and atherosclerosis
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Trends Biochem Sci 32:172-9. 2007
  6. ncbi request reprint Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
  7. ncbi request reprint Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken
    Alan D Attie
    Departments of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Lipid Res 43:1610-7. 2002
  8. ncbi request reprint Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Nutr Rev 65:S35-8. 2007
  9. ncbi request reprint Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
  10. ncbi request reprint Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    Novartis Found Symp 286:47-53; discussion 54-7, 162-3, 196-203. 2007

Research Grants

  1. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2006
  2. Genetics of Obesity and Diabetes
    ALAN ATTIE; Fiscal Year: 2005
  3. The Genetics of Obesity and Diabetes
    ALAN ATTIE; Fiscal Year: 2007
  4. The Genetics of Obesity and Diabetes
    ALAN ATTIE; Fiscal Year: 2009
  5. Genes and Gene Networks Associated with Obesity and Diabetes
    Alan D Attie; Fiscal Year: 2010
  6. The Genetics of Obesity and Diabetes
    Alan D Attie; Fiscal Year: 2010
  7. Genetic Mapping / Beta-cell Decomposition in Type 2 Diabetes
    Alan D Attie; Fiscal Year: 2010
  8. PLASMA LIPOPROTEIN ASSEMBLY AND SECRETION
    ALAN ATTIE; Fiscal Year: 2001
  9. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2003
  10. Genes and Gene Networks Associated with Obesity and Diabetes
    Alan D Attie; Fiscal Year: 2011

