Mark Atkinson

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment
    Lindsey Bierschenk
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Diabetes Care 32:1977-9. 2009
  2. pmc Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice
    Matthew J Parker
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Diabetes 58:2277-84. 2009
  3. pmc Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation
    Todd M Brusko
    Department of Pathology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 4:e7980. 2009
  4. pmc Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes
    Dustin Blanton
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Diabetes 60:2566-70. 2011
  5. doi request reprint Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora's box
    Mark A Atkinson
    Department of Pathology, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610 0275, USA
    Diabetologia 57:656-9. 2014
  6. doi request reprint Type 1 diabetes
    Mark A Atkinson
    Department of Pathology and Department of Pediatrics, University of Florida, Gainesville, FL, USA Electronic address
    Lancet 383:69-82. 2014
  7. pmc Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease
    M A Atkinson
    Department of Pathology, University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610 0275, USA
    Diabetologia 55:2868-77. 2012
  8. pmc The pancreas in human type 1 diabetes
    Patrick A Rowe
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Semin Immunopathol 33:29-43. 2011
  9. pmc Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 9:21. 2011
  10. ncbi request reprint ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?
    Mark A Atkinson
    Department of Pathology, College of Medicine, University of Florida, ARB R3 128, 1600 SW Archer Rd, Gainesville, FL 32610 0275, USA
    Diabetes 54:1253-63. 2005

Research Grants

Detail Information

Publications94

  1. pmc Vitamin D levels in subjects with and without type 1 diabetes residing in a solar rich environment
    Lindsey Bierschenk
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Diabetes Care 32:1977-9. 2009
    ..Previous studies, largely in northern Europe, have suggested an association between type 1 diabetes and reduced serum 25-hydroxy(OH) vitamin D levels, a concept we tested in individuals residing in a solar-rich region (Florida)...
  2. pmc Immune depletion with cellular mobilization imparts immunoregulation and reverses autoimmune diabetes in nonobese diabetic mice
    Matthew J Parker
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Diabetes 58:2277-84. 2009
    ....
  3. pmc Influence of membrane CD25 stability on T lymphocyte activity: implications for immunoregulation
    Todd M Brusko
    Department of Pathology, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 4:e7980. 2009
    ..However, the functional impact of CD25 cleavage, as well as the influence of sCD25 on immunoregulatory activities, remain largely unknown and form the basis of this effort...
  4. pmc Reduced serum vitamin D-binding protein levels are associated with type 1 diabetes
    Dustin Blanton
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    Diabetes 60:2566-70. 2011
    ..Here, we examined whether serum levels or genotypes of the vitamin D-binding protein (VDBP), a molecule key to the biologic actions of vitamin D, specifically associate with the disorder...
  5. doi request reprint Pancreatic biopsies in type 1 diabetes: revisiting the myth of Pandora's box
    Mark A Atkinson
    Department of Pathology, College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL, 32610 0275, USA
    Diabetologia 57:656-9. 2014
    ....
  6. doi request reprint Type 1 diabetes
    Mark A Atkinson
    Department of Pathology and Department of Pediatrics, University of Florida, Gainesville, FL, USA Electronic address
    Lancet 383:69-82. 2014
    ..This Seminar discusses current progress in epidemiology, pathology, diagnosis, and treatment of type 1 diabetes, and prospects for an improved future for individuals with this disease. ..
  7. pmc Does the gut microbiota have a role in type 1 diabetes? Early evidence from humans and animal models of the disease
    M A Atkinson
    Department of Pathology, University of Florida, College of Medicine, 1600 SW Archer Road, Gainesville, FL 32610 0275, USA
    Diabetologia 55:2868-77. 2012
    ....
  8. pmc The pancreas in human type 1 diabetes
    Patrick A Rowe
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Semin Immunopathol 33:29-43. 2011
    ..An improved understanding and appreciation for pancreatic pathology in T1D could lead to improved disease classification, an understanding of why the disorder occurs, and better therapies for disease prevention and management...
  9. pmc Alpha-1 antitrypsin protein and gene therapies decrease autoimmunity and delay arthritis development in mouse model
    Christian Grimstein
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 9:21. 2011
    ..In the present study we investigated the feasibility of hAAT monotherapy for the treatment of chronic arthritis in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA)...
