Mohammad Athar

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Erb-041, an Estrogen Receptor-β Agonist, Inhibits Skin Photocarcinogenesis in SKH-1 Hairless Mice by Downregulating the WNT Signaling Pathway
    Sandeep C Chaudhary
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294 0019
    Cancer Prev Res (Phila) 7:186-98. 2014
  2. pmc Pharmacological activation of p53 in cancer cells
    Mohammad Athar
    Department of Dermatology, The University of Alabama at Birmingham, Volker Hall, Room 509, 1530 3rd Avenue South, Birmingham, Alabama 35294 0019, USA
    Curr Pharm Des 17:631-9. 2011
  3. pmc Pathogenesis of nonmelanoma skin cancers in organ transplant recipients
    Mohammad Athar
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Arch Biochem Biophys 508:159-63. 2011
  4. pmc Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model
    Deepali Kurundkar
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294 0019, USA
    Toxicol Appl Pharmacol 266:233-44. 2013
  5. pmc Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis
    Sandeep C Chaudhary
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue South, VH509, Birmingham, AL 35294 0019, USA
    Toxicol Appl Pharmacol 268:249-55. 2013
  6. pmc Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progression
    Kwang Ho Kim
    Department of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, New York, USA
    J Invest Dermatol 131:195-202. 2011
  7. ncbi request reprint Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Res 64:7545-52. 2004
  8. pmc CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
    Xiuwei Tang
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:3753-64. 2007
  9. pmc Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:867-75. 2004
  10. pmc Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs
    Aadithya Arumugam
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Biochem Biophys Res Commun 425:177-81. 2012

Collaborators

Detail Information

Publications51

  1. doi request reprint Erb-041, an Estrogen Receptor-β Agonist, Inhibits Skin Photocarcinogenesis in SKH-1 Hairless Mice by Downregulating the WNT Signaling Pathway
    Sandeep C Chaudhary
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294 0019
    Cancer Prev Res (Phila) 7:186-98. 2014
    ..Our results show that Erb-041 is a potent skin cancer chemopreventive agent that acts by dampening the WNT/β-catenin signaling pathway. Cancer Prev Res; 7(2); 186-98. ©2013 AACR. ..
  2. pmc Pharmacological activation of p53 in cancer cells
    Mohammad Athar
    Department of Dermatology, The University of Alabama at Birmingham, Volker Hall, Room 509, 1530 3rd Avenue South, Birmingham, Alabama 35294 0019, USA
    Curr Pharm Des 17:631-9. 2011
    ..This review provides a description of various pharmacological approaches tested to activate p53 (both wild-type and mutant) and to assess the effects of activated p53 on neoplastic progression...
  3. pmc Pathogenesis of nonmelanoma skin cancers in organ transplant recipients
    Mohammad Athar
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Arch Biochem Biophys 508:159-63. 2011
    ..Finally, this review addresses possible strategies for the prevention of this cancer, particularly focusing on the aspects that may be incorporated to prevent negative effects of chemopreventive chemicals on graft survival...
  4. pmc Vorinostat, an HDAC inhibitor attenuates epidermoid squamous cell carcinoma growth by dampening mTOR signaling pathway in a human xenograft murine model
    Deepali Kurundkar
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, 1530 3rd Avenue South, VH 509, Birmingham, AL 35294 0019, USA
    Toxicol Appl Pharmacol 266:233-44. 2013
    ..Vorinostat may be utilized to cure skin neoplasms in organ transplant recipient (OTR). These patients have high morbidity and surgical removal of these lesions which frequently develop in these patients, is difficult...
  5. pmc Nitric oxide-releasing sulindac is a novel skin cancer chemopreventive agent for UVB-induced photocarcinogenesis
    Sandeep C Chaudhary
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue South, VH509, Birmingham, AL 35294 0019, USA
    Toxicol Appl Pharmacol 268:249-55. 2013
    ..Our data suggest that NO-sulindac is a potent inhibitor of UVB-induced skin carcinogenesis and acts by targeting proliferation-regulatory pathways...