Collaborators

Detail Information

Publications53

  1. pmc Genetic validation of whole-transcriptome sequencing for mapping expression affected by cis-regulatory variation
    Tomas Babak
    Rosetta Inpharmatics, LLC, 401 Terry Ave N, Seattle, WA 98109, USA
    BMC Genomics 11:473. 2010
    ....
  2. doi request reprint Gene co-expression modules and type 2 diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Results Probl Cell Differ 52:47-56. 2010
    ..e., expression quantitative trait loci. We have used these data to generate network models, which incorporate gene loci, mRNA abundance, and other phenotypes. One of these networks is involved in the regulation of β-cell proliferation...
  3. pmc Defending science education against intelligent design: a call to action
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706 1544, USA
    J Clin Invest 116:1134-8. 2006
    ..Finally, we provide some model legislation that has been introduced in Wisconsin to strengthen the teaching of science...
  4. pmc Insig: a significant integrator of nutrient and hormonal signals
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Clin Invest 113:1112-4. 2004
    ..A new study shows one way in which sterol and insulin regulation can be decoupled. In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin...
  5. ncbi request reprint ABCA1: at the nexus of cholesterol, HDL and atherosclerosis
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Trends Biochem Sci 32:172-9. 2007
    ..In the arterial wall, excess cholesterol in macrophages is associated with atherosclerosis; here, ABCA1 is anti-atherogenic because it enables macrophages to rid themselves of excess cholesterol...
  6. ncbi request reprint Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 43:1899-907. 2002
    ..We propose that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity...
  7. ncbi request reprint Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken
    Alan D Attie
    Departments of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    J Lipid Res 43:1610-7. 2002
    ..The WHAM chicken is a naturally occurring animal model for Tangier Disease...
  8. ncbi request reprint Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Nutr Rev 65:S35-8. 2007
    ..We also found that the Scd1(-/-) mice on a normal chow diet had dramatically improved insulin sensitivity. However, leptin(ob/ob) Scd1(-/-) mice had worse diabetes than leptin(ob/ob) Scd1(wt/wt) mice...
  9. ncbi request reprint Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
    ..Therefore, endogenous MUFA synthesis is essential during dietary unsaturated fat insufficiency and influences the dietary requirement of PUFA...
  10. ncbi request reprint Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    Novartis Found Symp 286:47-53; discussion 54-7, 162-3, 196-203. 2007
    ..But, surprisingly, leptin(ob/ob) Scd1(-/-) mice had worse diabetes than leptin(ob/ob) Scd1(wt/wt) mice. Thus, despite its effects on insulin sensitivity, Scdl deficiency worsens diabetes in leptin-deficient obese mice...
  11. ncbi request reprint Gene expression profiles of nondiabetic and diabetic obese mice suggest a role of hepatic lipogenic capacity in diabetes susceptibility
    Hong Lan
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Diabetes 52:688-700. 2003
    ..We propose that increased hepatic lipogenic capacity protects the B6-ob/ob mice from the development of type 2 diabetes...
  12. pmc Obesity and genetics regulate microRNAs in islets, liver, and adipose of diabetic mice
    Enpeng Zhao
    Biochemistry Department, University of Wisconsin, Madison, WI 53706, USA
    Mamm Genome 20:476-85. 2009
    ..Understanding the influence that obesity and genetics exert on the regulation of miRNA expression will reveal the role miRNAs play in the context of obesity-induced type 2 diabetes...
  13. pmc A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
    Mark P Keller
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53076, USA
    Genome Res 18:706-16. 2008
    ....
  14. ncbi request reprint Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice
    Mary E Rabaglia
    Dept of Biochemistry, Univ of Wisconsin Madison, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 289:E218-24. 2005
    ..However, succinate does not stimulate insulin secretion in mouse islets. Our data suggest that alpha-ketoglutarate may directly stimulate insulin secretion and that increased formation of alpha-ketoglutarate leads to hyperinsulinemia...
  15. ncbi request reprint Increased insulin translation from an insulin splice-variant overexpressed in diabetes, obesity, and insulin resistance
    Alexandra H Minn
    Department of Medicine, University of Wisconsin Madison, H4 526 Clinical Science Center, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Mol Endocrinol 19:794-803. 2005
    ..This raises the possibility that the mSPV may represent a compensatory beta-cell mechanism to enhance insulin biosynthesis when insulin requirements are elevated by hyperglycemia/insulin resistance...
  16. doi request reprint Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Physiol Genomics 33:361-72. 2008
    ....
  17. ncbi request reprint Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    Jessica B Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 537606, USA
    Diabetes 56:1228-39. 2007
    ..Therefore, although loss of Scd1 has beneficial effects on adiposity, this benefit may come at the expense of beta-cells, resulting in an increased risk of diabetes...
  18. ncbi request reprint ABCA1 is essential for efficient basolateral cholesterol efflux during the absorption of dietary cholesterol in chickens
    Jacob D Mulligan
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 278:13356-66. 2003
    ..0- and 4.4-fold, respectively), whereas biliary lipid concentrations were unaltered by the WHAM mutation. In summary, ABCA1 regulates the efflux of cholesterol from the basolateral but not apical membrane in the intestine and the liver...
  19. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage...
  20. ncbi request reprint Abdominal obesity in BTBR male mice is associated with peripheral but not hepatic insulin resistance
    Jessica B Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 292:E936-45. 2007
    ..These studies reveal a genetic difference in body composition that correlates with large differences in peripheral insulin sensitivity...
  21. pmc Combined expression trait correlations and expression quantitative trait locus mapping
    Hong Lan
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, USA
    PLoS Genet 2:e6. 2006
    ..The combined analysis is more sensitive compared with linkage mapping alone...
  22. pmc Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival
    Jeremy A Lavine
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Endocrinology 151:3577-88. 2010
    ..In summary, CCK is up-regulated by islet cells during obesity and functions as a paracrine or autocrine factor to increase beta-cell survival and expand beta-cell mass to compensate for obesity-induced insulin resistance...
  23. ncbi request reprint Genetic and genomic studies of the BTBR ob/ob mouse model of type 2 diabetes
    Susanne M Clee
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Am J Ther 12:491-8. 2005
    ..Conversely, hepatic lipogenic gene expression increases in obese mice, but to a much greater extent in the diabetes-resistant C57BL/6 strain. We propose that hepatic lipogenic capacity affects susceptibility to obesity-induced diabetes...
  24. pmc FoxM1 is up-regulated by obesity and stimulates beta-cell proliferation
    Dawn Belt Davis
    Department of Medicine, University of Wisconsin, Madison, WI, USA
    Mol Endocrinol 24:1822-34. 2010
    ..Our data suggest that beta-cell proliferation occurs in adult obese humans in an attempt to expand beta-cell mass to compensate for insulin resistance, and that the FoxM1 transcriptional program plays a key role in this process...
  25. pmc Adipocyte metabolism and obesity
    Alan D Attie
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    J Lipid Res 50:S395-9. 2009
    ..We discuss the role of adipose tissue inflammation in adipocyte metabolism and whole-body insulin sensitivity. Finally, we mention the role of adipokines in autocrine and paracrine signaling...
  26. pmc Dimension reduction for mapping mRNA abundance as quantitative traits
    Hong Lan
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, WI 53706, USA
    Genetics 164:1607-14. 2003
    ..As a further statistical refinement, we show that principal component analysis also effectively reduced dimensions for mapping phenotypes composed of mRNA abundances...
  27. ncbi request reprint Dual regulation of the LDL receptor--some clarity and new questions