  10. ncbi request reprint ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?
    Mark A Atkinson
    Department of Pathology, College of Medicine, University of Florida, ARB R3 128, 1600 SW Archer Rd, Gainesville, FL 32610 0275, USA
    Diabetes 54:1253-63. 2005
    ....
  11. ncbi request reprint Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet?
    M A Atkinson
    Department of Pathology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Diabetologia 48:2200-2. 2005
  12. ncbi request reprint The pancreas in human type 1 diabetes: providing new answers to age-old questions
    Mark A Atkinson
    Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, Florida 32610, USA
    Curr Opin Endocrinol Diabetes Obes 16:279-85. 2009
    ....
  13. ncbi request reprint Type 1 diabetes: new perspectives on disease pathogenesis and treatment
    M A Atkinson
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Lancet 358:221-9. 2001
    ..We focus this seminar on these changing views, and offer a new perspective on our understanding of the pathogenesis of type 1 diabetes and on principles for therapeutic management of patients with this disorder...
  14. ncbi request reprint Evaluating preclinical efficacy
    Mark A Atkinson
    Department of Pathology, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Sci Transl Med 3:96cm22. 2011
    ..This Commentary explores the need for standards in evaluating therapeutic efficacy in preclinical models of T1D...
  15. pmc Fatal attraction: chemokines and type 1 diabetes
    Mark A Atkinson
    Department of Pathology, University of Florida, Gainesville, Florida, USA
    J Clin Invest 110:1611-3. 2002
  16. ncbi request reprint Alpha1-antitrypsin protects beta-cells from apoptosis
    Bin Zhang
    Department of Pharmaceutics, University of Florida, Gainsville, FL 32610, USA
    Diabetes 56:1316-23. 2007
    ..These results propose a novel biological function for this molecule and suggest it may represent an effective candidate for attempts seeking to prevent or reverse type 1 diabetes...
  17. ncbi request reprint Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice
    Yuanqing Lu
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 17:625-34. 2006
    ..These results strongly suggest that rAAV1-mediated AAT gene therapy may be useful as a novel approach to prevent type 1 diabetes...
  18. ncbi request reprint No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes
    Todd Brusko
    Department of Pathology, College of Medicine, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610 0275, USA
    Diabetes 56:604-12. 2007
    ....
  19. ncbi request reprint Cystic fibrosis transmembrane conductance regulator deficiency exacerbates islet cell dysfunction after beta-cell injury
    Michael S Stalvey
    Department of Pathology, University of Florida, College of Medicine, PO Box 100275, Gainesville, FL 32610, USA
    Diabetes 55:1939-45. 2006
    ..These studies suggest metabolic derangements in CFRD originate from an islet dysfunction inherent to the CFTR(-/-) state...
  20. ncbi request reprint Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus--a new surrogate measure of non-progression?
    Desmond Schatz
    Department of Pediatrics, University of Florida, Gainesville, 32610, USA
    Pediatr Diabetes 5:72-9. 2004
    ..However, preservation of C-peptide production in the prediabetic period appears to indicate non-progression to clinical disease and may serve as a new surrogate for determining response to preventative efforts...
  21. pmc Persistent STAT5 phosphorylation and epigenetic dysregulation of GM-CSF and PGS2/COX2 expression in Type 1 diabetic human monocytes
    Erin Garrigan
    Department of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 8:e76919. 2013
    ..These findings suggest that the persistent activation of STAT5 by GM-CSF may be involved in altering the epigenetic regulation of these inflammatory response genes in T1D monocytes...
  22. pmc Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and granulocyte-macrophage colony-stimulating factor overproduction
    Sally A Litherland
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Immunol 175:4561-5. 2005
    ..1 and Idd4.2 loci. Idd4.3 encodes an abundance of cytokine genes that use STAT5 in their macrophage activation signaling and contributes approximately 50% of the NOD.LC11 resistance to diabetes...
