Research Topics
Genomes and GenesSpecies | J H AtkinsonSummaryAffiliation: University of California Country: USA Publications
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Publications
Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trialJ Hampton Atkinson
Department of Psychiatry, VA San Diego Healthcare System, San Diego, CA 92161, USA
J Clin Psychopharmacol 27:135-42. 2007....- Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensityJ H Atkinson
Department of Psychiatry, School of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
Pain 83:137-45. 1999..These results suggest that at standard dosages noradrenergic agents may provide more effective analgesia in back pain than do selective serotonergic reuptake inhibitors... 
Psychiatric context of acute/early HIV infection. The NIMH Multisite Acute HIV Infection Study: IVJ Hampton Atkinson
HIV Neurobehavioral Research Center, University of California of San Diego, La Jolla, CA, 92103, USA
AIDS Behav 13:1061-7. 2009..The psychiatric context of acute/early HIV infection may be a precursor to infection, but not necessarily a barrier to intervention to reduce forward transmission of HIV among persons newly infected...- A placebo-controlled randomized clinical trial of nortriptyline for chronic low back painJ H Atkinson
Department of Psychiatry, San Diego VA Healthcare System, CA 92161, USA
Pain 76:287-96. 1998..This modest reduction in pain intensity suggests that physicians should carefully weigh the risks and benefits of nortriptyline in chronic back pain without depression... - Psychiatric context of human immunodeficiency virus infection among former plasma donors in rural ChinaJ Hampton Atkinson
HIV Neurobehavioral Research Center, University of California, San Diego, 220 Dickinson St, San Diego, CA 92103, USA
J Affect Disord 130:421-8. 2011..Little is known of the psychiatric and substance use disorder characteristics of this population, or their impact on everyday function, employment, and life quality... - Two-year prospective study of major depressive disorder in HIV-infected menJ Hampton Atkinson
Department of Psychiatry, University of California San Diego, School of Medicine, La Jolla, California 92093, USA
J Affect Disord 108:225-34. 2008..This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N=297) and uninfected (HIV-) risk-group controls (N=90)... - Is there a therapeutic window with some antidepressants for analgesic response?J Hampton Atkinson
VA San Diego Healthcare System, 3350 La Jolla Village Drive, 116A, San Diego, CA 92161, USA
Curr Pain Headache Rep 13:93-9. 2009..This article reviews the strengths, limitations, and potential of therapeutic drug monitoring of antidepressants and anticonvulsants as analgesics for selected chronic pain syndromes... - Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIVC A Bousman
University of California San Diego, HIV Neurobehavioral Research Center, Department of Psychiatry, La Jolla, California 92103, USA
J Affect Disord 119:84-91. 2009..This study examined the contextual influence of METH, HIV-infection and their combination on mood states and sexual behavior... - Neurocognitive impairment is an independent risk factor for death in HIV infection. San Diego HIV Neurobehavioral Research Center GroupR J Ellis
Department of Neurosciences, University of California, Department of Medicine, San Diego, USA
Arch Neurol 54:416-24. 1997..To determine if mortality is increased in individuals with human immunodeficiency virus type 1 (HIV-1)-associated neurocognitive disorders less severe than frank dementia... - Quality of life in a placebo-controlled trial of zidovudine in patients with AIDS and AIDS-related complexA W Wu
Department of Medicine, University of California, San Diego
J Acquir Immune Defic Syndr 3:683-90. 1990..Whether existing measures can detect real differences among survivors will require testing in patients with less advanced disease... - Incidence of AIDS dementia in a two-year follow-up of AIDS and ARC patients on an initial phase II AZT placebo-controlled study: San Diego cohortJ J Day
School of Medicine, University of California, San Diego
J Neuropsychiatry Clin Neurosci 4:15-20. 1992..The results suggest that patients at CDC Stage IV who do not receive antiretroviral treatment earlier in their illness may develop clinical dementia at an annual rate of about 14%... - Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adultsMariana Cherner
Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
Drug Alcohol Depend 106:154-63. 2010..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine... - Treatment of major depression in HIV-seropositive men. HIV Neurobehavioral Research Center GroupS Zisook
University of California, San Diego, La Jolla 92093 0603, USA
J Clin Psychiatry 59:217-24. 1998..C.2) who had been diagnosed with major depressive disorder (DSM-III-R)... - Progressive cerebral volume loss in human immunodeficiency virus infection: a longitudinal volumetric magnetic resonance imaging study. HIV Neurobehavioral Research Center GroupJ C Stout
Department of Psychiatry, University of California, San Diego, USA