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Cell Metab 1:290-2. 2005
    ..While the mRNA expression of the LDLR and the newly studied proprotein convertase PCSK9 are coordinately upregulated in absence of sterols, the latter proteinase apparently enhances the degradation of the LDLR protein...
  28. pmc Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function
    Jeremy A Lavine
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Mol Endocrinol 22:2716-28. 2008
    ..CCK triggers beta-cell proliferation without disrupting islet function, up-regulates a distinct set of cell cycle regulators in islets, and signals independently of the CCK receptors...
  29. pmc Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes
    Junqin Chen
    Department of Medicine, University of Wisconsin, Madison, Wisconsin 53792, USA
    FASEB J 22:3581-94. 2008
    ..These results suggest that lowering beta-cell TXNIP expression could serve as a novel strategy for the treatment of type 1 and type 2 diabetes by promoting endogenous beta-cell survival...
  30. doi request reprint Physiological insights gained from gene expression analysis in obesity and diabetes
    Mark P Keller
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706 1544, USA
    Annu Rev Nutr 30:341-64. 2010
    ..When combined with genetic information, microarray data can be used to construct causal network models linking gene expression with disease...
  31. ncbi request reprint Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus
    Susanne M Clee
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nat Genet 38:688-93. 2006
    ..Our identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus...
  32. pmc Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB
    Daniel A Blasiole
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Biol Chem 283:11374-81. 2008
    ..Furthermore, the reuptake mechanism of degradation occurs via internalization of apoB through a constitutive endocytic pathway and apoE through a ligand-dependent pathway...
  33. pmc Inferring causal phenotype networks from segregating populations
    Elias Chaibub Neto
    Department of Statistics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 179:1089-100. 2008
    ..Finally, we illustrate our method with an example involving gene expression and metabolite traits from experimental crosses...
  34. pmc Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note
    Jeremy A Lavine
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin, USA
    Mol Endocrinol 24:464-7. 2010
    ....
  35. pmc Selective phenotyping for increased efficiency in genetic mapping studies
    Chunfang Jin
    Department of Statistics, University of Wisconsin, Madison, Wisconsin 53706, USA
    Genetics 168:2285-93. 2004
    ..The substantial improvement introduced by selective phenotyping is particularly useful when phenotyping is difficult or costly and thus limits the sample size in a genetic mapping study...
  36. ncbi request reprint The physiological and molecular regulation of lipoprotein assembly and secretion
    Daniel A Blasiole
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Mol Biosyst 3:608-19. 2007
    ..We selectively review recently-identified machinery, such as transcription factors and nuclear hormone receptors, which provide new clues to the regulation of lipoprotein secretion...
  37. pmc Endoplasmic reticulum localization of the low density lipoprotein receptor mediates presecretory degradation of apolipoprotein B
    Donald L Gillian-Daniel
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706 1544, USA
    Proc Natl Acad Sci U S A 99:4337-42. 2002
    ..The LDLR provides an example of a receptor that modulates export of its ligand from the ER...
  38. ncbi request reprint Distinguishing covariation from causation in diabetes: a lesson from the protein disulfide isomerase mRNA abundance trait
    Hong Lan
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Diabetes 53:240-4. 2004
    ..Genetic analysis is a powerful tool for distinguishing covariation from causation in expression array studies of disease traits...
  39. pmc The role of blood vessels, endothelial cells, and vascular pericytes in insulin secretion and peripheral insulin action
    Oliver C Richards
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Endocr Rev 31:343-63. 2010
    ..Here, we review the role of the vasculature in insulin secretion, islet function, and peripheral insulin delivery, and highlight a potential role for the vascular pericyte in these processes...
  40. ncbi request reprint The genetic landscape of type 2 diabetes in mice
    Susanne M Clee
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, Wisconsin 53706 1544, USA
    Endocr Rev 28:48-83. 2007
    ....
  41. ncbi request reprint Identification of major quantitative trait loci controlling body weight variation in ob/ob mice
    Jonathan P Stoehr
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Diabetes 53:245-9. 2004
    ..Thus, the identification of these loci may provide important new insights into the pathogenesis of human obesity...
  42. doi request reprint Gastrointestinal hormones and the regulation of β-cell mass
    Jeremy A Lavine
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI 53706, USA
    Ann N Y Acad Sci 1212:41-58. 2010
    ..Gastrointestinal hormones integrate nutrient signals from the gut to the β-cell, regulating insulin secretion and β-cell mass adaptation...
  43. ncbi request reprint High-maintenance proteins and hypertriglyceridemia
    Alan D Attie
    Nat Genet 39:1424-5. 2007
  44. ncbi request reprint The cellular trafficking of the secretory proprotein convertase PCSK9 and its dependence on the LDLR
    Nasha Nassoury
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
    Traffic 8:718-32. 2007
    ..Mutations that affect this transport can lead to hyper- or hypocholesterolemia...
  45. pmc Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling
    Christine T Ferrara
    Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS Genet 4:e1000034. 2008
    ..Thus, the methods described here have the potential to reveal regulatory networks that contribute to chronic, complex, and highly prevalent diseases and conditions such as obesity and diabetes...
  46. ncbi request reprint NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
    Suzanne Benjannet
    Laboratory of Biochemical Neuroendocrinology, Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 279:48865-75. 2004
    ..In conclusion, NARC-1 seems to affect both the level of LDLR and that of circulating apoB-containing lipoproteins in an LDLR-dependent and -independent fashion...
  47. ncbi request reprint The mystery of PCSK9
    Alan D Attie
    Arterioscler Thromb Vasc Biol 24:1337-9. 2004
  48. ncbi request reprint Mice lacking thioredoxin-interacting protein provide evidence linking cellular redox state to appropriate response to nutritional signals
    To Yuen Hui
    Mammalian Cell and Molecular Biology Laboratory, Department of Biology, Molecular Biology Institute and Heart Institute, San Diego State University, San Diego, California 92182, USA
    J Biol Chem 279:24387-93. 2004
    ..Our findings implicate Txnip-modulated sulfhydryl redox as a central regulator of insulin secretion in beta-cells and regulation of many of the branch-points of gluconeogenesis/glycolysis/lipogenesis...
  49. ncbi request reprint SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Blvd, Becker B 131, Los Angeles, CA 90048, USA
    Diabetes 56:1922-9. 2007
    ..Thus, we sought to determine whether variation in the human SORCS1 gene was associated with diabetes-related traits...
  50. ncbi request reprint PGC-1alpha at the crossroads of type 2 diabetes
    Alan D Attie
    Nat Genet 34:244-5. 2003
  51. ncbi request reprint Thioredoxin-interacting protein deficiency disrupts the fasting-feeding metabolic transition
    Sonal S Sheth
    Department of Human Genetics, Medicine, Molecular Biology Institute, University of California, Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    J Lipid Res 46:123-34. 2005
    ..These results indicate a role for Txnip in the metabolic response to feeding and the maintenance of the redox status...
  52. ncbi request reprint A liver-high-density lipoprotein-ovarian axis of fertility
    Alan D Attie
    Endocrinology 147:1575-6. 2006
  53. pmc Metabolic syndrome: from epidemiology to systems biology
    Aldons J Lusis
    Department of Medicine and Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Genet 9:819-30. 2008
    ..Systems-based approaches that integrate genomic, molecular and physiological data are complementing traditional genetic and biochemical approaches to more fully address the complexity of MetSyn...