  23. ncbi request reprint Adiponectin and leptin concentrations may aid in discriminating disease forms in children and adolescents with type 1 and type 2 diabetes
    Alba Morales
    Department of Pediatrics, University of Florida, Gainsville, Florida 32610 0275, USA
    Diabetes Care 27:2010-4. 2004
    ....
  24. doi request reprint Tyrphostin AG490 agent modestly but significantly prevents onset of type 1 in NOD mouse; implication of immunologic and metabolic effects of a Jak-Stat pathway inhibitor
    Abdoreza Davoodi-Semiromi
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, Gainesville, FL, USA
    J Clin Immunol 32:1038-47. 2012
    ....
  25. ncbi request reprint Treg in type 1 diabetes
    Todd Brusko
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL, USA
    Cell Biochem Biophys 48:165-75. 2007
    ..In addition, we hope to highlight the need for expanded studies that address specific knowledge gaps regarding the cellular and molecular mechanism(s) related to the frequency and function of Treg...
  26. ncbi request reprint The pivotal role of VEGF on glomerular macrophage infiltration in advanced diabetic nephropathy
    Waichi Sato
    Division of Nephrology, Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
    Lab Invest 88:949-61. 2008
    ..In summary, NO negatively regulates VEGF-induced macrophage migration by inhibiting Flt-1 expression. The VEGF-endothelial NO uncoupling pathway might partially explain how VEGF causes glomerular disease in diabetes...
  27. ncbi request reprint Adeno-associated virus transduction of islets with interleukin-4 results in impaired metabolic function in syngeneic marginal islet mass transplantation
    Y Clare Zhang
    Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Transplantation 74:1184-6. 2002
    ..Islet expression of IL-4 led to impaired metabolic function in mice receiving a marginal mass of syngeneic islets...
  28. doi request reprint Exendin-4 treatment of nonobese diabetic mice increases beta-cell proliferation and fractional insulin reactive area
    Song Xue
    Department of Pathology, University of Florida, Gainesville, FL 32610, USA
    J Diabetes Complications 24:163-7. 2010
    ....
  29. pmc Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice
    Tomoki Kosugi
    Division of Nephrology, University of Florida, Gainesville, Florida, USA
    Am J Pathol 174:1221-9. 2009
    ..This study could provide insights into the pathogenesis of advanced diabetic nephropathy in the presence of endothelial dysfunction...
  30. ncbi request reprint Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion
    Kevin S Goudy
    Department of Pathology, Powell Gene Therapy Center, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610, USA
    J Immunol 171:2270-8. 2003
    ..This study indicates the potential for immunomodulatory gene therapy to prevent autoimmune diseases, including type 1 diabetes, and implicates IL-10 as a molecule capable of increasing the percentages of regulatory cells in vivo...
  31. ncbi request reprint Changes in intestinal morphology and permeability in the biobreeding rat before the onset of type 1 diabetes
    Josef Neu
    Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
    J Pediatr Gastroenterol Nutr 40:589-95. 2005
    ..In these studies, we examined both the physical and functional permeability characteristics of the small intestine in diabetes-prone and control rats...
  32. ncbi request reprint Radial artery tonometry demonstrates arterial stiffness in children with type 1 diabetes
    Michael J Haller
    Pediatric Endocrinology, P O Box 100296, Gainesville, FL 32610, USA
    Diabetes Care 27:2911-7. 2004
    ..To determine if children with type 1 diabetes have increased arterial stiffness by estimating augmentation index with the simple noninvasive technique of radial artery tonometry...
  33. ncbi request reprint Diabetic endothelial nitric oxide synthase knockout mice develop advanced diabetic nephropathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610 0224, USA
    J Am Soc Nephrol 18:539-50. 2007
    ..It was postulated that endothelial dysfunction should predict nephropathy and that correction of the dysfunction may prevent these important complications...
  34. pmc Efforts to prevent and halt autoimmune beta cell destruction
    Michael J Haller
    Division of Endocrinology, Department of Pediatrics, University of Florida, PO Box 100296, Gainesville, FL 32610, USA
    Endocrinol Metab Clin North Am 39:527-39. 2010
    ....
  35. ncbi request reprint Changes in hippocampal IL-15, related cytokines, and neurogenesis in IL-2 deficient mice
    Ray D Beck
    McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA
    Brain Res 1041:223-30. 2005
    ....