Arch Neurol 55:161-8. 1998..To compare rates and anatomical patterns of brain atrophy during 3 stages of human immunodeficiency virus (HIV) disease... - Social and psychological characteristics of HIV-infected women and gay men. HIV Neurobehavioral Research Center (HNRC) GroupS J Semple
University of California, San Diego, USA
Women Health 24:17-41. 1996..These findings suggest the importance of considering subgroup differences in the design of counseling programs for HIV+ individuals... - HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER StudyR K Heaton
University of California, San Diego, USA
Neurology 75:2087-96. 2010.... - Cerebrospinal fluid tau protein is not elevated in HIV-associated neurologic disease in humans. HIV Neurobehavioral Research Center Group (HNRC)R J Ellis
Department of Neurosciences, University of California, San Diego, USA
Neurosci Lett 254:1-4. 1998..251 +/- 185; P = 23). In summary, CSF tau levels were not elevated in patients with HIV-associated neurologic disease... - Variable patterns of neuropsychological performance in HIV-1 infectionS Dawes
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
J Clin Exp Neuropsychol 30:613-26. 2008..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests... - Effects of HIV-1 infection and aging on neurobehavioral functioning: preliminary findingsMarianna Cherner
Department of Psychiatry, University of California San Diego, La Jolla, 92093-0603, USA
AIDS 18:S27-34. 2004..CONCLUSION: Although further studies with larger and older samples are needed, this investigation suggests that older adults may be at greater risk of HIV-related neurocognitive dysfunction... - Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care: Veterans Aging Cohort Five-Site StudyAmy C Justice
Veterans Aging Cohort Study Center, VA Pittsburgh Healthcare System, and University of Pittsburgh Center for Research on Health Care, School of Medicine, Division of General Internal Medicine, Pennsylvania, USA
AIDS 18:S49-59. 2004..Both groups reported increased memory problems with advancing age. This preliminary work suggests a substantial prevalence of psychiatric and neurocognitive problems among middle-aged and older HIV-infected individuals... - The influence of HIV-related support groups on survival in women who lived with HIV. A pilot studyJ Summers
University of California, Berkeley UCB School of Social Welfare, USA
Psychosomatics 41:262-8. 2000..0002). Factors related to group participation and ways in which support groups might promote longevity are discussed... 
Defining neurocognitive impairment in HIV: deficit scores versus clinical ratingsK Blackstone
San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, USA
Clin Neuropsychol 26:894-908. 2012..Clinicians and researchers should recognize the strengths and weaknesses of each method when evaluating neurocognitive complications in HIV...- Is hepatitis C infection associated with increased risk of depression in persons with methamphetamine dependence?Ofilio Vigil
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, USA
Am J Addict 16:418-23. 2007..Results from this study suggest that HCV infection does not confer an additive effect on the severity of depressive symptoms or the prevalence of major depression in persons with MA dependence... - Association of self-reported painful symptoms with clinical and neurophysiologic signs in HIV-associated sensory neuropathyJ Robinson-Papp
Department of Neurology, Mount Sinai, School of Medicine, New York, NY 10029, USA
Pain 151:732-6. 2010..This finding holds true regardless of demographic factors, depression or substance use history... - Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findingsMariana Cherner
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
J Int Neuropsychol Soc 16:890-901. 2010..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury... - Timing is everything: antiretroviral nonadherence is associated with impairment in time-based prospective memorySteven Paul Woods
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, California
J Int Neuropsychol Soc 15:42-52. 2009..jins, 2009, 15, 42-52.)... - Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populationsDavey M Smith
University of California San Diego, La Jolla, 92093, USA
Virology 385:204-8. 2009.... - Neurocognitive functioning in acute or early HIV infectionDavid J Moore
Department of Psychiatry, University of California, San Diego UCSD, San Diego, CA, USA
J Neurovirol 17:50-7. 2011..Although a significant monotonic trend existed and patterns of the data suggest the AEH individuals may fall intermediate to HIV- and chronic participants, we were not able to statistically confirm this hypothesis... - The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infectionSteven Paul Woods
HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 32:398-407. 2010.... - Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIVSteven Paul Woods
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Clin Neuropsychol 25:724-33. 2010.... - Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER StudyRonald J Ellis
HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
Arch Neurol 67:552-8. 2010..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era... - Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependenceChad A Bousman