  6. pmc Resveratrol targets transforming growth factor-β2 signaling to block UV-induced tumor progression
    Kwang Ho Kim
    Department of Dermatology, Columbia University Medical Center, Irving Cancer Research Center, New York, New York, USA
    J Invest Dermatol 131:195-202. 2011
    ....
  7. ncbi request reprint Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Cancer Res 64:7545-52. 2004
    ....
  8. pmc CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
    Xiuwei Tang
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    J Clin Invest 117:3753-64. 2007
    ..Blocking MPT diminished p53 translocation and apoptosis. These studies indicate that reconstituting p53 tumor suppressor functions in vivo by small molecular weight compounds may block the pathogenesis and progression of skin cancer...
  9. pmc Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Clin Invest 113:867-75. 2004
    ..These results demonstrate the crucial importance of ODC for the induction of BCCs and indicate that chemopreventive strategies directed at inhibiting this enzyme may be useful in reducing BCCs in human populations...
  10. pmc Combined inhibition of p38 and Akt signaling pathways abrogates cyclosporine A-mediated pathogenesis of aggressive skin SCCs
    Aadithya Arumugam
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294 0019, USA
    Biochem Biophys Res Commun 425:177-81. 2012
    ..These data provide first important combinatorial pharmacological approach to block the pathogenesis of CsA-induced highly aggressive cutaneous neoplasm in OTRs...
  11. pmc Unfolded protein response signaling and MAP kinase pathways underlie pathogenesis of arsenic-induced cutaneous inflammation
    Changzhao Li
    Department of Dermatology and Skin Diseases Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Prev Res (Phila) 4:2101-9. 2011
    ..Our results identify novel pathways involved in the pathogenesis of arsenic-mediated cutaneous inflammation which may also be related to enhanced cancer risk in arsenic exposed cohorts...
  12. pmc Nitric oxide donor exisulind is an effective inhibitor of murine photocarcinogenesis
    Tripti Singh
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Photochem Photobiol 88:1141-8. 2012
    ..These data suggest that NO-exisulind reduces tumor growth and inhibits tumor progression by blocking proliferation, inducing apoptosis and reducing EMT...
  13. pmc Targeting wild-type and mutant p53 with small molecule CP-31398 blocks the growth of rhabdomyosarcoma by inducing reactive oxygen species-dependent apoptosis
    Jianmin Xu
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0019, USA
    Cancer Res 70:6566-76. 2010
    ..Our findings indicate that the ability of CP-31398 to modulate wild-type and mutant p53 results in the inhibition of RMS growth and invasiveness...
  14. doi request reprint Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption
    Ritesh K Srivastava
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Toxicol Appl Pharmacol 272:879-87. 2013
    ..These data also provide a novel strategy to block the ATO-dependent impairment in innate immune responses. ..
  15. pmc Metformin, an antidiabetic agent reduces growth of cutaneous squamous cell carcinoma by targeting mTOR signaling pathway
    Sandeep C Chaudhary
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL, USA
    Photochem Photobiol 88:1149-56. 2012
    ..Consistently, decreased phosphorylation of GSK3β, which is carried out by AKT kinases was also observed. These results suggest that metformin blocks SCC growth by dampening NFkB and mTOR signaling pathways...
  16. pmc Cyclosporine a mediates pathogenesis of aggressive cutaneous squamous cell carcinoma by augmenting epithelial-mesenchymal transition: role of TGFβ signaling pathway
    Stephanie B Walsh
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, USA
    Mol Carcinog 50:516-27. 2011
    ....
  17. pmc Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
    Jung Ho Back
    Department of Dermatology, Columbia University Medical Center, New York, New York 10032, USA
    J Biol Chem 286:19100-8. 2011
    ..These results demonstrate that the inhibition of SIRT1 by mTOR fosters survival of DNA damage-induced prematurely senescent SCC cells via Bfl-1/A1 in the absence of functional p53...