  36. ncbi request reprint Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice
    Y Clare Zhang
    Department of Pathology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0275, USA
    Diabetes 52:708-16. 2003
    ..These studies support the utility of immunoregulatory cytokine gene therapy delivered by rAAV for preventing autoimmune disease recurrence in transplant-based therapies for type 1 diabetes...
  37. pmc MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Matthew J Delano
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 204:1463-74. 2007
    ..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
  38. pmc Autologous umbilical cord blood infusion for type 1 diabetes
    Michael J Haller
    Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Exp Hematol 36:710-5. 2008
    ..Herein, we describe the scientific and therapeutic rationale underlying efforts utilizing umbilical cord blood (UCB) as a therapy for ameliorating the progression of this autoimmune disease...
  39. ncbi request reprint Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts
    Scott A Loiler
    Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    Mol Ther 12:519-27. 2005
    ..This study demonstrates that rAAV vectors can be designed to deliver therapeutic genes efficiently to the pancreas and achieve high levels of gene expression and may be useful in treating pancreatic disorders, including T1D...
  40. pmc Autologous umbilical cord blood transfusion in very young children with type 1 diabetes
    Michael J Haller
    Department of Pediatrics, The University of Florida, Gainesville, Florida, USA
    Diabetes Care 32:2041-6. 2009
    ..We conducted an open-label phase I study using autologous umbilical cord blood infusion to ameliorate type 1 diabetes...
  41. ncbi request reprint The road not taken: a path to curing type 1 diabetes?
    Michael J Haller
    Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
    Eur J Immunol 39:2054-8. 2009
    ....
  42. ncbi request reprint Uncoupling of vascular endothelial growth factor with nitric oxide as a mechanism for diabetic vasculopathy
    Takahiko Nakagawa
    Division of Nephrology, Hypertension and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610, USA
    J Am Soc Nephrol 17:736-45. 2006
    ..These results may provide new insights into the understanding of the mechanism of diabetic vascular disease...
  43. pmc Hepatocellular carcinoma immunopathogenesis: clinical evidence for global T cell defects and an immunomodulatory role for soluble CD25 (sCD25)
    Roniel Cabrera
    Section of Hepatobiliary Diseases, Department of Medicine, University of Florida, 1600 SW Archer Rd, PO Box 100214, Gainesville, FL 32610 0214, USA
    Dig Dis Sci 55:484-95. 2010
    ..The mechanisms involved in hepatocellular carcinoma (HCC) establishing an immunologically tolerogenic tumor environment remain poorly characterized...
  44. ncbi request reprint IL-10 regulation of lupus in the NZM2410 murine model
    Kim R M Blenman
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL 32601 0275, USA
    Lab Invest 86:1136-48. 2006
    ..These results also reinforce the notion that IL-10 exerts multiple functions and commend caution in equating high levels of IL-10 and increased pathogenesis in systemic autoimmunity...
  45. pmc T regulatory cell function in idiopathic minimal lesion nephrotic syndrome
    Carlos Araya
    Department of Pediatrics, Division of Pediatric Nephrology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610 0296, USA
    Pediatr Nephrol 24:1691-8. 2009
    ..The impaired T reg cell function observed in these patients may have pathogenic and therapeutic implications, because it could explain the persistence of the proposed pathogenic cytokines observed in the patients with IMLNS...
  46. pmc The tyrphostin agent AG490 prevents and reverses type 1 diabetes in NOD mice
    Abdoreza Davoodi-Semiromi
    Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 7:e36079. 2012
    ..However, the therapeutic effects of AG490 on the development of T1D are unknown...
  47. pmc Network for Pancreatic Organ Donors with Diabetes (nPOD): developing a tissue biobank for type 1 diabetes
    Martha Campbell-Thompson
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0275, USA
    Diabetes Metab Res Rev 28:608-17. 2012
    ..These biospecimens are available to investigators for collaborative studies aimed at addressing questions related to T1D natural history and pathogenesis...