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
Psychiatry Res 178:295-8. 2010..Results provide preliminary support for further exploration and validation of candidate single nucleotide polymorphisms (SNPs) for methamphetamine (METH) dependence reported among Asian populations across other ethnic/ancestral groups... - HIV-associated prospective memory impairment in the laboratory predicts failures on a semi-naturalistic measure of health care complianceJennifer B Zogg
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Clin Neuropsychol 24:945-62. 2010..g., depression). Results support the hypothesis that ProM plays a unique role in compliance with health care instructions for HIV disease management and may inform interventions designed to improve treatment outcomes... - Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individualsErick T Tatro
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
J Neurovirol 16:399-404. 2010..Change in FKBP4 expression did not correlate with changes in clinical or depression measurements. Higher FKBP5 expression correlated with greater symptom change for GG carriers of rs3800373... - HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictorsRobert K Heaton
University of California, San Diego, CA, USA
J Neurovirol 17:3-16. 2011..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation... - Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural ChinaRobert K Heaton
HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
J Neurovirol 14:536-49. 2008..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments... - Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?Steven Paul Woods
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
Arch Clin Neuropsychol 23:257-70. 2008..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration... - Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteersMark Wallace
Department of Anesthesiology, University of California, San Diego, USA
Anesthesiology 107:785-96. 2007..Using a human experimental pain model, the authors hypothesized that inhaled cannabis would reduce the pain and hyperalgesia induced by intradermal capsaicin... - Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trialRonald J Ellis
Department of Neurosciences, University of California, San Diego, CA 92103, USA
Neuropsychopharmacology 34:672-80. 2009..Smoked cannabis was generally well tolerated and effective when added to concomitant analgesic therapy in patients with medically refractory pain due to HIV DSPN... - Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinenceJennifer E Iudicello
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
J Clin Exp Neuropsychol 32:704-18. 2010..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more... - Lithium improves HIV-associated neurocognitive impairmentScott L Letendre
Department of Medicine, University of California, San Diego, California 92103, USA
AIDS 20:1885-8. 2006..To determine the effects of low-dose oral lithium on the neuropsychological performance of individuals diagnosed with HIV-associated neurocognitive impairment... - Incident major depression does not affect neuropsychological functioning in HIV-infected menLucette A Cysique
Department of Psychiatry, University of California at San Diego, San Diego, California, USA
J Int Neuropsychol Soc 13:1-11. 2007..Our results suggest that neurocognitive impairment and major depression should be considered as two independent processes... - Psychometric characteristics of the memory for intentions screening testSteven Paul Woods
Department of Psychiatry, University of California, San Diego, CA, USA
Clin Neuropsychol 22:864-78. 2008..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST... - Prospective memory deficits are associated with unemployment in persons living with HIV infectionSteven Paul Woods
Department of Psychiatry, University of California, San Diego, USA
Rehabil Psychol 56:77-84. 2011..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection... - Chronic pain and depression among geriatric psychiatry inpatientsThomas W Meeks
Department of Psychiatry, Division of Geriatric Psychiatry, University of California, San Diego, CA, USA
Int J Geriatr Psychiatry 23:637-42. 2008..We examined whether chronic pain among depressed geriatric inpatients was associated with several clinical variables-comorbid psychiatric and medical diagnoses, length of hospitalization, suicidal ideation, and sleep duration... - COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV Infection and Methamphetamine DependenceC A Bousman
Department of Psychiatry, University of California San Diego, La Jolla, CA 92103, USA
Interdiscip Perspect Infect Dis 2010:678648. 2010.... - White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individualsAssawin Gongvatana
San Diego State University University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego and La Jolla, California, USA
J Neurovirol 15:187-95. 2009..The study also confirms that CNS injury is evident in persons infected with HIV despite effective antiretroviral treatment... - Temperament and risky behaviors: a pathway to HIV?David J Moore
San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92103, USA