  18. pmc Procarcinogenic effects of cyclosporine A are mediated through the activation of TAK1/TAB1 signaling pathway
    Jianmin Xu
    Department of Dermatology, University of Alabama at Birmingham, AL 35294, USA
    Biochem Biophys Res Commun 408:363-8. 2011
    ..Activation of both NFκB and p38 MAP kinase provide mitogenic stimuli to augment the growth of SCCs...
  19. ncbi request reprint Differential expression of E prostanoid receptors in murine and human non-melanoma skin cancer
    Juliette Lois Lee
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    J Invest Dermatol 125:818-25. 2005
    ..These data suggest that altered EP receptor expression may play a differential role in the development of UVB-induced SCC and BCC in murine and human skin...
  20. doi request reprint Cyclooxygenase-2 inhibitor nimesulide blocks ultraviolet B-induced photocarcinogenesis in SKH-1 hairless mice
    Xiuwei Tang
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Photochem Photobiol 84:522-7. 2008
    ..These results show that alternative classes of COX-2 inhibitors may likely be efficacious as cancer chemopreventive agents and may have an improved therapeutic index...
  21. ncbi request reprint Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:538-46. 2006
    ..Our results demonstrate that resveratrol affects multiple cellular targets in A431 cells, and that the downregulation of both AP-1 and pRb contributes to its antiproliferative activity in these cells...
  22. pmc Fisetin inhibits growth, induces G₂ /M arrest and apoptosis of human epidermoid carcinoma A431 cells: role of mitochondrial membrane potential disruption and consequent caspases activation
    Harish C Pal
    Department of Dermatology, University of Alabama at Birmingham, AL 35294, USA
    Exp Dermatol 22:470-5. 2013
    ..Overall, these results suggest that fisetin could be developed as a novel therapeutic agent for the management of NMSCs...
  23. pmc New agents for prevention of ultraviolet-induced nonmelanoma skin cancer
    William L Camp
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Semin Cutan Med Surg 30:6-13. 2011
    ....
  24. ncbi request reprint Role of p38 MAPK in UVB-induced inflammatory responses in the skin of SKH-1 hairless mice
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Invest Dermatol 124:1318-25. 2005
    ..Blockade of the p38 MAPK pathway may offer an effective approach to reducing or preventing skin damage resulting from acute solar radiation...
  25. pmc Inhibiting cycloxygenase and ornithine decarboxylase by diclofenac and alpha-difluoromethylornithine blocks cutaneous SCCs by targeting Akt-ERK axis
    Aadithya Arumugam
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e80076. 2013
    ..These data suggest that ODC+COX-2 over-expression together leads to pathogenesis of aggressive and invasive cutaneous carcinomas by activating Akt signaling pathway, which through augmenting EMT contributes to tumor invasion. ..
  26. doi request reprint Fisetin Inhibits Human Melanoma Cell Invasion through Promotion of Mesenchymal to Epithelial Transition and by Targeting MAPK and NFκB Signaling Pathways
    Harish Chandra Pal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 9:e86338. 2014
    ..These results indicate that fisetin inhibits melanoma cell invasion through promotion of mesenchymal to epithelial transition and by targeting MAPK and NFκB signaling pathways. ..
  27. doi request reprint Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model
    Samer Z Kaylani
    Division of Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, 1600 7th Avenue South, ACC 414, Birmingham, AL 35233, USA
    Biochem Biophys Res Commun 435:557-61. 2013
    ..Our data provide bases for using rapamycin either alone or in combination with traditional chemotherapeutic drugs to block the pathogenesis of high risk RMS...
  28. pmc IL-17 mediated inflammation promotes tumor growth and progression in the skin
    Donggou He
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 7:e32126. 2012
    ..These results demonstrate that IL-17 mediated inflammation is an important mechanism for inflammation mediated promotion of tumor development. The study has major implications for targeting IL-17 in prevention and treatment of tumors...