  48. ncbi request reprint Neonatal formula feeding leads to immunological alterations in an animal model of type 1 diabetes
    Ricardo A Caicedo
    Department of Pediatrics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Pediatr Res 63:303-7. 2008
    ..002) compared with MF animals. Formula versus maternal milk altered the hepatic cytokine profile at 75 d toward an inflammatory pattern but did not result in altered T(reg) cell frequencies or the development of T1D...
  49. pmc Reversal of streptozotocin-induced diabetes in mice by cellular transduction with recombinant pancreatic transcription factor pancreatic duodenal homeobox-1: a novel protein transduction domain-based therapy
    Vijay Koya
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0275, USA
    Diabetes 57:757-69. 2008
    ..We therefore sought to evaluate the capacity of in vivo-administered recombinant Pdx1 (rPdx1) to ameliorate hyperglycemia in mice with streptozotocin-induced diabetes...
  50. ncbi request reprint Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulation
    Greg Simon
    Department of Pathology, University of Florida, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    Diabetes 57:405-14. 2008
    ....
  51. pmc Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis
    Philip O Scumpia
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610 0286, USA
    Blood 110:3673-81. 2007
    ..These results indicate that CD4(+) T-cell dysfunction is a key component of sepsis and that improving T-cell effector function may be protective against sepsis-associated immunoparalysis...
  52. ncbi request reprint Glucose transporter-2 (GLUT2) promoter mediated transgenic insulin production reduces hyperglycemia in diabetic mice
    Brant R Burkhardt
    Department of Pathology, University of Florida College of Medicine, Gainesville, 32610, USA
    FEBS Lett 579:5759-64. 2005
    ..These findings indicate that the GLUT2 promoter may be a potential candidate for regulating transgenic insulin production for hepatic insulin gene therapy in the treatment of type I diabetes...
  53. ncbi request reprint IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease
    Wei Mu
    Division of Nephrology, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    J Am Soc Nephrol 16:3651-60. 2005
    ..The feasibility of long-term overexpression of a gene using the AAV serotype 1 vector system in a model of renal disease is also demonstrated...
  54. ncbi request reprint Type 1 diabetes mellitus: etiology, presentation, and management
    Michael J Haller
    Division of Pediatric Endocrinology, University of Florida College of Medicine, PO Box 100296, Gainesville, FL 32610, USA
    Pediatr Clin North Am 52:1553-78. 2005
    ..Finally, the article discusses the future of diabetes screening programs and the progress toward the ultimate goal of curing type 1 diabetes...
  55. ncbi request reprint Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes
    Todd M Brusko
    Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, ARB R3 128, 1600 SW Archer Rd, Gainesville, FL 32610 0275, USA
    Diabetes 54:1407-14. 2005
    ..These data suggest that age strongly influences the frequency of CD4+ CD25+ T-cells and that function, rather than frequency, may represent the means by which these cells associate with type 1 diabetes in humans...
  56. ncbi request reprint Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis
    Philip O Scumpia
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Immunol 177:7943-9. 2006
    ..These results demonstrate that, although sepsis causes a relative increase in Treg number and increases their suppressive function, their presence does not contribute significantly to overall survival in this model...
  57. doi request reprint CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes
    Michael S Stalvey
    Department of Pediatrics, University of Florida, College of Medicine, P O Box 100296, Gainesville, FL 32610, USA
    Cytokine 44:154-9. 2008
    ..These results suggest that, hyperglycemia may exacerbate the clinical course in CF by impacting immune reactivity. There is clear need to maximize metabolic management in CFRD...
  58. ncbi request reprint Murine model for cystic fibrosis bone disease demonstrates osteopenia and sex-related differences in bone formation
    Troy D Pashuck
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida 32610, USA
    Pediatr Res 65:311-6. 2009
    ..This proanabolic observation in male CF mice is consistent with other clinical sex differences in CF...
  59. doi request reprint Exendin-4 therapy in NOD mice with new-onset diabetes increases regulatory T cell frequency
    Song Xue
    Department of Pathology, University of Florida, Florida 32010, USA
    Ann N Y Acad Sci 1150:152-6. 2008
    ..Taken collectively, these data suggest that in addition to its potential effects on beta cell proliferation, Ex-4 may also act as a regulator of the immune response...