J Affect Disord 85:191-200. 2005..Because dispositional characteristics are likely to influence this process, we examined the association between temperament and HIV serostatus in subjects with heavy use of drugs and various sexual risk behaviors... - Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorderErick T Tatro
Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
J Neuroimmune Pharmacol 4:218-26. 2009..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD... - Preventing progression to chronicity in first onset, subacute low back pain: an exploratory studyMark A Slater
Department of Psychology, VA San Diego Healthcare System, San Diego, CA, USA
Arch Phys Med Rehabil 90:545-52. 2009..To evaluate the effects of a behavioral medicine intervention, relative to an attention control, in preventing chronic pain and disability in patients with first-onset, subacute low back pain (LBP) with limitations in work-role function... - Implications of hepatitis C virus infection for behavioral symptoms and activities of daily livingCarolina Posada
San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
J Clin Exp Neuropsychol 32:637-44. 2010..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed... - Diminished somatostatin gene expression in individuals with HIV and major depressive disorderI P Everall
Department of Psychiatry, University of California, San Diego, CA 92093 0603, USA
Neurology 67:1867-9. 2006..Whereas disruption of cytoskeletal genes has been noted in HIVE, dysregulation of somatostatin has not, indicating that dysregulation of somatostatin is part of the molecular pathologic process of MDD in the setting of HIV... - Neurocognitive effects of methamphetamine: a critical review and meta-analysisJ Cobb Scott
Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA 92120, USA
Neuropsychol Rev 17:275-97. 2007..other substance-related disorders) and neuromedical (e.g., HIV infection) comorbidities. Finally, these findings are discussed with respect to their potential contribution to the clinical management of persons with MA abuse/dependence... - Increased accumulation of intraneuronal amyloid beta in HIV-infected patientsCristian L Achim
Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
J Neuroimmune Pharmacol 4:190-9. 2009..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population... - HIV-1 RNA concentration and cognitive performance in a cohort of HIV-positive peopleBenedetto Vitiello
Institute of Mental Health, Bethesda, Maryland 20892, USA
AIDS 21:1415-22. 2007..To determine whether higher viral concentrations in the cerebrospinal fluid (CSF) and/or peripheral blood were associated with greater severity of cognitive impairment in HIV-1-seropositive subjects with cognitive-motor impairment... - Chronic back pain: searching for causes and curesJ Hampton Atkinson
J Rheumatol 31:2323-5. 2004 - Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendationsDennis C Turk
University of Washington, Seattle, WA 98195, USA
Pain 125:208-15. 2006 - Interrater reliability of the Psychiatric Research Interview for Substance and Mental Disorders in an HIV-infected cohort: experience of the National NeuroAIDS Tissue ConsortiumS Morgello
Mount Sinai School of Medicine, New York, NY10029, USA
Int J Methods Psychiatr Res 15:131-8. 2006..We conclude that the PRISM yields reliable diagnoses in a multicentre study of substance-experienced, HIV-infected individuals... - Shared and independent associations of psychosocial factors on work status among men with subacute low back painWilliam S Shaw
Liberty Mutual Research Institute for Disability Research, 71 Frankland Road, Hopkinton, MA 01748, USA
Clin J Pain 23:409-16. 2007..The objective of this prospective cohort study was to evaluate independent and shared associations of psychosocial variables on work status after first onset of low back pain (LBP) in working men... - Cerebrospinal and peripheral human immunodeficiency virus type 1 load in a multisite, randomized, double-blind, placebo-controlled trial of D-Ala1-peptide T-amide for HIV-1-associated cognitive-motor impairmentKarl Goodkin
Department of Psychiatry and Behavioral Sciences, University if Miami School of Medicine, Miami, Florida 33136, USA
J Neurovirol 12:178-89. 2006..Future studies should be undertaken to confirm the existence of this result and the CSF-periphery dissociation observed with respect to HIV-1-associated cognitive-motor impairment... - Undetectable cerebrospinal fluid HIV RNA and beta-2 microglobulin do not indicate inactive AIDS dementia complex in highly active antiretroviral therapy-treated patientsLucette A Cysique
St Vincent s Hospital Clinical School, University of New South Wales, Darlinghurst, Sydney, Australia
J Acquir Immune Defic Syndr 39:426-9. 2005.... - Gender, AIDS, and bereavement: a comparison of women and men living with HIVJacquelyn Summers
Department of Psychology, The University of Auckland, Auckland, New Zealand
Death Stud 28:225-41. 2004..It is critical that adequate mental health support services be available to this growing risk group of bereaved individuals...
Research Grants
- BETTER ANTIRETROVIRAL ADHERENCE: HIV+ AMPHETAMINE USERSJ Atkinson; Fiscal Year: 2003....