Research Grants28

  1. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2006
    ..This will enable us to differentiate between an interaction with apoB early in the secretory pathway and an interaction that occurs after apoB secretion leading to re-uptake of the lipoprotein particles. ..
  2. Genetics of Obesity and Diabetes
    ALAN ATTIE; Fiscal Year: 2005
    ..Identification of obesity and diabetes susceptibility genes will provide clues to novel pathways and biochemical mechanisms underlying complex disease problems. ..
  3. The Genetics of Obesity and Diabetes
    ALAN ATTIE; Fiscal Year: 2007
    ..We shall identify genetic variants of the SorCS1 gene in our two Mexican-American cohorts and test these variants for binding to several ligands and for their ability to promote angiogenesis in vitro. ..
  4. The Genetics of Obesity and Diabetes
    ALAN ATTIE; Fiscal Year: 2009
    ..We shall identify genetic variants of the SorCS1 gene in our two Mexican-American cohorts and test these variants for binding to several ligands and for their ability to promote angiogenesis in vitro. ..
  5. Genes and Gene Networks Associated with Obesity and Diabetes
    Alan D Attie; Fiscal Year: 2010
    ..Our research will help to understand how some, but not all obese people become diabetic and perhaps develop biomarkers to identify individuals at greatest risk for developing diabetes. ..
  6. The Genetics of Obesity and Diabetes
    Alan D Attie; Fiscal Year: 2010
    ..We shall identify genetic variants of the SorCS1 gene in our two Mexican-American cohorts and test these variants for binding to several ligands and for their ability to promote angiogenesis in vitro. ..
  7. Genetic Mapping / Beta-cell Decomposition in Type 2 Diabetes
    Alan D Attie; Fiscal Year: 2010
    ..abstract_text> ..
  8. PLASMA LIPOPROTEIN ASSEMBLY AND SECRETION
    ALAN ATTIE; Fiscal Year: 2001
    ....
  9. Regulation of Apolipoprotein B Secretion
    ALAN ATTIE; Fiscal Year: 2003
    ..This will enable us to differentiate between an interaction with apoB early in the secretory pathway and an interaction that occurs after apoB secretion leading to re-uptake of the lipoprotein particles. ..
  10. Genes and Gene Networks Associated with Obesity and Diabetes
    Alan D Attie; Fiscal Year: 2011
    ..Our research will help to understand how some, but not all obese people become diabetic and perhaps develop biomarkers to identify individuals at greatest risk for developing diabetes. ..