  60. ncbi request reprint Why can't we prevent type 1 diabetes?: maybe it's time to try a different combination
    Desmond Schatz
    Department of Pediatrics, University of Florida, Gainesville, Florida, USA
    Diabetes Care 26:3326-8. 2003
  61. pmc Diabetes acceleration or prevention by a coxsackievirus B4 infection: critical requirements for both interleukin-4 and gamma interferon
    David V Serreze
    Department of Pathology, University of Florida, Box 100275 JHMHC, 1600 SW Archer Rd, Gainesville, FL 32610, USA
    J Virol 79:1045-52. 2005
    ..The protective mechanism against diabetes elicited in NOD mice infected with CVB4 prior to the development of a critical threshold level of insulitis requires neither IL-4 nor IFN-gamma...
  62. pmc In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow
    Dong Qi Tang
    Department of Pathology, Immunology, and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
    Diabetes 53:1721-32. 2004
    ....
  63. ncbi request reprint Glucose-responsive expression of the human insulin promoter in HepG2 human hepatoma cells
    Brant R Burkhardt
    Department of Pathology, University of Florida, Gainesville, Florida 32610, USA
    Ann N Y Acad Sci 1005:237-41. 2003
    ..Our results suggest that the human insulin promoter represents a strong candidate as a robust, glucose-responsive promoter for regulated hepatic insulin production...
  64. pmc Novel detection of pancreatic and duodenal homeobox 1 autoantibodies (PAA) in human sera using luciferase immunoprecipitation systems (LIPS) assay
    William Donelan
    Department of Pathology, Immunology and Laboratory Medicine, Gainesville, Florida 32610, USA
    Int J Clin Exp Pathol 6:1202-10. 2013
    ..In conclusion, we have developed a liquid-phase, non-radioactive, sensitive and specific LIPS assay to detect PAA in human sera, providing a useful tool for evaluating the clinical relevance of PAA...
  65. ncbi request reprint Impact of humoral immune response on distribution and efficacy of recombinant adeno-associated virus-derived acid alpha-glucosidase in a model of glycogen storage disease type II
    Kerry O Cresawn
    Department of Pediatrics, and Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 16:68-80. 2005
    ..These findings highlight the importance of the immune response to rAAV-encoded GAA in correcting GSDII and provide additional understanding of the approach to treatment of GSDII...
  66. ncbi request reprint Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector
    Matthias Kapturczak
    Department of Medicine, University of Florida, Gainesville, Florida 32610, USA
    Mol Ther 5:154-60. 2002
    ..These data are the first report of efficient islet cell transduction with two genes using a single bicistronic rAAV vector and have direct implications for strategies aimed at enhancing islet transplant survival...
  67. ncbi request reprint Assessing the in vitro suppressive capacity of regulatory T cells
    Todd M Brusko
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, Florida, USA
    Immunol Invest 36:607-28. 2007
    ..As further immunomodulatory therapies are explored, the need for additional methodologies to understand the cellular and molecular mechanisms of immune regulation conferred by Treg will play an increasingly important role...
  68. ncbi request reprint Enhanced IgE allergic response to Aspergillus fumigatus in CFTR-/- mice
    Christian Muller
    Department of Pediatrics, Center for Immunology and Transplantation and Genetics Institute, University of Florida College of Medicine, Gainesville, FL 32610 0296, USA
    Lab Invest 86:130-40. 2006
    ..This system models a very specific type of airway inflammation in CF and could provide insights into pathogenesis and treatment of the disease...
  69. ncbi request reprint Autoantibody markers for the diagnosis and prediction of type 1 diabetes
    Clive H Wasserfall
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Health Science Center, 1600 SW Archer Road, Gainesville, FL 32610, USA
    Autoimmun Rev 5:424-8. 2006
    ....
  70. pmc Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats
    Ricardo Valladares
    Department of Microbiology and Cell Science, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 5:e10507. 2010
    ..In this study diabetes prone rats were administered pure cultures of L. johnsonii or L. reuteri isolated from diabetes resistant rats to determine the effect on type 1 diabetes development...