  29. doi request reprint Arsenic-induced cutaneous hyperplastic lesions are associated with the dysregulation of Yap, a Hippo signaling-related protein
    Changzhao Li
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35205, USA
    Biochem Biophys Res Commun 438:607-12. 2013
    ..These effects together may contribute to the carcinogenic effects of arsenic in the skin. ..
  30. pmc Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma
    Hee Kyung Kim
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Neoplasia 10:1411-20. 2008
    ....
  31. ncbi request reprint Hedgehog signalling in skin development and cancer
    Mohammad Athar
    Department of Dermatology, Columbia University, New York, NY 10032, USA
    Exp Dermatol 15:667-77. 2006
    ..This review therefore provides a current understanding of the role of the Shh pathway in skin development and neoplasia. It also provides a basis for the molecular target-based chemoprevention and therapeutic management of skin cancer...
  32. pmc Resveratrol: a review of preclinical studies for human cancer prevention
    Mohammad Athar
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street VC15 204, New York, NY 10032, USA
    Toxicol Appl Pharmacol 224:274-83. 2007
    ..This review discusses the current preclinical and mechanistic data available and assesses resveratrol's anticancer effects to support its potential as an anticancer agent in human populations...
  33. pmc Chlorine induces the unfolded protein response in murine lungs and skin
    Changzhao Li
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 49:197-203. 2013
    ..The data shown herein indicate for the first time the up-regulation of UPR signaling and hepcidin in the skin and lungs of Cl2-exposed mice, which persisted when the mice were returned to room air for 6 hours. ..
  34. pmc Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers
    Jennifer L Herrmann
    Department of Dermatology, University of Alabama at Birmingham, USA
    Cancer Lett 306:1-9. 2011
    ..In short, LKB1 is a tissue and context-specific kinase. This review aims to summarize our current understanding of its role in the pathogenesis of epithelial cancers...
  35. pmc A critical role for the proapoptotic protein bid in ultraviolet-induced immune suppression and cutaneous apoptosis
    Sanjay Pradhan
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:3077-88. 2008
    ..These studies provide evidence that Bid activation is a critical upstream mediator in UV-induced keratinocyte and LC apoptosis and that its absence abrogates UV-induced immune tolerance...
  36. pmc Liver kinase B1 (LKB1) in the pathogenesis of UVB-induced murine basal cell carcinoma
    Yevgeniya A Byekova
    Department of Dermatology and Skin Diseases Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Arch Biochem Biophys 508:204-11. 2011
    ..Thus, our data show that the LKB1/AMPK axis fails to regulate mTOR pathway, and a complex regulatory mechanism exists for the persistent mTOR activation in murine BCCs...
  37. pmc Rapamycin and mTORC1 inhibition in the mouse: skin cancer prevention
    Mohammad Athar
    Department of Dermatology, Skin Diseases Research Center and UAB Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Cancer Prev Res (Phila) 4:957-61. 2011
    ....
  38. ncbi request reprint Reduced cyclin D1 ubiquitination in UVB-induced murine squamous cell carcinomas
    Arianna L Kim
    Department of Dermatology, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Biochem Biophys Res Commun 298:377-82. 2002
    ....
  39. pmc The other end of the rainbow: infrared and skin
    Aton M Holzer
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Avenue S, Birmingham, AL 35294, USA
    J Invest Dermatol 130:1496-9. 2010
    ..Their work paves the way for new research directions in IRA photobiology and raises important clinical questions regarding photoprotection and IRR-based dermatotherapy...
  40. pmc Immunoprevention of basal cell carcinomas with recombinant hedgehog-interacting protein
    Annika Vogt
    Department of Dermatology, University of California San Francisco, 94143, USA
    J Exp Med 199:753-61. 2004
    ....