  71. ncbi request reprint Gene delivery in renal tubular epithelial cells using recombinant adeno-associated viral vectors
    Sifeng Chen
    Department of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Am Soc Nephrol 14:947-58. 2003
    ....
  72. ncbi request reprint An integral role for heme oxygenase-1 and carbon monoxide in maintaining peripheral tolerance by CD4+CD25+ regulatory T cells
    Todd M Brusko
    Department of Pathology, Immunology and Laboratory Medicine, University of Florida, Gainesville, FL 32610, USA
    J Immunol 174:5181-6. 2005
    ..This model, if validated, could act as a catalyst for new investigations into Treg function and ultimately result in novel methods to modulate Treg biology toward therapeutic applications...
  73. ncbi request reprint Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: II. Immunologic analysis
    Chul Ho Lee
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Diabetes 55:171-8. 2006
    ....
  74. ncbi request reprint Systemic overexpression of interleukin-10 fails to protect allogeneic islet transplants in nonobese diabetic mice
    Y Clare Zhang
    Department of Pediatrics, Children s Research Institute, University of South Florida, St Petersburg, FL, USA
    Transplantation 80:530-3. 2005
    ..Thus, IL-10 appears insufficient in protecting transplanted islet cells from allogeneic rejection and suggests important mechanistic variances between alloreactivity and autoimmunity in terms islet graft loss...
  75. ncbi request reprint Type 1 diabetes alters anti-hsp90 autoantibody isotype
    Hui Yu Qin
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada N6A 5C1
    J Autoimmun 20:237-45. 2003
    ..However, there is a higher level of IgG1 and IgG3 isotypes of hsp90AA in FDR and type 1 diabetic subjects. Thus, autoimmunity leading to type 1 diabetes significantly alters the autoantibody isotype to autoantigens, such as hsp90...
  76. pmc Heme oxygenase-1 modulates early inflammatory responses: evidence from the heme oxygenase-1-deficient mouse
    Matthias H Kapturczak
    Division of Nephrology, University of Alabama at Birmingham, Birmingham Alabama, USA
    Am J Pathol 165:1045-53. 2004
    ..The absence of HO-1 correlates with a Th1-weighted shift in cytokine responses suggesting a general pro-inflammatory tendency associated with HO-1 deficiency...
  77. ncbi request reprint PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21)
    Brant R Burkhardt
    Department of Pathology and Laboratory Medicine, 803D Abramson Research Center 3516 Civic Center Blvd, Children s Hospital of Philadelphia, Philadelphia, PA 19104 4318, United States
    Gene 369:134-41. 2006
    ..PANDER-induced downregulation of CDKN1A expression coupled with induced CASP3-activation may serve a central role in islet cell death and offers further insight into the mechanisms of cytokine-induced beta-cell apoptosis...
  78. pmc Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway
    Sifeng Chen
    Department of Medicine, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL 35294
    Proc Natl Acad Sci U S A 102:7251-6. 2005
    ....
  79. ncbi request reprint Islet cell autoantibodies: a case of a premature obituary
    Desmond A Schatz
    Pediatr Diabetes 6:181-3. 2005
  80. ncbi request reprint Novel leptin receptor mutation in NOD/LtJ mice suppresses type 1 diabetes progression: I. Pathophysiological analysis
    Chul Ho Lee
    The Jackson Laboratory, 600 Main St, Bar Harbor, ME 04609, USA
    Diabetes 54:2525-32. 2005
    ....
  81. ncbi request reprint Bioluminescent monitoring of islet graft survival after transplantation
    Yuxin Lu
    Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095 1735, USA
    Mol Ther 9:428-35. 2004
    ..Such imaging technologies may allow earlier detection of graft rejection and the adjustment of therapies to prolong graft survival posttransplantation...
  82. pmc Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors
    Sifeng Chen
    Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Hum Gene Ther 16:235-47. 2005
    ..These results suggest the unique potential of rAAV1 and rAAV5-based vectors for vascular-targeted gene-based therapeutic strategies...
  83. pmc Suppression by CD4+CD25+ regulatory T cells is dependent on expression of heme oxygenase-1 in antigen-presenting cells
    James F George
    Departments of Surgery, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 173:154-60. 2008
    ..These findings demonstrate that HO-1 activity in antigen-presenting cells is important for Treg-mediated suppression, providing an explanation for the apparent defect in immune regulation in HO-1(-/-) mice...
  84. ncbi request reprint A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene
    Marie King
    Department of Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01655, USA
    Clin Immunol 126:303-14. 2008
    ..These data suggest that humanized NOD-scid Il2rgamma(null) mice may represent an important surrogate for investigating in vivo mechanisms of human islet allograft rejection...
  85. pmc Characterization of human invariant natural killer T subsets in health and disease using a novel invariant natural killer T cell-clonotypic monoclonal antibody, 6B11
    Carlos J Montoya
    Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA
    Immunology 122:1-14. 2007
    ..These differences in iNKT cell subsets suggest that in humans the relative ratio of iNKT cell subsets may influence susceptibility vs. resistance to immune-mediated diseases...
  86. ncbi request reprint Research profile. Cell sleuth. The triggers of type 1 diabetes. Mark A. Atkinson, PhD
    Kate Ruder
    Diabetes Forecast 60:93-5. 2007
  87. ncbi request reprint The virtual NOD mouse: applying predictive biosimulation to research in type 1 diabetes
    Yanan Zheng
    Entelos, Inc, 110 Marsh Drive, Foster City, CA 94404, USA
    Ann N Y Acad Sci 1103:45-62. 2007
    ....
  88. ncbi request reprint Long-term monitoring of transplanted islets using positron emission tomography
    Yuxin Lu
    Department of Molecular and Medical Pharmacology, University of California at Los Angeles School of Medicine, Los Angeles, CA 90095 1735, USA
    Mol Ther 14:851-6. 2006
    ..These studies suggest that PET imaging of lentivirus-transduced islets could provide a safe and feasible method for long-term monitoring of islet graft survival...
  89. ncbi request reprint A comprehensive review of interventions in the NOD mouse and implications for translation
    Lisl K M Shoda
    Entelos Inc, Foster City, California 94404, USA
    Immunity 23:115-26. 2005
    ....

Research Grants13

  1. Cord Blood Immunoregulation of Type 1 Diabetes
    Mark Atkinson; Fiscal Year: 2007
    ....
  2. MECHANISMS OF IMMUNOTHERAPY IN IDD PREVENTION
    Mark Atkinson; Fiscal Year: 2000
    ..These findings could aid in understanding the beneficial effects for this form of immunotherapy aimed at interrupting beta cell autoimmunity and IDD. ..
  3. Immune function and the progression to type 1 diabetes
    Mark Atkinson; Fiscal Year: 2007
    ....
  4. Mechanisms of Immunotherapy in IDD Prevention Trials
    Mark Atkinson; Fiscal Year: 2004
    ..In sum, our purpose is to delineate the mechanism of disease prevention provided by prophylactic insulin therapy and to further understand the natural history of cellular immune responses in the prediabetic period. ..
  5. Mechanisms of Immunotherapy in IDD Prevention Trials
    Mark Atkinson; Fiscal Year: 2003
    ..In sum, our purpose is to delineate the mechanism of disease prevention provided by prophylactic insulin therapy and to further understand the natural history of cellular immune responses in the prediabetic period. ..
  6. Mechanisms of Immunotherapy in IDD Prevention Trials
    Mark Atkinson; Fiscal Year: 2002
    ..In sum, our purpose is to delineate the mechanism of disease prevention provided by prophylactic insulin therapy and to further understand the natural history of cellular immune responses in the prediabetic period. ..
  7. Mechanisms of Immunotherapy in IDD Prevention Trials
    Mark Atkinson; Fiscal Year: 2001
    ..In sum, our purpose is to delineate the mechanism of disease prevention provided by prophylactic insulin therapy and to further understand the natural history of cellular immune responses in the prediabetic period. ..
  8. MECHANISMS OF IMMUNOTHERAPY IN IDD PREVENTION
    Mark Atkinson; Fiscal Year: 1999
    ..These findings could aid in understanding the beneficial effects for this form of immunotherapy aimed at interrupting beta cell autoimmunity and IDD. ..