  41. pmc Targeting ornithine decarboxylase for the prevention of nonmelanoma skin cancer in humans
    Craig A Elmets
    Department of Dermatology, UAB Skin Diseases Research Center and UAB Comprehensive Cancer Center, The University of Alabama at Birmingham, 35294 0019, USA
    Cancer Prev Res (Phila) 3:8-11. 2010
    ..discusses our knowledge of the contribution of polyamines to BCC pathogenesis, how this knowledge advanced the development of a new method to prevent BCCs, and prospects for future studies of DFMO in BCC prevention...
  42. pmc Delphinidin reduces cell proliferation and induces apoptosis of non-small-cell lung cancer cells by targeting EGFR/VEGFR2 signaling pathways
    Harish Chandra Pal
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 8:e77270. 2013
    ..Based on these observations, we suggest that delphinidin, alone or as an adjuvant to current therapies, could be used for the management of NSCLC, especially those that overexpress EGFR and VEGFR2. ..
  43. pmc Prospects for skin cancer treatment and prevention: the potential contribution of an engineered virus
    Jennifer A Cafardi
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    J Invest Dermatol 131:559-61. 2011
    ..These results suggest that such an enzyme may be incorporated into regimens for the chemoprevention of skin cancers...
  44. ncbi request reprint Oxidative stress in the pathogenesis of skin disease
    David R Bickers
    Department of Dermatology, Columbia University Medical Center, New York, New York, USA
    J Invest Dermatol 126:2565-75. 2006
    ..Although many antioxidants have shown substantive efficacy in cell culture systems and in animal models of oxidant injury, unequivocal confirmation of their beneficial effects in human populations has proven elusive...
  45. ncbi request reprint Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches
    Kathy P An
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 76:73-80. 2002
    ..In summary, enhanced COX-2 expression serves as a marker of epidermal UVB exposure for murine and human NMSC. These results suggest that COX-2 inhibitors could have potent anticarcinogenic effects in UVB-induced skin cancer...
  46. pmc Low intensity shear stress increases endothelial ELR+ CXC chemokine production via a focal adhesion kinase-p38{beta} MAPK-NF-{kappa}B pathway
    Sadiq S Shaik
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Biol Chem 284:5945-55. 2009
    ....
  47. pmc Grape seeds: ripe for cancer chemoprevention
    Santosh K Katiyar
    Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Prev Res (Phila) 6:617-21. 2013
    ..Notably, the demonstration that miRNA expression is affected by dietary GSE suggests a novel underlying mechanism for the chemopreventive action of GSE in colon cancer and, potentially, other cancers...
  48. pmc Role of epidermal primary cilia in the homeostasis of skin and hair follicles
    Mandy J Croyle
    Department of Cell Biology, University of Alabama at Birmingham Medical School, Birmingham, AL 35294, USA
    Development 138:1675-85. 2011
    ..Collectively, these data indicate that epidermal primary cilia may function in stress responses and epidermal homeostasis involving pathways other than those typically associated with primary cilia...
  49. pmc TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine
    Akhil Maheshwari
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Gastroenterology 140:242-53. 2011
    ..We investigated whether NEC occurs in the preterm intestine due to incomplete noninflammatory differentiation of intestinal macrophages, which increases the risk of a severe mucosal inflammatory response to bacterial products...
  50. ncbi request reprint Stage-specific alterations of cyclin expression during UVB-induced murine skin tumor development
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Photochem Photobiol 75:58-67. 2002
    ..Cyclin D1 and p53 overexpression were coupled with the development of tumors, and these changes are likely to be relevant to the pathogenesis of these lesions...
  51. ncbi request reprint Ultraviolet-B-induced G1 arrest is mediated by downregulation of cyclin-dependent kinase 4 in transformed keratinocytes lacking functional p53
    Arianna L Kim
    Department of Dermatology, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Invest Dermatol 118:818-24. 2002
    ..This identifies a novel pathway for G1 cell cycle arrest in transformed keratinocytes following ultraviolet-B irradiation...